(23 nodes) Negative regulation of lipid catabolic process network (Delphinapterus leucas)

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Your Input:
	LTK	LOW QUALITY PROTEIN: leukocyte tyrosine kinase receptor. (922 aa)
	LOC111176900	GTPase IMAP family member 5-like isoform X1. (332 aa)
	ETFBKMT	Electron transfer flavoprotein beta subunit lysine methyltransferase. (266 aa)
	PLIN5	Perilipin; Belongs to the perilipin family. (454 aa)
	APOA2	Apolipoprotein A-II. (103 aa)
	IL1B	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (266 aa)
	TNF	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa)
	LOC111186928	Hydroxycarboxylic acid receptor 1-like; Belongs to the G-protein coupled receptor 1 family. (335 aa)
	PRKAA1	Non-specific serine/threonine protein kinase. (559 aa)
	BSCL2	Seipin isoform X4. (495 aa)
	APOC3	Apolipoprotein C-III. (99 aa)
	PDE3B	Phosphodiesterase. (1120 aa)
	SORL1	Sortilin-related receptor isoform X1. (2211 aa)
	GPLD1	Phosphatidylinositol-glycan-specific phospholipase D isoform X1. (849 aa)
	FMC1	Protein FMC1 homolog. (113 aa)
	ACACB	acetyl-CoA carboxylase 2 isoform X1. (2456 aa)
	CIDEA	Cell death activator CIDE-A. (219 aa)
	MFSD2A	Sodium-dependent lysophosphatidylcholine symporter 1 isoform X1. (565 aa)
	ADRA2A	alpha-2A adrenergic receptor. (465 aa)
	CRTC3	CREB-regulated transcription coactivator 3 isoform X1. (619 aa)
	INS	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
	LOC111183400	CREB-regulated transcription coactivator 3-like. (208 aa)
	LRRN4CL	LRRN4 C-terminal-like protein. (230 aa)

Your Current Organism:

Delphinapterus leucas

NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACACB	PRKAA1	A0A2Y9LD97	A0A2Y9Q9L7	acetyl-CoA carboxylase 2 isoform X1.	Non-specific serine/threonine protein kinase.	0.924
APOA2	APOC3	A0A2Y9LZM5	A0A2Y9LYW0	Apolipoprotein A-II.	Apolipoprotein C-III.	0.994
APOA2	GPLD1	A0A2Y9LZM5	A0A2Y9M7A3	Apolipoprotein A-II.	Phosphatidylinositol-glycan-specific phospholipase D isoform X1.	0.465
APOC3	APOA2	A0A2Y9LYW0	A0A2Y9LZM5	Apolipoprotein C-III.	Apolipoprotein A-II.	0.994
APOC3	GPLD1	A0A2Y9LYW0	A0A2Y9M7A3	Apolipoprotein C-III.	Phosphatidylinositol-glycan-specific phospholipase D isoform X1.	0.474
CIDEA	INS	A0A2Y9LJ46	A0A2Y9PTW5	Cell death activator CIDE-A.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.497
CIDEA	PLIN5	A0A2Y9LJ46	A0A2Y9LTJ3	Cell death activator CIDE-A.	Perilipin; Belongs to the perilipin family.	0.770
GPLD1	APOA2	A0A2Y9M7A3	A0A2Y9LZM5	Phosphatidylinositol-glycan-specific phospholipase D isoform X1.	Apolipoprotein A-II.	0.465
GPLD1	APOC3	A0A2Y9M7A3	A0A2Y9LYW0	Phosphatidylinositol-glycan-specific phospholipase D isoform X1.	Apolipoprotein C-III.	0.474
IL1B	INS	Q8WNR2	A0A2Y9PTW5	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.673
IL1B	TNF	Q8WNR2	Q8WNR1	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...]	0.936
INS	CIDEA	A0A2Y9PTW5	A0A2Y9LJ46	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Cell death activator CIDE-A.	0.497
INS	IL1B	A0A2Y9PTW5	Q8WNR2	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	0.673
INS	LTK	A0A2Y9PTW5	A0A2Y9P7V7	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	LOW QUALITY PROTEIN: leukocyte tyrosine kinase receptor.	0.486
INS	PLIN5	A0A2Y9PTW5	A0A2Y9LTJ3	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Perilipin; Belongs to the perilipin family.	0.544
INS	SORL1	A0A2Y9PTW5	A0A2Y9M4D5	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Sortilin-related receptor isoform X1.	0.503
INS	TNF	A0A2Y9PTW5	Q8WNR1	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...]	0.687
LTK	INS	A0A2Y9P7V7	A0A2Y9PTW5	LOW QUALITY PROTEIN: leukocyte tyrosine kinase receptor.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.486
PDE3B	PLIN5	A0A2Y9M275	A0A2Y9LTJ3	Phosphodiesterase.	Perilipin; Belongs to the perilipin family.	0.692
PLIN5	CIDEA	A0A2Y9LTJ3	A0A2Y9LJ46	Perilipin; Belongs to the perilipin family.	Cell death activator CIDE-A.	0.770