STRINGSTRING
IL10 IL10 TSPAN32 TSPAN32 DLG5 DLG5 VSIR VSIR NDFIP1 NDFIP1 LAX1 LAX1 PRKAR1A PRKAR1A TBC1D10C TBC1D10C CD74 CD74 LOC111182867 LOC111182867 TYROBP TYROBP FOXJ1 FOXJ1 GPNMB GPNMB SMAD7 SMAD7 IRF1 IRF1 SOCS6 SOCS6 PTPN22 PTPN22 THOC1 THOC1 TYRO3 TYRO3 TNFRSF21 TNFRSF21 IL4I1 IL4I1 TGFB1 TGFB1 AXL AXL IL20RB IL20RB BANK1 BANK1 RC3H2 RC3H2 LOC111176900 LOC111176900 LAG3 LAG3 LRRC1 LRRC1 BTK BTK LOC111178657 LOC111178657 HLX HLX PTPN6 PTPN6 PIBF1 PIBF1 NRARP NRARP SAMSN1 SAMSN1 SHH SHH PDCD1LG2 PDCD1LG2 LOC111175407 LOC111175407 IDO1 IDO1 FGL1 FGL1 ZC3H12A ZC3H12A CD274 CD274 SOCS5 SOCS5 ARG2 ARG2 ANXA1 ANXA1 PARP3 PARP3 NCKAP1L NCKAP1L CLNK CLNK INPP5D INPP5D SFRP1 SFRP1 CTLA4 CTLA4 BMP4 BMP4 BCL6 BCL6 MARCH7 MARCH7 IHH IHH DLG1 DLG1 MAD1L1 MAD1L1 RC3H1 RC3H1 CD86 CD86 SOX11 SOX11 TNFRSF13B TNFRSF13B DUSP3 DUSP3 CD80 CD80 FOXP3 FOXP3 TNFAIP8L2 TNFAIP8L2 LOXL3 LOXL3 VSIG4 VSIG4 PGLYRP2 PGLYRP2 HFE HFE ZBTB7B ZBTB7B RIPOR2 RIPOR2 ATM ATM CRTAM CRTAM ERBB2 ERBB2 ILDR2 ILDR2 PAWR PAWR TIGIT TIGIT LOC111167004 LOC111167004 LYN LYN TNFAIP3 TNFAIP3 PKN1 PKN1 TBX21 TBX21 LOC111166170 LOC111166170 ADORA2A ADORA2A FGL2 FGL2 PAG1 PAG1 PLA2G2D PLA2G2D GLMN GLMN PTPN2 PTPN2 TWSG1 TWSG1 SOCS1 SOCS1 RHBDD3 RHBDD3 BLK BLK FGR FGR PLA2G2F PLA2G2F MERTK MERTK FBXO7 FBXO7 TMEM131L TMEM131L PELI1 PELI1 ZC3H8 ZC3H8 CEBPB CEBPB LGALS9 LGALS9 GLI3 GLI3 ITCH ITCH CBLB CBLB DLG2 DLG2 LRRC32 LRRC32 RASSF5 RASSF5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IL10Interleukin-10. (178 aa)
TSPAN32Tetraspanin-32 isoform X1; Belongs to the tetraspanin (TM4SF) family. (571 aa)
DLG5Disks large homolog 5 isoform X1; Belongs to the MAGUK family. (1980 aa)
VSIRV-type immunoglobulin domain-containing suppressor of T-cell activation. (311 aa)
NDFIP1NEDD4 family-interacting protein 1. (221 aa)
LAX1LOW QUALITY PROTEIN: lymphocyte transmembrane adapter 1. (430 aa)
PRKAR1AcAMP-dependent protein kinase type I-alpha regulatory subunit. (380 aa)
TBC1D10CCarabin isoform X1. (458 aa)
CD74HLA class II histocompatibility antigen gamma chain isoform X1. (278 aa)
LOC111182867CMRF35-like molecule 8 isoform X1. (313 aa)
TYROBPTYRO protein tyrosine kinase-binding protein isoform X1. (126 aa)
FOXJ1Forkhead box protein J1. (422 aa)
GPNMBTransmembrane glycoprotein NMB. (553 aa)
SMAD7Mothers against decapentaplegic homolog. (426 aa)
IRF1Interferon regulatory factor. (322 aa)
SOCS6Suppressor of cytokine signaling 6. (535 aa)
PTPN22Tyrosine-protein phosphatase non-receptor type 22 isoform X1. (801 aa)
THOC1THO complex subunit 1. (657 aa)
TYRO3Tyrosine-protein kinase receptor TYRO3 isoform X3. (896 aa)
TNFRSF21Tumor necrosis factor receptor superfamily member 21 isoform X3. (701 aa)
IL4I1L-amino-acid oxidase isoform X1. (653 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
AXLLOW QUALITY PROTEIN: tyrosine-protein kinase receptor UFO. (887 aa)
IL20RBInterleukin-20 receptor subunit beta isoform X1. (342 aa)
BANK1B-cell scaffold protein with ankyrin repeats isoform X1. (785 aa)
RC3H2Roquin-2. (1189 aa)
LOC111176900GTPase IMAP family member 5-like isoform X1. (332 aa)
LAG3Lymphocyte activation gene 3 protein. (493 aa)
LRRC1Leucine-rich repeat-containing protein 1. (395 aa)
BTKTyrosine-protein kinase. (687 aa)
LOC111178657Leucine-rich repeat-containing protein 1-like isoform X1. (174 aa)
HLXH2.0-like homeobox protein. (488 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
PIBF1Progesterone-induced-blocking factor 1 isoform X1. (757 aa)
NRARPNotch-regulated ankyrin repeat-containing protein. (114 aa)
SAMSN1SAM domain-containing protein SAMSN-1. (373 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (461 aa)
PDCD1LG2Programmed cell death 1 ligand 2 isoform X1. (337 aa)
LOC111175407Amine oxidase. (524 aa)
IDO1Indoleamine 2,3-dioxygenase 1 isoform X1. (410 aa)
FGL1Fibrinogen-like protein 1. (315 aa)
ZC3H12AEndoribonuclease ZC3H12A. (583 aa)
CD274Programmed cell death 1 ligand 1 isoform X2. (312 aa)
SOCS5Suppressor of cytokine signaling 5. (536 aa)
ARG2Arginase. (354 aa)
ANXA1Annexin. (346 aa)
PARP3Poly [ADP-ribose] polymerase. (586 aa)
NCKAP1LNck-associated protein 1-like isoform X1. (1156 aa)
CLNKCytokine-dependent hematopoietic cell linker isoform X1. (452 aa)
INPP5DPhosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1. (1150 aa)
SFRP1Secreted frizzled-related protein 1. (308 aa)
CTLA4Cytotoxic T-lymphocyte protein 4 isoform X1. (223 aa)
BMP4Bone morphogenetic protein 4 isoform X2. (408 aa)
BCL6B-cell lymphoma 6 protein. (706 aa)
MARCH7E3 ubiquitin-protein ligase MARCH7 isoform X1. (717 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (410 aa)
DLG1Disks large homolog 1 isoform X1; Belongs to the MAGUK family. (927 aa)
MAD1L1Mitotic spindle assembly checkpoint protein MAD1 isoform X2. (735 aa)
RC3H1Roquin-1 isoform X1. (1135 aa)
CD86T-lymphocyte activation antigen CD86 isoform X1. (344 aa)
SOX11Transcription factor SOX. (454 aa)
TNFRSF13BTumor necrosis factor receptor superfamily member 13B isoform X1. (284 aa)
DUSP3Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (185 aa)
CD80T-lymphocyte activation antigen CD80 isoform X1. (295 aa)
FOXP3Forkhead box protein P3. (431 aa)
TNFAIP8L2Tumor necrosis factor alpha-induced protein 8-like protein 2 isoform X1. (204 aa)
LOXL3Lysyl oxidase homolog 3 isoform X1. (772 aa)
VSIG4V-set and immunoglobulin domain-containing protein 4. (399 aa)
PGLYRP2N-acetylmuramoyl-L-alanine amidase isoform X1. (581 aa)
HFEHereditary hemochromatosis protein isoform X1; Belongs to the MHC class I family. (356 aa)
ZBTB7BZinc finger and BTB domain-containing protein 7B. (541 aa)
RIPOR2Rho family-interacting cell polarization regulator 2 isoform X2. (1048 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3064 aa)
CRTAMCytotoxic and regulatory T-cell molecule isoform X1. (391 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
ILDR2Immunoglobulin-like domain-containing receptor 2. (639 aa)
PAWRPRKC apoptosis WT1 regulator protein. (345 aa)
TIGITT-cell immunoreceptor with Ig and ITIM domains. (243 aa)
LOC111167004LOW QUALITY PROTEIN: peptidoglycan recognition protein 3-like. (277 aa)
LYNTyrosine-protein kinase. (518 aa)
TNFAIP3Tumor necrosis factor alpha-induced protein 3. (785 aa)
PKN1Serine/threonine-protein kinase N1 isoform X1. (950 aa)
TBX21T-box transcription factor TBX21. (535 aa)
LOC111166170C-type lectin domain family 4 member G-like isoform X1. (313 aa)
ADORA2AAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (408 aa)
FGL2Fibroleukin. (440 aa)
PAG1Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 isoform X2. (436 aa)
PLA2G2DPhospholipase A(2). (161 aa)
GLMNGlomulin. (592 aa)
PTPN2Tyrosine-protein phosphatase non-receptor type 2 isoform X3. (474 aa)
TWSG1Twisted gastrulation protein homolog 1. (223 aa)
SOCS1Suppressor of cytokine signaling 1. (215 aa)
RHBDD3Rhomboid domain-containing protein 3. (386 aa)
BLKTyrosine-protein kinase. (501 aa)
FGRTyrosine-protein kinase. (526 aa)
PLA2G2FPhospholipase A(2). (300 aa)
MERTKTyrosine-protein kinase Mer. (999 aa)
FBXO7F-box only protein 7 isoform X1. (523 aa)
TMEM131LTransmembrane protein 131-like isoform X1. (1608 aa)
PELI1E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (418 aa)
ZC3H8Zinc finger CCCH domain-containing protein 8 isoform X1. (308 aa)
CEBPBCCAAT/enhancer-binding protein. (345 aa)
LGALS9Galectin. (356 aa)
GLI3Transcriptional activator GLI3 isoform X1. (1587 aa)
ITCHE3 ubiquitin-protein ligase. (862 aa)
CBLBE3 ubiquitin-protein ligase CBL-B. (983 aa)
DLG2Disks large homolog 2 isoform X1. (994 aa)
LRRC32Leucine-rich repeat-containing protein 32 isoform X1. (676 aa)
RASSF5Ras association domain-containing protein 5 isoform X1. (422 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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