STRINGSTRING
MYORG MYORG CCL19 CCL19 FAM110D FAM110D CCL21 CCL21 NTS NTS OSM OSM F3 F3 RET RET ITGB1BP1 ITGB1BP1 TEK TEK PIK3CG PIK3CG INSR INSR CSF3 CSF3 PHB PHB GDF15 GDF15 OSBPL8 OSBPL8 MYOC MYOC HAX1 HAX1 FAM110B FAM110B FAM110C FAM110C MYDGF MYDGF PDGFA PDGFA CX3CR1 CX3CR1 HCLS1 HCLS1 CD28 CD28 LRP2 LRP2 MFHAS1 MFHAS1 TCF7L2 TCF7L2 PIK3CA PIK3CA ADAM8 ADAM8 THPO THPO FERMT2 FERMT2 FGFR1 FGFR1 TNFSF11 TNFSF11 F10 F10 IL26 IL26 ENG ENG MST1R MST1R GAS6 GAS6 SPRY2 SPRY2 F7 F7 GFRAL GFRAL PIK3CB PIK3CB GATA3 GATA3 MEIS3 MEIS3 AXL AXL TGFB1 TGFB1 GCNT2 GCNT2 STK3 STK3 MAZ MAZ HBEGF HBEGF LOC111181354 LOC111181354 LEP LEP TPBG TPBG THBS1 THBS1 STOX1 STOX1 C1QTNF1 C1QTNF1 SRC SRC INS INS NOX4 NOX4 FAM110A FAM110A RAMP3 RAMP3 EGFR EGFR CHI3L1 CHI3L1 ARRB2 ARRB2 C1QBP C1QBP C1QTNF12 C1QTNF12 IGF1R IGF1R C1QTNF6 C1QTNF6 RTN4 RTN4 CASS4 CASS4 TGFBR1 TGFBR1 PIK3CD PIK3CD RICTOR RICTOR HPSE HPSE Ob Ob TNF TNF
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MYORGUncharacterized family 31 glucosidase KIAA1161 homolog isoform X1; Belongs to the glycosyl hydrolase 31 family. (791 aa)
CCL19C-C motif chemokine. (159 aa)
FAM110DProtein FAM110D. (304 aa)
CCL21C-C motif chemokine 21 isoform X1. (131 aa)
NTSNeurotensin/neuromedin N isoform X1. (170 aa)
OSMoncostatin-M. (246 aa)
F3Tissue factor; Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade. (292 aa)
RETProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1113 aa)
ITGB1BP1Integrin beta-1-binding protein 1 isoform X1. (206 aa)
TEKAngiopoietin-1 receptor. (1125 aa)
PIK3CGPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1; Belongs to the PI3/PI4-kinase family. (1102 aa)
INSRTyrosine-protein kinase receptor. (1392 aa)
CSF3Granulocyte colony-stimulating factor. (195 aa)
PHBProhibitin. (272 aa)
GDF15Growth/differentiation factor 15. (308 aa)
OSBPL8Oxysterol-binding protein; Belongs to the OSBP family. (889 aa)
MYOCMyocilin. (476 aa)
HAX1HCLS1-associated protein X-1; Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex. Slows down the rate of inactivation of KCNC3 channels. Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools. (276 aa)
FAM110BProtein FAM110B. (370 aa)
FAM110CProtein FAM110C. (321 aa)
MYDGFMyeloid-derived growth factor isoform X1. (175 aa)
PDGFAPlatelet-derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (196 aa)
CX3CR1CX3C chemokine receptor 1 isoform X1; Belongs to the G-protein coupled receptor 1 family. (475 aa)
HCLS1Hematopoietic lineage cell-specific protein. (481 aa)
CD28T-cell-specific surface glycoprotein CD28. (265 aa)
LRP2Low-density lipoprotein receptor-related protein 2. (4838 aa)
MFHAS1Malignant fibrous histiocytoma-amplified sequence 1 isoform X1. (1058 aa)
TCF7L2Transcription factor 7-like 2 isoform X1. (668 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
ADAM8Disintegrin and metalloproteinase domain-containing protein 8 isoform X1. (838 aa)
THPOThrombopoietin isoform X1. (324 aa)
FERMT2Fermitin family homolog 2 isoform X2. (691 aa)
FGFR1Fibroblast growth factor receptor. (823 aa)
TNFSF11Tumor necrosis factor ligand superfamily member 11; Belongs to the tumor necrosis factor family. (322 aa)
F10Coagulation factor X isoform X1. (480 aa)
IL26Interleukin-26. (171 aa)
ENGEndoglin. (652 aa)
MST1RMacrophage-stimulating protein receptor isoform X1. (1406 aa)
GAS6Growth arrest-specific protein 6. (671 aa)
SPRY2Protein sprouty homolog 2. (315 aa)
F7Coagulation factor VII isoform X1. (447 aa)
GFRALLOW QUALITY PROTEIN: GDNF family receptor alpha-like. (397 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
GATA3Trans-acting T-cell-specific transcription factor GATA-3 isoform X1. (444 aa)
MEIS3Homeobox protein Meis3 isoform X1. (379 aa)
AXLLOW QUALITY PROTEIN: tyrosine-protein kinase receptor UFO. (887 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
GCNT2N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase isoform X1. (419 aa)
STK3Serine/threonine-protein kinase 3. (491 aa)
MAZMyc-associated zinc finger protein isoform X1. (495 aa)
HBEGFProheparin-binding EGF-like growth factor. (208 aa)
LOC111181354N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase-like. (321 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (166 aa)
TPBGTrophoblast glycoprotein. (419 aa)
THBS1Thrombospondin-1. (1170 aa)
STOX1Storkhead-box protein 1 isoform X1. (990 aa)
C1QTNF1LOW QUALITY PROTEIN: complement C1q tumor necrosis factor-related protein 1. (279 aa)
SRCTyrosine-protein kinase. (562 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
NOX4NADPH oxidase 4. (530 aa)
FAM110AProtein FAM110A. (295 aa)
RAMP3Receptor activity-modifying protein 3. (151 aa)
EGFRReceptor protein-tyrosine kinase. (1209 aa)
CHI3L1LOW QUALITY PROTEIN: chitinase-3-like protein 1; Belongs to the glycosyl hydrolase 18 family. (393 aa)
ARRB2Beta-arrestin-2 isoform X1. (409 aa)
C1QBPComplement component 1 Q subcomponent-binding protein, mitochondrial. (278 aa)
C1QTNF12Adipolin. (299 aa)
IGF1RTyrosine-protein kinase receptor. (1368 aa)
C1QTNF6Complement C1q tumor necrosis factor-related protein 6. (266 aa)
RTN4Reticulon. (1192 aa)
CASS4Cas scaffolding protein family member 4 isoform X1. (821 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (919 aa)
RICTORRapamycin-insensitive companion of mTOR isoform X1. (1732 aa)
HPSEHeparanase isoform X1. (542 aa)
ObLeptin isoform X1. (167 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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