STRINGSTRING
LDLRAP1 LDLRAP1 PLA2G10 PLA2G10 MED13 MED13 XBP1 XBP1 LOC111164038 LOC111164038 ABHD4 ABHD4 ACOX3 ACOX3 RALYL RALYL ACACA ACACA GPIHBP1 GPIHBP1 NR1D2 NR1D2 ABCG1 ABCG1 ADCK5 ADCK5 ZBTB20 ZBTB20 SOAT1 SOAT1 DDX3X DDX3X LOC111164821 LOC111164821 ANGPTL8 ANGPTL8 LOC111164929 LOC111164929 LOC111165853 LOC111165853 NFE2L1 NFE2L1 DGAT1 DGAT1 G6PC G6PC ABHD5 ABHD5 NR1D1 NR1D1 TM6SF2 TM6SF2 APOC3 APOC3 APOA1 APOA1 APOA2 APOA2 NUS1 NUS1 PNPLA4 PNPLA4 ANGPTL4 ANGPTL4 TMEM136 TMEM136 LOC111167399 LOC111167399 LOC111167138 LOC111167138 ABCG4 ABCG4 ORMDL3 ORMDL3 ABHD8 ABHD8 LDLR LDLR APOA4 APOA4 LPL LPL SLC37A4 SLC37A4 APOA5 APOA5 USF1 USF1 LOC111167398 LOC111167398 PNPLA2 PNPLA2 FUNDC2 FUNDC2 ABCD1 ABCD1 NR5A2 NR5A2 CAV3 CAV3 GPAM GPAM ABCB11 ABCB11 LAMTOR1 LAMTOR1 SOAT2 SOAT2 LOC111171395 LOC111171395 GOT1 GOT1 ORMDL1 ORMDL1 ABCG5 ABCG5 TTC39B TTC39B TTC39A TTC39A GCKR GCKR THADA THADA ACOX2 ACOX2 APOB APOB PCSK9 PCSK9 ORMDL2 ORMDL2 LIMA1 LIMA1 ABCA2 ABCA2 RORA RORA ADCK1 ADCK1 SURF4 SURF4 ANGPTL3 ANGPTL3 INSIG1 INSIG1 MTTP MTTP LCAT LCAT MALRD1 MALRD1 LIPG LIPG LIPC LIPC CAV1 CAV1 TREM2 TREM2 NR1H2 NR1H2 TGFB1 TGFB1 APOC4 APOC4 LOC111178887 LOC111178887 COMMD9 COMMD9 POLD1 POLD1 MYLIP MYLIP NPC1 NPC1 FAM57B FAM57B RCN3 RCN3 SAR1B SAR1B USF2 USF2 ACOX1 ACOX1 SIRT1 SIRT1 PLA2G12B PLA2G12B FITM2 FITM2 EHD1 EHD1 NR1H3 NR1H3 MTCH2 MTCH2 INS INS LRP5 LRP5 SLC25A46 SLC25A46 TSKU TSKU HNF4A HNF4A TLCD2 TLCD2 COL4A3BP COL4A3BP RALY RALY PNPLA8 PNPLA8 NPC1L1 NPC1L1 LOC111185591 LOC111185591 LOC111185777 LOC111185777 EPHX2 EPHX2 PLSCR3 PLSCR3 TLCD1 TLCD1 SCARB1 SCARB1 FAM57A FAM57A NR1H4 NR1H4 SREBF2 SREBF2 PNPLA3 PNPLA3 RTN4 RTN4 C1QTNF3 C1QTNF3 ATP13A2 ATP13A2 ACOXL ACOXL ABCA1 ABCA1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LDLRAP1LOW QUALITY PROTEIN: low density lipoprotein receptor adapter protein 1. (309 aa)
PLA2G10Phospholipase A(2). (159 aa)
MED13Mediator of RNA polymerase II transcription subunit 13; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (2174 aa)
XBP1LOW QUALITY PROTEIN: X-box-binding protein 1. (392 aa)
LOC111164038Transmembrane protein 56-like. (263 aa)
ABHD4Protein ABHD4 isoform X1. (355 aa)
ACOX3Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (606 aa)
RALYLRNA-binding Raly-like protein. (310 aa)
ACACAacetyl-CoA carboxylase 1 isoform X1. (2383 aa)
GPIHBP1Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1. (199 aa)
NR1D2Nuclear receptor subfamily 1 group D member 2 isoform X1. (575 aa)
ABCG1ATP-binding cassette sub-family G member 1 isoform X1. (693 aa)
ADCK5Uncharacterized aarF domain-containing protein kinase 5 isoform X1. (591 aa)
ZBTB20Zinc finger and BTB domain-containing protein 20 isoform X1. (741 aa)
SOAT1O-acyltransferase. (550 aa)
DDX3XATP-dependent RNA helicase DDX3X isoform X1; Belongs to the DEAD box helicase family. (662 aa)
LOC111164821Peroxisomal acyl-coenzyme A oxidase 3-like. (484 aa)
ANGPTL8Angiopoietin-like protein 8 isoform X1. (242 aa)
LOC111164929Fatty acid-binding protein, adipocyte; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (132 aa)
LOC111165853Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. (501 aa)
NFE2L1Nuclear factor erythroid 2-related factor 1 isoform X1. (777 aa)
DGAT1O-acyltransferase. (491 aa)
G6PCGlucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (357 aa)
ABHD51-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform X1. (389 aa)
NR1D1Nuclear receptor subfamily 1 group D member 1. (613 aa)
TM6SF2Transmembrane 6 superfamily member 2. (376 aa)
APOC3Apolipoprotein C-III. (99 aa)
APOA1Apolipoprotein A-I. (265 aa)
APOA2Apolipoprotein A-II. (103 aa)
NUS1Dehydrodolichyl diphosphate synthase complex subunit NUS1 isoform X1. (326 aa)
PNPLA4Patatin-like phospholipase domain-containing protein 4 isoform X1. (256 aa)
ANGPTL4Angiopoietin-related protein 4. (412 aa)
TMEM136Transmembrane protein 136 isoform X1. (267 aa)
LOC111167399GRAM domain-containing protein 2B-like isoform X1. (304 aa)
LOC111167138LOW QUALITY PROTEIN: olfactory receptor 10J5-like. (299 aa)
ABCG4ATP-binding cassette sub-family G member 4 isoform X1. (646 aa)
ORMDL3ORM1-like protein; Negative regulator of sphingolipid synthesis. (153 aa)
ABHD8Protein ABHD8. (432 aa)
LDLRLow-density lipoprotein receptor. (857 aa)
APOA4Apolipoprotein A-IV isoform X1. (380 aa)
LPLLipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans. (478 aa)
SLC37A4Glucose-6-phosphate exchanger SLC37A4 isoform X1. (429 aa)
APOA5Apolipoprotein A-V isoform X1. (390 aa)
USF1Upstream stimulatory factor 1 isoform X1. (310 aa)
LOC111167398GRAM domain-containing protein 1B isoform X1. (694 aa)
PNPLA2Patatin-like phospholipase domain-containing protein 2 isoform X1. (489 aa)
FUNDC2FUN14 domain-containing protein 2. (189 aa)
ABCD1ATP-binding cassette sub-family D member 1 isoform X1. (774 aa)
NR5A2Nuclear receptor subfamily 5 group A member 2 isoform X1. (501 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
GPAMGlycerol-3-phosphate acyltransferase 1, mitochondrial. (877 aa)
ABCB11Bile salt export pump isoform X1. (1340 aa)
LAMTOR1Ragulator complex protein LAMTOR1. (161 aa)
SOAT2O-acyltransferase. (539 aa)
LOC111171395Cation-transporting ATPase 13A2-like. (209 aa)
GOT1Aspartate aminotransferase. (413 aa)
ORMDL1ORM1-like protein; Negative regulator of sphingolipid synthesis. (153 aa)
ABCG5LOW QUALITY PROTEIN: ATP-binding cassette sub-family G member 5. (652 aa)
TTC39BTetratricopeptide repeat protein 39B isoform X1. (691 aa)
TTC39ATetratricopeptide repeat protein 39A isoform X1. (581 aa)
GCKRLOW QUALITY PROTEIN: glucokinase regulatory protein. (618 aa)
THADAThyroid adenoma-associated protein isoform X1. (1945 aa)
ACOX2Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (733 aa)
APOBApolipoprotein B-100. (4566 aa)
PCSK9Proprotein convertase subtilisin/kexin type 9 isoform X1. (692 aa)
ORMDL2ORM1-like protein; Negative regulator of sphingolipid synthesis. (153 aa)
LIMA1LIM domain and actin-binding protein 1 isoform X1. (766 aa)
ABCA2ATP-binding cassette sub-family A member 2 isoform X1. (2438 aa)
RORANuclear receptor ROR-alpha isoform X1. (523 aa)
ADCK1Uncharacterized aarF domain-containing protein kinase 1 isoform X1. (544 aa)
SURF4Surfeit locus protein 4. (269 aa)
ANGPTL3Angiopoietin-related protein 3. (460 aa)
INSIG1Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. (294 aa)
MTTPMicrosomal triglyceride transfer protein large subunit. (894 aa)
LCATPhosphatidylcholine-sterol acyltransferase isoform X1. (440 aa)
MALRD1MAM and LDL-receptor class A domain-containing protein 1. (2150 aa)
LIPGEndothelial lipase. (505 aa)
LIPCHepatic triacylglycerol lipase isoform X1. (510 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (294 aa)
NR1H2Oxysterols receptor LXR-beta isoform X1. (450 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
APOC4Apolipoprotein C-IV. (127 aa)
LOC11117888724-hydroxycholesterol 7-alpha-hydroxylase; Belongs to the cytochrome P450 family. (469 aa)
COMMD9COMM domain-containing protein 9 isoform X1. (205 aa)
POLD1DNA polymerase. (1107 aa)
MYLIPE3 ubiquitin-protein ligase MYLIP. (445 aa)
NPC1Niemann-Pick C1 protein isoform X1. (1277 aa)
FAM57BProtein FAM57B. (275 aa)
RCN3Reticulocalbin-3 isoform X1. (360 aa)
SAR1BGTP-binding protein SAR1b; Belongs to the small GTPase superfamily. SAR1 family. (198 aa)
USF2Upstream stimulatory factor 2. (347 aa)
ACOX1Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (661 aa)
SIRT1NAD-dependent protein deacetylase sirtuin-1 isoform X1. (735 aa)
PLA2G12BGroup XIIB secretory phospholipase A2-like protein isoform X1. (195 aa)
FITM2Fat storage-inducing transmembrane protein 2. (271 aa)
EHD1EH domain-containing protein 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (534 aa)
NR1H3Oxysterols receptor LXR-alpha isoform X1. (447 aa)
MTCH2Mitochondrial carrier homolog 2; Belongs to the mitochondrial carrier (TC 2.A.29) family. (303 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
LRP5Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1622 aa)
SLC25A46Solute carrier family 25 member 46 isoform X2; Belongs to the mitochondrial carrier (TC 2.A.29) family. (445 aa)
TSKUTsukushin isoform X1. (367 aa)
HNF4AHepatocyte nuclear factor 4-alpha isoform X1. (484 aa)
TLCD2TLC domain-containing protein 2 isoform X1. (264 aa)
COL4A3BPCollagen type IV alpha-3-binding protein isoform X2. (755 aa)
RALYRNA-binding protein Raly isoform X1. (310 aa)
PNPLA8Calcium-independent phospholipase A2-gamma isoform X1. (784 aa)
NPC1L1Niemann-Pick C1-like protein 1 isoform X1. (1331 aa)
LOC11118559125-hydroxycholesterol 7-alpha-hydroxylase isoform X1; Belongs to the cytochrome P450 family. (502 aa)
LOC111185777Asialoglycoprotein receptor 2-like isoform X1. (302 aa)
EPHX2Bifunctional epoxide hydrolase 2 isoform X1. (555 aa)
PLSCR3Phospholipid scramblase; May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. Belongs to the phospholipid scramblase family. (295 aa)
TLCD1Calfacilitin. (247 aa)
SCARB1Scavenger receptor class B member 1 isoform X1; Belongs to the CD36 family. (511 aa)
FAM57AProtein FAM57A isoform X1. (258 aa)
NR1H4Bile acid receptor isoform X1. (486 aa)
SREBF2Sterol regulatory element-binding protein 2 isoform X1. (1135 aa)
PNPLA3Patatin-like phospholipase domain-containing protein 3 isoform X1. (415 aa)
RTN4Reticulon. (1192 aa)
C1QTNF3Complement C1q tumor necrosis factor-related protein 3 isoform X1. (319 aa)
ATP13A2Cation-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. (966 aa)
ACOXLLOW QUALITY PROTEIN: acyl-coenzyme A oxidase-like protein. (524 aa)
ABCA1ATP-binding cassette sub-family A member 1 isoform X1. (2273 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
Server load: low (30%) [HD]