(48 nodes) Cardiac septum morphogenesis network (Delphinapterus leucas)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PARVA	Alpha-parvin isoform X1. (416 aa)
	ISL1	Insulin gene enhancer protein ISL-1. (349 aa)
	HEY2	Hairy/enhancer-of-split related with YRPW motif protein 2. (337 aa)
	SEMA3C	semaphorin-3C; Belongs to the semaphorin family. (751 aa)
	MKS1	Meckel syndrome type 1 protein isoform X3. (618 aa)
	NSD2	Histone-lysine N-methyltransferase NSD2 isoform X1. (1375 aa)
	JAG1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1221 aa)
	BMPR1A	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
	CITED2	Cbp/p300-interacting transactivator 2. (272 aa)
	BMPR2	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
	FZD2	Frizzled-2; Belongs to the G-protein coupled receptor Fz/Smo family. (565 aa)
	NRP2	Neuropilin; Belongs to the neuropilin family. (931 aa)
	BMP4	Bone morphogenetic protein 4 isoform X2. (408 aa)
	LRP2	Low-density lipoprotein receptor-related protein 2. (4838 aa)
	SAV1	Protein salvador homolog 1. (385 aa)
	HES1	Transcription factor HES-1. (280 aa)
	WNT5A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (458 aa)
	DHRS3	Short-chain dehydrogenase/reductase 3 isoform X1. (360 aa)
	TGFBR1	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
	BMP7	Bone morphogenetic protein 7. (431 aa)
	SLIT3	Slit homolog 3 protein isoform X2. (1523 aa)
	CHD7	chromodomain-helicase-DNA-binding protein 7 isoform X1. (3050 aa)
	GATA4	Transcription factor GATA-4 isoform X1. (437 aa)
	APLNR	Apelin receptor; Belongs to the G-protein coupled receptor 1 family. (383 aa)
	NKX2-5	Homeobox protein Nkx-2.5. (323 aa)
	PROX1	Prospero homeobox protein 1 isoform X1. (738 aa)
	WNT11	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
	HAND1	Heart- and neural crest derivatives-expressed protein 1. (218 aa)
	SMAD7	Mothers against decapentaplegic homolog. (426 aa)
	GATA6	Transcription factor GATA-6. (592 aa)
	NOTCH2	Neurogenic locus notch homolog protein 2 isoform X1. (2471 aa)
	ZFPM2	Zinc finger protein ZFPM2. (1151 aa)
	TBX20	T-box transcription factor TBX20. (449 aa)
	SMAD4	Mothers against decapentaplegic homolog. (553 aa)
	RBM15	Putative RNA-binding protein 15. (962 aa)
	SMAD6	Mothers against decapentaplegic homolog. (495 aa)
	NOTCH1	Neurogenic locus notch homolog protein 1 isoform X1. (2521 aa)
	CYR61	Protein CYR61. (382 aa)
	ZFPM1	Zinc finger protein ZFPM1 isoform X1. (1069 aa)
	SMO	Smoothened homolog; Belongs to the G-protein coupled receptor Fz/Smo family. (782 aa)
	ENG	Endoglin. (652 aa)
	HEYL	Hairy/enhancer-of-split related with YRPW motif-like protein isoform X1. (357 aa)
	FGF8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
	TBX3	T-box transcription factor TBX3 isoform X1. (745 aa)
	TBX5	T-box transcription factor TBX5 isoform X1. (519 aa)
	NOG	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
	EGLN1	Egl nine homolog 1. (439 aa)
	TBX2	T-box transcription factor TBX2. (713 aa)

Your Current Organism:

Delphinapterus leucas

NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMP4	BMP7	A0A2Y9MV04	A0A2Y9QCJ3	Bone morphogenetic protein 4 isoform X2.	Bone morphogenetic protein 7.	0.802
BMP4	BMPR1A	A0A2Y9MV04	A0A2Y9M7N1	Bone morphogenetic protein 4 isoform X2.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.994
BMP4	BMPR2	A0A2Y9MV04	A0A2Y9MMB7	Bone morphogenetic protein 4 isoform X2.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.990
BMP4	FGF8	A0A2Y9MV04	A0A2Y9N7L2	Bone morphogenetic protein 4 isoform X2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.605
BMP4	GATA4	A0A2Y9MV04	A0A2Y9PYQ9	Bone morphogenetic protein 4 isoform X2.	Transcription factor GATA-4 isoform X1.	0.643
BMP4	GATA6	A0A2Y9MV04	A0A2Y9PB94	Bone morphogenetic protein 4 isoform X2.	Transcription factor GATA-6.	0.597
BMP4	ISL1	A0A2Y9MV04	A0A2Y9LQ30	Bone morphogenetic protein 4 isoform X2.	Insulin gene enhancer protein ISL-1.	0.510
BMP4	JAG1	A0A2Y9MV04	A0A2Y9M4A2	Bone morphogenetic protein 4 isoform X2.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.634
BMP4	NKX2-5	A0A2Y9MV04	A0A2Y9PVK9	Bone morphogenetic protein 4 isoform X2.	Homeobox protein Nkx-2.5.	0.437
BMP4	NOG	A0A2Y9MV04	A0A2Y9LFG3	Bone morphogenetic protein 4 isoform X2.	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.	0.995
BMP4	SMAD4	A0A2Y9MV04	A0A2Y9NZ77	Bone morphogenetic protein 4 isoform X2.	Mothers against decapentaplegic homolog.	0.863
BMP4	SMAD6	A0A2Y9MV04	A0A2Y9NWK6	Bone morphogenetic protein 4 isoform X2.	Mothers against decapentaplegic homolog.	0.719
BMP4	SMAD7	A0A2Y9MV04	A0A2Y9PCL8	Bone morphogenetic protein 4 isoform X2.	Mothers against decapentaplegic homolog.	0.700
BMP4	TBX3	A0A2Y9MV04	A0A2Y9LAH3	Bone morphogenetic protein 4 isoform X2.	T-box transcription factor TBX3 isoform X1.	0.462
BMP4	TBX5	A0A2Y9MV04	A0A2Y9LAN0	Bone morphogenetic protein 4 isoform X2.	T-box transcription factor TBX5 isoform X1.	0.516
BMP4	TGFBR1	A0A2Y9MV04	A0A2Y9QES0	Bone morphogenetic protein 4 isoform X2.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.762
BMP4	WNT11	A0A2Y9MV04	A0A2Y9PRI0	Bone morphogenetic protein 4 isoform X2.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.418
BMP4	WNT5A	A0A2Y9MV04	A0A2Y9N641	Bone morphogenetic protein 4 isoform X2.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.539
BMP7	BMP4	A0A2Y9QCJ3	A0A2Y9MV04	Bone morphogenetic protein 7.	Bone morphogenetic protein 4 isoform X2.	0.802
BMP7	BMPR1A	A0A2Y9QCJ3	A0A2Y9M7N1	Bone morphogenetic protein 7.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.977