(34 nodes) Lung epithelium development network (Delphinapterus leucas)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	THRB	Thyroid hormone receptor beta isoform X3. (476 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
	KLF2	Krueppel-like factor 2. (355 aa)
	CTNNB1	Catenin beta-1. (781 aa)
	YAP1	Transcriptional coactivator YAP1 isoform X1. (511 aa)
	NUMA1	Nuclear mitotic apparatus protein 1 isoform X1. (2125 aa)
	BMP4	Bone morphogenetic protein 4 isoform X2. (408 aa)
	CREB1	Cyclic AMP-responsive element-binding protein 1 isoform X1. (341 aa)
	FNDC3B	Fibronectin type III domain-containing protein 3B isoform X1. (1215 aa)
	SAV1	Protein salvador homolog 1. (385 aa)
	FOXA1	Hepatocyte nuclear factor 3-alpha. (466 aa)
	NKX2-1	Homeobox protein Nkx-2.1 isoform X1. (396 aa)
	NFIB	Nuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (570 aa)
	SHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (461 aa)
	KRAS	GTPase KRas. (188 aa)
	ADAMTSL2	ADAMTS-like protein 2 isoform X1. (1040 aa)
	SPDEF	SAM pointed domain-containing Ets transcription factor. (337 aa)
	STRA6	Stimulated by retinoic acid gene 6 protein homolog. (668 aa)
	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
	WNT2	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
	HOXA5	Homeobox protein Hox-A5. (381 aa)
	AGR2	Anterior gradient protein 2 homolog. (175 aa)
	GATA6	Transcription factor GATA-6. (592 aa)
	RCN3	Reticulocalbin-3 isoform X1. (360 aa)
	FOXJ1	Forkhead box protein J1. (422 aa)
	LOC111182889	LOW QUALITY PROTEIN: transcription factor SOX-9-like. (510 aa)
	AIMP2	Aminoacyl tRNA synthase complex-interacting multifunctional protein 2. (339 aa)
	RBBP9	Putative hydrolase RBBP9. (186 aa)
	PKD1	Polycystin-1 isoform X1. (4335 aa)
	PPP3R1	Calcineurin subunit B type 1. (170 aa)
	PPP3R2	LOW QUALITY PROTEIN: calcineurin subunit B type 2. (231 aa)
	ERRFI1	ERBB receptor feedback inhibitor 1. (459 aa)
	ASCL1	Achaete-scute homolog 1. (225 aa)
	TMEM38B	Trimeric intracellular cation channel type B. (293 aa)

Your Current Organism:

Delphinapterus leucas

NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGR2	FOXA1	A0A2Y9P894	A0A2Y9N4R7	Anterior gradient protein 2 homolog.	Hepatocyte nuclear factor 3-alpha.	0.432
AGR2	SPDEF	A0A2Y9P894	A0A2Y9NWR2	Anterior gradient protein 2 homolog.	SAM pointed domain-containing Ets transcription factor.	0.577
ASCL1	CREB1	A0A2Y9QJY2	A0A2Y9MW12	Achaete-scute homolog 1.	Cyclic AMP-responsive element-binding protein 1 isoform X1.	0.567
ASCL1	LOC111182889	A0A2Y9QJY2	A0A2Y9PEX3	Achaete-scute homolog 1.	LOW QUALITY PROTEIN: transcription factor SOX-9-like.	0.606
ASCL1	NFIB	A0A2Y9QJY2	A0A2Y9NDC3	Achaete-scute homolog 1.	Nuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.	0.437
ASCL1	NKX2-1	A0A2Y9QJY2	A0A2Y9NB78	Achaete-scute homolog 1.	Homeobox protein Nkx-2.1 isoform X1.	0.461
ASCL1	SHH	A0A2Y9QJY2	A0A2Y9NDZ2	Achaete-scute homolog 1.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.521
BMP4	CTNNB1	A0A2Y9MV04	A0A2Y9MAY9	Bone morphogenetic protein 4 isoform X2.	Catenin beta-1.	0.619
BMP4	FGF10	A0A2Y9MV04	A0A2Y9LQ50	Bone morphogenetic protein 4 isoform X2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.765
BMP4	GATA6	A0A2Y9MV04	A0A2Y9PB94	Bone morphogenetic protein 4 isoform X2.	Transcription factor GATA-6.	0.597
BMP4	LOC111182889	A0A2Y9MV04	A0A2Y9PEX3	Bone morphogenetic protein 4 isoform X2.	LOW QUALITY PROTEIN: transcription factor SOX-9-like.	0.602
BMP4	SHH	A0A2Y9MV04	A0A2Y9NDZ2	Bone morphogenetic protein 4 isoform X2.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.683
CREB1	ASCL1	A0A2Y9MW12	A0A2Y9QJY2	Cyclic AMP-responsive element-binding protein 1 isoform X1.	Achaete-scute homolog 1.	0.567
CREB1	CTNNB1	A0A2Y9MW12	A0A2Y9MAY9	Cyclic AMP-responsive element-binding protein 1 isoform X1.	Catenin beta-1.	0.658
CTNNB1	BMP4	A0A2Y9MAY9	A0A2Y9MV04	Catenin beta-1.	Bone morphogenetic protein 4 isoform X2.	0.619
CTNNB1	CREB1	A0A2Y9MAY9	A0A2Y9MW12	Catenin beta-1.	Cyclic AMP-responsive element-binding protein 1 isoform X1.	0.658
CTNNB1	FGF10	A0A2Y9MAY9	A0A2Y9LQ50	Catenin beta-1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.542
CTNNB1	KLF2	A0A2Y9MAY9	A0A2Y9LXB9	Catenin beta-1.	Krueppel-like factor 2.	0.419
CTNNB1	KRAS	A0A2Y9MAY9	A0A2Y9NF08	Catenin beta-1.	GTPase KRas.	0.656
CTNNB1	LOC111182889	A0A2Y9MAY9	A0A2Y9PEX3	Catenin beta-1.	LOW QUALITY PROTEIN: transcription factor SOX-9-like.	0.861