STRINGSTRING
TBX3 TBX3 MED1 MED1 ESR1 ESR1 AR AR KDM5B KDM5B DDR1 DDR1 BTRC BTRC CSMD1 CSMD1 VDR VDR WNT5A WNT5A CSMD2 CSMD2 PHB2 PHB2 PML PML TGFB1 TGFB1 CSF1 CSF1 SRC SRC LRP5 LRP5 LOC111185794 LOC111185794 AREG AREG EPHA2 EPHA2 LOC111187154 LOC111187154
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TBX3T-box transcription factor TBX3 isoform X1. (745 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1579 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (595 aa)
ARAndrogen receptor. (893 aa)
KDM5BLysine-specific demethylase 5B. (1539 aa)
DDR1Tyrosine-protein kinase receptor. (917 aa)
BTRCF-box/WD repeat-containing protein 1A isoform X1. (607 aa)
CSMD1CUB and sushi domain-containing protein 1. (3564 aa)
VDRVitamin D3 receptor isoform X1. (503 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (458 aa)
CSMD2CUB and sushi domain-containing protein 2. (3609 aa)
PHB2Prohibitin. (299 aa)
PMLProtein PML isoform X1. (861 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
CSF1Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (554 aa)
SRCTyrosine-protein kinase. (562 aa)
LRP5Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1622 aa)
LOC111185794C-C motif chemokine. (97 aa)
AREGAmphiregulin isoform X1. (254 aa)
EPHA2Ephrin type-A receptor 2. (975 aa)
LOC111187154Ephrin type-A receptor 2-like. (171 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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