node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AR | ESR1 | A0A2Y9M4V8 | A0A2Y9M1Z4 | Androgen receptor. | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. | 0.570 |
AR | MED1 | A0A2Y9M4V8 | A0A2Y9LY66 | Androgen receptor. | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | 0.595 |
AR | SRC | A0A2Y9M4V8 | A0A2Y9PSD7 | Androgen receptor. | Tyrosine-protein kinase. | 0.644 |
AREG | EPHA2 | A0A2Y9Q7W5 | A0A2Y9Q9I4 | Amphiregulin isoform X1. | Ephrin type-A receptor 2. | 0.677 |
AREG | ESR1 | A0A2Y9Q7W5 | A0A2Y9M1Z4 | Amphiregulin isoform X1. | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. | 0.440 |
AREG | SRC | A0A2Y9Q7W5 | A0A2Y9PSD7 | Amphiregulin isoform X1. | Tyrosine-protein kinase. | 0.660 |
CSF1 | EPHA2 | A0A2Y9PBL1 | A0A2Y9Q9I4 | Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] | Ephrin type-A receptor 2. | 0.681 |
CSF1 | LOC111185794 | A0A2Y9PBL1 | A0A2Y9Q1T0 | Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] | C-C motif chemokine. | 0.528 |
CSF1 | SRC | A0A2Y9PBL1 | A0A2Y9PSD7 | Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] | Tyrosine-protein kinase. | 0.655 |
CSF1 | TGFB1 | A0A2Y9PBL1 | A0A2Y9P5D5 | Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] | Transforming growth factor beta; Belongs to the TGF-beta family. | 0.631 |
EPHA2 | AREG | A0A2Y9Q9I4 | A0A2Y9Q7W5 | Ephrin type-A receptor 2. | Amphiregulin isoform X1. | 0.677 |
EPHA2 | CSF1 | A0A2Y9Q9I4 | A0A2Y9PBL1 | Ephrin type-A receptor 2. | Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] | 0.681 |
ESR1 | AR | A0A2Y9M1Z4 | A0A2Y9M4V8 | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. | Androgen receptor. | 0.570 |
ESR1 | AREG | A0A2Y9M1Z4 | A0A2Y9Q7W5 | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. | Amphiregulin isoform X1. | 0.440 |
ESR1 | MED1 | A0A2Y9M1Z4 | A0A2Y9LY66 | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | 0.984 |
ESR1 | PHB2 | A0A2Y9M1Z4 | A0A2Y9NGL2 | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. | Prohibitin. | 0.704 |
ESR1 | SRC | A0A2Y9M1Z4 | A0A2Y9PSD7 | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. | Tyrosine-protein kinase. | 0.996 |
ESR1 | TGFB1 | A0A2Y9M1Z4 | A0A2Y9P5D5 | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. | Transforming growth factor beta; Belongs to the TGF-beta family. | 0.520 |
KDM5B | MED1 | A0A2Y9M7G5 | A0A2Y9LY66 | Lysine-specific demethylase 5B. | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | 0.438 |
LOC111185794 | CSF1 | A0A2Y9Q1T0 | A0A2Y9PBL1 | C-C motif chemokine. | Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] | 0.528 |