STRINGSTRING
LHX1 LHX1 EXT1 EXT1 USP9X USP9X FGF10 FGF10 TBX2 TBX2 WASF1 WASF1 CUNH9orf72 CUNH9orf72 KDM5B KDM5B CSF1 CSF1 NRN1L NRN1L PTK7 PTK7 RYK RYK TGFB1 TGFB1 SPG11 SPG11 TMEM108 TMEM108 AUTS2 AUTS2 LOC111182889 LOC111182889 JADE2 JADE2 CYFIP2 CYFIP2 NRN1 NRN1 IMPACT IMPACT EDN1 EDN1 POU4F3 POU4F3 VCL VCL CYFIP1 CYFIP1 EFNA5 EFNA5 FGF1 FGF1 WNT11 WNT11 FLRT3 FLRT3 COBL COBL RDH10 RDH10 LOC111185794 LOC111185794 NDEL1 NDEL1 ALCAM ALCAM SPRY1 SPRY1 SLIT3 SLIT3 MAP1B MAP1B ULK1 ULK1 AREG AREG DVL1 DVL1 PRKCZ PRKCZ CDH4 CDH4 EDNRA EDNRA POU4F2 POU4F2 SFRP2 SFRP2 DCLK1 DCLK1 SHH SHH EDN2 EDN2 SPART SPART WNT5A WNT5A LLPH LLPH MST1 MST1 SEMA3F SEMA3F RAPH1 RAPH1 SEMA5B SEMA5B SLIT1 SLIT1 LZTS2 LZTS2 RARG RARG FMN1 FMN1 SFRP1 SFRP1 STK11 STK11 HOXD13 HOXD13 NIN NIN BMP4 BMP4 PLXNA3 PLXNA3 NDN NDN IQGAP1 IQGAP1 NRP2 NRP2 TRIM28 TRIM28 YAP1 YAP1 SLIT2 SLIT2 EPB41L5 EPB41L5 DDR1 DDR1 MED12 MED12 MESP1 MESP1 WNT3A WNT3A LAMB2 LAMB2 HDAC6 HDAC6 CTNNB1 CTNNB1 BIN3 BIN3 PLXNA1 PLXNA1 TNR TNR LIMK1 LIMK1 EMX1 EMX1 TNN TNN ADPRH ADPRH ESR1 ESR1 DCX DCX MED1 MED1 SEMA5A SEMA5A S1PR1 S1PR1 KIF26B KIF26B ITGB1 ITGB1 SPAG6 SPAG6 LHX2 LHX2 NOTCH1 NOTCH1 IST1 IST1 LPAR3 LPAR3 SRF SRF SSNA1 SSNA1 SEMA7A SEMA7A SPRY2 SPRY2 APP APP
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LHX1LIM/homeobox protein Lhx1. (406 aa)
EXT1Exostosin-1; Belongs to the glycosyltransferase 47 family. (746 aa)
USP9XProbable ubiquitin carboxyl-terminal hydrolase FAF-X isoform X1; Belongs to the peptidase C19 family. (2559 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
TBX2T-box transcription factor TBX2. (713 aa)
WASF1wiskott-Aldrich syndrome protein family member 1. (559 aa)
CUNH9orf72Guanine nucleotide exchange C9orf72 homolog isoform X1. (481 aa)
KDM5BLysine-specific demethylase 5B. (1539 aa)
CSF1Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (554 aa)
NRN1LNeuritin-like protein isoform X1. (206 aa)
PTK7Inactive tyrosine-protein kinase 7; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1070 aa)
RYKTyrosine-protein kinase RYK isoform X1. (609 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
SPG11Spatacsin isoform X1. (2443 aa)
TMEM108Transmembrane protein 108. (583 aa)
AUTS2Autism susceptibility gene 2 protein. (1264 aa)
LOC111182889LOW QUALITY PROTEIN: transcription factor SOX-9-like. (510 aa)
JADE2E3 ubiquitin-protein ligase Jade-2 isoform X1. (827 aa)
CYFIP2Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1278 aa)
NRN1Neuritin isoform X1. (142 aa)
IMPACTProtein IMPACT isoform X1. (318 aa)
EDN1Endothelin-1. (202 aa)
POU4F3POU domain protein. (338 aa)
VCLVinculin isoform X2. (1134 aa)
CYFIP1Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1253 aa)
EFNA5ephrin-A5 isoform X1; Belongs to the ephrin family. (228 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (189 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
FLRT3Leucine-rich repeat transmembrane protein FLRT3. (649 aa)
COBLProtein cordon-bleu isoform X3. (1381 aa)
RDH10Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (341 aa)
LOC111185794C-C motif chemokine. (97 aa)
NDEL1Nuclear distribution protein nudE-like 1 isoform X1. (346 aa)
ALCAMCD166 antigen isoform X1. (583 aa)
SPRY1Protein sprouty homolog 1. (319 aa)
SLIT3Slit homolog 3 protein isoform X2. (1523 aa)
MAP1BMicrotubule-associated protein 1B. (2474 aa)
ULK1Serine/threonine-protein kinase ULK1 isoform X1. (1055 aa)
AREGAmphiregulin isoform X1. (254 aa)
DVL1Segment polarity protein dishevelled homolog DVL-1 isoform X1. (700 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (629 aa)
CDH4Cadherin-4 isoform X1; Cadherins are calcium-dependent cell adhesion proteins. (914 aa)
EDNRAEndothelin-1 receptor isoform X1; Belongs to the G-protein coupled receptor 1 family. (427 aa)
POU4F2POU domain protein. (407 aa)
SFRP2Secreted frizzled-related protein 2. (294 aa)
DCLK1Serine/threonine-protein kinase DCLK1 isoform X1. (741 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (461 aa)
EDN2Endothelin-2. (147 aa)
SPARTSpartin. (668 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (458 aa)
LLPHProtein LLP homolog. (127 aa)
MST1Hepatocyte growth factor-like protein isoform X1; Belongs to the peptidase S1 family. Plasminogen subfamily. (725 aa)
SEMA3Fsemaphorin-3F isoform X1; Belongs to the semaphorin family. (785 aa)
RAPH1Ras-associated and pleckstrin homology domains-containing protein 1 isoform X1. (1239 aa)
SEMA5Bsemaphorin-5B isoform X1. (1093 aa)
SLIT1Slit homolog 1 protein isoform X1. (1534 aa)
LZTS2Leucine zipper putative tumor suppressor 2; Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta- catenin. (663 aa)
RARGRetinoic acid receptor gamma isoform X1. (458 aa)
FMN1Formin-1 isoform X2. (1200 aa)
SFRP1Secreted frizzled-related protein 1. (308 aa)
STK11Serine/threonine-protein kinase STK11 isoform X1. (544 aa)
HOXD13Homeobox protein Hox-D13. (341 aa)
NINNinein isoform X1. (2180 aa)
BMP4Bone morphogenetic protein 4 isoform X2. (408 aa)
PLXNA3plexin-A3. (1872 aa)
NDNNecdin. (325 aa)
IQGAP1Ras GTPase-activating-like protein IQGAP1. (1657 aa)
NRP2Neuropilin; Belongs to the neuropilin family. (931 aa)
TRIM28Transcription intermediary factor 1-beta. (837 aa)
YAP1Transcriptional coactivator YAP1 isoform X1. (511 aa)
SLIT2Slit homolog 2 protein isoform X1. (1534 aa)
EPB41L5Band 4.1-like protein 5 isoform X1. (726 aa)
DDR1Tyrosine-protein kinase receptor. (917 aa)
MED12Mediator of RNA polymerase II transcription subunit 12. (2177 aa)
MESP1Mesoderm posterior protein 1. (265 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
LAMB2Laminin subunit beta-2 isoform X1. (1812 aa)
HDAC6Histone deacetylase 6 isoform X1. (1149 aa)
CTNNB1Catenin beta-1. (781 aa)
BIN3Bridging integrator 3 isoform X1. (253 aa)
PLXNA1plexin-A1 isoform X1. (1954 aa)
TNRtenascin-R isoform X1. (1358 aa)
LIMK1LIM domain kinase 1 isoform X1. (647 aa)
EMX1Homeobox protein EMX1. (288 aa)
TNNtenascin-N. (1296 aa)
ADPRHADP-ribosylarginine hydrolase. (373 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (595 aa)
DCXNeuronal migration protein doublecortin isoform X3. (366 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1579 aa)
SEMA5Asemaphorin-5A isoform X1. (1079 aa)
S1PR1Sphingosine 1-phosphate receptor 1 isoform X1; Belongs to the G-protein coupled receptor 1 family. (455 aa)
KIF26BKinesin-like protein KIF26B isoform X1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (2113 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (798 aa)
SPAG6Sperm-associated antigen 6 isoform X1. (509 aa)
LHX2LIM/homeobox protein Lhx2. (406 aa)
NOTCH1Neurogenic locus notch homolog protein 1 isoform X1. (2521 aa)
IST1IST1 homolog isoform X1. (362 aa)
LPAR3Lysophosphatidic acid receptor 3; Belongs to the G-protein coupled receptor 1 family. (355 aa)
SRFSerum response factor isoform X2. (535 aa)
SSNA1Sjoegren syndrome nuclear autoantigen 1. (119 aa)
SEMA7Asemaphorin-7A; Belongs to the semaphorin family. (665 aa)
SPRY2Protein sprouty homolog 2. (315 aa)
APPAmyloid beta A4 protein isoform X1. (767 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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