(16 nodes) Apoptotic process involved in morphogenesis network (Delphinapterus leucas)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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Known Interactions

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Predicted Interactions

gene neighborhood

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protein homology

Your Input:
	PPP2R1B	Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform. (601 aa)
	CRYAB	Alpha-crystallin B chain; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. (175 aa)
	LEF1	Lymphoid enhancer-binding factor 1 isoform X1. (414 aa)
	FZD5	Frizzled-5; Belongs to the G-protein coupled receptor Fz/Smo family. (588 aa)
	VDR	Vitamin D3 receptor isoform X1. (503 aa)
	JAG2	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1233 aa)
	LOC111178657	Leucine-rich repeat-containing protein 1-like isoform X1. (174 aa)
	BAK1	Bcl-2 homologous antagonist/killer isoform X1. (239 aa)
	LRRC1	Leucine-rich repeat-containing protein 1. (395 aa)
	CYR61	Protein CYR61. (382 aa)
	NOTCH1	Neurogenic locus notch homolog protein 1 isoform X1. (2521 aa)
	FGF4	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
	LRP5	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1622 aa)
	HAND2	LOW QUALITY PROTEIN: heart- and neural crest derivatives-expressed protein 2. (217 aa)
	BCL2L11	Bcl-2-like protein 11 isoform X1. (288 aa)
	BMP7	Bone morphogenetic protein 7. (431 aa)

Your Current Organism:

Delphinapterus leucas

NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BAK1	BCL2L11	A0A2Y9NQC8	A0A2Y9Q748	Bcl-2 homologous antagonist/killer isoform X1.	Bcl-2-like protein 11 isoform X1.	0.904
BCL2L11	BAK1	A0A2Y9Q748	A0A2Y9NQC8	Bcl-2-like protein 11 isoform X1.	Bcl-2 homologous antagonist/killer isoform X1.	0.904
BMP7	FGF4	A0A2Y9QCJ3	A0A2Y9PM63	Bone morphogenetic protein 7.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.443
BMP7	LEF1	A0A2Y9QCJ3	A0A2Y9MLC4	Bone morphogenetic protein 7.	Lymphoid enhancer-binding factor 1 isoform X1.	0.446
BMP7	LRP5	A0A2Y9QCJ3	A0A2Y9PUA1	Bone morphogenetic protein 7.	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	0.475
FGF4	BMP7	A0A2Y9PM63	A0A2Y9QCJ3	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Bone morphogenetic protein 7.	0.443
FZD5	LRP5	A0A2Y9MML7	A0A2Y9PUA1	Frizzled-5; Belongs to the G-protein coupled receptor Fz/Smo family.	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	0.940
JAG2	NOTCH1	A0A2Y9NBN6	A0A2Y9NWE7	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Neurogenic locus notch homolog protein 1 isoform X1.	0.997
LEF1	BMP7	A0A2Y9MLC4	A0A2Y9QCJ3	Lymphoid enhancer-binding factor 1 isoform X1.	Bone morphogenetic protein 7.	0.446
LEF1	LRP5	A0A2Y9MLC4	A0A2Y9PUA1	Lymphoid enhancer-binding factor 1 isoform X1.	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	0.608
LEF1	NOTCH1	A0A2Y9MLC4	A0A2Y9NWE7	Lymphoid enhancer-binding factor 1 isoform X1.	Neurogenic locus notch homolog protein 1 isoform X1.	0.455
LOC111178657	LRRC1	A0A2Y9NQ38	A0A2Y9NS30	Leucine-rich repeat-containing protein 1-like isoform X1.	Leucine-rich repeat-containing protein 1.	0.912
LRP5	BMP7	A0A2Y9PUA1	A0A2Y9QCJ3	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	Bone morphogenetic protein 7.	0.475
LRP5	FZD5	A0A2Y9PUA1	A0A2Y9MML7	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	Frizzled-5; Belongs to the G-protein coupled receptor Fz/Smo family.	0.940
LRP5	LEF1	A0A2Y9PUA1	A0A2Y9MLC4	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	Lymphoid enhancer-binding factor 1 isoform X1.	0.608
LRRC1	LOC111178657	A0A2Y9NS30	A0A2Y9NQ38	Leucine-rich repeat-containing protein 1.	Leucine-rich repeat-containing protein 1-like isoform X1.	0.912
NOTCH1	JAG2	A0A2Y9NWE7	A0A2Y9NBN6	Neurogenic locus notch homolog protein 1 isoform X1.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.997
NOTCH1	LEF1	A0A2Y9NWE7	A0A2Y9MLC4	Neurogenic locus notch homolog protein 1 isoform X1.	Lymphoid enhancer-binding factor 1 isoform X1.	0.455