30 items (Delphinapterus leucas) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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textmining

co-expression

protein homology

Your Input:
	LEP	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (166 aa)
	DYRK1B	Dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform X1. (686 aa)
	VPS13B	Vacuolar protein sorting-associated protein 13B isoform X1. (4018 aa)
	PPARD	Peroxisome proliferator-activated receptor delta isoform X1. (441 aa)
	SLC25A25	Calcium-binding mitochondrial carrier protein SCaMC-2 isoform X5; Belongs to the mitochondrial carrier (TC 2.A.29) family. (513 aa)
	PAXIP1	PAX-interacting protein 1 isoform X1. (1030 aa)
	BBS4	Bardet-Biedl syndrome 4 protein isoform X1. (528 aa)
	SPTLC2	Serine palmitoyltransferase 2 isoform X1. (561 aa)
	ATF2	Cyclic AMP-dependent transcription factor ATF-2 isoform X1. (505 aa)
	SPART	Spartin. (668 aa)
	PUM2	Pumilio homolog 2 isoform X1. (1065 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	PPARGC1A	Peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X1. (803 aa)
	AMER1	APC membrane recruitment protein 1. (1129 aa)
	LOC111165935	Ras-like protein isoform X1. (285 aa)
	FTO	Alpha-ketoglutarate-dependent dioxygenase FTO isoform X1. (505 aa)
	ARID5B	AT-rich interactive domain-containing protein 5B isoform X1. (1184 aa)
	ZNF516	Zinc finger protein 516 isoform X1. (1134 aa)
	PGRMC2	LOW QUALITY PROTEIN: membrane-associated progesterone receptor component 2; Belongs to the cytochrome b5 family. (247 aa)
	DHRS7B	Dehydrogenase/reductase SDR family member 7B; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (325 aa)
	HRAS	GTPase HRas isoform X1. (189 aa)
	Ob	Leptin isoform X1. (167 aa)
	LRP5	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1622 aa)
	RASAL2	Ras GTPase-activating protein nGAP isoform X1. (1414 aa)
	UMODL1	Uromodulin-like 1. (1321 aa)
	XBP1	LOW QUALITY PROTEIN: X-box-binding protein 1. (392 aa)
	SELENOM	Selenoprotein M. (142 aa)
	ARRDC3	Arrestin domain-containing protein 3 isoform X1. (414 aa)
	SOX8	Transcription factor SOX-8. (463 aa)
	CSF1	Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (554 aa)

Your Current Organism:

Delphinapterus leucas

NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AMER1	LRP5	A0A2Y9MRP1	A0A2Y9PUA1	APC membrane recruitment protein 1.	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	0.418
ATF2	PPARGC1A	A0A2Y9N962	A0A2Y9MTR6	Cyclic AMP-dependent transcription factor ATF-2 isoform X1.	Peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X1.	0.416
HRAS	PIK3CA	A0A2Y9MGR2	A0A2Y9MZW2	GTPase HRas isoform X1.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.979
HRAS	RASAL2	A0A2Y9MGR2	A0A2Y9LSG1	GTPase HRas isoform X1.	Ras GTPase-activating protein nGAP isoform X1.	0.791
LEP	PPARGC1A	A0A2Y9PHF5	A0A2Y9MTR6	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...]	Peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X1.	0.518
LOC111165935	PIK3CA	A0A2Y9LSR3	A0A2Y9MZW2	Ras-like protein isoform X1.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.804
LOC111165935	RASAL2	A0A2Y9LSR3	A0A2Y9LSG1	Ras-like protein isoform X1.	Ras GTPase-activating protein nGAP isoform X1.	0.428
LRP5	AMER1	A0A2Y9PUA1	A0A2Y9MRP1	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	APC membrane recruitment protein 1.	0.418
Ob	PPARGC1A	G8DLG4	A0A2Y9MTR6	Leptin isoform X1.	Peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X1.	0.518
PIK3CA	HRAS	A0A2Y9MZW2	A0A2Y9MGR2	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	GTPase HRas isoform X1.	0.979
PIK3CA	LOC111165935	A0A2Y9MZW2	A0A2Y9LSR3	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	Ras-like protein isoform X1.	0.804
PPARD	PPARGC1A	A0A2Y9NTM9	A0A2Y9MTR6	Peroxisome proliferator-activated receptor delta isoform X1.	Peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X1.	0.607
PPARGC1A	ATF2	A0A2Y9MTR6	A0A2Y9N962	Peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X1.	Cyclic AMP-dependent transcription factor ATF-2 isoform X1.	0.416
PPARGC1A	LEP	A0A2Y9MTR6	A0A2Y9PHF5	Peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X1.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...]	0.518
PPARGC1A	Ob	A0A2Y9MTR6	G8DLG4	Peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X1.	Leptin isoform X1.	0.518
PPARGC1A	PPARD	A0A2Y9MTR6	A0A2Y9NTM9	Peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X1.	Peroxisome proliferator-activated receptor delta isoform X1.	0.607
RASAL2	HRAS	A0A2Y9LSG1	A0A2Y9MGR2	Ras GTPase-activating protein nGAP isoform X1.	GTPase HRas isoform X1.	0.791
RASAL2	LOC111165935	A0A2Y9LSG1	A0A2Y9LSR3	Ras GTPase-activating protein nGAP isoform X1.	Ras-like protein isoform X1.	0.428