(31 nodes) Labyrinthine layer development network (Delphinapterus leucas)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	VASH1	Vasohibin-1 isoform X1. (387 aa)
	BIRC6	LOW QUALITY PROTEIN: baculoviral IAP repeat-containing protein 6. (4861 aa)
	ZFP36L1	mRNA decay activator protein ZFP36L1. (338 aa)
	CDX2	Homeobox protein CDX-2. (303 aa)
	HES1	Transcription factor HES-1. (280 aa)
	PLCD3	Phosphoinositide phospholipase C. (784 aa)
	NSDHL	Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating; Belongs to the 3-beta-HSD family. (392 aa)
	SPINT2	Kunitz-type protease inhibitor 2. (249 aa)
	SPINT1	Kunitz-type protease inhibitor 1 isoform X2. (510 aa)
	PCDH12	LOW QUALITY PROTEIN: protocadherin-12. (1199 aa)
	SOCS3	Suppressor of cytokine signaling 3. (237 aa)
	GRB2	Growth factor receptor-bound protein 2. (217 aa)
	HS6ST1	Heparan-sulfate 6-O-sulfotransferase; 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate. (411 aa)
	GCM1	Chorion-specific transcription factor GCMa. (434 aa)
	WNT2	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
	VASH2	Vasohibin-2 isoform X1. (355 aa)
	BMP7	Bone morphogenetic protein 7. (431 aa)
	FBXW8	F-box/WD repeat-containing protein 8. (599 aa)
	FZD5	Frizzled-5; Belongs to the G-protein coupled receptor Fz/Smo family. (588 aa)
	LEF1	Lymphoid enhancer-binding factor 1 isoform X1. (414 aa)
	PLG	Plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...] (812 aa)
	JUNB	Transcription factor jun-B. (347 aa)
	RSPO3	R-spondin-3. (275 aa)
	ST14	Suppressor of tumorigenicity 14 protein homolog; Degrades extracellular matrix. Belongs to the peptidase S1 family. (855 aa)
	HEY2	Hairy/enhancer-of-split related with YRPW motif protein 2. (337 aa)
	EGLN1	Egl nine homolog 1. (439 aa)
	GGNBP2	Gametogenetin-binding protein 2 isoform X1. (740 aa)
	MAPK1	Mitogen-activated protein kinase. (380 aa)
	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
	CDX4	Homeobox protein CDX-4. (283 aa)
	CYR61	Protein CYR61. (382 aa)

Your Current Organism:

Delphinapterus leucas

NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMP7	LEF1	A0A2Y9QCJ3	A0A2Y9MLC4	Bone morphogenetic protein 7.	Lymphoid enhancer-binding factor 1 isoform X1.	0.446
CDX2	GCM1	A0A2Y9N765	A0A2Y9P1J5	Homeobox protein CDX-2.	Chorion-specific transcription factor GCMa.	0.604
FZD5	WNT2	A0A2Y9MML7	A0A2Y9P4P7	Frizzled-5; Belongs to the G-protein coupled receptor Fz/Smo family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.872
GCM1	CDX2	A0A2Y9P1J5	A0A2Y9N765	Chorion-specific transcription factor GCMa.	Homeobox protein CDX-2.	0.604
GCM1	PCDH12	A0A2Y9P1J5	A0A2Y9PIQ5	Chorion-specific transcription factor GCMa.	LOW QUALITY PROTEIN: protocadherin-12.	0.508
GCM1	VASH2	A0A2Y9P1J5	A0A2Y9PUA2	Chorion-specific transcription factor GCMa.	Vasohibin-2 isoform X1.	0.514
GRB2	MAP2K1	A0A2Y9PJ90	A0A2Y9P0A4	Growth factor receptor-bound protein 2.	Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily.	0.460
GRB2	MAPK1	A0A2Y9PJ90	A0A2Y9LEH4	Growth factor receptor-bound protein 2.	Mitogen-activated protein kinase.	0.604
LEF1	BMP7	A0A2Y9MLC4	A0A2Y9QCJ3	Lymphoid enhancer-binding factor 1 isoform X1.	Bone morphogenetic protein 7.	0.446
LEF1	WNT2	A0A2Y9MLC4	A0A2Y9P4P7	Lymphoid enhancer-binding factor 1 isoform X1.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.443
MAP2K1	GRB2	A0A2Y9P0A4	A0A2Y9PJ90	Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily.	Growth factor receptor-bound protein 2.	0.460
MAP2K1	MAPK1	A0A2Y9P0A4	A0A2Y9LEH4	Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase.	0.994
MAPK1	GRB2	A0A2Y9LEH4	A0A2Y9PJ90	Mitogen-activated protein kinase.	Growth factor receptor-bound protein 2.	0.604
MAPK1	MAP2K1	A0A2Y9LEH4	A0A2Y9P0A4	Mitogen-activated protein kinase.	Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily.	0.994
MAPK1	VASH2	A0A2Y9LEH4	A0A2Y9PUA2	Mitogen-activated protein kinase.	Vasohibin-2 isoform X1.	0.446
PCDH12	GCM1	A0A2Y9PIQ5	A0A2Y9P1J5	LOW QUALITY PROTEIN: protocadherin-12.	Chorion-specific transcription factor GCMa.	0.508
RSPO3	WNT2	A0A2Y9LXG2	A0A2Y9P4P7	R-spondin-3.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.493
SPINT1	ST14	A0A2Y9PIN6	A0A2Y9LT85	Kunitz-type protease inhibitor 1 isoform X2.	Suppressor of tumorigenicity 14 protein homolog; Degrades extracellular matrix. Belongs to the peptidase S1 family.	0.909
SPINT2	ST14	A0A2Y9PFR2	A0A2Y9LT85	Kunitz-type protease inhibitor 2.	Suppressor of tumorigenicity 14 protein homolog; Degrades extracellular matrix. Belongs to the peptidase S1 family.	0.566
ST14	SPINT1	A0A2Y9LT85	A0A2Y9PIN6	Suppressor of tumorigenicity 14 protein homolog; Degrades extracellular matrix. Belongs to the peptidase S1 family.	Kunitz-type protease inhibitor 1 isoform X2.	0.909