STRINGSTRING
ARFGEF1 ARFGEF1 THBD THBD F2R F2R FGB FGB PHLDB2 PHLDB2 AJAP1 AJAP1 MTOR MTOR C1QTNF6 C1QTNF6 FGG FGG HPSE HPSE TNF TNF EMILIN2 EMILIN2 F2RL1 F2RL1 EPHB2 EPHB2 XBP1 XBP1 LOC111165062 LOC111165062 FERMT1 FERMT1 LOC111165935 LOC111165935 CASK CASK INSL3 INSL3 ST3GAL4 ST3GAL4 UBASH3B UBASH3B PLG PLG PDGFA PDGFA PDGFRA PDGFRA SMOC2 SMOC2 SERPINC1 SERPINC1 F12 F12 HRAS HRAS DMTN DMTN SERPINE2 SERPINE2 LOC111171320 LOC111171320 VIL1 VIL1 ALOX5 ALOX5 CLDN1 CLDN1 LOC111173428 LOC111173428 ADRA2A ADRA2A TFPI TFPI KNG1 KNG1 ANXA1 ANXA1 FERMT2 FERMT2 PRKCE PRKCE CPB2 CPB2 PRKG1 PRKG1 CLDN19 CLDN19 NFE2L2 NFE2L2 PRKCD PRKCD LOC111176754 LOC111176754 ANO6 ANO6 KANK1 KANK1 LOC111177240 LOC111177240 PROS1 PROS1 SMAD3 SMAD3 WFDC1 WFDC1 CAV1 CAV1 ENPP4 ENPP4 MMRN1 MMRN1 CADM4 CADM4 ADAMTS18 ADAMTS18 ADTRP ADTRP CLDN3 CLDN3 HBEGF HBEGF RREB1 RREB1 PLAU PLAU ACTG1 ACTG1 THBS1 THBS1 MYOZ1 MYOZ1 CLDN4 CLDN4 SERPINE1 SERPINE1 C1QTNF1 C1QTNF1 SERPING1 SERPING1 APOH APOH SRSF6 SRSF6 FOXA2 FOXA2 CD109 CD109 PROC PROC CRK CRK F2 F2 ALOX12 ALOX12 SERPINF2 SERPINF2 PDGFB PDGFB SH2B3 SH2B3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ARFGEF1Brefeldin A-inhibited guanine nucleotide-exchange protein 1 isoform X1. (1849 aa)
THBDThrombomodulin. (584 aa)
F2RProteinase-activated receptor 1; Belongs to the G-protein coupled receptor 1 family. (427 aa)
FGBFibrinogen beta chain isoform X1. (495 aa)
PHLDB2Pleckstrin homology-like domain family B member 2 isoform X1. (1364 aa)
AJAP1Adherens junction-associated protein 1. (410 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2548 aa)
C1QTNF6Complement C1q tumor necrosis factor-related protein 6. (266 aa)
FGGFibrinogen gamma chain isoform X1. (445 aa)
HPSEHeparanase isoform X1. (542 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa)
EMILIN2EMILIN-2. (1070 aa)
F2RL1Proteinase-activated receptor 2. (315 aa)
EPHB2Ephrin type-B receptor 2 isoform X1. (987 aa)
XBP1LOW QUALITY PROTEIN: X-box-binding protein 1. (392 aa)
LOC111165062WNT1-inducible-signaling pathway protein 1-like. (398 aa)
FERMT1Fermitin family homolog 1. (677 aa)
LOC111165935Ras-like protein isoform X1. (285 aa)
CASKPeripheral plasma membrane protein CASK isoform X1; Belongs to the MAGUK family. (926 aa)
INSL3Insulin-like 3. (133 aa)
ST3GAL4CMP-N-acetylneuraminate-beta-galactosamide- alpha-2,3-sialyltransferase 4 isoform X4; Belongs to the glycosyltransferase 29 family. (341 aa)
UBASH3BUbiquitin-associated and SH3 domain-containing protein B isoform X1. (649 aa)
PLGPlasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...] (812 aa)
PDGFAPlatelet-derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (196 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
SMOC2SPARC-related modular calcium-binding protein 2 isoform X1. (456 aa)
SERPINC1antithrombin-III isoform X1; Belongs to the serpin family. (501 aa)
F12LOW QUALITY PROTEIN: coagulation factor XII. (650 aa)
HRASGTPase HRas isoform X1. (189 aa)
DMTNDematin isoform X1. (405 aa)
SERPINE2Glia-derived nexin isoform X2; Belongs to the serpin family. (397 aa)
LOC111171320Mucin-16-like. (855 aa)
VIL1Villin-1 isoform X1. (827 aa)
ALOX5Arachidonate 5-lipoxygenase. (674 aa)
CLDN1Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
LOC111173428Coagulation factor XI; Belongs to the peptidase S1 family. (633 aa)
ADRA2Aalpha-2A adrenergic receptor. (465 aa)
TFPITissue factor pathway inhibitor isoform X1. (307 aa)
KNG1Kininogen-1 isoform X1. (627 aa)
ANXA1Annexin. (346 aa)
FERMT2Fermitin family homolog 2 isoform X2. (691 aa)
PRKCEProtein kinase C. (746 aa)
CPB2Carboxypeptidase B2. (423 aa)
PRKG1cGMP-dependent protein kinase. (686 aa)
CLDN19Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (224 aa)
NFE2L2Nuclear factor erythroid 2-related factor 2 isoform X1. (622 aa)
PRKCDProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (733 aa)
LOC111176754C-type lectin domain family 7 member A-like isoform X1. (244 aa)
ANO6Anoctamin. (951 aa)
KANK1KN motif and ankyrin repeat domain-containing protein 1 isoform X3. (1351 aa)
LOC111177240LOW QUALITY PROTEIN: serine/arginine-rich splicing factor 6-like. (346 aa)
PROS1Vitamin K-dependent protein S. (675 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
WFDC1WAP four-disulfide core domain protein 1 isoform X1. (217 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
ENPP4Bis(5'-adenosyl)-triphosphatase ENPP4. (456 aa)
MMRN1Multimerin-1. (1216 aa)
CADM4Cell adhesion molecule 4. (388 aa)
ADAMTS18A disintegrin and metalloproteinase with thrombospondin motifs 18 isoform X1. (1227 aa)
ADTRPAndrogen-dependent TFPI-regulating protein isoform X1. (230 aa)
CLDN3Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (220 aa)
HBEGFProheparin-binding EGF-like growth factor. (208 aa)
RREB1Ras-responsive element-binding protein 1 isoform X1. (1760 aa)
PLAUUrokinase-type plasminogen activator. (431 aa)
ACTG1Actin, cytoplasmic 2. (375 aa)
THBS1Thrombospondin-1. (1170 aa)
MYOZ1Myozenin-1. (298 aa)
CLDN4Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (209 aa)
SERPINE1Plasminogen activator inhibitor 1; Belongs to the serpin family. (402 aa)
C1QTNF1LOW QUALITY PROTEIN: complement C1q tumor necrosis factor-related protein 1. (279 aa)
SERPING1Plasma protease C1 inhibitor; Belongs to the serpin family. (471 aa)
APOHBeta-2-glycoprotein 1 isoform X1. (345 aa)
SRSF6Serine/arginine-rich splicing factor 6 isoform X1. (345 aa)
FOXA2Hepatocyte nuclear factor 3-beta isoform X1. (462 aa)
CD109CD109 antigen isoform X1. (1440 aa)
PROCVitamin K-dependent protein C. (480 aa)
CRKAdapter molecule crk isoform X1. (304 aa)
F2Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (623 aa)
ALOX12Arachidonate 12-lipoxygenase, 12S-type. (663 aa)
SERPINF2Alpha-2-antiplasmin isoform X1; Belongs to the serpin family. (558 aa)
PDGFBPlatelet-derived growth factor subunit B isoform X1; Belongs to the PDGF/VEGF growth factor family. (278 aa)
SH2B3SH2B adapter protein 3 isoform X1. (618 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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