STRINGSTRING
TBX3 TBX3 SFRP2 SFRP2 HHIP HHIP PAX8 PAX8 CTNNBIP1 CTNNBIP1 LOC111187154 LOC111187154 PPP3R2 PPP3R2 EDNRA EDNRA BMP7 BMP7 PPP3R1 PPP3R1 SOX10 SOX10 GDNF GDNF EPHA2 EPHA2 AREG AREG LAMA5 LAMA5 CTSZ CTSZ NKX3-1 NKX3-1 CELSR1 CELSR1 SPRY1 SPRY1 LOC111185794 LOC111185794 GLI3 GLI3 EYA1 EYA1 RDH10 RDH10 PKD1 PKD1 TGM2 TGM2 STK4 STK4 GZF1 GZF1 DLG2 DLG2 PAK1 PAK1 PROX1 PROX1 LRP5 LRP5 DLG5 DLG5 SOX8 SOX8 SRC SRC FGF1 FGF1 HOXA11 HOXA11 FGF7 FGF7 GRB2 GRB2 PPP1CA PPP1CA SOCS3 SOCS3 SPINT1 SPINT1 EDN1 EDN1 SPINT2 SPINT2 HOXA13 HOXA13 GNA13 GNA13 LOC111182889 LOC111182889 RASIP1 RASIP1 CSF1 CSF1 WT1 WT1 BCL2 BCL2 DLL4 DLL4 TGFB1 TGFB1 HOXA5 HOXA5 TBX20 TBX20 GCM1 GCM1 FEM1B FEM1B SMAD4 SMAD4 ESRP2 ESRP2 RBM15 RBM15 FOXF1 FOXF1 MET MET NOTCH1 NOTCH1 PKD2 PKD2 PKHD1 PKHD1 PML PML SRF SRF ADAMTS16 ADAMTS16 SPRY2 SPRY2 COL4A1 COL4A1 NRARP NRARP ENG ENG PHB2 PHB2 BTBD7 BTBD7 WNT1 WNT1 KRAS KRAS TIMELESS TIMELESS SHH SHH NKX2-1 NKX2-1 TIE1 TIE1 TP63 TP63 CSMD2 CSMD2 FGF8 FGF8 WNT5A WNT5A GDF7 GDF7 FOXA1 FOXA1 VDR VDR WNT6 WNT6 SIX1 SIX1 FRS2 FRS2 GBX2 GBX2 CSMD1 CSMD1 SFRP1 SFRP1 CITED1 CITED1 HOXD13 HOXD13 BMP4 BMP4 BTRC BTRC IHH IHH KDR KDR PAX2 PAX2 DLG1 DLG1 NPNT NPNT FZD5 FZD5 SEMA3E SEMA3E LEF1 LEF1 YAP1 YAP1 SLIT2 SLIT2 ILK ILK DDR1 DDR1 GDF2 GDF2 DCHS1 DCHS1 CTNNB1 CTNNB1 PLXND1 PLXND1 PLXNA1 PLXNA1 KDM5B KDM5B HS3ST3A1 HS3ST3A1 AR AR HS3ST3B1 HS3ST3B1 ESR1 ESR1 TMEM59L TMEM59L BMP2 BMP2 PTCH1 PTCH1 HOXB13 HOXB13 MED1 MED1 GPC3 GPC3 RSPO3 RSPO3 MMP14 MMP14 TCF21 TCF21 ST14 ST14 LHX1 LHX1 MKS1 MKS1 SEMA3C SEMA3C EXT1 EXT1 NFATC4 NFATC4 FGF10 FGF10 TBX2 TBX2 CTSH CTSH NOG NOG CLIC4 CLIC4 LAMA1 LAMA1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TBX3T-box transcription factor TBX3 isoform X1. (745 aa)
SFRP2Secreted frizzled-related protein 2. (294 aa)
HHIPHedgehog-interacting protein isoform X1. (700 aa)
PAX8Paired box protein Pax-8. (457 aa)
CTNNBIP1Beta-catenin-interacting protein 1. (81 aa)
LOC111187154Ephrin type-A receptor 2-like. (171 aa)
PPP3R2LOW QUALITY PROTEIN: calcineurin subunit B type 2. (231 aa)
EDNRAEndothelin-1 receptor isoform X1; Belongs to the G-protein coupled receptor 1 family. (427 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
PPP3R1Calcineurin subunit B type 1. (170 aa)
SOX10Transcription factor SOX-10. (468 aa)
GDNFGlial cell line-derived neurotrophic factor. (185 aa)
EPHA2Ephrin type-A receptor 2. (975 aa)
AREGAmphiregulin isoform X1. (254 aa)
LAMA5Laminin subunit alpha-5. (3687 aa)
CTSZCathepsin Z; Belongs to the peptidase C1 family. (303 aa)
NKX3-1Homeobox protein Nkx-3.1. (241 aa)
CELSR1Cadherin EGF LAG seven-pass G-type receptor 1 isoform X1; Belongs to the G-protein coupled receptor 2 family. (3038 aa)
SPRY1Protein sprouty homolog 1. (319 aa)
LOC111185794C-C motif chemokine. (97 aa)
GLI3Transcriptional activator GLI3 isoform X1. (1587 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (589 aa)
RDH10Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (341 aa)
PKD1Polycystin-1 isoform X1. (4335 aa)
TGM2Protein-glutamine gamma-glutamyltransferase 2. (687 aa)
STK4Serine/threonine-protein kinase 4 isoform X1. (487 aa)
GZF1GDNF-inducible zinc finger protein 1. (717 aa)
DLG2Disks large homolog 2 isoform X1. (994 aa)
PAK1Non-specific serine/threonine protein kinase. (543 aa)
PROX1Prospero homeobox protein 1 isoform X1. (738 aa)
LRP5Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1622 aa)
DLG5Disks large homolog 5 isoform X1; Belongs to the MAGUK family. (1980 aa)
SOX8Transcription factor SOX-8. (463 aa)
SRCTyrosine-protein kinase. (562 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (189 aa)
HOXA11Homeobox protein Hox-A11. (313 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
SOCS3Suppressor of cytokine signaling 3. (237 aa)
SPINT1Kunitz-type protease inhibitor 1 isoform X2. (510 aa)
EDN1Endothelin-1. (202 aa)
SPINT2Kunitz-type protease inhibitor 2. (249 aa)
HOXA13Homeobox protein Hox-A13. (387 aa)
GNA13Guanine nucleotide-binding protein subunit alpha-13. (377 aa)
LOC111182889LOW QUALITY PROTEIN: transcription factor SOX-9-like. (510 aa)
RASIP1Ras-interacting protein 1. (961 aa)
CSF1Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (554 aa)
WT1Wilms tumor protein isoform X1. (450 aa)
BCL2Apoptosis regulator Bcl-2. (233 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (685 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
HOXA5Homeobox protein Hox-A5. (381 aa)
TBX20T-box transcription factor TBX20. (449 aa)
GCM1Chorion-specific transcription factor GCMa. (434 aa)
FEM1BProtein fem-1 homolog B. (627 aa)
SMAD4Mothers against decapentaplegic homolog. (553 aa)
ESRP2Epithelial splicing regulatory protein 2 isoform X3. (717 aa)
RBM15Putative RNA-binding protein 15. (962 aa)
FOXF1Forkhead box protein F1. (375 aa)
METHepatocyte growth factor receptor isoform X1. (1382 aa)
NOTCH1Neurogenic locus notch homolog protein 1 isoform X1. (2521 aa)
PKD2Polycystin-2 isoform X1. (975 aa)
PKHD1Fibrocystin isoform X1. (4074 aa)
PMLProtein PML isoform X1. (861 aa)
SRFSerum response factor isoform X2. (535 aa)
ADAMTS16A disintegrin and metalloproteinase with thrombospondin motifs 16 isoform X1. (1252 aa)
SPRY2Protein sprouty homolog 2. (315 aa)
COL4A1Collagen alpha-1(IV) chain isoform X1. (1668 aa)
NRARPNotch-regulated ankyrin repeat-containing protein. (114 aa)
ENGEndoglin. (652 aa)
PHB2Prohibitin. (299 aa)
BTBD7BTB/POZ domain-containing protein 7 isoform X1. (1123 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
KRASGTPase KRas. (188 aa)
TIMELESSProtein timeless homolog isoform X1. (1202 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (461 aa)
NKX2-1Homeobox protein Nkx-2.1 isoform X1. (396 aa)
TIE1Tyrosine-protein kinase receptor Tie-1 isoform X1. (1139 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
CSMD2CUB and sushi domain-containing protein 2. (3609 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (458 aa)
GDF7Growth/differentiation factor 7. (449 aa)
FOXA1Hepatocyte nuclear factor 3-alpha. (466 aa)
VDRVitamin D3 receptor isoform X1. (503 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
SIX1Homeobox protein SIX1. (284 aa)
FRS2Fibroblast growth factor receptor substrate 2. (508 aa)
GBX2Homeobox protein GBX-2 isoform X1. (348 aa)
CSMD1CUB and sushi domain-containing protein 1. (3564 aa)
SFRP1Secreted frizzled-related protein 1. (308 aa)
CITED1Cbp/p300-interacting transactivator 1 isoform X1. (359 aa)
HOXD13Homeobox protein Hox-D13. (341 aa)
BMP4Bone morphogenetic protein 4 isoform X2. (408 aa)
BTRCF-box/WD repeat-containing protein 1A isoform X1. (607 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (410 aa)
KDRVascular endothelial growth factor receptor 2 isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
PAX2Paired box protein Pax-2 isoform X1. (432 aa)
DLG1Disks large homolog 1 isoform X1; Belongs to the MAGUK family. (927 aa)
NPNTNephronectin isoform X3. (595 aa)
FZD5Frizzled-5; Belongs to the G-protein coupled receptor Fz/Smo family. (588 aa)
SEMA3Esemaphorin-3E; Belongs to the semaphorin family. (775 aa)
LEF1Lymphoid enhancer-binding factor 1 isoform X1. (414 aa)
YAP1Transcriptional coactivator YAP1 isoform X1. (511 aa)
SLIT2Slit homolog 2 protein isoform X1. (1534 aa)
ILKIntegrin-linked protein kinase. (452 aa)
DDR1Tyrosine-protein kinase receptor. (917 aa)
GDF2Growth/differentiation factor 2. (431 aa)
DCHS1Protocadherin-16. (3294 aa)
CTNNB1Catenin beta-1. (781 aa)
PLXND1plexin-D1. (1927 aa)
PLXNA1plexin-A1 isoform X1. (1954 aa)
KDM5BLysine-specific demethylase 5B. (1539 aa)
HS3ST3A1Sulfotransferase; Belongs to the sulfotransferase 1 family. (406 aa)
ARAndrogen receptor. (893 aa)
HS3ST3B1Sulfotransferase; Belongs to the sulfotransferase 1 family. (390 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (595 aa)
TMEM59LTransmembrane protein 59-like isoform X1. (350 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
PTCH1Protein patched homolog 1 isoform X1. (1447 aa)
HOXB13Homeobox protein Hox-B13. (285 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1579 aa)
GPC3Glypican-3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (580 aa)
RSPO3R-spondin-3. (275 aa)
MMP14Matrix metalloproteinase-14. (582 aa)
TCF21Transcription factor 21. (179 aa)
ST14Suppressor of tumorigenicity 14 protein homolog; Degrades extracellular matrix. Belongs to the peptidase S1 family. (855 aa)
LHX1LIM/homeobox protein Lhx1. (406 aa)
MKS1Meckel syndrome type 1 protein isoform X3. (618 aa)
SEMA3Csemaphorin-3C; Belongs to the semaphorin family. (751 aa)
EXT1Exostosin-1; Belongs to the glycosyltransferase 47 family. (746 aa)
NFATC4LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 4. (901 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
TBX2T-box transcription factor TBX2. (713 aa)
CTSHPro-cathepsin H; Belongs to the peptidase C1 family. (335 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
CLIC4Chloride intracellular channel protein; Belongs to the chloride channel CLIC family. (253 aa)
LAMA1Laminin subunit alpha-1 isoform X1. (3081 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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