(84 nodes) Positive regulation of small molecule metabolic process network (Delphinapterus leucas)

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second shell of interactors

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Predicted Interactions

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Your Input:
	AKT2	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
	MLXIPL	Carbohydrate-responsive element-binding protein isoform X1. (929 aa)
	NR1H3	Oxysterols receptor LXR-alpha isoform X1. (447 aa)
	FGF1	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (189 aa)
	SLC45A3	Solute carrier family 45 member 3. (553 aa)
	KAT2B	Histone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (828 aa)
	PTPN2	Tyrosine-protein phosphatase non-receptor type 2 isoform X3. (474 aa)
	EPM2AIP1	EPM2A-interacting protein 1. (608 aa)
	PLA2G3	Group 3 secretory phospholipase A2 isoform X1. (516 aa)
	INMT	LOW QUALITY PROTEIN: indolethylamine N-methyltransferase. (263 aa)
	SCAP	Sterol regulatory element-binding protein cleavage-activating protein isoform X1. (1280 aa)
	NCS1	Neuronal calcium sensor 1. (190 aa)
	GUCA2A	Guanylin. (109 aa)
	HTR2A	5-hydroxytryptamine receptor 2A. (470 aa)
	GPD1	Glycerol-3-phosphate dehydrogenase [NAD(+)]. (405 aa)
	NOS3	Nitric oxide synthase; Produces nitric oxide (NO). (1205 aa)
	CLYBL	Citrate lyase subunit beta-like protein, mitochondrial isoform X1. (337 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
	GUCA2B	Guanylate cyclase activator 2B. (113 aa)
	IRS2	Insulin receptor substrate 2. (1347 aa)
	AKT1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
	PODN	Podocan. (607 aa)
	FOXO1	Forkhead box protein O1. (663 aa)
	PRKCE	Protein kinase C. (746 aa)
	PARK7	Protein DJ-1. (189 aa)
	IGF1	Insulin-like growth factor I isoform X1. (186 aa)
	ENO1	Alpha-enolase isoform X1. (450 aa)
	NR1H4	Bile acid receptor isoform X1. (486 aa)
	P2RX7	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (595 aa)
	PPARA	Peroxisome proliferator-activated receptor alpha. (468 aa)
	LPGAT1	acyl-CoA:lysophosphatidylglycerol acyltransferase 1 isoform X1. (420 aa)
	PTGS2	Prostaglandin G/H synthase 2. (604 aa)
	AVPR1B	Vasopressin V1b receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (423 aa)
	P2RY6	P2Y purinoceptor 6. (328 aa)
	DDB1	DNA damage-binding protein 1. (1140 aa)
	INS	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
	GCK	Phosphotransferase. (537 aa)
	TWIST1	Twist-related protein 1. (205 aa)
	LHCGR	Lutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (700 aa)
	ANXA1	Annexin. (346 aa)
	ABCD2	ATP-binding cassette sub-family D member 2. (741 aa)
	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2. (601 aa)
	GCG	Glucagon isoform X1. (180 aa)
	PPARGC1A	Peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X1. (803 aa)
	PID1	PTB-containing, cubilin and LRP1-interacting protein isoform X1. (268 aa)
	IRS1	Insulin receptor substrate 1. (1248 aa)
	ABCD1	ATP-binding cassette sub-family D member 1 isoform X1. (774 aa)
	GPER1	G-protein coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (354 aa)
	APOA5	Apolipoprotein A-V isoform X1. (390 aa)
	SREBF1	Sterol regulatory element-binding protein 1 isoform X1. (1213 aa)
	AAED1	Thioredoxin-like protein AAED1 isoform X1. (234 aa)
	GPLD1	Phosphatidylinositol-glycan-specific phospholipase D isoform X1. (849 aa)
	APOA4	Apolipoprotein A-IV isoform X1. (380 aa)
	ADORA2B	Adenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (333 aa)
	ABCG4	ATP-binding cassette sub-family G member 4 isoform X1. (646 aa)
	KAT2A	Histone acetyltransferase KAT2A isoform X1. (878 aa)
	PTH	Parathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion; Belongs to the parathyroid hormone family. (115 aa)
	NNMT	Nicotinamide N-methyltransferase. (264 aa)
	APOA1	Apolipoprotein A-I. (265 aa)
	NR1D1	Nuclear receptor subfamily 1 group D member 1. (613 aa)
	PLIN5	Perilipin; Belongs to the perilipin family. (454 aa)
	INSR	Tyrosine-protein kinase receptor. (1392 aa)
	ZBTB20	Zinc finger and BTB domain-containing protein 20 isoform X1. (741 aa)
	MID1IP1	Mid1-interacting protein 1. (183 aa)
	APP	Amyloid beta A4 protein isoform X1. (767 aa)
	WDR5	WD repeat-containing protein 5. (334 aa)
	PSEN1	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (468 aa)
	PPARD	Peroxisome proliferator-activated receptor delta isoform X1. (441 aa)
	GUCA1A	Guanylyl cyclase-activating protein 1. (205 aa)
	MLYCD	malonyl-CoA decarboxylase, mitochondrial isoform X1. (528 aa)
	ELOVL5	Elongation of very long chain fatty acids protein 5; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate to the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involv [...] (295 aa)
	SIRT1	NAD-dependent protein deacetylase sirtuin-1 isoform X1. (735 aa)
	CD74	HLA class II histocompatibility antigen gamma chain isoform X1. (278 aa)
	GUCA1B	Guanylyl cyclase-activating protein 2. (201 aa)
	TREM2	Triggering receptor expressed on myeloid cells 2. (294 aa)
	PMAIP1	Phorbol-12-myristate-13-acetate-induced protein 1. (54 aa)
	BEND3	BEN domain-containing protein 3. (828 aa)
	ACTN3	Alpha-actinin-3 isoform X1. (902 aa)
	STARD4	stAR-related lipid transfer protein 4 isoform X1. (241 aa)
	NR1H2	Oxysterols receptor LXR-beta isoform X1. (450 aa)
	BMP6	Bone morphogenetic protein 6. (496 aa)
	LOC111182058	General transcription factor II-I repeat domain-containing protein 2 isoform X1. (948 aa)
	IL1B	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (266 aa)
	TNF	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa)

Your Current Organism:

Delphinapterus leucas

NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABCD1	ABCD2	A0A2Y9MKI9	A0A2Y9N1V0	ATP-binding cassette sub-family D member 1 isoform X1.	ATP-binding cassette sub-family D member 2.	0.917
ABCD2	ABCD1	A0A2Y9N1V0	A0A2Y9MKI9	ATP-binding cassette sub-family D member 2.	ATP-binding cassette sub-family D member 1 isoform X1.	0.917
AKT1	AKT2	A0A2Y9NBQ2	A0A2Y9PDM4	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.900
AKT1	FOXO1	A0A2Y9NBQ2	A0A2Y9N6T9	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Forkhead box protein O1.	0.973
AKT1	IGF1	A0A2Y9NBQ2	A0A2Y9QDF3	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Insulin-like growth factor I isoform X1.	0.467
AKT1	INS	A0A2Y9NBQ2	A0A2Y9PTW5	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.556
AKT1	IRS1	A0A2Y9NBQ2	A0A2Y9MMM9	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Insulin receptor substrate 1.	0.529
AKT1	IRS2	A0A2Y9NBQ2	A0A2Y9NC55	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Insulin receptor substrate 2.	0.446
AKT1	NOS3	A0A2Y9NBQ2	A0A2Y9NEZ8	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Nitric oxide synthase; Produces nitric oxide (NO).	0.951
AKT1	TNF	A0A2Y9NBQ2	Q8WNR1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...]	0.434
AKT2	AKT1	A0A2Y9PDM4	A0A2Y9NBQ2	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.900
AKT2	FOXO1	A0A2Y9PDM4	A0A2Y9N6T9	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Forkhead box protein O1.	0.973
AKT2	IGF1	A0A2Y9PDM4	A0A2Y9QDF3	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Insulin-like growth factor I isoform X1.	0.467
AKT2	INS	A0A2Y9PDM4	A0A2Y9PTW5	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.556
AKT2	IRS1	A0A2Y9PDM4	A0A2Y9MMM9	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Insulin receptor substrate 1.	0.529
AKT2	IRS2	A0A2Y9PDM4	A0A2Y9NC55	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Insulin receptor substrate 2.	0.446
AKT2	NOS3	A0A2Y9PDM4	A0A2Y9NEZ8	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Nitric oxide synthase; Produces nitric oxide (NO).	0.951
AKT2	TNF	A0A2Y9PDM4	Q8WNR1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...]	0.434
ANXA1	APP	A0A2Y9N3F3	A0A2Y9NJ25	Annexin.	Amyloid beta A4 protein isoform X1.	0.517
ANXA1	ENO1	A0A2Y9N3F3	A0A2Y9Q9B9	Annexin.	Alpha-enolase isoform X1.	0.442