STRINGSTRING
BAK1 BAK1 RNF186 RNF186 MAP3K5 MAP3K5 AIFM1 AIFM1 BAG6 BAG6 ITPR1 ITPR1 DDIT3 DDIT3 PDX1 PDX1 QRICH1 QRICH1 ERO1A ERO1A TMEM117 TMEM117 PML PML DAB2IP DAB2IP BAX BAX BCL2 BCL2 ERN2 ERN2 ERN1 ERN1 BBC3 BBC3 CHAC1 CHAC1 ATP2A1 ATP2A1 TRIB3 TRIB3 ATF4 ATF4 ATP2A3 ATP2A3 CEBPB CEBPB APAF1 APAF1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BAK1Bcl-2 homologous antagonist/killer isoform X1. (239 aa)
RNF186RING finger protein 186. (226 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5 isoform X1. (1366 aa)
AIFM1Apoptosis-inducing factor 1, mitochondrial isoform X1. (613 aa)
BAG6Large proline-rich protein BAG6 isoform X1. (1164 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1 isoform X1. (2749 aa)
DDIT3DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (168 aa)
PDX1Pancreas/duodenum homeobox protein 1. (289 aa)
QRICH1Glutamine-rich protein 1. (780 aa)
ERO1AERO1-like protein alpha. (468 aa)
TMEM117Transmembrane protein 117 isoform X1. (515 aa)
PMLProtein PML isoform X1. (861 aa)
DAB2IPDisabled homolog 2-interacting protein isoform X1. (1193 aa)
BAXApoptosis regulator BAX isoform X2. (223 aa)
BCL2Apoptosis regulator Bcl-2. (233 aa)
ERN2Serine/threonine-protein kinase/endoribonuclease IRE2. (927 aa)
ERN1Serine/threonine-protein kinase/endoribonuclease IRE1. (975 aa)
BBC3Bcl-2-binding component 3. (193 aa)
CHAC1Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family. (215 aa)
ATP2A1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1006 aa)
TRIB3LOW QUALITY PROTEIN: tribbles homolog 3. (357 aa)
ATF4Cyclic AMP-dependent transcription factor ATF-4 isoform X1. (350 aa)
ATP2A3Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1057 aa)
CEBPBCCAAT/enhancer-binding protein. (345 aa)
APAF1Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1248 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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