STRINGSTRING
ABL1 ABL1 CRKL CRKL CCL19 CCL19 PLA2G5 PLA2G5 F2RL1 F2RL1 CCL21 CCL21 LOC111163731 LOC111163731 LOC111163732 LOC111163732 PDE8A PDE8A CCL5 CCL5 LOC111163729 LOC111163729 LOC111163733 LOC111163733 NOD2 NOD2 TEK TEK FGF10 FGF10 CCL22 CCL22 CX3CL1 CX3CL1 NDRG4 NDRG4 LOC111165935 LOC111165935 CTGF CTGF FGFR3 FGFR3 HTR2C HTR2C PHB PHB CCL17 CCL17 BMP2 BMP2 SHC1 SHC1 FBXW9 FBXW9 OPRM1 OPRM1 XCL1 XCL1 ALKAL1 ALKAL1 PTPRC PTPRC SLAMF1 SLAMF1 PDGFA PDGFA AAED1 AAED1 PDGFRA PDGFRA GPER1 GPER1 PDGFD PDGFD HRAS HRAS CAVIN3 CAVIN3 ALKAL2 ALKAL2 AGER AGER CIB1 CIB1 FGFR4 FGFR4 GPR55 GPR55 CCL20 CCL20 NPNT NPNT ERBB4 ERBB4 ABCA7 ABCA7 KDR KDR ACKR3 ACKR3 FFAR4 FFAR4 GCG GCG BMP4 BMP4 MFHAS1 MFHAS1 FLT4 FLT4 MAP3K12 MAP3K12 LOC111171209 LOC111171209 HTR2B HTR2B THPO THPO FERMT2 FERMT2 GAREM2 GAREM2 TNFSF11 TNFSF11 FGF8 FGF8 JUN JUN LOC111176429 LOC111176429 HCRTR1 HCRTR1 IL26 IL26 FSHR FSHR DNAJC27 DNAJC27 FGF23 FGF23 HTR2A HTR2A PHB2 PHB2 SLC30A10 SLC30A10 APP APP GAS6 GAS6 SPRY2 SPRY2 NPTN NPTN SEMA7A SEMA7A BRAF BRAF CARD9 CARD9 PDGFC PDGFC BMPER BMPER NOTCH1 NOTCH1 MAP2K1 MAP2K1 PRKD2 PRKD2 TREM2 TREM2 RAP1A RAP1A NOD1 NOD1 APELA APELA TNFRSF11A TNFRSF11A C5AR1 C5AR1 C5AR2 C5AR2 TGFB1 TGFB1 FGF21 FGF21 RAPGEF2 RAPGEF2 CD44 CD44 GAREM1 GAREM1 PYCARD PYCARD GCNT2 GCNT2 NOTCH2 NOTCH2 PTPN22 PTPN22 CCL26 CCL26 RASGRP1 RASGRP1 MAPK3 MAPK3 LOC111181354 LOC111181354 PRKCA PRKCA ADCYAP1 ADCYAP1 TPBG TPBG PDGFRB PDGFRB CD74 CD74 FGF4 FGF4 CCL24 CCL24 FGF1 FGF1 CSF1R CSF1R SRC SRC DSTYK DSTYK NOX4 NOX4 P2RY6 P2RY6 SCIMP SCIMP HAND2 HAND2 RAMP3 RAMP3 SERPINF2 SERPINF2 PDGFB PDGFB EGFR EGFR LOC111185731 LOC111185731 CHI3L1 CHI3L1 LOC111185794 LOC111185794 ARRB1 ARRB1 ARRB2 ARRB2 ALOX15 ALOX15 F2R F2R PTK2B PTK2B FGF18 FGF18 LOC111185888 LOC111185888 FGB FGB PRKCZ PRKCZ FGG FGG FBXW7 FBXW7 IGF1 IGF1 GLIPR2 GLIPR2 PTPN11 PTPN11 TRPV4 TRPV4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ABL1Tyrosine-protein kinase. (1148 aa)
CRKLCrk-like protein. (303 aa)
CCL19C-C motif chemokine. (159 aa)
PLA2G5Phospholipase A(2). (156 aa)
F2RL1Proteinase-activated receptor 2. (315 aa)
CCL21C-C motif chemokine 21 isoform X1. (131 aa)
LOC111163731C-C motif chemokine. (93 aa)
LOC111163732C-C motif chemokine. (92 aa)
PDE8APhosphodiesterase. (657 aa)
CCL5C-C motif chemokine. (91 aa)
LOC111163729C-C motif chemokine. (194 aa)
LOC111163733C-C motif chemokine. (90 aa)
NOD2Nucleotide-binding oligomerization domain-containing protein 2 isoform X1. (1086 aa)
TEKAngiopoietin-1 receptor. (1125 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
CCL22C-C motif chemokine. (93 aa)
CX3CL1Fractalkine. (469 aa)
NDRG4Protein NDRG4 isoform X1. (404 aa)
LOC111165935Ras-like protein isoform X1. (285 aa)
CTGFConnective tissue growth factor isoform X1. (349 aa)
FGFR3Fibroblast growth factor receptor. (805 aa)
HTR2C5-hydroxytryptamine receptor 2C. (456 aa)
PHBProhibitin. (272 aa)
CCL17C-C motif chemokine. (109 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
SHC1SHC-transforming protein 1 isoform X1. (609 aa)
FBXW9F-box/WD repeat-containing protein 9 isoform X1. (461 aa)
OPRM1Mu-type opioid receptor isoform X1; Belongs to the G-protein coupled receptor 1 family. (462 aa)
XCL1Lymphotactin. (111 aa)
ALKAL1ALK and LTK ligand 1. (121 aa)
PTPRCReceptor-type tyrosine-protein phosphatase C isoform X1. (1258 aa)
SLAMF1Signaling lymphocytic activation molecule isoform X1. (378 aa)
PDGFAPlatelet-derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (196 aa)
AAED1Thioredoxin-like protein AAED1 isoform X1. (234 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
GPER1G-protein coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (354 aa)
PDGFDPlatelet-derived growth factor D isoform X1. (402 aa)
HRASGTPase HRas isoform X1. (189 aa)
CAVIN3Caveolae-associated protein 3. (262 aa)
ALKAL2ALK and LTK ligand 2 isoform X1. (152 aa)
AGERAdvanced glycosylation end product-specific receptor isoform X1. (631 aa)
CIB1Calcium and integrin-binding protein 1. (191 aa)
FGFR4Fibroblast growth factor receptor. (801 aa)
GPR55G-protein coupled receptor 55 isoform X1; Belongs to the G-protein coupled receptor 1 family. (407 aa)
CCL20C-C motif chemokine. (97 aa)
NPNTNephronectin isoform X3. (595 aa)
ERBB4Receptor protein-tyrosine kinase. (1308 aa)
ABCA7LOW QUALITY PROTEIN: ATP-binding cassette sub-family A member 7. (2103 aa)
KDRVascular endothelial growth factor receptor 2 isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
ACKR3Atypical chemokine receptor 3 isoform X1; Belongs to the G-protein coupled receptor 1 family. (417 aa)
FFAR4Free fatty acid receptor 4 isoform X3. (375 aa)
GCGGlucagon isoform X1. (180 aa)
BMP4Bone morphogenetic protein 4 isoform X2. (408 aa)
MFHAS1Malignant fibrous histiocytoma-amplified sequence 1 isoform X1. (1058 aa)
FLT4Vascular endothelial growth factor receptor 3 isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1367 aa)
MAP3K12Mitogen-activated protein kinase kinase kinase 12; May be an activator of the JNK/SAPK pathway. (929 aa)
LOC111171209C-C motif chemokine 13-like. (116 aa)
HTR2B5-hydroxytryptamine receptor 2B. (490 aa)
THPOThrombopoietin isoform X1. (324 aa)
FERMT2Fermitin family homolog 2 isoform X2. (691 aa)
GAREM2GRB2-associated and regulator of MAPK protein 2 isoform X1. (880 aa)
TNFSF11Tumor necrosis factor ligand superfamily member 11; Belongs to the tumor necrosis factor family. (322 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
JUNTranscription factor AP-1; Belongs to the bZIP family. (343 aa)
LOC111176429G-protein coupled receptor 183; Belongs to the G-protein coupled receptor 1 family. (360 aa)
HCRTR1Orexin receptor type 1; Belongs to the G-protein coupled receptor 1 family. (425 aa)
IL26Interleukin-26. (171 aa)
FSHRFollicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. (695 aa)
DNAJC27dnaJ homolog subfamily C member 27 isoform X1. (273 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (315 aa)
HTR2A5-hydroxytryptamine receptor 2A. (470 aa)
PHB2Prohibitin. (299 aa)
SLC30A10Zinc transporter 10. (485 aa)
APPAmyloid beta A4 protein isoform X1. (767 aa)
GAS6Growth arrest-specific protein 6. (671 aa)
SPRY2Protein sprouty homolog 2. (315 aa)
NPTNNeuroplastin isoform X1. (398 aa)
SEMA7Asemaphorin-7A; Belongs to the semaphorin family. (665 aa)
BRAFSerine/threonine-protein kinase B-raf isoform X1. (762 aa)
CARD9Caspase recruitment domain-containing protein 9 isoform X1. (539 aa)
PDGFCPlatelet-derived growth factor C isoform X2. (380 aa)
BMPERBMP-binding endothelial regulator protein isoform X1. (685 aa)
NOTCH1Neurogenic locus notch homolog protein 1 isoform X1. (2521 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
PRKD2Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (878 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (294 aa)
RAP1ARas-related protein Rap-1A. (184 aa)
NOD1Nucleotide-binding oligomerization domain-containing protein 1 isoform X1. (953 aa)
APELAApelin receptor early endogenous ligand. (54 aa)
TNFRSF11ATumor necrosis factor receptor superfamily member 11A isoform X1. (551 aa)
C5AR1C5a anaphylatoxin chemotactic receptor 1 isoform X1; Belongs to the G-protein coupled receptor 1 family. (424 aa)
C5AR2C5a anaphylatoxin chemotactic receptor 2 isoform X1. (343 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
FGF21Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
RAPGEF2Rap guanine nucleotide exchange factor 2 isoform X1. (1651 aa)
CD44CD44 antigen isoform X1. (742 aa)
GAREM1GRB2-associated and regulator of MAPK protein 1 isoform X2. (876 aa)
PYCARDApoptosis-associated speck-like protein containing a CARD. (195 aa)
GCNT2N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase isoform X1. (419 aa)
NOTCH2Neurogenic locus notch homolog protein 2 isoform X1. (2471 aa)
PTPN22Tyrosine-protein phosphatase non-receptor type 22 isoform X1. (801 aa)
CCL26C-C motif chemokine 26. (94 aa)
RASGRP1RAS guanyl-releasing protein 1 isoform X1. (870 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (382 aa)
LOC111181354N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase-like. (321 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (670 aa)
ADCYAP1Pituitary adenylate cyclase-activating polypeptide isoform X1. (176 aa)
TPBGTrophoblast glycoprotein. (419 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1103 aa)
CD74HLA class II histocompatibility antigen gamma chain isoform X1. (278 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
CCL24C-C motif chemokine 24. (119 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (189 aa)
CSF1RMacrophage colony-stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (961 aa)
SRCTyrosine-protein kinase. (562 aa)
DSTYKDual serine/threonine and tyrosine protein kinase isoform X1. (929 aa)
NOX4NADPH oxidase 4. (530 aa)
P2RY6P2Y purinoceptor 6. (328 aa)
SCIMPSLP adapter and CSK-interacting membrane protein. (143 aa)
HAND2LOW QUALITY PROTEIN: heart- and neural crest derivatives-expressed protein 2. (217 aa)
RAMP3Receptor activity-modifying protein 3. (151 aa)
SERPINF2Alpha-2-antiplasmin isoform X1; Belongs to the serpin family. (558 aa)
PDGFBPlatelet-derived growth factor subunit B isoform X1; Belongs to the PDGF/VEGF growth factor family. (278 aa)
EGFRReceptor protein-tyrosine kinase. (1209 aa)
LOC111185731C-C motif chemokine. (99 aa)
CHI3L1LOW QUALITY PROTEIN: chitinase-3-like protein 1; Belongs to the glycosyl hydrolase 18 family. (393 aa)
LOC111185794C-C motif chemokine. (97 aa)
ARRB1Beta-arrestin-1 isoform X1. (430 aa)
ARRB2Beta-arrestin-2 isoform X1. (409 aa)
ALOX15LOW QUALITY PROTEIN: arachidonate 15-lipoxygenase. (663 aa)
F2RProteinase-activated receptor 1; Belongs to the G-protein coupled receptor 1 family. (427 aa)
PTK2BProtein-tyrosine kinase 2-beta isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1015 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
LOC111185888C-C motif chemokine. (99 aa)
FGBFibrinogen beta chain isoform X1. (495 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (629 aa)
FGGFibrinogen gamma chain isoform X1. (445 aa)
FBXW7F-box/WD repeat-containing protein 7 isoform X1. (707 aa)
IGF1Insulin-like growth factor I isoform X1. (186 aa)
GLIPR2Golgi-associated plant pathogenesis-related protein 1 isoform X1; Belongs to the CRISP family. (154 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (623 aa)
TRPV4Transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (870 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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