STRINGSTRING
ATF2 ATF2 FOXO1 FOXO1 PRKCE PRKCE EPAS1 EPAS1 LIMD1 LIMD1 ADAM8 ADAM8 CXCR4 CXCR4 ITPR1 ITPR1 VEGFC VEGFC HIF1A HIF1A ATP6AP1 ATP6AP1 BNIP3 BNIP3 PLAT PLAT EGLN3 EGLN3 SFRP1 SFRP1 NR4A2 NR4A2 BACH1 BACH1 PDK1 PDK1 HIF1AN HIF1AN CPEB2 CPEB2 DPP4 DPP4 LOC111169978 LOC111169978 FAS FAS ARNT2 ARNT2 AJUBA AJUBA EGLN1 EGLN1 OPRD1 OPRD1 AQP3 AQP3 PINK1 PINK1 HP1BP3 HP1BP3 ARNT ARNT SUV39H1 SUV39H1 SOD3 SOD3 FAM162A FAM162A MECP2 MECP2 AGER AGER LOC111170864 LOC111170864 LOC111169240 LOC111169240 VEGFD VEGFD MYOCD MYOCD CRYAB CRYAB NDUFS2 NDUFS2 USF1 USF1 LOC111169295 LOC111169295 CITED2 CITED2 CHRNB2 CHRNB2 ALKBH5 ALKBH5 ADO ADO GUCY1A2 GUCY1A2 HYOU1 HYOU1 FNDC1 FNDC1 NPEPPS NPEPPS UBQLN1 UBQLN1 LMNA LMNA MMP2 MMP2 MGARP MGARP BMP2 BMP2 WDR83 WDR83 ATP6V1A ATP6V1A RYR2 RYR2 EDN1 EDN1 PLAU PLAU TBL2 TBL2 SIRT1 SIRT1 STOX1 STOX1 KCNMA1 KCNMA1 EPO EPO DDIT4 DDIT4 ASCL2 ASCL2 ANGPT4 ANGPT4 PIN1 PIN1 LONP1 LONP1 LOC111165042 LOC111165042 MYOD1 MYOD1 BBC3 BBC3 RNASE4 RNASE4 EGR1 EGR1 NOP53 NOP53 GATA6 GATA6 BCL2 BCL2 HILPDA HILPDA NARF NARF P4HB P4HB FMN2 FMN2 TH TH TWIST1 TWIST1 NARFL NARFL HMOX2 HMOX2 BAD BAD VEGFB VEGFB P2RX3 P2RX3 ADA ADA FAM167A FAM167A TM9SF4 TM9SF4 LOXL2 LOXL2 NDNF NDNF PTGS2 PTGS2 TMEM199 TMEM199 PTGIS PTGIS LOC111185989 LOC111185989 CHRNA4 CHRNA4 P2RX2 P2RX2 VASN VASN PICK1 PICK1 NKX3-1 NKX3-1 EP300 EP300 PDPN PDPN NF1 NF1 ATP6V0A2 ATP6V0A2 PLOD1 PLOD1 MTOR MTOR EDNRA EDNRA NOS1 NOS1 PLEKHN1 PLEKHN1 HSP90B1 HSP90B1 HMOX1 HMOX1 ALAS2 ALAS2 AQP1 AQP1 CBFA2T3 CBFA2T3 WTIP WTIP SIRT2 SIRT2 PLOD2 PLOD2 ATP6V0D1 ATP6V0D1 GUCY1B3 GUCY1B3 HIF3A HIF3A PMAIP1 PMAIP1 PGK1 PGK1 RYR1 RYR1 NOX1 NOX1 EGLN2 EGLN2 TERT TERT CAV1 CAV1 SMAD4 SMAD4 SMAD3 SMAD3 NOTCH1 NOTCH1 NOL3 NOL3 GUCY1A3 GUCY1A3 ATP6V1G1 ATP6V1G1 PPARD PPARD TGFB3 TGFB3 PML PML SRF SRF SUV39H2 SUV39H2 TIGAR TIGAR TGFB2 TGFB2 CHRNA7 CHRNA7 SLC2A8 SLC2A8 RORA RORA SCAP SCAP SLC11A2 SLC11A2 ITPR2 ITPR2 PLK3 PLK3 PGF PGF NGB NGB ZFP36L1 ZFP36L1 NFE2L2 NFE2L2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ATF2Cyclic AMP-dependent transcription factor ATF-2 isoform X1. (505 aa)
FOXO1Forkhead box protein O1. (663 aa)
PRKCEProtein kinase C. (746 aa)
EPAS1Endothelial PAS domain-containing protein 1 isoform X1. (866 aa)
LIMD1LIM domain-containing protein 1. (669 aa)
ADAM8Disintegrin and metalloproteinase domain-containing protein 8 isoform X1. (838 aa)
CXCR4C-X-C chemokine receptor type 4; Belongs to the G-protein coupled receptor 1 family. (353 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1 isoform X1. (2749 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (420 aa)
HIF1AHypoxia-inducible factor 1-alpha isoform X1. (823 aa)
ATP6AP1V-type proton ATPase subunit S1. (469 aa)
BNIP3BCL2/adenovirus E1B 19 kDa protein-interacting protein 3. (196 aa)
PLATPlasminogen activator; Belongs to the peptidase S1 family. (565 aa)
EGLN3Egl nine homolog 3. (239 aa)
SFRP1Secreted frizzled-related protein 1. (308 aa)
NR4A2Nuclear receptor subfamily 4 group A member 2 isoform X1. (598 aa)
BACH1Transcription regulator protein BACH1 isoform X1. (744 aa)
PDK1Protein-serine/threonine kinase. (438 aa)
HIF1ANHypoxia-inducible factor 1-alpha inhibitor. (349 aa)
CPEB2LOW QUALITY PROTEIN: cytoplasmic polyadenylation element-binding protein 2. (1043 aa)
DPP4Dipeptidyl peptidase 4 isoform X1; Belongs to the peptidase S9B family. (804 aa)
LOC111169978Von Hippel-Lindau disease tumor suppressor. (166 aa)
FASTumor necrosis factor receptor superfamily member 6 isoform X1. (334 aa)
ARNT2Aryl hydrocarbon receptor nuclear translocator 2 isoform X1. (717 aa)
AJUBALIM domain-containing protein ajuba isoform X1. (557 aa)
EGLN1Egl nine homolog 1. (439 aa)
OPRD1Delta-type opioid receptor; Belongs to the G-protein coupled receptor 1 family. (368 aa)
AQP3Aquaporin-3; Belongs to the MIP/aquaporin (TC 1.A.8) family. (292 aa)
PINK1Serine/threonine-protein kinase PINK1, mitochondrial isoform X1. (584 aa)
HP1BP3Heterochromatin protein 1-binding protein 3 isoform X1. (553 aa)
ARNTAryl hydrocarbon receptor nuclear translocator isoform X1. (790 aa)
SUV39H1Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily. (419 aa)
SOD3Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family. (244 aa)
FAM162AProtein FAM162A isoform X1. (156 aa)
MECP2Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (486 aa)
AGERAdvanced glycosylation end product-specific receptor isoform X1. (631 aa)
LOC111170864Recombining binding protein suppressor of hairless isoform X1. (500 aa)
LOC111169240RE1-silencing transcription factor-like isoform X2. (976 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (354 aa)
MYOCDMyocardin isoform X1. (985 aa)
CRYABAlpha-crystallin B chain; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. (175 aa)
NDUFS2NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial; Belongs to the complex I 49 kDa subunit family. (463 aa)
USF1Upstream stimulatory factor 1 isoform X1. (310 aa)
LOC111169295RE1-silencing transcription factor-like isoform X1. (981 aa)
CITED2Cbp/p300-interacting transactivator 2. (272 aa)
CHRNB2Neuronal acetylcholine receptor subunit beta-2. (502 aa)
ALKBH5RNA demethylase ALKBH5. (394 aa)
ADO2-aminoethanethiol dioxygenase. (270 aa)
GUCY1A2Guanylate cyclase soluble subunit alpha-2 isoform X1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (726 aa)
HYOU1Hypoxia up-regulated protein 1 isoform X1. (998 aa)
FNDC1Fibronectin type III domain-containing protein 1. (1876 aa)
NPEPPSAminopeptidase. (921 aa)
UBQLN1Ubiquilin-1 isoform X1. (590 aa)
LMNALamin; Belongs to the intermediate filament family. (664 aa)
MMP272 kDa type IV collagenase. (661 aa)
MGARPProtein MGARP isoform X1. (240 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
WDR83WD repeat domain-containing protein 83. (315 aa)
ATP6V1ALOW QUALITY PROTEIN: V-type proton ATPase catalytic subunit A. (621 aa)
RYR2Ryanodine receptor 2 isoform X1. (4965 aa)
EDN1Endothelin-1. (202 aa)
PLAUUrokinase-type plasminogen activator. (431 aa)
TBL2Transducin beta-like protein 2. (446 aa)
SIRT1NAD-dependent protein deacetylase sirtuin-1 isoform X1. (735 aa)
STOX1Storkhead-box protein 1 isoform X1. (990 aa)
KCNMA1LOW QUALITY PROTEIN: calcium-activated potassium channel subunit alpha-1. (1320 aa)
EPOErythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. (193 aa)
DDIT4DNA damage-inducible transcript 4 protein. (229 aa)
ASCL2Achaete-scute homolog 2. (191 aa)
ANGPT4Angiopoietin-4. (498 aa)
PIN1Peptidyl-prolyl cis-trans isomerase. (163 aa)
LONP1Lon protease homolog, mitochondrial; ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial promoters and RNA in a single-stranded, site-specific, and strand- specific manner. May regulate mi [...] (961 aa)
LOC111165042Protein NDRG1. (374 aa)
MYOD1Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (319 aa)
BBC3Bcl-2-binding component 3. (193 aa)
RNASE4Ribonuclease 4; Belongs to the pancreatic ribonuclease family. (147 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (531 aa)
NOP53Ribosome biogenesis protein NOP53. (486 aa)
GATA6Transcription factor GATA-6. (592 aa)
BCL2Apoptosis regulator Bcl-2. (233 aa)
HILPDALOW QUALITY PROTEIN: hypoxia-inducible lipid droplet-associated protein. (63 aa)
NARFNuclear prelamin A recognition factor; Belongs to the NARF family. (456 aa)
P4HBProtein disulfide-isomerase. (510 aa)
FMN2LOW QUALITY PROTEIN: formin-2. (1445 aa)
THTyrosine 3-monooxygenase. (492 aa)
TWIST1Twist-related protein 1. (205 aa)
NARFLCytosolic Fe-S cluster assembly factor NARFL isoform X1; Belongs to the NARF family. (476 aa)
HMOX2Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (316 aa)
BADBcl2-associated agonist of cell death. (168 aa)
VEGFBVascular endothelial growth factor B isoform X1; Belongs to the PDGF/VEGF growth factor family. (209 aa)
P2RX3P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (397 aa)
ADAAdenosine deaminase isoform X1. (416 aa)
FAM167AProtein FAM167A. (210 aa)
TM9SF4Transmembrane 9 superfamily member; Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family. (642 aa)
LOXL2Lysyl oxidase homolog 2. (774 aa)
NDNFProtein NDNF. (568 aa)
PTGS2Prostaglandin G/H synthase 2. (604 aa)
TMEM199Transmembrane protein 199 isoform X1. (208 aa)
PTGISProstacyclin synthase; Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2); Belongs to the cytochrome P450 family. (500 aa)
LOC111185989Nitric oxide synthase; Produces nitric oxide (NO). (1146 aa)
CHRNA4Neuronal acetylcholine receptor subunit alpha-4 isoform X1. (826 aa)
P2RX2P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (479 aa)
VASNVasorin. (676 aa)
PICK1PRKCA-binding protein isoform X1. (417 aa)
NKX3-1Homeobox protein Nkx-3.1. (241 aa)
EP300Histone acetyltransferase p300. (2420 aa)
PDPNPodoplanin isoform X1. (235 aa)
NF1Neurofibromin isoform X1. (2873 aa)
ATP6V0A2V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (867 aa)
PLOD1Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 isoform X1. (735 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2548 aa)
EDNRAEndothelin-1 receptor isoform X1; Belongs to the G-protein coupled receptor 1 family. (427 aa)
NOS1Nitric oxide synthase, brain isoform X1. (1461 aa)
PLEKHN1Pleckstrin homology domain-containing family N member 1 isoform X1. (634 aa)
HSP90B1Endoplasmin. (805 aa)
HMOX1Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (288 aa)
ALAS25-aminolevulinate synthase, erythroid-specific, mitochondrial; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. (582 aa)
AQP1Aquaporin-1; Belongs to the MIP/aquaporin (TC 1.A.8) family. (271 aa)
CBFA2T3Protein CBFA2T3 isoform X1. (648 aa)
WTIPWilms tumor protein 1-interacting protein isoform X1. (434 aa)
SIRT2NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (389 aa)
PLOD2Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 isoform X1. (760 aa)
ATP6V0D1V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family. (351 aa)
GUCY1B3Guanylate cyclase soluble subunit beta-1 isoform X1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (619 aa)
HIF3AHypoxia-inducible factor 3-alpha isoform X1. (669 aa)
PMAIP1Phorbol-12-myristate-13-acetate-induced protein 1. (54 aa)
PGK1Phosphoglycerate kinase. (417 aa)
RYR1LOW QUALITY PROTEIN: ryanodine receptor 1. (5030 aa)
NOX1LOW QUALITY PROTEIN: NADPH oxidase 1. (567 aa)
EGLN2Egl nine homolog 2. (402 aa)
TERTTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1203 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
SMAD4Mothers against decapentaplegic homolog. (553 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
NOTCH1Neurogenic locus notch homolog protein 1 isoform X1. (2521 aa)
NOL3Nucleolar protein 3. (202 aa)
GUCY1A3Guanylate cyclase soluble subunit alpha-3 isoform X1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (691 aa)
ATP6V1G1V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (118 aa)
PPARDPeroxisome proliferator-activated receptor delta isoform X1. (441 aa)
TGFB3Transforming growth factor beta-3. (456 aa)
PMLProtein PML isoform X1. (861 aa)
SRFSerum response factor isoform X2. (535 aa)
SUV39H2Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily. (350 aa)
TIGARFructose-2,6-bisphosphatase TIGAR isoform X1. (325 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
CHRNA7Neuronal acetylcholine receptor subunit alpha-7 isoform X2. (499 aa)
SLC2A8Solute carrier family 2, facilitated glucose transporter member 8 isoform X1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (477 aa)
RORANuclear receptor ROR-alpha isoform X1. (523 aa)
SCAPSterol regulatory element-binding protein cleavage-activating protein isoform X1. (1280 aa)
SLC11A2Natural resistance-associated macrophage protein 2 isoform X1. (579 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2 isoform X1. (2701 aa)
PLK3Serine/threonine-protein kinase PLK. (647 aa)
PGFPlacenta growth factor isoform X1; Belongs to the PDGF/VEGF growth factor family. (170 aa)
NGBNeuroglobin isoform X1; Belongs to the globin family. (205 aa)
ZFP36L1mRNA decay activator protein ZFP36L1. (338 aa)
NFE2L2Nuclear factor erythroid 2-related factor 2 isoform X1. (622 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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