STRINGSTRING
N4BP1 N4BP1 HSF1 HSF1 SCX SCX NFATC4 NFATC4 PTPRK PTPRK KDM1A KDM1A MYD88 MYD88 LOC111163571 LOC111163571 SLC9A1 SLC9A1 ERCC4 ERCC4 CHEK2 CHEK2 SPIDR SPIDR LOC111165935 LOC111165935 DDX3X DDX3X TNFSF14 TNFSF14 RAB11B RAB11B PCNA PCNA LRRC8E LRRC8E LRRC8D LRRC8D LOC111165064 LOC111165064 GNA11 GNA11 GRM1 GRM1 BRCA1 BRCA1 TMEM161A TMEM161A TRPM1 TRPM1 CERS1 CERS1 INSRR INSRR MMP2 MMP2 TLR7 TLR7 TLR8 TLR8 USP47 USP47 RCSD1 RCSD1 GTF2H5 GTF2H5 NEUROD2 NEUROD2 TIMP1 TIMP1 RP1 RP1 MCOLN1 MCOLN1 MFAP4 MFAP4 ATM ATM CUL4B CUL4B GPLD1 GPLD1 RIPOR2 RIPOR2 CRADD CRADD RGR RGR XPC XPC AQP10 AQP10 OPN4 OPN4 COL1A1 COL1A1 LOC111169295 LOC111169295 LOC111169056 LOC111169056 WNK3 WNK3 F11R F11R SMPD1 SMPD1 CLOCK CLOCK BLM BLM CRYAB CRYAB CHEK1 CHEK1 CD40 CD40 MAP3K14 MAP3K14 HRAS HRAS PALM PALM LOC111169240 LOC111169240 CNN2 CNN2 YAP1 YAP1 CASP10 CASP10 RHO RHO RHBDD1 RHBDD1 MMP9 MMP9 COPS9 COPS9 RS1 RS1 CASP8 CASP8 XRCC5 XRCC5 KCNK18 KCNK18 BRCC3 BRCC3 FAS FAS BAG3 BAG3 NET1 NET1 RDH11 RDH11 EIF2S1 EIF2S1 STK11 STK11 SFRP1 SFRP1 STK39 STK39 PRAP1 PRAP1 BNIP3 BNIP3 ZBTB1 ZBTB1 ECT2 ECT2 AQP2 AQP2 ASIC1 ASIC1 PIK3CA PIK3CA PKD2L1 PKD2L1 TLR3 TLR3 ANKRD1 ANKRD1 TANK TANK TREX1 TREX1 CDC25A CDC25A BABAM2 BABAM2 WRN WRN HYAL1 HYAL1 SLC38A3 SLC38A3 AQP5 AQP5 MAP3K20 MAP3K20 ZFP36L1 ZFP36L1 LOC111175787 LOC111175787 PRKCD PRKCD GPR68 GPR68 HYAL3 HYAL3 YY1 YY1 BDKRB2 BDKRB2 SLC24A4 SLC24A4 LTBR LTBR ZMPSTE24 ZMPSTE24 RHNO1 RHNO1 CCND2 CCND2 HYAL2 HYAL2 GNAT1 GNAT1 OPN3 OPN3 YBX3 YBX3 BRCA2 BRCA2 ADSS ADSS LIG4 LIG4 DHRS12 DHRS12 RAD51AP1 RAD51AP1 SCNN1A SCNN1A CASP2 CASP2 CRB1 CRB1 OPN5 OPN5 SDE2 SDE2 PARP1 PARP1 BAK1 BAK1 GNB5 GNB5 CUNH9orf116 CUNH9orf116 NEDD4 NEDD4 GADD45A GADD45A MAPK13 MAPK13 CDKN1A CDKN1A TNFRSF1A TNFRSF1A POLH POLH RPE65 RPE65 PKD2 PKD2 PIEZO1 PIEZO1 ERCC1 ERCC1 OPN1SW OPN1SW TP53INP1 TP53INP1 NOX1 NOX1 BCL10 BCL10 NFKB1 NFKB1 ATR ATR DHX36 DHX36 TGFB1 TGFB1 PPID PPID RAD51 RAD51 SLC12A6 SLC12A6 METTL3 METTL3 AQP1 AQP1 POLD1 POLD1 GPR88 GPR88 IRF1 IRF1 EGR1 EGR1 INO80 INO80 MAPK3 MAPK3 RUVBL2 RUVBL2 BBC3 BBC3 LOC111182889 LOC111182889 IMPACT IMPACT MAP3K2 MAP3K2 RGS9 RGS9 CAPN3 CAPN3 RAD9A RAD9A GRB2 GRB2 BMF BMF SIRT1 SIRT1 TNKS1BP1 TNKS1BP1 SCNN1G SCNN1G EPO EPO SCNN1B SCNN1B FADD FADD KCNK4 KCNK4 TLK2 TLK2 HUS1 HUS1 NUCKS1 NUCKS1 WNT11 WNT11 PDE2A PDE2A ACTR5 ACTR5 FIGNL1 FIGNL1 INTS7 INTS7 POLD3 POLD3 DDB1 DDB1 TMEM109 TMEM109 BAD BAD AURKB AURKB DDB2 DDB2 POLK POLK MAP2K4 MAP2K4 CREBBP CREBBP PBK PBK SLC2A4 SLC2A4 PTGS2 PTGS2 TRPV1 TRPV1 XRCC6 XRCC6 CASP9 CASP9 EP300 EP300 MAP3K1 MAP3K1 RAD9B RAD9B PIK3R1 PIK3R1 NOC2L NOC2L FBXO4 FBXO4 TNFRSF8 TNFRSF8 TMEM150C TMEM150C PCK1 PCK1 HVCN1 HVCN1 XPA XPA PTGER4 PTGER4 NIPBL NIPBL RAD1 RAD1 SFRP2 SFRP2 TRPV4 TRPV4 IL1B IL1B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
N4BP1NEDD4-binding protein 1 isoform X1. (906 aa)
HSF1Heat shock factor protein 1 isoform X1. (564 aa)
SCXBasic helix-loop-helix transcription factor scleraxis isoform X2. (203 aa)
NFATC4LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 4. (901 aa)
PTPRKReceptor-type tyrosine-protein phosphatase kappa isoform X1. (1485 aa)
KDM1ALysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (876 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
LOC111163571Death domain-containing protein CRADD-like isoform X1. (182 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (816 aa)
ERCC4DNA repair endonuclease XPF. (916 aa)
CHEK2Serine/threonine-protein kinase Chk2. (544 aa)
SPIDRDNA repair-scaffolding protein isoform X1. (931 aa)
LOC111165935Ras-like protein isoform X1. (285 aa)
DDX3XATP-dependent RNA helicase DDX3X isoform X1; Belongs to the DEAD box helicase family. (662 aa)
TNFSF14Tumor necrosis factor ligand superfamily member 14 isoform X1. (241 aa)
RAB11BRas-related protein Rab-11B. (218 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
LRRC8EVolume-regulated anion channel subunit LRRC8E. (795 aa)
LRRC8DVolume-regulated anion channel subunit LRRC8D. (855 aa)
LOC111165064Plectin isoform X1. (4685 aa)
GNA11Guanine nucleotide-binding protein subunit alpha-11. (359 aa)
GRM1Metabotropic glutamate receptor 1. (1195 aa)
BRCA1Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1866 aa)
TMEM161ATransmembrane protein 161A. (479 aa)
TRPM1LOW QUALITY PROTEIN: transient receptor potential cation channel subfamily M member 1. (1649 aa)
CERS1Ceramide synthase 1 isoform X1. (350 aa)
INSRRTyrosine-protein kinase receptor. (1301 aa)
MMP272 kDa type IV collagenase. (661 aa)
TLR7Toll-like receptor 7 isoform X1. (1086 aa)
TLR8Toll-like receptor 8; Belongs to the Toll-like receptor family. (1035 aa)
USP47Ubiquitin carboxyl-terminal hydrolase 47 isoform X1; Belongs to the peptidase C19 family. (1375 aa)
RCSD1capZ-interacting protein isoform X1. (507 aa)
GTF2H5General transcription factor IIH subunit 5. (71 aa)
NEUROD2Neurogenic differentiation factor. (382 aa)
TIMP1Metalloproteinase inhibitor 1. (257 aa)
RP1Oxygen-regulated protein 1. (2137 aa)
MCOLN1Mucolipin-1 isoform X1. (585 aa)
MFAP4Microfibril-associated glycoprotein 4 isoform X2. (255 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3064 aa)
CUL4Bcullin-4B isoform X1; Belongs to the cullin family. (904 aa)
GPLD1Phosphatidylinositol-glycan-specific phospholipase D isoform X1. (849 aa)
RIPOR2Rho family-interacting cell polarization regulator 2 isoform X2. (1048 aa)
CRADDDeath domain-containing protein CRADD. (115 aa)
RGRRPE-retinal G protein-coupled receptor isoform X2; Belongs to the G-protein coupled receptor 1 family. Opsin subfamily. (295 aa)
XPCDNA repair protein complementing XP-C cells isoform X1. (959 aa)
AQP10LOW QUALITY PROTEIN: aquaporin-10; Belongs to the MIP/aquaporin (TC 1.A.8) family. (298 aa)
OPN4Melanopsin isoform X1. (490 aa)
COL1A1Collagen alpha-1(I) chain. (1463 aa)
LOC111169295RE1-silencing transcription factor-like isoform X1. (981 aa)
LOC111169056LOW QUALITY PROTEIN: peptidyl-prolyl cis-trans isomerase D-like. (370 aa)
WNK3Serine/threonine-protein kinase WNK3 isoform X1. (1780 aa)
F11RJunctional adhesion molecule A. (299 aa)
SMPD1Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. (623 aa)
CLOCKLOW QUALITY PROTEIN: circadian locomoter output cycles protein kaput. (858 aa)
BLMBloom syndrome protein isoform X1. (1429 aa)
CRYABAlpha-crystallin B chain; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. (175 aa)
CHEK1Serine/threonine-protein kinase Chk1 isoform X1. (540 aa)
CD40Tumor necrosis factor receptor superfamily member 5 isoform X1. (284 aa)
MAP3K14Mitogen-activated protein kinase kinase kinase 14 isoform X1. (961 aa)
HRASGTPase HRas isoform X1. (189 aa)
PALMParalemmin-1 isoform X1. (391 aa)
LOC111169240RE1-silencing transcription factor-like isoform X2. (976 aa)
CNN2Calponin; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. (380 aa)
YAP1Transcriptional coactivator YAP1 isoform X1. (511 aa)
CASP10Caspase-10; Belongs to the peptidase C14A family. (518 aa)
RHORhodopsin. (348 aa)
RHBDD1Rhomboid-related protein 4 isoform X1. (326 aa)
MMP9Matrix metalloproteinase-9. (709 aa)
COPS9COP9 signalosome complex subunit 9 isoform X2. (57 aa)
RS1Retinoschisin. (224 aa)
CASP8Caspase-8; Belongs to the peptidase C14A family. (486 aa)
XRCC5X-ray repair cross-complementing protein 5. (733 aa)
KCNK18LOW QUALITY PROTEIN: potassium channel subfamily K member 18; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (380 aa)
BRCC3Lys-63-specific deubiquitinase BRCC36 isoform X1. (316 aa)
FASTumor necrosis factor receptor superfamily member 6 isoform X1. (334 aa)
BAG3BAG family molecular chaperone regulator 3. (577 aa)
NET1Neuroepithelial cell-transforming gene 1 protein isoform X1. (596 aa)
RDH11Retinol dehydrogenase 11 isoform X1; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (316 aa)
EIF2S1Eukaryotic translation initiation factor 2 subunit 1. (315 aa)
STK11Serine/threonine-protein kinase STK11 isoform X1. (544 aa)
SFRP1Secreted frizzled-related protein 1. (308 aa)
STK39STE20/SPS1-related proline-alanine-rich protein kinase isoform X1. (539 aa)
PRAP1Proline-rich acidic protein 1 isoform X1. (153 aa)
BNIP3BCL2/adenovirus E1B 19 kDa protein-interacting protein 3. (196 aa)
ZBTB1Zinc finger and BTB domain-containing protein 1. (713 aa)
ECT2Protein ECT2 isoform X1. (973 aa)
AQP2Aquaporin-2; Belongs to the MIP/aquaporin (TC 1.A.8) family. (309 aa)
ASIC1Acid-sensing ion channel 1 isoform X1; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (640 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PKD2L1LOW QUALITY PROTEIN: polycystic kidney disease 2-like 1 protein. (811 aa)
TLR3Toll-like receptor 3; Belongs to the Toll-like receptor family. (905 aa)
ANKRD1Ankyrin repeat domain-containing protein 1. (319 aa)
TANKTRAF family member-associated NF-kappa-B activator isoform X1. (531 aa)
TREX1Three-prime repair exonuclease 1. (314 aa)
CDC25AM-phase inducer phosphatase 1 isoform X1. (524 aa)
BABAM2BRISC and BRCA1-A complex member 2 isoform X1. (383 aa)
WRNWerner syndrome ATP-dependent helicase isoform X1. (1454 aa)
HYAL1Hyaluronidase. (448 aa)
SLC38A3Sodium-coupled neutral amino acid transporter 3 isoform X1. (531 aa)
AQP5Aquaporin-5 isoform X1; Belongs to the MIP/aquaporin (TC 1.A.8) family. (261 aa)
MAP3K20Mitogen-activated protein kinase kinase kinase 20 isoform X1. (800 aa)
ZFP36L1mRNA decay activator protein ZFP36L1. (338 aa)
LOC111175787LOW QUALITY PROTEIN: cullin-4B-like; Belongs to the cullin family. (891 aa)
PRKCDProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (733 aa)
GPR68Ovarian cancer G-protein coupled receptor 1; Belongs to the G-protein coupled receptor 1 family. (371 aa)
HYAL3Hyaluronidase. (415 aa)
YY1Transcriptional repressor protein YY1. (412 aa)
BDKRB2B2 bradykinin receptor; Belongs to the G-protein coupled receptor 1 family. (360 aa)
SLC24A4Sodium/potassium/calcium exchanger 4 isoform X1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (618 aa)
LTBRTumor necrosis factor receptor superfamily member 3. (421 aa)
ZMPSTE24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (473 aa)
RHNO1RAD9, HUS1, RAD1-interacting nuclear orphan protein 1. (240 aa)
CCND2G1/S-specific cyclin-D2; Belongs to the cyclin family. (289 aa)
HYAL2Hyaluronidase. (476 aa)
GNAT1Guanine nucleotide-binding protein G(T) subunit alpha-1. (350 aa)
OPN3LOW QUALITY PROTEIN: opsin-3. (515 aa)
YBX3Y-box-binding protein 3 isoform X1. (371 aa)
BRCA2Breast cancer type 2 susceptibility protein. (3435 aa)
ADSSAdenylosuccinate synthetase isozyme 2; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. (456 aa)
LIG4DNA ligase. (911 aa)
DHRS12Dehydrogenase/reductase SDR family member 12 isoform X2. (328 aa)
RAD51AP1RAD51-associated protein 1 isoform X1. (331 aa)
SCNN1AAmiloride-sensitive sodium channel subunit alpha; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (648 aa)
CASP2Caspase-2 isoform X1; Belongs to the peptidase C14A family. (452 aa)
CRB1Protein crumbs homolog 1 isoform X1. (1457 aa)
OPN5Opsin-5; Belongs to the G-protein coupled receptor 1 family. (362 aa)
SDE2Protein SDE2 homolog isoform X1. (453 aa)
PARP1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1013 aa)
BAK1Bcl-2 homologous antagonist/killer isoform X1. (239 aa)
GNB5Guanine nucleotide-binding protein subunit beta-5 isoform X1. (414 aa)
CUNH9orf116UPF0691 protein C9orf116 homolog isoform X1. (136 aa)
NEDD4E3 ubiquitin-protein ligase NEDD4 isoform X3. (1319 aa)
GADD45AGrowth arrest and DNA damage-inducible protein GADD45 alpha. (165 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (164 aa)
TNFRSF1ATumor necrosis factor receptor superfamily member 1A. (445 aa)
POLHDNA polymerase eta isoform X1. (709 aa)
RPE65Retinoid isomerohydrolase. (533 aa)
PKD2Polycystin-2 isoform X1. (975 aa)
PIEZO1Piezo-type mechanosensitive ion channel component. (2501 aa)
ERCC1DNA excision repair protein ERCC-1 isoform X1. (414 aa)
OPN1SWShort-wave-sensitive opsin 1. (343 aa)
TP53INP1Tumor protein p53-inducible nuclear protein 1 isoform X1. (240 aa)
NOX1LOW QUALITY PROTEIN: NADPH oxidase 1. (567 aa)
BCL10B-cell lymphoma/leukemia 10. (233 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit isoform X1. (972 aa)
ATRSerine/threonine-protein kinase ATR isoform X1; Belongs to the PI3/PI4-kinase family. (2655 aa)
DHX36ATP-dependent RNA helicase DHX36 isoform X1. (1020 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
PPIDPeptidyl-prolyl cis-trans isomerase D isoform X1. (383 aa)
RAD51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa)
SLC12A6Solute carrier family 12 member 6 isoform X1. (1150 aa)
METTL3N6-adenosine-methyltransferase 70 kDa subunit; Belongs to the MT-A70-like family. (580 aa)
AQP1Aquaporin-1; Belongs to the MIP/aquaporin (TC 1.A.8) family. (271 aa)
POLD1DNA polymerase. (1107 aa)
GPR88Probable G-protein coupled receptor 88. (383 aa)
IRF1Interferon regulatory factor. (322 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (531 aa)
INO80DNA helicase INO80 isoform X1. (1563 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (382 aa)
RUVBL2RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (463 aa)
BBC3Bcl-2-binding component 3. (193 aa)
LOC111182889LOW QUALITY PROTEIN: transcription factor SOX-9-like. (510 aa)
IMPACTProtein IMPACT isoform X1. (318 aa)
MAP3K2Mitogen-activated protein kinase kinase kinase 2. (620 aa)
RGS9Regulator of G-protein signaling 9 isoform X1. (696 aa)
CAPN3Calpain-3 isoform X4; Belongs to the peptidase C2 family. (822 aa)
RAD9ACell cycle checkpoint control protein; Belongs to the rad9 family. (420 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
BMFLOW QUALITY PROTEIN: bcl-2-modifying factor. (269 aa)
SIRT1NAD-dependent protein deacetylase sirtuin-1 isoform X1. (735 aa)
TNKS1BP1182 kDa tankyrase-1-binding protein isoform X1. (1717 aa)
SCNN1GAmiloride-sensitive sodium channel subunit gamma; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (651 aa)
EPOErythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. (193 aa)
SCNN1BAmiloride-sensitive sodium channel subunit beta; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (641 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (211 aa)
KCNK4Potassium channel subfamily K member 4; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (401 aa)
TLK2Serine/threonine-protein kinase tousled-like 2 isoform X1. (750 aa)
HUS1Checkpoint protein; Belongs to the HUS1 family. (280 aa)
NUCKS1Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 isoform X1. (243 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
PDE2APhosphodiesterase. (971 aa)
ACTR5Actin-related protein 5; Belongs to the actin family. (615 aa)
FIGNL1Fidgetin-like protein 1; Belongs to the AAA ATPase family. (677 aa)
INTS7Integrator complex subunit 7 isoform X1. (962 aa)
POLD3DNA polymerase delta subunit 3 isoform X1. (464 aa)
DDB1DNA damage-binding protein 1. (1140 aa)
TMEM109Transmembrane protein 109. (243 aa)
BADBcl2-associated agonist of cell death. (168 aa)
AURKBAurora kinase B isoform X1; Belongs to the protein kinase superfamily. (345 aa)
DDB2DNA damage-binding protein 2 isoform X1. (457 aa)
POLKDNA polymerase kappa. (878 aa)
MAP2K4Dual specificity mitogen-activated protein kinase kinase 4 isoform X4; Belongs to the protein kinase superfamily. (410 aa)
CREBBPCREB-binding protein isoform X1. (2442 aa)
PBKLymphokine-activated killer T-cell-originated protein kinase. (322 aa)
SLC2A4Solute carrier family 2, facilitated glucose transporter member 4 isoform X1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (509 aa)
PTGS2Prostaglandin G/H synthase 2. (604 aa)
TRPV1Transient receptor potential cation channel subfamily V member 1; Belongs to the transient receptor (TC 1.A.4) family. (864 aa)
XRCC6X-ray repair cross-complementing protein 6. (609 aa)
CASP9Caspase-9; Belongs to the peptidase C14A family. (452 aa)
EP300Histone acetyltransferase p300. (2420 aa)
MAP3K1Mitogen-activated protein kinase kinase kinase 1 isoform X1. (1508 aa)
RAD9BCell cycle checkpoint control protein; Belongs to the rad9 family. (413 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
NOC2LNucleolar complex protein 2 homolog isoform X1. (738 aa)
FBXO4F-box only protein 4 isoform X1. (387 aa)
TNFRSF8Tumor necrosis factor receptor superfamily member 8. (598 aa)
TMEM150CTransmembrane protein 150C. (249 aa)
PCK1Phosphoenolpyruvate carboxykinase, cytosolic [GTP] isoform X1. (687 aa)
HVCN1Voltage-gated hydrogen channel 1 isoform X1. (293 aa)
XPADNA repair protein complementing XP-A cells. (273 aa)
PTGER4Prostaglandin E2 receptor EP4 subtype; Belongs to the G-protein coupled receptor 1 family. (486 aa)
NIPBLNipped-B protein. (2803 aa)
RAD1Cell cycle checkpoint protein RAD1. (279 aa)
SFRP2Secreted frizzled-related protein 2. (294 aa)
TRPV4Transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (870 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (266 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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