STRINGSTRING
LHCGR LHCGR RHOQ RHOQ PRKCI PRKCI JAK2 JAK2 CAPN10 CAPN10 APPL1 APPL1 LOC111171817 LOC111171817 GOT1 GOT1 STAT6 STAT6 INHBB INHBB GRB14 GRB14 NR4A2 NR4A2 CPEB2 CPEB2 IRS1 IRS1 OTOP1 OTOP1 NCOA5 NCOA5 SYAP1 SYAP1 GSK3B GSK3B GPER1 GPER1 STAT3 STAT3 LOC111166483 LOC111166483 STAT5A STAT5A LOC111165107 LOC111165107 TYK2 TYK2 PRKDC PRKDC IRS4 IRS4 INSR INSR WDTC1 WDTC1 AGTR2 AGTR2 FOXO4 FOXO4 USF1 USF1 SLC39A14 SLC39A14 EDNRA EDNRA PCK1 PCK1 IGF1R IGF1R LOC111187339 LOC111187339 AGTRAP AGTRAP PIK3R1 PIK3R1 TUSC5 TUSC5 GLP2R GLP2R PDPK1 PDPK1 NDEL1 NDEL1 SLC2A4 SLC2A4 INPP5K INPP5K INS INS INSIG2 INSIG2 TRIB3 TRIB3 SRC SRC LPIN3 LPIN3 CAMK2A CAMK2A GCGR GCGR LOC111182618 LOC111182618 FER FER GRB10 GRB10 RELA RELA PTPRA PTPRA APC APC SOGA1 SOGA1 SH2B2 SH2B2 ZNF106 ZNF106 LOC111181964 LOC111181964 GRB2 GRB2 CRHBP CRHBP STXBP4 STXBP4 KAT2B KAT2B LPIN1 LPIN1 DNAI1 DNAI1 PTPN2 PTPN2 UMODL1 UMODL1 LPIN2 LPIN2 PCK2 PCK2 RPS6KB1 RPS6KB1 XBP1 XBP1 BCAR3 BCAR3 ACTN2 ACTN2 SOCS2 SOCS2 RAB31 RAB31 RAB12 RAB12 AGTR1 AGTR1 MAS1 MAS1 RAB8A RAB8A SLC27A1 SLC27A1 PPP1R12A PPP1R12A PDK2 PDK2 PKLR PKLR GPLD1 GPLD1 GNRHR GNRHR ENPP1 ENPP1 JAK3 JAK3 RAB13 RAB13 CA2 CA2 INSRR INSRR SHC1 SHC1 PTPN1 PTPN1 NR4A3 NR4A3 SLC25A33 SLC25A33 POU4F2 POU4F2 Ob Ob PIK3R2 PIK3R2 EIF4EBP2 EIF4EBP2 EDN1 EDN1 LEP LEP PHIP PHIP GHRHR GHRHR AKT2 AKT2 CRHR1 CRHR1 PDK4 PDK4 GSK3A GSK3A NFKB1 NFKB1 JAK1 JAK1 CSRP3 CSRP3 ZDHHC7 ZDHHC7 CAV2 CAV2 MGARP MGARP CAV1 CAV1 AHCYL1 AHCYL1 CRHR2 CRHR2 GLP1R GLP1R RPE65 RPE65 INSIG1 INSIG1 PARP6 PARP6 PARP1 PARP1 C2CD5 C2CD5 TBC1D4 TBC1D4 EPRS EPRS RAB10 RAB10 GPR21 GPR21 SLC2A8 SLC2A8 SLC30A10 SLC30A10 RARRES2 RARRES2 SLC27A4 SLC27A4 KL KL NR4A1 NR4A1 DENND4C DENND4C IRS2 IRS2 AKT1 AKT1 PCSK9 PCSK9 PRKCD PRKCD PIK3R3 PIK3R3 RAB15 RAB15 ZFP36L1 ZFP36L1 GHSR GHSR SMARCC1 SMARCC1 FOXO1 FOXO1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LHCGRLutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (700 aa)
RHOQRho-related GTP-binding protein RhoQ. (169 aa)
PRKCIProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (707 aa)
JAK2Tyrosine-protein kinase. (1132 aa)
CAPN10Calpain-10 isoform X1; Belongs to the peptidase C2 family. (704 aa)
APPL1DCC-interacting protein 13-alpha isoform X1. (708 aa)
LOC111171817C-X-C chemokine receptor type 2-like; Belongs to the G-protein coupled receptor 1 family. (368 aa)
GOT1Aspartate aminotransferase. (413 aa)
STAT6Signal transducer and activator of transcription. (847 aa)
INHBBInhibin beta B chain. (407 aa)
GRB14Growth factor receptor-bound protein 14 isoform X1. (540 aa)
NR4A2Nuclear receptor subfamily 4 group A member 2 isoform X1. (598 aa)
CPEB2LOW QUALITY PROTEIN: cytoplasmic polyadenylation element-binding protein 2. (1043 aa)
IRS1Insulin receptor substrate 1. (1248 aa)
OTOP1Otopetrin-1. (606 aa)
NCOA5Nuclear receptor coactivator 5 isoform X1. (579 aa)
SYAP1Synapse-associated protein 1 isoform X1. (358 aa)
GSK3BGlycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
GPER1G-protein coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (354 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
LOC111166483Signal transducer and activator of transcription. (787 aa)
STAT5ASignal transducer and activator of transcription. (818 aa)
LOC111165107Cytochrome P450 11B1, mitochondrial isoform X1; Belongs to the cytochrome P450 family. (503 aa)
TYK2Tyrosine-protein kinase. (1188 aa)
PRKDCDNA-dependent protein kinase catalytic subunit isoform X1; Belongs to the PI3/PI4-kinase family. (4131 aa)
IRS4Insulin receptor substrate 4 isoform X1. (1267 aa)
INSRTyrosine-protein kinase receptor. (1392 aa)
WDTC1WD and tetratricopeptide repeats protein 1 isoform X1. (680 aa)
AGTR2Type-2 angiotensin II receptor; Belongs to the G-protein coupled receptor 1 family. (362 aa)
FOXO4Forkhead box protein O4. (512 aa)
USF1Upstream stimulatory factor 1 isoform X1. (310 aa)
SLC39A14Zinc transporter ZIP14 isoform X1. (510 aa)
EDNRAEndothelin-1 receptor isoform X1; Belongs to the G-protein coupled receptor 1 family. (427 aa)
PCK1Phosphoenolpyruvate carboxykinase, cytosolic [GTP] isoform X1. (687 aa)
IGF1RTyrosine-protein kinase receptor. (1368 aa)
LOC111187339LOW QUALITY PROTEIN: growth factor receptor-bound protein 10-like. (665 aa)
AGTRAPType-1 angiotensin II receptor-associated protein. (148 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
TUSC5Tumor suppressor candidate 5. (204 aa)
GLP2RGlucagon-like peptide 2 receptor; Belongs to the G-protein coupled receptor 2 family. (553 aa)
PDPK13-phosphoinositide-dependent protein kinase 1 isoform X1. (558 aa)
NDEL1Nuclear distribution protein nudE-like 1 isoform X1. (346 aa)
SLC2A4Solute carrier family 2, facilitated glucose transporter member 4 isoform X1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (509 aa)
INPP5KInositol polyphosphate 5-phosphatase K isoform X1. (476 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
INSIG2Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (229 aa)
TRIB3LOW QUALITY PROTEIN: tribbles homolog 3. (357 aa)
SRCTyrosine-protein kinase. (562 aa)
LPIN3Phosphatidate phosphatase LPIN3 isoform X3. (886 aa)
CAMK2ACalcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1; Belongs to the protein kinase superfamily. (489 aa)
GCGRGlucagon receptor isoform X1; Belongs to the G-protein coupled receptor 2 family. (575 aa)
LOC111182618Somatotropin isoform X1. (262 aa)
FERTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (822 aa)
GRB10Growth factor receptor-bound protein 10 isoform X1. (588 aa)
RELATranscription factor p65 isoform X1. (562 aa)
PTPRAReceptor-type tyrosine-protein phosphatase alpha. (802 aa)
APCAdenomatous polyposis coli protein isoform X1. (2864 aa)
SOGA1Protein SOGA1 isoform X1. (1903 aa)
SH2B2SH2B adapter protein 2 isoform X1. (703 aa)
ZNF106Zinc finger protein 106 isoform X1. (1917 aa)
LOC111181964Uncharacterized protein LOC111181964 isoform X1. (833 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
CRHBPCorticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family. (322 aa)
STXBP4Syntaxin-binding protein 4 isoform X1. (558 aa)
KAT2BHistone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (828 aa)
LPIN1Phosphatidate phosphatase LPIN1 isoform X1. (946 aa)
DNAI1Dynein intermediate chain 1, axonemal. (693 aa)
PTPN2Tyrosine-protein phosphatase non-receptor type 2 isoform X3. (474 aa)
UMODL1Uromodulin-like 1. (1321 aa)
LPIN2Phosphatidate phosphatase LPIN2 isoform X1. (962 aa)
PCK2Phosphoenolpyruvate carboxykinase [GTP], mitochondrial isoform X1. (655 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
XBP1LOW QUALITY PROTEIN: X-box-binding protein 1. (392 aa)
BCAR3Breast cancer anti-estrogen resistance protein 3 isoform X1. (832 aa)
ACTN2Alpha-actinin-2. (894 aa)
SOCS2Suppressor of cytokine signaling 2. (198 aa)
RAB31Ras-related protein Rab-31 isoform X1. (194 aa)
RAB12Ras-related protein Rab-12 isoform X1. (244 aa)
AGTR1Type-1 Angiotensin II receptor; Belongs to the G-protein coupled receptor 1 family. (359 aa)
MAS1Proto-oncogene Mas; Belongs to the G-protein coupled receptor 1 family. (325 aa)
RAB8ARas-related protein Rab-8A. (207 aa)
SLC27A1Long-chain fatty acid transport protein 1 isoform X1. (675 aa)
PPP1R12AProtein phosphatase 1 regulatory subunit. (1030 aa)
PDK2Protein-serine/threonine kinase. (407 aa)
PKLRPyruvate kinase; Belongs to the pyruvate kinase family. (556 aa)
GPLD1Phosphatidylinositol-glycan-specific phospholipase D isoform X1. (849 aa)
GNRHRGonadotropin-releasing hormone receptor; Belongs to the G-protein coupled receptor 1 family. (328 aa)
ENPP1Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 isoform X1. (925 aa)
JAK3Tyrosine-protein kinase. (1104 aa)
RAB13Ras-related protein Rab-13. (203 aa)
CA2Carbonic anhydrase 2; Belongs to the alpha-carbonic anhydrase family. (260 aa)
INSRRTyrosine-protein kinase receptor. (1301 aa)
SHC1SHC-transforming protein 1 isoform X1. (609 aa)
PTPN1Tyrosine-protein phosphatase non-receptor type. (451 aa)
NR4A3Nuclear receptor subfamily 4 group A member 3 isoform X1. (641 aa)
SLC25A33Solute carrier family 25 member 33; Belongs to the mitochondrial carrier (TC 2.A.29) family. (321 aa)
POU4F2POU domain protein. (407 aa)
ObLeptin isoform X1. (167 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (723 aa)
EIF4EBP2Eukaryotic translation initiation factor 4E-binding protein 2. (120 aa)
EDN1Endothelin-1. (202 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (166 aa)
PHIPPH-interacting protein isoform X2. (1650 aa)
GHRHRGrowth hormone-releasing hormone receptor isoform X1; Belongs to the G-protein coupled receptor 2 family. (427 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
CRHR1Corticotropin-releasing factor receptor 1 isoform X1; Belongs to the G-protein coupled receptor 2 family. (475 aa)
PDK4Protein-serine/threonine kinase. (407 aa)
GSK3AGlycogen synthase kinase-3 alpha; Belongs to the protein kinase superfamily. (483 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit isoform X1. (972 aa)
JAK1Tyrosine-protein kinase. (1153 aa)
CSRP3Cysteine and glycine-rich protein 3 isoform X2. (194 aa)
ZDHHC7Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (308 aa)
CAV2Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (162 aa)
MGARPProtein MGARP isoform X1. (240 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
AHCYL1Adenosylhomocysteinase. (530 aa)
CRHR2Corticotropin-releasing factor receptor 2 isoform X1; Belongs to the G-protein coupled receptor 2 family. (537 aa)
GLP1RGlucagon-like peptide 1 receptor; Belongs to the G-protein coupled receptor 2 family. (463 aa)
RPE65Retinoid isomerohydrolase. (533 aa)
INSIG1Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. (294 aa)
PARP6Poly [ADP-ribose] polymerase. (640 aa)
PARP1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1013 aa)
C2CD5C2 domain-containing protein 5 isoform X1. (1051 aa)
TBC1D4TBC1 domain family member 4 isoform X4. (1300 aa)
EPRSBifunctional glutamate/proline--tRNA ligase. (1511 aa)
RAB10Ras-related protein Rab-10. (200 aa)
GPR21Probable G-protein coupled receptor 21; Belongs to the G-protein coupled receptor 1 family. (349 aa)
SLC2A8Solute carrier family 2, facilitated glucose transporter member 8 isoform X1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (477 aa)
SLC30A10Zinc transporter 10. (485 aa)
RARRES2Retinoic acid receptor responder protein 2. (166 aa)
SLC27A4Long-chain fatty acid transport protein 4. (643 aa)
KLKlotho. (1010 aa)
NR4A1Nuclear receptor subfamily 4 group A member 1. (593 aa)
DENND4CDENN domain-containing protein 4C isoform X1. (1958 aa)
IRS2Insulin receptor substrate 2. (1347 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
PCSK9Proprotein convertase subtilisin/kexin type 9 isoform X1. (692 aa)
PRKCDProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (733 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1. (461 aa)
RAB15Ras-related protein Rab-15 isoform X1. (212 aa)
ZFP36L1mRNA decay activator protein ZFP36L1. (338 aa)
GHSRGrowth hormone secretagogue receptor type 1; Belongs to the G-protein coupled receptor 1 family. (366 aa)
SMARCC1SWI/SNF complex subunit SMARCC1 isoform X1. (1105 aa)
FOXO1Forkhead box protein O1. (663 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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