STRINGSTRING
NIPBL NIPBL FBXO4 FBXO4 HSF1 HSF1 SPIDR SPIDR RAD9B RAD9B XRCC6 XRCC6 LOC111165935 LOC111165935 BRCA1 BRCA1 GTF2H5 GTF2H5 ATM ATM CLOCK CLOCK BLM BLM CHEK2 CHEK2 KDM1A KDM1A RAD51AP1 RAD51AP1 LIG4 LIG4 BRCA2 BRCA2 CCND2 CCND2 RHNO1 RHNO1 ZMPSTE24 ZMPSTE24 MAP3K20 MAP3K20 WRN WRN BABAM2 BABAM2 TREX1 TREX1 TANK TANK ECT2 ECT2 FIGNL1 FIGNL1 NUCKS1 NUCKS1 HUS1 HUS1 TLK2 TLK2 TNKS1BP1 TNKS1BP1 SIRT1 SIRT1 GRB2 GRB2 GADD45A GADD45A RAD9A RAD9A BBC3 BBC3 INO80 INO80 EGR1 EGR1 RAD51 RAD51 TGFB1 TGFB1 INTS7 INTS7 TMEM109 TMEM109 PRAP1 PRAP1 SFRP1 SFRP1 NET1 NET1 BRCC3 BRCC3 XRCC5 XRCC5 YAP1 YAP1 HRAS HRAS CRYAB CRYAB ATR ATR CDKN1A CDKN1A SFRP2 SFRP2 RAD1 RAD1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NIPBLNipped-B protein. (2803 aa)
FBXO4F-box only protein 4 isoform X1. (387 aa)
HSF1Heat shock factor protein 1 isoform X1. (564 aa)
SPIDRDNA repair-scaffolding protein isoform X1. (931 aa)
RAD9BCell cycle checkpoint control protein; Belongs to the rad9 family. (413 aa)
XRCC6X-ray repair cross-complementing protein 6. (609 aa)
LOC111165935Ras-like protein isoform X1. (285 aa)
BRCA1Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1866 aa)
GTF2H5General transcription factor IIH subunit 5. (71 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3064 aa)
CLOCKLOW QUALITY PROTEIN: circadian locomoter output cycles protein kaput. (858 aa)
BLMBloom syndrome protein isoform X1. (1429 aa)
CHEK2Serine/threonine-protein kinase Chk2. (544 aa)
KDM1ALysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (876 aa)
RAD51AP1RAD51-associated protein 1 isoform X1. (331 aa)
LIG4DNA ligase. (911 aa)
BRCA2Breast cancer type 2 susceptibility protein. (3435 aa)
CCND2G1/S-specific cyclin-D2; Belongs to the cyclin family. (289 aa)
RHNO1RAD9, HUS1, RAD1-interacting nuclear orphan protein 1. (240 aa)
ZMPSTE24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (473 aa)
MAP3K20Mitogen-activated protein kinase kinase kinase 20 isoform X1. (800 aa)
WRNWerner syndrome ATP-dependent helicase isoform X1. (1454 aa)
BABAM2BRISC and BRCA1-A complex member 2 isoform X1. (383 aa)
TREX1Three-prime repair exonuclease 1. (314 aa)
TANKTRAF family member-associated NF-kappa-B activator isoform X1. (531 aa)
ECT2Protein ECT2 isoform X1. (973 aa)
FIGNL1Fidgetin-like protein 1; Belongs to the AAA ATPase family. (677 aa)
NUCKS1Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 isoform X1. (243 aa)
HUS1Checkpoint protein; Belongs to the HUS1 family. (280 aa)
TLK2Serine/threonine-protein kinase tousled-like 2 isoform X1. (750 aa)
TNKS1BP1182 kDa tankyrase-1-binding protein isoform X1. (1717 aa)
SIRT1NAD-dependent protein deacetylase sirtuin-1 isoform X1. (735 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
GADD45AGrowth arrest and DNA damage-inducible protein GADD45 alpha. (165 aa)
RAD9ACell cycle checkpoint control protein; Belongs to the rad9 family. (420 aa)
BBC3Bcl-2-binding component 3. (193 aa)
INO80DNA helicase INO80 isoform X1. (1563 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (531 aa)
RAD51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
INTS7Integrator complex subunit 7 isoform X1. (962 aa)
TMEM109Transmembrane protein 109. (243 aa)
PRAP1Proline-rich acidic protein 1 isoform X1. (153 aa)
SFRP1Secreted frizzled-related protein 1. (308 aa)
NET1Neuroepithelial cell-transforming gene 1 protein isoform X1. (596 aa)
BRCC3Lys-63-specific deubiquitinase BRCC36 isoform X1. (316 aa)
XRCC5X-ray repair cross-complementing protein 5. (733 aa)
YAP1Transcriptional coactivator YAP1 isoform X1. (511 aa)
HRASGTPase HRas isoform X1. (189 aa)
CRYABAlpha-crystallin B chain; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. (175 aa)
ATRSerine/threonine-protein kinase ATR isoform X1; Belongs to the PI3/PI4-kinase family. (2655 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (164 aa)
SFRP2Secreted frizzled-related protein 2. (294 aa)
RAD1Cell cycle checkpoint protein RAD1. (279 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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