STRINGSTRING
WNT2 WNT2 EID2 EID2 CDH5 CDH5 ONECUT2 ONECUT2 GLG1 GLG1 SMAD3 SMAD3 SMAD6 SMAD6 SOX5 SOX5 WWOX WWOX TGFB3 TGFB3 PML PML HIPK2 HIPK2 ZFYVE9 ZFYVE9 CILP CILP TGFB2 TGFB2 ZFP36L2 ZFP36L2 ONECUT1 ONECUT1 CLEC3B CLEC3B HYAL2 HYAL2 ENG ENG SKIL SKIL ACVRL1 ACVRL1 COL4A2 COL4A2 ADAM9 ADAM9 JUN JUN ZFP36L1 ZFP36L1 DLX1 DLX1 SMAD9 SMAD9 WNT5A WNT5A FERMT2 FERMT2 FUT8 FUT8 APPL1 APPL1 SIRT1 SIRT1 LPXN LPXN LTBP3 LTBP3 MEF2C MEF2C PDE2A PDE2A SRC SRC ZMIZ1 ZMIZ1 LRRC32 LRRC32 HPGD HPGD TAB1 TAB1 ARRB2 ARRB2 NLK NLK CHST11 CHST11 SMAD1 SMAD1 APPL2 APPL2 PXN PXN TGFBR1 TGFBR1 ITGB8 ITGB8 ANKRD1 ANKRD1 USP15 USP15 SFRP1 SFRP1 PPM1A PPM1A CITED1 CITED1 NRROS NRROS ACVR1 ACVR1 COL3A1 COL3A1 NPNT NPNT WNT10A WNT10A MSTN MSTN ITGB5 ITGB5 EPB41L5 EPB41L5 CX3CR1 CX3CR1 CITED2 CITED2 TGFBR3L TGFBR3L MAPK7 MAPK7 FLCN FLCN STAT3 STAT3 SOX6 SOX6 WFIKKN2 WFIKKN2 FOXH1 FOXH1 PTPRK PTPRK USP9X USP9X SCX SCX TGFBR2 TGFBR2 FYN FYN TGFBR3 TGFBR3 MTMR4 MTMR4 TWSG1 TWSG1 CLDN5 CLDN5 CRKL CRKL CAV2 CAV2 CAV1 CAV1 SMAD2 SMAD2 SMAD4 SMAD4 SMAD5 SMAD5 COL1A2 COL1A2 LOC111181354 LOC111181354 LOC111182889 LOC111182889 SMAD7 SMAD7 ZYX ZYX GCNT2 GCNT2 PDCD5 PDCD5 LTBP4 LTBP4 TGFB1 TGFB1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
EID2EP300-interacting inhibitor of differentiation 2. (203 aa)
CDH5Cadherin-5; Cadherins are calcium-dependent cell adhesion proteins. (782 aa)
ONECUT2One cut domain family member. (509 aa)
GLG1Golgi apparatus protein 1. (1181 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
SMAD6Mothers against decapentaplegic homolog. (495 aa)
SOX5Transcription factor SOX-5 isoform X1. (788 aa)
WWOXWW domain-containing oxidoreductase isoform X1. (418 aa)
TGFB3Transforming growth factor beta-3. (456 aa)
PMLProtein PML isoform X1. (861 aa)
HIPK2Homeodomain-interacting protein kinase 2 isoform X1. (1248 aa)
ZFYVE9Zinc finger FYVE domain-containing protein. (1423 aa)
CILPCartilage intermediate layer protein 1 isoform X1. (1201 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
ZFP36L2mRNA decay activator protein ZFP36L2. (493 aa)
ONECUT1One cut domain family member. (465 aa)
CLEC3BTetranectin. (202 aa)
HYAL2Hyaluronidase. (476 aa)
ENGEndoglin. (652 aa)
SKILSki-like protein isoform X1. (684 aa)
ACVRL1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (515 aa)
COL4A2Collagen alpha-2(IV) chain isoform X1. (1760 aa)
ADAM9Disintegrin and metalloproteinase domain-containing protein 9 isoform X1. (841 aa)
JUNTranscription factor AP-1; Belongs to the bZIP family. (343 aa)
ZFP36L1mRNA decay activator protein ZFP36L1. (338 aa)
DLX1Homeobox protein DLX-1 isoform X1. (255 aa)
SMAD9Mothers against decapentaplegic homolog. (430 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (458 aa)
FERMT2Fermitin family homolog 2 isoform X2. (691 aa)
FUT8Alpha-(1,6)-fucosyltransferase; Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans. Belongs to the glycosyltransferase 23 family. (575 aa)
APPL1DCC-interacting protein 13-alpha isoform X1. (708 aa)
SIRT1NAD-dependent protein deacetylase sirtuin-1 isoform X1. (735 aa)
LPXNLeupaxin isoform X2; Belongs to the paxillin family. (387 aa)
LTBP3Latent-transforming growth factor beta-binding protein 3 isoform X1. (1557 aa)
MEF2CMyocyte-specific enhancer factor 2C isoform X6. (483 aa)
PDE2APhosphodiesterase. (971 aa)
SRCTyrosine-protein kinase. (562 aa)
ZMIZ1Zinc finger MIZ domain-containing protein 1 isoform X1. (1071 aa)
LRRC32Leucine-rich repeat-containing protein 32 isoform X1. (676 aa)
HPGD15-hydroxyprostaglandin dehydrogenase [NAD(+)]; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (266 aa)
TAB1TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1. (504 aa)
ARRB2Beta-arrestin-2 isoform X1. (409 aa)
NLKMitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (527 aa)
CHST11Carbohydrate sulfotransferase. (418 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
APPL2DCC-interacting protein 13-beta isoform X2. (661 aa)
PXNPaxillin isoform X2. (617 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
ITGB8Integrin beta; Belongs to the integrin beta chain family. (767 aa)
ANKRD1Ankyrin repeat domain-containing protein 1. (319 aa)
USP15Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (981 aa)
SFRP1Secreted frizzled-related protein 1. (308 aa)
PPM1AProtein phosphatase 1A. (382 aa)
CITED1Cbp/p300-interacting transactivator 1 isoform X1. (359 aa)
NRROSNegative regulator of reactive oxygen species isoform X1. (699 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
COL3A1Collagen alpha-1(III) chain. (1464 aa)
NPNTNephronectin isoform X3. (595 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa)
MSTNGrowth/differentiation factor 8. (375 aa)
ITGB5Integrin beta; Belongs to the integrin beta chain family. (800 aa)
EPB41L5Band 4.1-like protein 5 isoform X1. (726 aa)
CX3CR1CX3C chemokine receptor 1 isoform X1; Belongs to the G-protein coupled receptor 1 family. (475 aa)
CITED2Cbp/p300-interacting transactivator 2. (272 aa)
TGFBR3LTransforming growth factor-beta receptor type 3-like protein isoform X1. (348 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (775 aa)
FLCNFolliculin isoform X1. (591 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
SOX6Transcription factor SOX-6 isoform X1. (802 aa)
WFIKKN2WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2. (574 aa)
FOXH1Forkhead box protein H1. (360 aa)
PTPRKReceptor-type tyrosine-protein phosphatase kappa isoform X1. (1485 aa)
USP9XProbable ubiquitin carboxyl-terminal hydrolase FAF-X isoform X1; Belongs to the peptidase C19 family. (2559 aa)
SCXBasic helix-loop-helix transcription factor scleraxis isoform X2. (203 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (567 aa)
FYNTyrosine-protein kinase. (537 aa)
TGFBR3Transforming growth factor beta receptor type 3 isoform X1. (851 aa)
MTMR4Myotubularin-related protein 4 isoform X1. (1211 aa)
TWSG1Twisted gastrulation protein homolog 1. (223 aa)
CLDN5Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (218 aa)
CRKLCrk-like protein. (303 aa)
CAV2Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (162 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
SMAD4Mothers against decapentaplegic homolog. (553 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
COL1A2Collagen alpha-2(I) chain. (1366 aa)
LOC111181354N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase-like. (321 aa)
LOC111182889LOW QUALITY PROTEIN: transcription factor SOX-9-like. (510 aa)
SMAD7Mothers against decapentaplegic homolog. (426 aa)
ZYXZyxin. (573 aa)
GCNT2N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase isoform X1. (419 aa)
PDCD5Programmed cell death protein 5. (125 aa)
LTBP4Latent-transforming growth factor beta-binding protein 4 isoform X1. (1628 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
Server load: low (32%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.