STRINGSTRING
PAX8 PAX8 DLG2 DLG2 GZF1 GZF1 PKD1 PKD1 ADAMTS16 ADAMTS16 SMO SMO TFAP2B TFAP2B PTPRO PTPRO PKD2 PKD2 BMPER BMPER NOTCH1 NOTCH1 SMAD6 SMAD6 SMAD3 SMAD3 SMAD4 SMAD4 KIF26B KIF26B HS2ST1 HS2ST1 NPHS1 NPHS1 GATA3 GATA3 CALB1 CALB1 IRX2 IRX2 IRX1 IRX1 TGFB1 TGFB1 FMN1 FMN1 AQP1 AQP1 BCL2 BCL2 GREM1 GREM1 WT1 WT1 LGR4 LGR4 NOTCH2 NOTCH2 SMAD7 SMAD7 FOXJ1 FOXJ1 LOC111182889 LOC111182889 LOC111182630 LOC111182630 SMAD5 SMAD5 KLHL3 KLHL3 PECAM1 PECAM1 MEF2C MEF2C HOXA11 HOXA11 FGF1 FGF1 WNT11 WNT11 SOX8 SOX8 UMOD UMOD NOG NOG MTSS1 MTSS1 RET RET COMMD5 COMMD5 IRX3 IRX3 NPHS2 NPHS2 EXT1 EXT1 LHX1 LHX1 EPHA7 EPHA7 RARB RARB TCF21 TCF21 KANK2 KANK2 SALL1 SALL1 RARA RARA AHI1 AHI1 GPC3 GPC3 PTCH1 PTCH1 BMP2 BMP2 TMEM59L TMEM59L HS3ST3B1 HS3ST3B1 JAG1 JAG1 CRLF1 CRLF1 HS3ST3A1 HS3ST3A1 CTNNB1 CTNNB1 DCHS1 DCHS1 DLL1 DLL1 ILK ILK SLIT2 SLIT2 NPNT NPNT DLG1 DLG1 PAX2 PAX2 IQGAP1 IQGAP1 PROM1 PROM1 BMP4 BMP4 SFRP1 SFRP1 GDF11 GDF11 SIX1 SIX1 LZTS2 LZTS2 HES1 HES1 EPHA4 EPHA4 ARG2 ARG2 WNT6 WNT6 FGF8 FGF8 CER1 CER1 SIX2 SIX2 HEYL HEYL SHH SHH WNT1 WNT1 LAMB2 LAMB2 POU3F4 POU3F4 EDNRB EDNRB MYO1E MYO1E TACSTD2 TACSTD2 ASXL1 ASXL1 EYA1 EYA1 GLI3 GLI3 AQP11 AQP11 SPRY1 SPRY1 HES5 HES5 LAMA5 LAMA5 GDNF GDNF POU3F3 POU3F3 BMP7 BMP7 SMAD1 SMAD1 EDNRA EDNRA CTNNBIP1 CTNNBIP1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PAX8Paired box protein Pax-8. (457 aa)
DLG2Disks large homolog 2 isoform X1. (994 aa)
GZF1GDNF-inducible zinc finger protein 1. (717 aa)
PKD1Polycystin-1 isoform X1. (4335 aa)
ADAMTS16A disintegrin and metalloproteinase with thrombospondin motifs 16 isoform X1. (1252 aa)
SMOSmoothened homolog; Belongs to the G-protein coupled receptor Fz/Smo family. (782 aa)
TFAP2BTranscription factor AP-2-beta isoform X1. (467 aa)
PTPROReceptor-type tyrosine-protein phosphatase O isoform X1. (1216 aa)
PKD2Polycystin-2 isoform X1. (975 aa)
BMPERBMP-binding endothelial regulator protein isoform X1. (685 aa)
NOTCH1Neurogenic locus notch homolog protein 1 isoform X1. (2521 aa)
SMAD6Mothers against decapentaplegic homolog. (495 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
SMAD4Mothers against decapentaplegic homolog. (553 aa)
KIF26BKinesin-like protein KIF26B isoform X1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (2113 aa)
HS2ST1Heparan sulfate 2-O-sulfotransferase 1 isoform X1. (357 aa)
NPHS1Nephrin. (1270 aa)
GATA3Trans-acting T-cell-specific transcription factor GATA-3 isoform X1. (444 aa)
CALB1Calbindin. (261 aa)
IRX2Iroquois-class homeodomain protein IRX-2 isoform X2. (477 aa)
IRX1Iroquois-class homeodomain protein IRX-1. (476 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
FMN1Formin-1 isoform X2. (1200 aa)
AQP1Aquaporin-1; Belongs to the MIP/aquaporin (TC 1.A.8) family. (271 aa)
BCL2Apoptosis regulator Bcl-2. (233 aa)
GREM1Gremlin. (184 aa)
WT1Wilms tumor protein isoform X1. (450 aa)
LGR4Leucine-rich repeat-containing G-protein coupled receptor 4 isoform X1. (951 aa)
NOTCH2Neurogenic locus notch homolog protein 2 isoform X1. (2471 aa)
SMAD7Mothers against decapentaplegic homolog. (426 aa)
FOXJ1Forkhead box protein J1. (422 aa)
LOC111182889LOW QUALITY PROTEIN: transcription factor SOX-9-like. (510 aa)
LOC111182630Platelet endothelial cell adhesion molecule-like isoform X2. (305 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
KLHL3Kelch-like protein 3. (601 aa)
PECAM1Platelet endothelial cell adhesion molecule isoform X1. (701 aa)
MEF2CMyocyte-specific enhancer factor 2C isoform X6. (483 aa)
HOXA11Homeobox protein Hox-A11. (313 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (189 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
SOX8Transcription factor SOX-8. (463 aa)
UMODUromodulin. (643 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
MTSS1Metastasis suppressor protein 1 isoform X1. (762 aa)
RETProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1113 aa)
COMMD5COMM domain-containing protein 5 isoform X1. (283 aa)
IRX3Iroquois-class homeodomain protein IRX-3. (502 aa)
NPHS2Podocin isoform X1. (383 aa)
EXT1Exostosin-1; Belongs to the glycosyltransferase 47 family. (746 aa)
LHX1LIM/homeobox protein Lhx1. (406 aa)
EPHA7Ephrin type-A receptor 7 isoform X1. (998 aa)
RARBRetinoic acid receptor beta isoform X1. (448 aa)
TCF21Transcription factor 21. (179 aa)
KANK2KN motif and ankyrin repeat domain-containing protein 2 isoform X1. (857 aa)
SALL1Sal-like protein 1. (1317 aa)
RARARetinoic acid receptor alpha isoform X5. (584 aa)
AHI1Jouberin isoform X2. (1180 aa)
GPC3Glypican-3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (580 aa)
PTCH1Protein patched homolog 1 isoform X1. (1447 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
TMEM59LTransmembrane protein 59-like isoform X1. (350 aa)
HS3ST3B1Sulfotransferase; Belongs to the sulfotransferase 1 family. (390 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1221 aa)
CRLF1Cytokine receptor-like factor 1. (446 aa)
HS3ST3A1Sulfotransferase; Belongs to the sulfotransferase 1 family. (406 aa)
CTNNB1Catenin beta-1. (781 aa)
DCHS1Protocadherin-16. (3294 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (799 aa)
ILKIntegrin-linked protein kinase. (452 aa)
SLIT2Slit homolog 2 protein isoform X1. (1534 aa)
NPNTNephronectin isoform X3. (595 aa)
DLG1Disks large homolog 1 isoform X1; Belongs to the MAGUK family. (927 aa)
PAX2Paired box protein Pax-2 isoform X1. (432 aa)
IQGAP1Ras GTPase-activating-like protein IQGAP1. (1657 aa)
PROM1Prominin-1 isoform X1. (887 aa)
BMP4Bone morphogenetic protein 4 isoform X2. (408 aa)
SFRP1Secreted frizzled-related protein 1. (308 aa)
GDF11Growth/differentiation factor 11. (406 aa)
SIX1Homeobox protein SIX1. (284 aa)
LZTS2Leucine zipper putative tumor suppressor 2; Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta- catenin. (663 aa)
HES1Transcription factor HES-1. (280 aa)
EPHA4Ephrin type-A receptor 4 isoform X1. (986 aa)
ARG2Arginase. (354 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
CER1Cerberus. (325 aa)
SIX2Homeobox protein SIX2. (296 aa)
HEYLHairy/enhancer-of-split related with YRPW motif-like protein isoform X1. (357 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (461 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
LAMB2Laminin subunit beta-2 isoform X1. (1812 aa)
POU3F4POU domain protein. (363 aa)
EDNRBEndothelin receptor type B; Belongs to the G-protein coupled receptor 1 family. (443 aa)
MYO1EUnconventional myosin-Ie isoform X2; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1108 aa)
TACSTD2Tumor-associated calcium signal transducer 2. (323 aa)
ASXL1LOW QUALITY PROTEIN: putative Polycomb group protein ASXL1. (1545 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (589 aa)
GLI3Transcriptional activator GLI3 isoform X1. (1587 aa)
AQP11Aquaporin; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes. (271 aa)
SPRY1Protein sprouty homolog 1. (319 aa)
HES5Transcription factor HES-5 isoform X1. (205 aa)
LAMA5Laminin subunit alpha-5. (3687 aa)
GDNFGlial cell line-derived neurotrophic factor. (185 aa)
POU3F3POU domain protein. (505 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
EDNRAEndothelin-1 receptor isoform X1; Belongs to the G-protein coupled receptor 1 family. (427 aa)
CTNNBIP1Beta-catenin-interacting protein 1. (81 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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