(15 nodes) Ureter development network (Delphinapterus leucas)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	NPHP3	Nephrocystin-3 isoform X1. (1345 aa)
	RET	Proto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1113 aa)
	LHX1	LIM/homeobox protein Lhx1. (406 aa)
	SOX17	Transcription factor SOX-17. (408 aa)
	TBX18	T-box transcription factor TBX18. (612 aa)
	EMX2	Homeobox protein EMX2 isoform X1. (252 aa)
	BMP4	Bone morphogenetic protein 4 isoform X2. (408 aa)
	SIX1	Homeobox protein SIX1. (284 aa)
	LZTS2	Leucine zipper putative tumor suppressor 2; Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta- catenin. (663 aa)
	NFIA	Nuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (550 aa)
	ALDH1A2	Retinal dehydrogenase 2; Belongs to the aldehyde dehydrogenase family. (518 aa)
	FOXF1	Forkhead box protein F1. (375 aa)
	GATA3	Trans-acting T-cell-specific transcription factor GATA-3 isoform X1. (444 aa)
	LOC111182889	LOW QUALITY PROTEIN: transcription factor SOX-9-like. (510 aa)
	SOX8	Transcription factor SOX-8. (463 aa)

Your Current Organism:

Delphinapterus leucas

NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALDH1A2	TBX18	A0A2Y9NQZ4	A0A2Y9MLN5	Retinal dehydrogenase 2; Belongs to the aldehyde dehydrogenase family.	T-box transcription factor TBX18.	0.438
BMP4	FOXF1	A0A2Y9MV04	A0A2Y9NXD1	Bone morphogenetic protein 4 isoform X2.	Forkhead box protein F1.	0.488
BMP4	LOC111182889	A0A2Y9MV04	A0A2Y9PEX3	Bone morphogenetic protein 4 isoform X2.	LOW QUALITY PROTEIN: transcription factor SOX-9-like.	0.602
BMP4	SOX17	A0A2Y9MV04	A0A2Y9M570	Bone morphogenetic protein 4 isoform X2.	Transcription factor SOX-17.	0.762
BMP4	TBX18	A0A2Y9MV04	A0A2Y9MLN5	Bone morphogenetic protein 4 isoform X2.	T-box transcription factor TBX18.	0.493
FOXF1	BMP4	A0A2Y9NXD1	A0A2Y9MV04	Forkhead box protein F1.	Bone morphogenetic protein 4 isoform X2.	0.488
FOXF1	LOC111182889	A0A2Y9NXD1	A0A2Y9PEX3	Forkhead box protein F1.	LOW QUALITY PROTEIN: transcription factor SOX-9-like.	0.402
GATA3	LHX1	A0A2Y9P1J9	A0A2Y9LSS0	Trans-acting T-cell-specific transcription factor GATA-3 isoform X1.	LIM/homeobox protein Lhx1.	0.462
GATA3	SOX17	A0A2Y9P1J9	A0A2Y9M570	Trans-acting T-cell-specific transcription factor GATA-3 isoform X1.	Transcription factor SOX-17.	0.431
LHX1	GATA3	A0A2Y9LSS0	A0A2Y9P1J9	LIM/homeobox protein Lhx1.	Trans-acting T-cell-specific transcription factor GATA-3 isoform X1.	0.462
LHX1	SIX1	A0A2Y9LSS0	A0A2Y9MZZ4	LIM/homeobox protein Lhx1.	Homeobox protein SIX1.	0.517
LOC111182889	BMP4	A0A2Y9PEX3	A0A2Y9MV04	LOW QUALITY PROTEIN: transcription factor SOX-9-like.	Bone morphogenetic protein 4 isoform X2.	0.602
LOC111182889	FOXF1	A0A2Y9PEX3	A0A2Y9NXD1	LOW QUALITY PROTEIN: transcription factor SOX-9-like.	Forkhead box protein F1.	0.402
LOC111182889	NFIA	A0A2Y9PEX3	A0A2Y9NJF5	LOW QUALITY PROTEIN: transcription factor SOX-9-like.	Nuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.	0.505
NFIA	LOC111182889	A0A2Y9NJF5	A0A2Y9PEX3	Nuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.	LOW QUALITY PROTEIN: transcription factor SOX-9-like.	0.505
RET	SIX1	A0A2Y9LJM0	A0A2Y9MZZ4	Proto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands.	Homeobox protein SIX1.	0.434
SIX1	LHX1	A0A2Y9MZZ4	A0A2Y9LSS0	Homeobox protein SIX1.	LIM/homeobox protein Lhx1.	0.517
SIX1	RET	A0A2Y9MZZ4	A0A2Y9LJM0	Homeobox protein SIX1.	Proto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands.	0.434
SOX17	BMP4	A0A2Y9M570	A0A2Y9MV04	Transcription factor SOX-17.	Bone morphogenetic protein 4 isoform X2.	0.762
SOX17	GATA3	A0A2Y9M570	A0A2Y9P1J9	Transcription factor SOX-17.	Trans-acting T-cell-specific transcription factor GATA-3 isoform X1.	0.431