STRINGSTRING
AGT AGT HTRA3 HTRA3 CASK CASK SKOR2 SKOR2 MMRN2 MMRN2 IL12B IL12B SPRY3 SPRY3 FSTL3 FSTL3 SLIT2 SLIT2 HTRA1 HTRA1 VWC2L VWC2L GPC1 GPC1 TNFAIP6 TNFAIP6 SOST SOST CHRD CHRD LRP2 LRP2 PPM1A PPM1A SFRP1 SFRP1 WNT5A WNT5A ADGRA2 ADGRA2 CRIM1 CRIM1 XDH XDH SPART SPART CER1 CER1 DLX1 DLX1 SHISA2 SHISA2 LEMD3 LEMD3 LOC111176725 LOC111176725 WNT1 WNT1 SKIL SKIL IL12A IL12A EMILIN1 EMILIN1 SPRY2 SPRY2 HIPK2 HIPK2 LOC111176553 LOC111176553 BAMBI BAMBI PDCD6 PDCD6 BMPER BMPER NOTCH1 NOTCH1 SMAD6 SMAD6 ABL1 ABL1 DAB2IP DAB2IP PIK3CB PIK3CB TRIM33 TRIM33 GATA3 GATA3 LEMD2 LEMD2 HFE2 HFE2 CADM4 CADM4 GREM1 GREM1 CTDSPL2 CTDSPL2 FUZ FUZ SMAD7 SMAD7 HGS HGS FBN1 FBN1 THBS1 THBS1 SEMA6A SEMA6A SMURF1 SMURF1 SMURF2 SMURF2 VWC2 VWC2 CREB3L1 CREB3L1 LOC111183874 LOC111183874 SPRY4 SPRY4 SOSTDC1 SOSTDC1 ATP2B4 ATP2B4 PRDM14 PRDM14 SFRP2 SFRP2 ADAMTS12 ADAMTS12 CXCL13 CXCL13 PTPN1 PTPN1 TMPRSS6 TMPRSS6 SULF1 SULF1 SPRY1 SPRY1 CHRDL2 CHRDL2 NGFR NGFR TOB1 TOB1 EPN2 EPN2 SORL1 SORL1 CHRDL1 CHRDL1 TWSG1 TWSG1 NOG NOG NBL1 NBL1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AGTAngiotensinogen; Belongs to the serpin family. (477 aa)
HTRA3Serine protease HTRA3 isoform X1. (453 aa)
CASKPeripheral plasma membrane protein CASK isoform X1; Belongs to the MAGUK family. (926 aa)
SKOR2SKI family transcriptional corepressor 2. (1010 aa)
MMRN2Multimerin-2 isoform X1. (935 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (329 aa)
SPRY3Protein sprouty homolog 3. (288 aa)
FSTL3Follistatin-related protein 3. (262 aa)
SLIT2Slit homolog 2 protein isoform X1. (1534 aa)
HTRA1Serine protease HTRA1. (509 aa)
VWC2LVon Willebrand factor C domain-containing protein 2-like. (222 aa)
GPC1Glypican-1 isoform X1; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (559 aa)
TNFAIP6Tumor necrosis factor-inducible gene 6 protein isoform X1. (284 aa)
SOSTSclerostin. (212 aa)
CHRDChordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes. (958 aa)
LRP2Low-density lipoprotein receptor-related protein 2. (4838 aa)
PPM1AProtein phosphatase 1A. (382 aa)
SFRP1Secreted frizzled-related protein 1. (308 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (458 aa)
ADGRA2Adhesion G protein-coupled receptor A2; Belongs to the G-protein coupled receptor 2 family. (1337 aa)
CRIM1Cysteine-rich motor neuron 1 protein isoform X1. (1037 aa)
XDHXanthine dehydrogenase/oxidase isoform X1. (1334 aa)
SPARTSpartin. (668 aa)
CER1Cerberus. (325 aa)
DLX1Homeobox protein DLX-1 isoform X1. (255 aa)
SHISA2Protein shisa-2 homolog. (294 aa)
LEMD3Inner nuclear membrane protein Man1 isoform X1. (925 aa)
LOC111176725Homeobox protein NANOG-like. (245 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
SKILSki-like protein isoform X1. (684 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (222 aa)
EMILIN1EMILIN-1. (1015 aa)
SPRY2Protein sprouty homolog 2. (315 aa)
HIPK2Homeodomain-interacting protein kinase 2 isoform X1. (1248 aa)
LOC111176553Homeobox protein NANOG-like. (306 aa)
BAMBIBMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (260 aa)
PDCD6Programmed cell death protein 6 isoform X1. (189 aa)
BMPERBMP-binding endothelial regulator protein isoform X1. (685 aa)
NOTCH1Neurogenic locus notch homolog protein 1 isoform X1. (2521 aa)
SMAD6Mothers against decapentaplegic homolog. (495 aa)
ABL1Tyrosine-protein kinase. (1148 aa)
DAB2IPDisabled homolog 2-interacting protein isoform X1. (1193 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
TRIM33LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase TRIM33. (1127 aa)
GATA3Trans-acting T-cell-specific transcription factor GATA-3 isoform X1. (444 aa)
LEMD2LEM domain-containing protein 2 isoform X1. (515 aa)
HFE2Hemojuvelin isoform X1. (427 aa)
CADM4Cell adhesion molecule 4. (388 aa)
GREM1Gremlin. (184 aa)
CTDSPL2CTD small phosphatase-like protein 2 isoform X1. (465 aa)
FUZProtein fuzzy homolog isoform X1. (474 aa)
SMAD7Mothers against decapentaplegic homolog. (426 aa)
HGSHepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] (777 aa)
FBN1Fibrillin-1 isoform X1. (2871 aa)
THBS1Thrombospondin-1. (1170 aa)
SEMA6Asemaphorin-6A isoform X1; Belongs to the semaphorin family. (1044 aa)
SMURF1E3 ubiquitin-protein ligase. (757 aa)
SMURF2E3 ubiquitin-protein ligase. (747 aa)
VWC2Brorin. (319 aa)
CREB3L1Cyclic AMP-responsive element-binding protein 3-like protein 1. (520 aa)
LOC111183874Protein Tob1-like. (205 aa)
SPRY4Protein sprouty homolog 4. (299 aa)
SOSTDC1Sclerostin domain-containing protein 1. (206 aa)
ATP2B4Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1243 aa)
PRDM14PR domain zinc finger protein 14. (571 aa)
SFRP2Secreted frizzled-related protein 2. (294 aa)
ADAMTS12A disintegrin and metalloproteinase with thrombospondin motifs 12 isoform X1. (1601 aa)
CXCL13C-X-C motif chemokine 13. (109 aa)
PTPN1Tyrosine-protein phosphatase non-receptor type. (451 aa)
TMPRSS6Transmembrane protease serine 6 isoform X1; Belongs to the peptidase S1 family. (800 aa)
SULF1Extracellular sulfatase; Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C- 6 position of glucosamine within specific subregions of intact heparin. Belongs to the sulfatase family. (882 aa)
SPRY1Protein sprouty homolog 1. (319 aa)
CHRDL2Chordin-like protein 2 isoform X2. (452 aa)
NGFRTumor necrosis factor receptor superfamily member 16. (427 aa)
TOB1Protein Tob1. (344 aa)
EPN2Epsin-2 isoform X1. (582 aa)
SORL1Sortilin-related receptor isoform X1. (2211 aa)
CHRDL1Chordin-like protein 1 isoform X1. (527 aa)
TWSG1Twisted gastrulation protein homolog 1. (223 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
NBL1Neuroblastoma suppressor of tumorigenicity 1 isoform X3. (214 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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