STRINGSTRING
SFN SFN PRKD1 PRKD1 ITGB1BP1 ITGB1BP1 FYN FYN ZFAND1 ZFAND1 SEC16B SEC16B LOC111165935 LOC111165935 CEMIP CEMIP JUP JUP OAZ1 OAZ1 PIK3R2 PIK3R2 PRKACA PRKACA FBXW9 FBXW9 SLC35D3 SLC35D3 SIRT6 SIRT6 ERBB2 ERBB2 SORL1 SORL1 MIEF2 MIEF2 ZPR1 ZPR1 OAZ3 OAZ3 GSK3B GSK3B HCLS1 HCLS1 HRAS HRAS BCAP31 BCAP31 FLNA FLNA EMD EMD LOC111170664 LOC111170664 CIB1 CIB1 CAMK1 CAMK1 TRIM28 TRIM28 BAG3 BAG3 AKAP5 AKAP5 TMEM30B TMEM30B PPM1A PPM1A MFF MFF PCM1 PCM1 ECT2 ECT2 TCF7L2 TCF7L2 RAPGEF3 RAPGEF3 XPO4 XPO4 ZC3H12A ZC3H12A EDEM1 EDEM1 PRKCD PRKCD IFNG IFNG SHH SHH PLK3 PLK3 PDCD10 PDCD10 HYAL2 HYAL2 TCAF1 TCAF1 IPO5 IPO5 GAS6 GAS6 LOC111177285 LOC111177285 EFCAB7 EFCAB7 DMAP1 DMAP1 SLC51B SLC51B SMO SMO CDK5 CDK5 C2CD5 C2CD5 OAZ2 OAZ2 PSEN1 PSEN1 LOC111177759 LOC111177759 PDZK1 PDZK1 UBR5 UBR5 ICE1 ICE1 RIPOR1 RIPOR1 PRR5L PRR5L TGFB1 TGFB1 GSK3A GSK3A PDCD5 PDCD5 CDH1 CDH1 CTDSPL2 CTDSPL2 PTPN22 PTPN22 FIS1 FIS1 BBC3 BBC3 TOMM7 TOMM7 SAR1B SAR1B CHP2 CHP2 LEP LEP SAR1A SAR1A CD81 CD81 TMEM30A TMEM30A HDAC3 HDAC3 RBM22 RBM22 ERGIC3 ERGIC3 EDEM2 EDEM2 TPR TPR RAB29 RAB29 B3GAT3 B3GAT3 TM9SF4 TM9SF4 MAVS MAVS GLI3 GLI3 Ob Ob CDK5R1 CDK5R1 MIEF1 MIEF1 TARDBP TARDBP KCNB1 KCNB1 MYO1C MYO1C YWHAE YWHAE PIK3R1 PIK3R1 PRKAA1 PRKAA1 ANP32B ANP32B FBXW7 FBXW7
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SFN14-3-3 protein sigma; Belongs to the 14-3-3 family. (248 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (910 aa)
ITGB1BP1Integrin beta-1-binding protein 1 isoform X1. (206 aa)
FYNTyrosine-protein kinase. (537 aa)
ZFAND1AN1-type zinc finger protein 1 isoform X1. (267 aa)
SEC16BProtein transport protein sec16; Plays a role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus. (1065 aa)
LOC111165935Ras-like protein isoform X1. (285 aa)
CEMIPCell migration-inducing and hyaluronan-binding protein. (1431 aa)
JUPJunction plakoglobin. (744 aa)
OAZ1LOW QUALITY PROTEIN: ornithine decarboxylase antizyme 1. (227 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (723 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
FBXW9F-box/WD repeat-containing protein 9 isoform X1. (461 aa)
SLC35D3Solute carrier family 35 member D3. (422 aa)
SIRT6NAD-dependent protein deacetylase sirtuin-6 isoform X3. (375 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
SORL1Sortilin-related receptor isoform X1. (2211 aa)
MIEF2Mitochondrial dynamics protein MID49 isoform X1. (460 aa)
ZPR1Zinc finger protein ZPR1. (459 aa)
OAZ3LOW QUALITY PROTEIN: ornithine decarboxylase antizyme 3. (186 aa)
GSK3BGlycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
HCLS1Hematopoietic lineage cell-specific protein. (481 aa)
HRASGTPase HRas isoform X1. (189 aa)
BCAP31B-cell receptor-associated protein 31. (245 aa)
FLNAfilamin-A isoform X1. (2647 aa)
EMDEmerin isoform X1. (261 aa)
LOC111170664Heat shock 70 kDa protein 1-like; Belongs to the heat shock protein 70 family. (641 aa)
CIB1Calcium and integrin-binding protein 1. (191 aa)
CAMK1Calcium/calmodulin-dependent protein kinase type 1; Belongs to the protein kinase superfamily. (370 aa)
TRIM28Transcription intermediary factor 1-beta. (837 aa)
BAG3BAG family molecular chaperone regulator 3. (577 aa)
AKAP5A-kinase anchor protein 5. (428 aa)
TMEM30BCell cycle control protein; Belongs to the CDC50/LEM3 family. (353 aa)
PPM1AProtein phosphatase 1A. (382 aa)
MFFMitochondrial fission factor isoform X1. (353 aa)
PCM1Pericentriolar material 1 protein isoform X1. (2196 aa)
ECT2Protein ECT2 isoform X1. (973 aa)
TCF7L2Transcription factor 7-like 2 isoform X1. (668 aa)
RAPGEF3Rap guanine nucleotide exchange factor 3 isoform X2. (958 aa)
XPO4Exportin-4 isoform X1. (1152 aa)
ZC3H12AEndoribonuclease ZC3H12A. (583 aa)
EDEM1alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (660 aa)
PRKCDProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (733 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (461 aa)
PLK3Serine/threonine-protein kinase PLK. (647 aa)
PDCD10Programmed cell death protein 10. (212 aa)
HYAL2Hyaluronidase. (476 aa)
TCAF1TRPM8 channel-associated factor 1 isoform X1. (1016 aa)
IPO5Importin-5. (1097 aa)
GAS6Growth arrest-specific protein 6. (671 aa)
LOC111177285TRPM8 channel-associated factor 2-like. (919 aa)
EFCAB7EF-hand calcium-binding domain-containing protein 7 isoform X1. (656 aa)
DMAP1DNA methyltransferase 1-associated protein 1 isoform X1. (468 aa)
SLC51BLOW QUALITY PROTEIN: organic solute transporter subunit beta. (130 aa)
SMOSmoothened homolog; Belongs to the G-protein coupled receptor Fz/Smo family. (782 aa)
CDK5Cyclin-dependent-like kinase 5; Belongs to the protein kinase superfamily. (292 aa)
C2CD5C2 domain-containing protein 5 isoform X1. (1051 aa)
OAZ2LOW QUALITY PROTEIN: ornithine decarboxylase antizyme 2. (189 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (468 aa)
LOC111177759LOW QUALITY PROTEIN: ornithine decarboxylase antizyme 2-like. (189 aa)
PDZK1Na(+)/H(+) exchange regulatory cofactor NHE-RF3 isoform X1. (518 aa)
UBR5E3 ubiquitin-protein ligase UBR5 isoform X1. (2798 aa)
ICE1Little elongation complex subunit 1 isoform X1. (2241 aa)
RIPOR1Rho family-interacting cell polarization regulator 1 isoform X1. (1331 aa)
PRR5LProline-rich protein 5-like isoform X1. (428 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
GSK3AGlycogen synthase kinase-3 alpha; Belongs to the protein kinase superfamily. (483 aa)
PDCD5Programmed cell death protein 5. (125 aa)
CDH1Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. (885 aa)
CTDSPL2CTD small phosphatase-like protein 2 isoform X1. (465 aa)
PTPN22Tyrosine-protein phosphatase non-receptor type 22 isoform X1. (801 aa)
FIS1Mitochondrial fission 1 protein; Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. (152 aa)
BBC3Bcl-2-binding component 3. (193 aa)
TOMM7Mitochondrial import receptor subunit TOM7 homolog isoform X1. (55 aa)
SAR1BGTP-binding protein SAR1b; Belongs to the small GTPase superfamily. SAR1 family. (198 aa)
CHP2Calcineurin B homologous protein 2. (198 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (166 aa)
SAR1AGTP-binding protein SAR1a; Belongs to the small GTPase superfamily. SAR1 family. (198 aa)
CD81Tetraspanin. (236 aa)
TMEM30ACell cycle control protein; Belongs to the CDC50/LEM3 family. (362 aa)
HDAC3Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (428 aa)
RBM22pre-mRNA-splicing factor RBM22 isoform X1. (420 aa)
ERGIC3Endoplasmic reticulum-Golgi intermediate compartment protein 3. (383 aa)
EDEM2alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (578 aa)
TPRNucleoprotein TPR isoform X2. (2438 aa)
RAB29Ras-related protein Rab-7L1 isoform X1. (203 aa)
B3GAT3Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase; Belongs to the glycosyltransferase 43 family. (335 aa)
TM9SF4Transmembrane 9 superfamily member; Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family. (642 aa)
MAVSMitochondrial antiviral-signaling protein isoform X1. (581 aa)
GLI3Transcriptional activator GLI3 isoform X1. (1587 aa)
ObLeptin isoform X1. (167 aa)
CDK5R1Cyclin-dependent kinase 5 activator. (307 aa)
MIEF1Mitochondrial dynamics protein MID51. (463 aa)
TARDBPTAR DNA-binding protein 43. (414 aa)
KCNB1Potassium voltage-gated channel subfamily B member 1; Belongs to the potassium channel family. (858 aa)
MYO1CUnconventional myosin-Ic isoform X1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1063 aa)
YWHAE14-3-3 protein epsilon; Belongs to the 14-3-3 family. (255 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
PRKAA1Non-specific serine/threonine protein kinase. (559 aa)
ANP32BAcidic leucine-rich nuclear phosphoprotein 32 family member B. (261 aa)
FBXW7F-box/WD repeat-containing protein 7 isoform X1. (707 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
Server load: low (32%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.