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| | CTTN | Src substrate cortactin isoform X3. (538 aa) |
| | FADD | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (211 aa) |
| | DDX5 | Probable ATP-dependent RNA helicase DDX5; Belongs to the DEAD box helicase family. (614 aa) |
| | SGPL1 | Sphingosine-1-phosphate lyase 1. (568 aa) |
| | IL1A | Interleukin-1; Belongs to the IL-1 family. (265 aa) |
| | TNFSF12 | Tumor necrosis factor ligand superfamily member 12 isoform X2; Belongs to the tumor necrosis factor family. (249 aa) |
| | P2RX4 | P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (388 aa) |
| | ATAD5 | ATPase family AAA domain-containing protein 5 isoform X1. (1898 aa) |
| | HIC1 | Hypermethylated in cancer 1 protein isoform X1. (864 aa) |
| | INCA1 | Protein INCA1. (366 aa) |
| | TP73 | Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (637 aa) |
| | TNFRSF1B | Tumor necrosis factor receptor superfamily member 1B. (454 aa) |
| | PIK3R1 | Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa) |
| | EPHA2 | Ephrin type-A receptor 2. (975 aa) |
| | UBE4B | Ubiquitin conjugation factor E4 B isoform X3. (1360 aa) |
| | APAF1 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1248 aa) |
| | INHBA | Inhibin beta A chain. (425 aa) |
| | DIABLO | Diablo homolog, mitochondrial isoform X1. (237 aa) |
| | LOC111187154 | Ephrin type-A receptor 2-like. (171 aa) |
| | MELK | Non-specific serine/threonine protein kinase. (650 aa) |
| | TNF | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa) |
| | CTNNB1 | Catenin beta-1. (781 aa) |
| | NDUFA13 | LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13. (164 aa) |
| | HTRA2 | Serine protease HTRA2, mitochondrial. (458 aa) |
| | PDK2 | Protein-serine/threonine kinase. (407 aa) |
| | AIFM1 | Apoptosis-inducing factor 1, mitochondrial isoform X1. (613 aa) |
| | CRADD | Death domain-containing protein CRADD. (115 aa) |
| | MAP3K5 | Mitogen-activated protein kinase kinase kinase 5 isoform X1. (1366 aa) |
| | ATM | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3064 aa) |
| | PTPRC | Receptor-type tyrosine-protein phosphatase C isoform X1. (1258 aa) |
| | PHLDA3 | Pleckstrin homology-like domain family A member 3. (123 aa) |
| | MAEL | Protein maelstrom homolog isoform X1. (434 aa) |
| | FLCN | Folliculin isoform X1. (591 aa) |
| | CASP1 | Caspase-1; Belongs to the peptidase C14A family. (404 aa) |
| | LOC111167555 | Caspase-13 isoform X1; Belongs to the peptidase C14A family. (377 aa) |
| | PCGF2 | Polycomb group RING finger protein 2. (411 aa) |
| | USP47 | Ubiquitin carboxyl-terminal hydrolase 47 isoform X1; Belongs to the peptidase C19 family. (1375 aa) |
| | PAWR | PRKC apoptosis WT1 regulator protein. (345 aa) |
| | IL7 | Interleukin-7 isoform X1. (226 aa) |
| | DEDD | Death effector domain-containing protein. (318 aa) |
| | DAPK1 | Death-associated protein kinase 1 isoform X1. (1440 aa) |
| | NANOS3 | Nanos homolog 3 isoform X1; Belongs to the nanos family. (175 aa) |
| | BRCA1 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1866 aa) |
| | YJEFN3 | yjeF N-terminal domain-containing protein 3 isoform X1. (312 aa) |
| | FGFR3 | Fibroblast growth factor receptor. (805 aa) |
| | DDX3X | ATP-dependent RNA helicase DDX3X isoform X1; Belongs to the DEAD box helicase family. (662 aa) |
| | RB1CC1 | RB1-inducible coiled-coil protein 1 isoform X1. (1589 aa) |
| | PRKDC | DNA-dependent protein kinase catalytic subunit isoform X1; Belongs to the PI3/PI4-kinase family. (4131 aa) |
| | LOC111165935 | Ras-like protein isoform X1. (285 aa) |
| | NFATC4 | LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 4. (901 aa) |
| | FGF10 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa) |
| | LOC111164110 | Bcl-2-like protein 2. (193 aa) |
| | ADORA2A | Adenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (408 aa) |
| | FOXO3 | Forkhead box protein O3. (672 aa) |
| | BCL2A1 | Bcl-2-related protein A1. (175 aa) |
| | MYC | Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (439 aa) |
| | PPM1F | Protein phosphatase 1F. (433 aa) |
| | LOC111163571 | Death domain-containing protein CRADD-like isoform X1. (182 aa) |
| | E2F2 | Transcription factor E2F2 isoform X1. (437 aa) |
| | SFN | 14-3-3 protein sigma; Belongs to the 14-3-3 family. (248 aa) |
| | CASP8AP2 | CASP8-associated protein 2 isoform X2. (1974 aa) |
| | TOPORS | E3 ubiquitin-protein ligase Topors. (1044 aa) |
| | RNF186 | RING finger protein 186. (226 aa) |
| | RTL10 | Protein Bop isoform X1. (462 aa) |
| | ITPRIPL2 | Inositol 1,4,5-trisphosphate receptor-interacting protein-like 2. (532 aa) |
| | UMOD | Uromodulin. (643 aa) |
| | CHEK2 | Serine/threonine-protein kinase Chk2. (544 aa) |
| | TRIB3 | LOW QUALITY PROTEIN: tribbles homolog 3. (357 aa) |
| | VDAC2 | Voltage-dependent anion-selective channel protein 2. (294 aa) |
| | TMEM109 | Transmembrane protein 109. (243 aa) |
| | BAD | Bcl2-associated agonist of cell death. (168 aa) |
| | LGALS12 | Galectin. (318 aa) |
| | CD5 | T-cell surface glycoprotein CD5 isoform X1. (500 aa) |
| | STK4 | Serine/threonine-protein kinase 4 isoform X1. (487 aa) |
| | LOC111184077 | Tumor necrosis factor receptor superfamily member 26-like. (308 aa) |
| | E2F1 | Transcription factor E2F1. (437 aa) |
| | BNIP3L | BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like isoform X1. (218 aa) |
| | BCL2L1 | Bcl-2-like protein 1 isoform X1. (233 aa) |
| | CDIP1 | Cell death-inducing p53-target protein 1. (208 aa) |
| | ATF4 | Cyclic AMP-dependent transcription factor ATF-4 isoform X1. (350 aa) |
| | EYA1 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (589 aa) |
| | IVNS1ABP | Influenza virus NS1A-binding protein. (642 aa) |
| | RNF41 | E3 ubiquitin-protein ligase NRDP1 isoform X1. (317 aa) |
| | TP63 | Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa) |
| | QRICH1 | Glutamine-rich protein 1. (780 aa) |
| | PDX1 | Pancreas/duodenum homeobox protein 1. (289 aa) |
| | COL2A1 | Collagen alpha-1(II) chain. (1487 aa) |
| | MSH6 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1361 aa) |
| | SENP1 | Sentrin-specific protease 1 isoform X1. (690 aa) |
| | SHISA5 | Protein shisa-5 isoform X1. (239 aa) |
| | KRT8 | Keratin, type II cytoskeletal 8; Belongs to the intermediate filament family. (489 aa) |
| | DDIT3 | DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (168 aa) |
| | FHIT | Bis(5'-adenosyl)-triphosphatase. (175 aa) |
| | TLR3 | Toll-like receptor 3; Belongs to the Toll-like receptor family. (905 aa) |
| | ITPR1 | Inositol 1,4,5-trisphosphate receptor type 1 isoform X1. (2749 aa) |
| | CASP3 | Caspase-3 isoform X1; Belongs to the peptidase C14A family. (412 aa) |
| | ERBB3 | Receptor tyrosine-protein kinase erbB-3. (1338 aa) |
| | FAIM2 | Protein lifeguard 2; Belongs to the BI1 family. (316 aa) |
| | DYRK2 | Dual specificity tyrosine-phosphorylation-regulated kinase 2. (601 aa) |
| | INHBB | Inhibin beta B chain. (407 aa) |
| | SGPP1 | Sphingosine-1-phosphate phosphatase 1. (445 aa) |
| | BNIP3 | BCL2/adenovirus E1B 19 kDa protein-interacting protein 3. (196 aa) |
| | DAPL1 | Death-associated protein-like 1. (107 aa) |
| | BOK | Bcl-2-related ovarian killer protein. (213 aa) |
| | SFRP1 | Secreted frizzled-related protein 1. (308 aa) |
| | G0S2 | G0/G1 switch protein 2. (103 aa) |
| | RHOT1 | Mitochondrial Rho GTPase; Mitochondrial GTPase involved in mitochondrial trafficking. Belongs to the mitochondrial Rho GTPase family. (720 aa) |
| | IKBKE | Inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1. (807 aa) |
| | PTGIS | Prostacyclin synthase; Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2); Belongs to the cytochrome P450 family. (500 aa) |
| | STK11 | Serine/threonine-protein kinase STK11 isoform X1. (544 aa) |
| | PDK1 | Protein-serine/threonine kinase. (438 aa) |
| | CASP6 | Caspase-6 isoform X1; Belongs to the peptidase C14A family. (294 aa) |
| | PIDD1 | P53-induced death domain-containing protein 1 isoform X1. (971 aa) |
| | EYA2 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (549 aa) |
| | BAG3 | BAG family molecular chaperone regulator 3. (577 aa) |
| | FAS | Tumor necrosis factor receptor superfamily member 6 isoform X1. (334 aa) |
| | BAG6 | Large proline-rich protein BAG6 isoform X1. (1164 aa) |
| | MCL1 | Induced myeloid leukemia cell differentiation protein Mcl-1 isoform X1. (351 aa) |
| | ITPRIP | Inositol 1,4,5-trisphosphate receptor-interacting protein isoform X1. (667 aa) |
| | CD28 | T-cell-specific surface glycoprotein CD28. (265 aa) |
| | CASP8 | Caspase-8; Belongs to the peptidase C14A family. (486 aa) |
| | STK25 | Serine/threonine-protein kinase 25 isoform X2. (426 aa) |
| | ITGAV | Integrin alpha-V isoform X2; Belongs to the integrin alpha chain family. (1048 aa) |
| | RAF1 | RAF proto-oncogene serine/threonine-protein kinase isoform X1. (648 aa) |
| | CASP10 | Caspase-10; Belongs to the peptidase C14A family. (518 aa) |
| | CFLAR | CASP8 and FADD-like apoptosis regulator isoform X1; Belongs to the peptidase C14A family. (547 aa) |
| | YAP1 | Transcriptional coactivator YAP1 isoform X1. (511 aa) |
| | AEN | Apoptosis-enhancing nuclease. (316 aa) |
| | MAPK9 | Mitogen-activated protein kinase. (424 aa) |
| | HRAS | GTPase HRas isoform X1. (189 aa) |
| | FASLG | Tumor necrosis factor ligand superfamily member 6; Belongs to the tumor necrosis factor family. (262 aa) |
| | ERCC6 | DNA excision repair protein ERCC-6. (1485 aa) |
| | GSK3B | Glycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa) |
| | RRP8 | Ribosomal RNA-processing protein 8; Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone- modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and pr [...] (482 aa) |
| | LOC111168862 | Keratin, type II cytoskeletal 8-like; Belongs to the intermediate filament family. (486 aa) |
| | ATP2A3 | Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1057 aa) |
| | MYBBP1A | Myb-binding protein 1A. (1407 aa) |
| | JMY | Junction-mediating and -regulatory protein isoform X1. (992 aa) |
| | P2RX7 | P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (595 aa) |
| | RHOT2 | Mitochondrial Rho GTPase; Mitochondrial GTPase involved in mitochondrial trafficking. Belongs to the mitochondrial Rho GTPase family. (644 aa) |
| | PDPK1 | 3-phosphoinositide-dependent protein kinase 1 isoform X1. (558 aa) |
| | CASP9 | Caspase-9; Belongs to the peptidase C14A family. (452 aa) |
| | EP300 | Histone acetyltransferase p300. (2420 aa) |
| | LOC111185435 | Tumor necrosis factor receptor superfamily member 10A-like isoform X1. (454 aa) |
| | LOC111185436 | Tumor necrosis factor receptor superfamily member 10B-like isoform X1. (456 aa) |
| | NF1 | Neurofibromin isoform X1. (2873 aa) |
| | CEBPB | CCAAT/enhancer-binding protein. (345 aa) |
| | BCL2L11 | Bcl-2-like protein 11 isoform X1. (288 aa) |
| | DIDO1 | Death-inducer obliterator 1 isoform X1. (2220 aa) |
| | SNW1 | SNW domain-containing protein 1. (536 aa) |
| | CD27 | CD27 antigen isoform X1. (251 aa) |
| | SKIL | Ski-like protein isoform X1. (684 aa) |
| | TMEM117 | Transmembrane protein 117 isoform X1. (515 aa) |
| | APOPT1 | Apoptogenic protein 1, mitochondrial isoform X2. (233 aa) |
| | DNM1L | Dynamin-1-like protein isoform X1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (763 aa) |
| | LOC111174870 | Cytochrome P450 1B1; Belongs to the cytochrome P450 family. (543 aa) |
| | SHH | Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (461 aa) |
| | IFNG | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa) |
| | POLB | DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (335 aa) |
| | BDKRB2 | B2 bradykinin receptor; Belongs to the G-protein coupled receptor 1 family. (360 aa) |
| | PPP1R13B | Apoptosis-stimulating of p53 protein 1 isoform X1. (1075 aa) |
| | ERO1A | ERO1-like protein alpha. (468 aa) |
| | ZNF385B | Zinc finger protein 385B isoform X1. (506 aa) |
| | ATF2 | Cyclic AMP-dependent transcription factor ATF-2 isoform X1. (505 aa) |
| | ACVR1B | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (546 aa) |
| | KRT18 | Keratin, type I cytoskeletal 18; Belongs to the intermediate filament family. (429 aa) |
| | DDX47 | Probable ATP-dependent RNA helicase DDX47; Belongs to the DEAD box helicase family. (455 aa) |
| | PDCD10 | Programmed cell death protein 10. (212 aa) |
| | POU4F1 | POU domain protein. (422 aa) |
| | IL12A | Interleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (222 aa) |
| | TM2D1 | TM2 domain-containing protein 1 isoform X1. (214 aa) |
| | SIVA1 | Apoptosis regulatory protein Siva; Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl- x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis. (175 aa) |
| | MSH2 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (934 aa) |
| | GSKIP | GSK3-beta interaction protein isoform X3. (152 aa) |
| | TGFB2 | Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa) |
| | BRCA2 | Breast cancer type 2 susceptibility protein. (3435 aa) |
| | BMI1 | Polycomb complex protein BMI-1. (326 aa) |
| | CASP2 | Caspase-2 isoform X1; Belongs to the peptidase C14A family. (452 aa) |
| | DAP | Death-associated protein 1. (102 aa) |
| | BAK1 | Bcl-2 homologous antagonist/killer isoform X1. (239 aa) |
| | HIPK2 | Homeodomain-interacting protein kinase 2 isoform X1. (1248 aa) |
| | PML | Protein PML isoform X1. (861 aa) |
| | LOC111178986 | LOW QUALITY PROTEIN: catenin alpha-1-like. (908 aa) |
| | PSEN1 | Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (468 aa) |
| | PPARD | Peroxisome proliferator-activated receptor delta isoform X1. (441 aa) |
| | CDKN1A | Cyclin-dependent kinase inhibitor 1. (164 aa) |
| | TNFRSF1A | Tumor necrosis factor receptor superfamily member 1A. (445 aa) |
| | WWOX | WW domain-containing oxidoreductase isoform X1. (418 aa) |
| | ZNF622 | Zinc finger protein 622. (465 aa) |
| | NOL3 | Nucleolar protein 3. (202 aa) |
| | SMAD3 | Mothers against decapentaplegic homolog. (425 aa) |
| | UACA | Uveal autoantigen with coiled-coil domains and ankyrin repeats isoform X1. (1417 aa) |
| | DAB2IP | Disabled homolog 2-interacting protein isoform X1. (1193 aa) |
| | TP53BP2 | Apoptosis-stimulating of p53 protein 2. (1136 aa) |
| | CAV1 | Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa) |
| | GGCT | Gamma-glutamylcyclotransferase isoform X1. (219 aa) |
| | SORT1 | Sortilin. (864 aa) |
| | DEDD2 | DNA-binding death effector domain-containing protein 2. (322 aa) |
| | NOX1 | LOW QUALITY PROTEIN: NADPH oxidase 1. (567 aa) |
| | TFPT | TCF3 fusion partner. (253 aa) |
| | PMAIP1 | Phorbol-12-myristate-13-acetate-induced protein 1. (54 aa) |
| | BCL3 | B-cell lymphoma 3 protein. (454 aa) |
| | DAXX | Death domain-associated protein 6 isoform X1. (742 aa) |
| | TGFB1 | Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa) |
| | TIMM50 | Mitochondrial import inner membrane translocase subunit TIM50; Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. (357 aa) |
| | NBN | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (727 aa) |
| | BAX | Apoptosis regulator BAX isoform X2. (223 aa) |
| | TRADD | Tumor necrosis factor receptor type 1-associated DEATH domain protein. (315 aa) |
| | GSK3A | Glycogen synthase kinase-3 alpha; Belongs to the protein kinase superfamily. (483 aa) |
| | HIPK1 | Homeodomain-interacting protein kinase 1 isoform X1. (1209 aa) |
| | BCL2 | Apoptosis regulator Bcl-2. (233 aa) |
| | PYCARD | Apoptosis-associated speck-like protein containing a CARD. (195 aa) |
| | RIPK1 | Receptor-interacting serine/threonine-protein kinase 1 isoform X1. (687 aa) |
| | NUPR1 | Nuclear protein 1. (82 aa) |
| | NGF | Beta-nerve growth factor; Belongs to the NGF-beta family. (241 aa) |
| | ERN2 | Serine/threonine-protein kinase/endoribonuclease IRE2. (927 aa) |
| | ELL3 | RNA polymerase II elongation factor ELL3 isoform X2. (397 aa) |
| | PDIA3 | Protein disulfide-isomerase. (505 aa) |
| | FIS1 | Mitochondrial fission 1 protein; Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. (152 aa) |
| | STK3 | Serine/threonine-protein kinase 3. (491 aa) |
| | ERN1 | Serine/threonine-protein kinase/endoribonuclease IRE1. (975 aa) |
| | BBC3 | Bcl-2-binding component 3. (193 aa) |
| | CTNNA1 | Catenin alpha-1. (906 aa) |
| | TMBIM7P | LOW QUALITY PROTEIN: protein lifeguard 2; Belongs to the BI1 family. (310 aa) |
| | RAD9A | Cell cycle checkpoint control protein; Belongs to the rad9 family. (420 aa) |
| | ANXA6 | Annexin. (673 aa) |
| | KIAA0141 | Death ligand signal enhancer isoform X1. (517 aa) |
| | CHAC1 | Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family. (215 aa) |
| | HIP1 | Huntingtin-interacting protein 1 isoform X1. (1037 aa) |
| | PARP2 | Poly [ADP-ribose] polymerase. (563 aa) |
| | SIRT1 | NAD-dependent protein deacetylase sirtuin-1 isoform X1. (735 aa) |
| | DDIT4 | DNA damage-inducible transcript 4 protein. (229 aa) |
| | ATP2A1 | Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1006 aa) |
