STRINGSTRING
CTTN CTTN FADD FADD DDX5 DDX5 SGPL1 SGPL1 IL1A IL1A TNFSF12 TNFSF12 P2RX4 P2RX4 ATAD5 ATAD5 HIC1 HIC1 INCA1 INCA1 TP73 TP73 TNFRSF1B TNFRSF1B PIK3R1 PIK3R1 EPHA2 EPHA2 UBE4B UBE4B APAF1 APAF1 INHBA INHBA DIABLO DIABLO LOC111187154 LOC111187154 MELK MELK TNF TNF CTNNB1 CTNNB1 NDUFA13 NDUFA13 HTRA2 HTRA2 PDK2 PDK2 AIFM1 AIFM1 CRADD CRADD MAP3K5 MAP3K5 ATM ATM PTPRC PTPRC PHLDA3 PHLDA3 MAEL MAEL FLCN FLCN CASP1 CASP1 LOC111167555 LOC111167555 PCGF2 PCGF2 USP47 USP47 PAWR PAWR IL7 IL7 DEDD DEDD DAPK1 DAPK1 NANOS3 NANOS3 BRCA1 BRCA1 YJEFN3 YJEFN3 FGFR3 FGFR3 DDX3X DDX3X RB1CC1 RB1CC1 PRKDC PRKDC LOC111165935 LOC111165935 NFATC4 NFATC4 FGF10 FGF10 LOC111164110 LOC111164110 ADORA2A ADORA2A FOXO3 FOXO3 BCL2A1 BCL2A1 MYC MYC PPM1F PPM1F LOC111163571 LOC111163571 E2F2 E2F2 SFN SFN CASP8AP2 CASP8AP2 TOPORS TOPORS RNF186 RNF186 RTL10 RTL10 ITPRIPL2 ITPRIPL2 UMOD UMOD CHEK2 CHEK2 TRIB3 TRIB3 VDAC2 VDAC2 TMEM109 TMEM109 BAD BAD LGALS12 LGALS12 CD5 CD5 STK4 STK4 LOC111184077 LOC111184077 E2F1 E2F1 BNIP3L BNIP3L BCL2L1 BCL2L1 CDIP1 CDIP1 ATF4 ATF4 EYA1 EYA1 IVNS1ABP IVNS1ABP RNF41 RNF41 TP63 TP63 QRICH1 QRICH1 PDX1 PDX1 COL2A1 COL2A1 MSH6 MSH6 SENP1 SENP1 SHISA5 SHISA5 KRT8 KRT8 DDIT3 DDIT3 FHIT FHIT TLR3 TLR3 ITPR1 ITPR1 CASP3 CASP3 ERBB3 ERBB3 FAIM2 FAIM2 DYRK2 DYRK2 INHBB INHBB SGPP1 SGPP1 BNIP3 BNIP3 DAPL1 DAPL1 BOK BOK SFRP1 SFRP1 G0S2 G0S2 RHOT1 RHOT1 IKBKE IKBKE PTGIS PTGIS STK11 STK11 PDK1 PDK1 CASP6 CASP6 PIDD1 PIDD1 EYA2 EYA2 BAG3 BAG3 FAS FAS BAG6 BAG6 MCL1 MCL1 ITPRIP ITPRIP CD28 CD28 CASP8 CASP8 STK25 STK25 ITGAV ITGAV RAF1 RAF1 CASP10 CASP10 CFLAR CFLAR YAP1 YAP1 AEN AEN MAPK9 MAPK9 HRAS HRAS FASLG FASLG ERCC6 ERCC6 GSK3B GSK3B RRP8 RRP8 LOC111168862 LOC111168862 ATP2A3 ATP2A3 MYBBP1A MYBBP1A JMY JMY P2RX7 P2RX7 RHOT2 RHOT2 PDPK1 PDPK1 CASP9 CASP9 EP300 EP300 LOC111185435 LOC111185435 LOC111185436 LOC111185436 NF1 NF1 CEBPB CEBPB BCL2L11 BCL2L11 DIDO1 DIDO1 SNW1 SNW1 CD27 CD27 SKIL SKIL TMEM117 TMEM117 APOPT1 APOPT1 DNM1L DNM1L LOC111174870 LOC111174870 SHH SHH IFNG IFNG POLB POLB BDKRB2 BDKRB2 PPP1R13B PPP1R13B ERO1A ERO1A ZNF385B ZNF385B ATF2 ATF2 ACVR1B ACVR1B KRT18 KRT18 DDX47 DDX47 PDCD10 PDCD10 POU4F1 POU4F1 IL12A IL12A TM2D1 TM2D1 SIVA1 SIVA1 MSH2 MSH2 GSKIP GSKIP TGFB2 TGFB2 BRCA2 BRCA2 BMI1 BMI1 CASP2 CASP2 DAP DAP BAK1 BAK1 HIPK2 HIPK2 PML PML LOC111178986 LOC111178986 PSEN1 PSEN1 PPARD PPARD CDKN1A CDKN1A TNFRSF1A TNFRSF1A WWOX WWOX ZNF622 ZNF622 NOL3 NOL3 SMAD3 SMAD3 UACA UACA DAB2IP DAB2IP TP53BP2 TP53BP2 CAV1 CAV1 GGCT GGCT SORT1 SORT1 DEDD2 DEDD2 NOX1 NOX1 TFPT TFPT PMAIP1 PMAIP1 BCL3 BCL3 DAXX DAXX TGFB1 TGFB1 TIMM50 TIMM50 NBN NBN BAX BAX TRADD TRADD GSK3A GSK3A HIPK1 HIPK1 BCL2 BCL2 PYCARD PYCARD RIPK1 RIPK1 NUPR1 NUPR1 NGF NGF ERN2 ERN2 ELL3 ELL3 PDIA3 PDIA3 FIS1 FIS1 STK3 STK3 ERN1 ERN1 BBC3 BBC3 CTNNA1 CTNNA1 TMBIM7P TMBIM7P RAD9A RAD9A ANXA6 ANXA6 KIAA0141 KIAA0141 CHAC1 CHAC1 HIP1 HIP1 PARP2 PARP2 SIRT1 SIRT1 DDIT4 DDIT4 ATP2A1 ATP2A1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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CTTNSrc substrate cortactin isoform X3. (538 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (211 aa)
DDX5Probable ATP-dependent RNA helicase DDX5; Belongs to the DEAD box helicase family. (614 aa)
SGPL1Sphingosine-1-phosphate lyase 1. (568 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (265 aa)
TNFSF12Tumor necrosis factor ligand superfamily member 12 isoform X2; Belongs to the tumor necrosis factor family. (249 aa)
P2RX4P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (388 aa)
ATAD5ATPase family AAA domain-containing protein 5 isoform X1. (1898 aa)
HIC1Hypermethylated in cancer 1 protein isoform X1. (864 aa)
INCA1Protein INCA1. (366 aa)
TP73Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (637 aa)
TNFRSF1BTumor necrosis factor receptor superfamily member 1B. (454 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
EPHA2Ephrin type-A receptor 2. (975 aa)
UBE4BUbiquitin conjugation factor E4 B isoform X3. (1360 aa)
APAF1Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1248 aa)
INHBAInhibin beta A chain. (425 aa)
DIABLODiablo homolog, mitochondrial isoform X1. (237 aa)
LOC111187154Ephrin type-A receptor 2-like. (171 aa)
MELKNon-specific serine/threonine protein kinase. (650 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa)
CTNNB1Catenin beta-1. (781 aa)
NDUFA13LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13. (164 aa)
HTRA2Serine protease HTRA2, mitochondrial. (458 aa)
PDK2Protein-serine/threonine kinase. (407 aa)
AIFM1Apoptosis-inducing factor 1, mitochondrial isoform X1. (613 aa)
CRADDDeath domain-containing protein CRADD. (115 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5 isoform X1. (1366 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3064 aa)
PTPRCReceptor-type tyrosine-protein phosphatase C isoform X1. (1258 aa)
PHLDA3Pleckstrin homology-like domain family A member 3. (123 aa)
MAELProtein maelstrom homolog isoform X1. (434 aa)
FLCNFolliculin isoform X1. (591 aa)
CASP1Caspase-1; Belongs to the peptidase C14A family. (404 aa)
LOC111167555Caspase-13 isoform X1; Belongs to the peptidase C14A family. (377 aa)
PCGF2Polycomb group RING finger protein 2. (411 aa)
USP47Ubiquitin carboxyl-terminal hydrolase 47 isoform X1; Belongs to the peptidase C19 family. (1375 aa)
PAWRPRKC apoptosis WT1 regulator protein. (345 aa)
IL7Interleukin-7 isoform X1. (226 aa)
DEDDDeath effector domain-containing protein. (318 aa)
DAPK1Death-associated protein kinase 1 isoform X1. (1440 aa)
NANOS3Nanos homolog 3 isoform X1; Belongs to the nanos family. (175 aa)
BRCA1Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1866 aa)
YJEFN3yjeF N-terminal domain-containing protein 3 isoform X1. (312 aa)
FGFR3Fibroblast growth factor receptor. (805 aa)
DDX3XATP-dependent RNA helicase DDX3X isoform X1; Belongs to the DEAD box helicase family. (662 aa)
RB1CC1RB1-inducible coiled-coil protein 1 isoform X1. (1589 aa)
PRKDCDNA-dependent protein kinase catalytic subunit isoform X1; Belongs to the PI3/PI4-kinase family. (4131 aa)
LOC111165935Ras-like protein isoform X1. (285 aa)
NFATC4LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 4. (901 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
LOC111164110Bcl-2-like protein 2. (193 aa)
ADORA2AAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (408 aa)
FOXO3Forkhead box protein O3. (672 aa)
BCL2A1Bcl-2-related protein A1. (175 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (439 aa)
PPM1FProtein phosphatase 1F. (433 aa)
LOC111163571Death domain-containing protein CRADD-like isoform X1. (182 aa)
E2F2Transcription factor E2F2 isoform X1. (437 aa)
SFN14-3-3 protein sigma; Belongs to the 14-3-3 family. (248 aa)
CASP8AP2CASP8-associated protein 2 isoform X2. (1974 aa)
TOPORSE3 ubiquitin-protein ligase Topors. (1044 aa)
RNF186RING finger protein 186. (226 aa)
RTL10Protein Bop isoform X1. (462 aa)
ITPRIPL2Inositol 1,4,5-trisphosphate receptor-interacting protein-like 2. (532 aa)
UMODUromodulin. (643 aa)
CHEK2Serine/threonine-protein kinase Chk2. (544 aa)
TRIB3LOW QUALITY PROTEIN: tribbles homolog 3. (357 aa)
VDAC2Voltage-dependent anion-selective channel protein 2. (294 aa)
TMEM109Transmembrane protein 109. (243 aa)
BADBcl2-associated agonist of cell death. (168 aa)
LGALS12Galectin. (318 aa)
CD5T-cell surface glycoprotein CD5 isoform X1. (500 aa)
STK4Serine/threonine-protein kinase 4 isoform X1. (487 aa)
LOC111184077Tumor necrosis factor receptor superfamily member 26-like. (308 aa)
E2F1Transcription factor E2F1. (437 aa)
BNIP3LBCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like isoform X1. (218 aa)
BCL2L1Bcl-2-like protein 1 isoform X1. (233 aa)
CDIP1Cell death-inducing p53-target protein 1. (208 aa)
ATF4Cyclic AMP-dependent transcription factor ATF-4 isoform X1. (350 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (589 aa)
IVNS1ABPInfluenza virus NS1A-binding protein. (642 aa)
RNF41E3 ubiquitin-protein ligase NRDP1 isoform X1. (317 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
QRICH1Glutamine-rich protein 1. (780 aa)
PDX1Pancreas/duodenum homeobox protein 1. (289 aa)
COL2A1Collagen alpha-1(II) chain. (1487 aa)
MSH6DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1361 aa)
SENP1Sentrin-specific protease 1 isoform X1. (690 aa)
SHISA5Protein shisa-5 isoform X1. (239 aa)
KRT8Keratin, type II cytoskeletal 8; Belongs to the intermediate filament family. (489 aa)
DDIT3DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (168 aa)
FHITBis(5'-adenosyl)-triphosphatase. (175 aa)
TLR3Toll-like receptor 3; Belongs to the Toll-like receptor family. (905 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1 isoform X1. (2749 aa)
CASP3Caspase-3 isoform X1; Belongs to the peptidase C14A family. (412 aa)
ERBB3Receptor tyrosine-protein kinase erbB-3. (1338 aa)
FAIM2Protein lifeguard 2; Belongs to the BI1 family. (316 aa)
DYRK2Dual specificity tyrosine-phosphorylation-regulated kinase 2. (601 aa)
INHBBInhibin beta B chain. (407 aa)
SGPP1Sphingosine-1-phosphate phosphatase 1. (445 aa)
BNIP3BCL2/adenovirus E1B 19 kDa protein-interacting protein 3. (196 aa)
DAPL1Death-associated protein-like 1. (107 aa)
BOKBcl-2-related ovarian killer protein. (213 aa)
SFRP1Secreted frizzled-related protein 1. (308 aa)
G0S2G0/G1 switch protein 2. (103 aa)
RHOT1Mitochondrial Rho GTPase; Mitochondrial GTPase involved in mitochondrial trafficking. Belongs to the mitochondrial Rho GTPase family. (720 aa)
IKBKEInhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1. (807 aa)
PTGISProstacyclin synthase; Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2); Belongs to the cytochrome P450 family. (500 aa)
STK11Serine/threonine-protein kinase STK11 isoform X1. (544 aa)
PDK1Protein-serine/threonine kinase. (438 aa)
CASP6Caspase-6 isoform X1; Belongs to the peptidase C14A family. (294 aa)
PIDD1P53-induced death domain-containing protein 1 isoform X1. (971 aa)
EYA2Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (549 aa)
BAG3BAG family molecular chaperone regulator 3. (577 aa)
FASTumor necrosis factor receptor superfamily member 6 isoform X1. (334 aa)
BAG6Large proline-rich protein BAG6 isoform X1. (1164 aa)
MCL1Induced myeloid leukemia cell differentiation protein Mcl-1 isoform X1. (351 aa)
ITPRIPInositol 1,4,5-trisphosphate receptor-interacting protein isoform X1. (667 aa)
CD28T-cell-specific surface glycoprotein CD28. (265 aa)
CASP8Caspase-8; Belongs to the peptidase C14A family. (486 aa)
STK25Serine/threonine-protein kinase 25 isoform X2. (426 aa)
ITGAVIntegrin alpha-V isoform X2; Belongs to the integrin alpha chain family. (1048 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (648 aa)
CASP10Caspase-10; Belongs to the peptidase C14A family. (518 aa)
CFLARCASP8 and FADD-like apoptosis regulator isoform X1; Belongs to the peptidase C14A family. (547 aa)
YAP1Transcriptional coactivator YAP1 isoform X1. (511 aa)
AENApoptosis-enhancing nuclease. (316 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
HRASGTPase HRas isoform X1. (189 aa)
FASLGTumor necrosis factor ligand superfamily member 6; Belongs to the tumor necrosis factor family. (262 aa)
ERCC6DNA excision repair protein ERCC-6. (1485 aa)
GSK3BGlycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
RRP8Ribosomal RNA-processing protein 8; Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone- modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and pr [...] (482 aa)
LOC111168862Keratin, type II cytoskeletal 8-like; Belongs to the intermediate filament family. (486 aa)
ATP2A3Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1057 aa)
MYBBP1AMyb-binding protein 1A. (1407 aa)
JMYJunction-mediating and -regulatory protein isoform X1. (992 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (595 aa)
RHOT2Mitochondrial Rho GTPase; Mitochondrial GTPase involved in mitochondrial trafficking. Belongs to the mitochondrial Rho GTPase family. (644 aa)
PDPK13-phosphoinositide-dependent protein kinase 1 isoform X1. (558 aa)
CASP9Caspase-9; Belongs to the peptidase C14A family. (452 aa)
EP300Histone acetyltransferase p300. (2420 aa)
LOC111185435Tumor necrosis factor receptor superfamily member 10A-like isoform X1. (454 aa)
LOC111185436Tumor necrosis factor receptor superfamily member 10B-like isoform X1. (456 aa)
NF1Neurofibromin isoform X1. (2873 aa)
CEBPBCCAAT/enhancer-binding protein. (345 aa)
BCL2L11Bcl-2-like protein 11 isoform X1. (288 aa)
DIDO1Death-inducer obliterator 1 isoform X1. (2220 aa)
SNW1SNW domain-containing protein 1. (536 aa)
CD27CD27 antigen isoform X1. (251 aa)
SKILSki-like protein isoform X1. (684 aa)
TMEM117Transmembrane protein 117 isoform X1. (515 aa)
APOPT1Apoptogenic protein 1, mitochondrial isoform X2. (233 aa)
DNM1LDynamin-1-like protein isoform X1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (763 aa)
LOC111174870Cytochrome P450 1B1; Belongs to the cytochrome P450 family. (543 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (461 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
POLBDNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (335 aa)
BDKRB2B2 bradykinin receptor; Belongs to the G-protein coupled receptor 1 family. (360 aa)
PPP1R13BApoptosis-stimulating of p53 protein 1 isoform X1. (1075 aa)
ERO1AERO1-like protein alpha. (468 aa)
ZNF385BZinc finger protein 385B isoform X1. (506 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2 isoform X1. (505 aa)
ACVR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (546 aa)
KRT18Keratin, type I cytoskeletal 18; Belongs to the intermediate filament family. (429 aa)
DDX47Probable ATP-dependent RNA helicase DDX47; Belongs to the DEAD box helicase family. (455 aa)
PDCD10Programmed cell death protein 10. (212 aa)
POU4F1POU domain protein. (422 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (222 aa)
TM2D1TM2 domain-containing protein 1 isoform X1. (214 aa)
SIVA1Apoptosis regulatory protein Siva; Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl- x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis. (175 aa)
MSH2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (934 aa)
GSKIPGSK3-beta interaction protein isoform X3. (152 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
BRCA2Breast cancer type 2 susceptibility protein. (3435 aa)
BMI1Polycomb complex protein BMI-1. (326 aa)
CASP2Caspase-2 isoform X1; Belongs to the peptidase C14A family. (452 aa)
DAPDeath-associated protein 1. (102 aa)
BAK1Bcl-2 homologous antagonist/killer isoform X1. (239 aa)
HIPK2Homeodomain-interacting protein kinase 2 isoform X1. (1248 aa)
PMLProtein PML isoform X1. (861 aa)
LOC111178986LOW QUALITY PROTEIN: catenin alpha-1-like. (908 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (468 aa)
PPARDPeroxisome proliferator-activated receptor delta isoform X1. (441 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (164 aa)
TNFRSF1ATumor necrosis factor receptor superfamily member 1A. (445 aa)
WWOXWW domain-containing oxidoreductase isoform X1. (418 aa)
ZNF622Zinc finger protein 622. (465 aa)
NOL3Nucleolar protein 3. (202 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
UACAUveal autoantigen with coiled-coil domains and ankyrin repeats isoform X1. (1417 aa)
DAB2IPDisabled homolog 2-interacting protein isoform X1. (1193 aa)
TP53BP2Apoptosis-stimulating of p53 protein 2. (1136 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
GGCTGamma-glutamylcyclotransferase isoform X1. (219 aa)
SORT1Sortilin. (864 aa)
DEDD2DNA-binding death effector domain-containing protein 2. (322 aa)
NOX1LOW QUALITY PROTEIN: NADPH oxidase 1. (567 aa)
TFPTTCF3 fusion partner. (253 aa)
PMAIP1Phorbol-12-myristate-13-acetate-induced protein 1. (54 aa)
BCL3B-cell lymphoma 3 protein. (454 aa)
DAXXDeath domain-associated protein 6 isoform X1. (742 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
TIMM50Mitochondrial import inner membrane translocase subunit TIM50; Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. (357 aa)
NBNNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (727 aa)
BAXApoptosis regulator BAX isoform X2. (223 aa)
TRADDTumor necrosis factor receptor type 1-associated DEATH domain protein. (315 aa)
GSK3AGlycogen synthase kinase-3 alpha; Belongs to the protein kinase superfamily. (483 aa)
HIPK1Homeodomain-interacting protein kinase 1 isoform X1. (1209 aa)
BCL2Apoptosis regulator Bcl-2. (233 aa)
PYCARDApoptosis-associated speck-like protein containing a CARD. (195 aa)
RIPK1Receptor-interacting serine/threonine-protein kinase 1 isoform X1. (687 aa)
NUPR1Nuclear protein 1. (82 aa)
NGFBeta-nerve growth factor; Belongs to the NGF-beta family. (241 aa)
ERN2Serine/threonine-protein kinase/endoribonuclease IRE2. (927 aa)
ELL3RNA polymerase II elongation factor ELL3 isoform X2. (397 aa)
PDIA3Protein disulfide-isomerase. (505 aa)
FIS1Mitochondrial fission 1 protein; Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. (152 aa)
STK3Serine/threonine-protein kinase 3. (491 aa)
ERN1Serine/threonine-protein kinase/endoribonuclease IRE1. (975 aa)
BBC3Bcl-2-binding component 3. (193 aa)
CTNNA1Catenin alpha-1. (906 aa)
TMBIM7PLOW QUALITY PROTEIN: protein lifeguard 2; Belongs to the BI1 family. (310 aa)
RAD9ACell cycle checkpoint control protein; Belongs to the rad9 family. (420 aa)
ANXA6Annexin. (673 aa)
KIAA0141Death ligand signal enhancer isoform X1. (517 aa)
CHAC1Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family. (215 aa)
HIP1Huntingtin-interacting protein 1 isoform X1. (1037 aa)
PARP2Poly [ADP-ribose] polymerase. (563 aa)
SIRT1NAD-dependent protein deacetylase sirtuin-1 isoform X1. (735 aa)
DDIT4DNA damage-inducible transcript 4 protein. (229 aa)
ATP2A1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1006 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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