STRINGSTRING
DAPK1 DAPK1 DEDD DEDD IL7 IL7 PTPRC PTPRC EYA2 EYA2 BAG3 BAG3 FAS FAS MCL1 MCL1 ITPRIP ITPRIP CASP8 CASP8 ITGAV ITGAV RAF1 RAF1 CASP10 CASP10 YAP1 YAP1 FASLG FASLG GSK3B GSK3B LOC111168862 LOC111168862 NDUFA13 NDUFA13 ITPRIPL2 ITPRIPL2 TNF TNF PIK3R1 PIK3R1 TNFRSF1B TNFRSF1B TNFSF12 TNFSF12 IL1A IL1A BCL2L11 BCL2L11 NF1 NF1 LOC111185436 LOC111185436 LOC111185435 LOC111185435 PDPK1 PDPK1 P2RX7 P2RX7 G0S2 G0S2 EYA1 EYA1 BCL2L1 BCL2L1 LOC111184077 LOC111184077 STK4 STK4 BAD BAD INHBA INHBA FADD FADD CTTN CTTN PARP2 PARP2 KIAA0141 KIAA0141 CTNNA1 CTNNA1 STK3 STK3 PDIA3 PDIA3 NGF NGF RIPK1 RIPK1 BCL2 BCL2 HIPK1 HIPK1 GSK3A GSK3A TRADD TRADD BAX BAX TGFB1 TGFB1 DAXX DAXX DEDD2 DEDD2 SORT1 SORT1 DAB2IP DAB2IP SMAD3 SMAD3 WWOX WWOX LOC111178986 LOC111178986 PML PML BAK1 BAK1 CASP2 CASP2 TGFB2 TGFB2 SIVA1 SIVA1 IL12A IL12A DDX47 DDX47 CD27 CD27 SKIL SKIL IFNG IFNG ACVR1B ACVR1B KRT18 KRT18 RNF41 RNF41 COL2A1 COL2A1 KRT8 KRT8 TLR3 TLR3 ERBB3 ERBB3 SGPP1 SGPP1 BOK BOK SFRP1 SFRP1 PIDD1 PIDD1 FGF10 FGF10 LOC111164110 LOC111164110 FOXO3 FOXO3 BCL2A1 BCL2A1 CASP8AP2 CASP8AP2 RB1CC1 RB1CC1 DDX3X DDX3X FGFR3 FGFR3 YJEFN3 YJEFN3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DAPK1Death-associated protein kinase 1 isoform X1. (1440 aa)
DEDDDeath effector domain-containing protein. (318 aa)
IL7Interleukin-7 isoform X1. (226 aa)
PTPRCReceptor-type tyrosine-protein phosphatase C isoform X1. (1258 aa)
EYA2Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (549 aa)
BAG3BAG family molecular chaperone regulator 3. (577 aa)
FASTumor necrosis factor receptor superfamily member 6 isoform X1. (334 aa)
MCL1Induced myeloid leukemia cell differentiation protein Mcl-1 isoform X1. (351 aa)
ITPRIPInositol 1,4,5-trisphosphate receptor-interacting protein isoform X1. (667 aa)
CASP8Caspase-8; Belongs to the peptidase C14A family. (486 aa)
ITGAVIntegrin alpha-V isoform X2; Belongs to the integrin alpha chain family. (1048 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (648 aa)
CASP10Caspase-10; Belongs to the peptidase C14A family. (518 aa)
YAP1Transcriptional coactivator YAP1 isoform X1. (511 aa)
FASLGTumor necrosis factor ligand superfamily member 6; Belongs to the tumor necrosis factor family. (262 aa)
GSK3BGlycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
LOC111168862Keratin, type II cytoskeletal 8-like; Belongs to the intermediate filament family. (486 aa)
NDUFA13LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13. (164 aa)
ITPRIPL2Inositol 1,4,5-trisphosphate receptor-interacting protein-like 2. (532 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
TNFRSF1BTumor necrosis factor receptor superfamily member 1B. (454 aa)
TNFSF12Tumor necrosis factor ligand superfamily member 12 isoform X2; Belongs to the tumor necrosis factor family. (249 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (265 aa)
BCL2L11Bcl-2-like protein 11 isoform X1. (288 aa)
NF1Neurofibromin isoform X1. (2873 aa)
LOC111185436Tumor necrosis factor receptor superfamily member 10B-like isoform X1. (456 aa)
LOC111185435Tumor necrosis factor receptor superfamily member 10A-like isoform X1. (454 aa)
PDPK13-phosphoinositide-dependent protein kinase 1 isoform X1. (558 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (595 aa)
G0S2G0/G1 switch protein 2. (103 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (589 aa)
BCL2L1Bcl-2-like protein 1 isoform X1. (233 aa)
LOC111184077Tumor necrosis factor receptor superfamily member 26-like. (308 aa)
STK4Serine/threonine-protein kinase 4 isoform X1. (487 aa)
BADBcl2-associated agonist of cell death. (168 aa)
INHBAInhibin beta A chain. (425 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (211 aa)
CTTNSrc substrate cortactin isoform X3. (538 aa)
PARP2Poly [ADP-ribose] polymerase. (563 aa)
KIAA0141Death ligand signal enhancer isoform X1. (517 aa)
CTNNA1Catenin alpha-1. (906 aa)
STK3Serine/threonine-protein kinase 3. (491 aa)
PDIA3Protein disulfide-isomerase. (505 aa)
NGFBeta-nerve growth factor; Belongs to the NGF-beta family. (241 aa)
RIPK1Receptor-interacting serine/threonine-protein kinase 1 isoform X1. (687 aa)
BCL2Apoptosis regulator Bcl-2. (233 aa)
HIPK1Homeodomain-interacting protein kinase 1 isoform X1. (1209 aa)
GSK3AGlycogen synthase kinase-3 alpha; Belongs to the protein kinase superfamily. (483 aa)
TRADDTumor necrosis factor receptor type 1-associated DEATH domain protein. (315 aa)
BAXApoptosis regulator BAX isoform X2. (223 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
DAXXDeath domain-associated protein 6 isoform X1. (742 aa)
DEDD2DNA-binding death effector domain-containing protein 2. (322 aa)
SORT1Sortilin. (864 aa)
DAB2IPDisabled homolog 2-interacting protein isoform X1. (1193 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
WWOXWW domain-containing oxidoreductase isoform X1. (418 aa)
LOC111178986LOW QUALITY PROTEIN: catenin alpha-1-like. (908 aa)
PMLProtein PML isoform X1. (861 aa)
BAK1Bcl-2 homologous antagonist/killer isoform X1. (239 aa)
CASP2Caspase-2 isoform X1; Belongs to the peptidase C14A family. (452 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
SIVA1Apoptosis regulatory protein Siva; Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl- x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis. (175 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (222 aa)
DDX47Probable ATP-dependent RNA helicase DDX47; Belongs to the DEAD box helicase family. (455 aa)
CD27CD27 antigen isoform X1. (251 aa)
SKILSki-like protein isoform X1. (684 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
ACVR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (546 aa)
KRT18Keratin, type I cytoskeletal 18; Belongs to the intermediate filament family. (429 aa)
RNF41E3 ubiquitin-protein ligase NRDP1 isoform X1. (317 aa)
COL2A1Collagen alpha-1(II) chain. (1487 aa)
KRT8Keratin, type II cytoskeletal 8; Belongs to the intermediate filament family. (489 aa)
TLR3Toll-like receptor 3; Belongs to the Toll-like receptor family. (905 aa)
ERBB3Receptor tyrosine-protein kinase erbB-3. (1338 aa)
SGPP1Sphingosine-1-phosphate phosphatase 1. (445 aa)
BOKBcl-2-related ovarian killer protein. (213 aa)
SFRP1Secreted frizzled-related protein 1. (308 aa)
PIDD1P53-induced death domain-containing protein 1 isoform X1. (971 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
LOC111164110Bcl-2-like protein 2. (193 aa)
FOXO3Forkhead box protein O3. (672 aa)
BCL2A1Bcl-2-related protein A1. (175 aa)
CASP8AP2CASP8-associated protein 2 isoform X2. (1974 aa)
RB1CC1RB1-inducible coiled-coil protein 1 isoform X1. (1589 aa)
DDX3XATP-dependent RNA helicase DDX3X isoform X1; Belongs to the DEAD box helicase family. (662 aa)
FGFR3Fibroblast growth factor receptor. (805 aa)
YJEFN3yjeF N-terminal domain-containing protein 3 isoform X1. (312 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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