26 items (Delphinapterus leucas) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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co-expression

protein homology

Your Input:
	MPIG6B	Megakaryocyte and platelet inhibitory receptor G6b isoform X1. (286 aa)
	PTPN11	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (623 aa)
	MEIS1	Homeobox protein Meis1 isoform X1. (465 aa)
	LRRK1	Leucine-rich repeat serine/threonine-protein kinase 1. (2015 aa)
	EP300	Histone acetyltransferase p300. (2420 aa)
	SH2B3	SH2B adapter protein 3 isoform X1. (618 aa)
	PAFAH1B1	Platelet-activating factor acetylhydrolase IB subunit alpha; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ven [...] (410 aa)
	SRC	Tyrosine-protein kinase. (562 aa)
	ZFPM1	Zinc finger protein ZFPM1 isoform X1. (1069 aa)
	PIP4K2A	Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha isoform X1. (461 aa)
	SRF	Serum response factor isoform X2. (535 aa)
	ABI1	Abl interactor 1 isoform X1. (508 aa)
	PTPN6	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
	TAL1	T-cell acute lymphocytic leukemia protein 1 isoform X1. (328 aa)
	FOXP1	Forkhead box protein P1 isoform X1. (673 aa)
	GPR68	Ovarian cancer G-protein coupled receptor 1; Belongs to the G-protein coupled receptor 1 family. (371 aa)
	TNFSF11	Tumor necrosis factor ligand superfamily member 11; Belongs to the tumor necrosis factor family. (322 aa)
	THPO	Thrombopoietin isoform X1. (324 aa)
	ZNF385A	Zinc finger protein 385A isoform X1. (388 aa)
	ATP6AP1	V-type proton ATPase subunit S1. (469 aa)
	GP9	Platelet glycoprotein IX. (177 aa)
	KIT	Mast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (977 aa)
	VPS33B	Vacuolar protein sorting-associated protein 33B; Belongs to the STXBP/unc-18/SEC1 family. (617 aa)
	MED1	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1579 aa)
	FLI1	Friend leukemia integration 1 transcription factor isoform X1. (452 aa)
	WASF2	wiskott-Aldrich syndrome protein family member 2. (498 aa)

Your Current Organism:

Delphinapterus leucas

NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABI1	SRC	A0A2Y9NLR9	A0A2Y9PSD7	Abl interactor 1 isoform X1.	Tyrosine-protein kinase.	0.568
ABI1	WASF2	A0A2Y9NLR9	A0A2Y9LRC7	Abl interactor 1 isoform X1.	wiskott-Aldrich syndrome protein family member 2.	0.941
EP300	MED1	A0A2Y9Q5F4	A0A2Y9LY66	Histone acetyltransferase p300.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.929
EP300	TAL1	A0A2Y9Q5F4	A0A2Y9NIS6	Histone acetyltransferase p300.	T-cell acute lymphocytic leukemia protein 1 isoform X1.	0.519
EP300	ZFPM1	A0A2Y9Q5F4	A0A2Y9NUI0	Histone acetyltransferase p300.	Zinc finger protein ZFPM1 isoform X1.	0.453
FLI1	TAL1	A0A2Y9LY20	A0A2Y9NIS6	Friend leukemia integration 1 transcription factor isoform X1.	T-cell acute lymphocytic leukemia protein 1 isoform X1.	0.499
KIT	PTPN11	A0A2Y9MC24	A0A2Y9QEG1	Mast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.975
KIT	PTPN6	A0A2Y9MC24	A0A2Y9NJV6	Mast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.646
KIT	SH2B3	A0A2Y9MC24	A0A2Y9Q391	Mast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	SH2B adapter protein 3 isoform X1.	0.539
KIT	SRC	A0A2Y9MC24	A0A2Y9PSD7	Mast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	Tyrosine-protein kinase.	0.494
MED1	EP300	A0A2Y9LY66	A0A2Y9Q5F4	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Histone acetyltransferase p300.	0.929
MED1	SRC	A0A2Y9LY66	A0A2Y9PSD7	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Tyrosine-protein kinase.	0.903
MPIG6B	PTPN11	A0A2Y9MSG5	A0A2Y9QEG1	Megakaryocyte and platelet inhibitory receptor G6b isoform X1.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.829
MPIG6B	PTPN6	A0A2Y9MSG5	A0A2Y9NJV6	Megakaryocyte and platelet inhibitory receptor G6b isoform X1.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.818
PTPN11	KIT	A0A2Y9QEG1	A0A2Y9MC24	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	Mast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.975
PTPN11	MPIG6B	A0A2Y9QEG1	A0A2Y9MSG5	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	Megakaryocyte and platelet inhibitory receptor G6b isoform X1.	0.829
PTPN11	PTPN6	A0A2Y9QEG1	A0A2Y9NJV6	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.953
PTPN11	SRC	A0A2Y9QEG1	A0A2Y9PSD7	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	Tyrosine-protein kinase.	0.790
PTPN6	KIT	A0A2Y9NJV6	A0A2Y9MC24	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	Mast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.646
PTPN6	MPIG6B	A0A2Y9NJV6	A0A2Y9MSG5	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	Megakaryocyte and platelet inhibitory receptor G6b isoform X1.	0.818