STRINGSTRING
PRKD1 PRKD1 LOC111162707 LOC111162707 LIF LIF SESN2 SESN2 FYN FYN KAT7 KAT7 CDK5RAP3 CDK5RAP3 NGFR NGFR JUP JUP PIK3R2 PIK3R2 ORMDL3 ORMDL3 CDK1 CDK1 ZPR1 ZPR1 HCLS1 HCLS1 FLNA FLNA YAP1 YAP1 PARP9 PARP9 TRIM28 TRIM28 TRIM8 TRIM8 BAG3 BAG3 DTX3L DTX3L STK11 STK11 ECT2 ECT2 MCRS1 MCRS1 FERMT2 FERMT2 ZC3H12A ZC3H12A PRKCD PRKCD NMD3 NMD3 IFNG IFNG SHH SHH HYAL2 HYAL2 IPO5 IPO5 EFCAB7 EFCAB7 DMAP1 DMAP1 SMO SMO CD2AP CD2AP PSEN1 PSEN1 WWTR1 WWTR1 UBR5 UBR5 TERT TERT TGFB1 TGFB1 CDH1 CDH1 PTPN22 PTPN22 MEPCE MEPCE CHP2 CHP2 LEP LEP HDAC3 HDAC3 SRC SRC RBM22 RBM22 INS INS TPR TPR F2 F2 GLIS2 GLIS2 MAVS MAVS PINX1 PINX1 GLI3 GLI3 LARP7 LARP7 TARDBP TARDBP LOC111186398 LOC111186398 PIK3R1 PIK3R1 TESK1 TESK1 PARK7 PARK7 Ob Ob
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (910 aa)
LOC111162707LIM domain kinase 2 isoform X1. (837 aa)
LIFLeukemia inhibitory factor. (202 aa)
SESN2Sestrin-2. (471 aa)
FYNTyrosine-protein kinase. (537 aa)
KAT7Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (611 aa)
CDK5RAP3CDK5 regulatory subunit-associated protein 3 isoform X1. (544 aa)
NGFRTumor necrosis factor receptor superfamily member 16. (427 aa)
JUPJunction plakoglobin. (744 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (723 aa)
ORMDL3ORM1-like protein; Negative regulator of sphingolipid synthesis. (153 aa)
CDK1Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily. (297 aa)
ZPR1Zinc finger protein ZPR1. (459 aa)
HCLS1Hematopoietic lineage cell-specific protein. (481 aa)
FLNAfilamin-A isoform X1. (2647 aa)
YAP1Transcriptional coactivator YAP1 isoform X1. (511 aa)
PARP9Poly [ADP-ribose] polymerase 9 isoform X1. (847 aa)
TRIM28Transcription intermediary factor 1-beta. (837 aa)
TRIM8Probable E3 ubiquitin-protein ligase TRIM8. (510 aa)
BAG3BAG family molecular chaperone regulator 3. (577 aa)
DTX3LE3 ubiquitin-protein ligase DTX3L. (742 aa)
STK11Serine/threonine-protein kinase STK11 isoform X1. (544 aa)
ECT2Protein ECT2 isoform X1. (973 aa)
MCRS1Microspherule protein 1 isoform X1. (462 aa)
FERMT2Fermitin family homolog 2 isoform X2. (691 aa)
ZC3H12AEndoribonuclease ZC3H12A. (583 aa)
PRKCDProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (733 aa)
NMD360S ribosomal export protein NMD3; Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit; Belongs to the NMD3 family. (525 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (461 aa)
HYAL2Hyaluronidase. (476 aa)
IPO5Importin-5. (1097 aa)
EFCAB7EF-hand calcium-binding domain-containing protein 7 isoform X1. (656 aa)
DMAP1DNA methyltransferase 1-associated protein 1 isoform X1. (468 aa)
SMOSmoothened homolog; Belongs to the G-protein coupled receptor Fz/Smo family. (782 aa)
CD2APCD2-associated protein isoform X1. (680 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (468 aa)
WWTR1WW domain-containing transcription regulator protein 1. (400 aa)
UBR5E3 ubiquitin-protein ligase UBR5 isoform X1. (2798 aa)
TERTTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1203 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
CDH1Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. (885 aa)
PTPN22Tyrosine-protein phosphatase non-receptor type 22 isoform X1. (801 aa)
MEPCE7SK snRNA methylphosphate capping enzyme. (690 aa)
CHP2Calcineurin B homologous protein 2. (198 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (166 aa)
HDAC3Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (428 aa)
SRCTyrosine-protein kinase. (562 aa)
RBM22pre-mRNA-splicing factor RBM22 isoform X1. (420 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
TPRNucleoprotein TPR isoform X2. (2438 aa)
F2Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (623 aa)
GLIS2LOW QUALITY PROTEIN: zinc finger protein GLIS2. (590 aa)
MAVSMitochondrial antiviral-signaling protein isoform X1. (581 aa)
PINX1PIN2/TERF1-interacting telomerase inhibitor 1. (314 aa)
GLI3Transcriptional activator GLI3 isoform X1. (1587 aa)
LARP7La-related protein 7 isoform X1. (579 aa)
TARDBPTAR DNA-binding protein 43. (414 aa)
LOC111186398Caspase recruitment domain-containing protein 10 isoform X1. (1027 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
TESK1Dual specificity testis-specific protein kinase 1 isoform X1. (628 aa)
PARK7Protein DJ-1. (189 aa)
ObLeptin isoform X1. (167 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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