STRINGSTRING
AGTR1 AGTR1 RAB12 RAB12 RAB31 RAB31 CHMP5 CHMP5 SOCS2 SOCS2 ACTN2 ACTN2 BCAR3 BCAR3 XBP1 XBP1 RPS6KB1 RPS6KB1 PCK2 PCK2 LPIN2 LPIN2 UMODL1 UMODL1 PTPN2 PTPN2 DNAI1 DNAI1 LPIN1 LPIN1 LDOC1 LDOC1 KAT2B KAT2B FYN FYN STXBP4 STXBP4 NOD2 NOD2 CRHBP CRHBP WDTC1 WDTC1 INSR INSR IRS4 IRS4 PRKDC PRKDC PRNP PRNP TYK2 TYK2 LOC111165107 LOC111165107 NGFR NGFR CACNB1 CACNB1 STAT5A STAT5A LOC111166483 LOC111166483 STAT3 STAT3 PIK3R2 PIK3R2 CACNA2D1 CACNA2D1 MGARP MGARP SHC1 SHC1 INSRR INSRR CA2 CA2 RAB13 RAB13 ARHGEF2 ARHGEF2 JAK3 JAK3 ENPP1 ENPP1 CACNA1A CACNA1A GNRHR GNRHR GPLD1 GPLD1 PKLR PKLR PDK2 PDK2 PPP1R12A PPP1R12A SLC27A1 SLC27A1 RAB8A RAB8A MAS1 MAS1 SLC39A14 SLC39A14 USF1 USF1 FOXO4 FOXO4 AGTR2 AGTR2 GPER1 GPER1 GSK3B GSK3B SYAP1 SYAP1 NCOA5 NCOA5 AGER AGER OTOP1 OTOP1 IRS1 IRS1 ITGA4 ITGA4 CPEB2 CPEB2 NR4A2 NR4A2 GRB14 GRB14 INHBB INHBB STAT6 STAT6 GOT1 GOT1 LOC111171817 LOC111171817 EPHA4 EPHA4 APPL1 APPL1 CAPN10 CAPN10 JAK2 JAK2 PRKCI PRKCI RHOQ RHOQ LHCGR LHCGR FOXO1 FOXO1 SMARCC1 SMARCC1 GHSR GHSR ZFP36L1 ZFP36L1 RAB15 RAB15 PIK3R3 PIK3R3 PRKCD PRKCD PCSK9 PCSK9 AKT1 AKT1 IRS2 IRS2 DENND4C DENND4C TIMELESS TIMELESS NR4A1 NR4A1 KL KL SLC27A4 SLC27A4 RARRES2 RARRES2 SLC30A10 SLC30A10 APP APP SLC2A8 SLC2A8 GPR21 GPR21 LGMN LGMN RAB10 RAB10 EPRS EPRS TBC1D4 TBC1D4 C2CD5 C2CD5 PARP1 PARP1 PARP6 PARP6 PSEN1 PSEN1 INSIG1 INSIG1 VIM VIM RPE65 RPE65 GLP1R GLP1R CRHR2 CRHR2 AHCYL1 AHCYL1 CAV1 CAV1 CAV2 CAV2 ZDHHC7 ZDHHC7 CSRP3 CSRP3 TREM2 TREM2 NOD1 NOD1 JAK1 JAK1 NFKB1 NFKB1 GSK3A GSK3A PDK4 PDK4 SMPD3 SMPD3 PTPN22 PTPN22 CRHR1 CRHR1 AKT2 AKT2 GHRHR GHRHR PHIP PHIP LEP LEP EDN1 EDN1 EIF4EBP2 EIF4EBP2 GRB2 GRB2 LOC111181964 LOC111181964 ZNF106 ZNF106 SH2B2 SH2B2 SOGA1 SOGA1 APC APC PTPRA PTPRA RELA RELA GRB10 GRB10 FER FER LOC111182618 LOC111182618 GCGR GCGR ADRB2 ADRB2 CAMK2A CAMK2A LPIN3 LPIN3 SRC SRC TRIB3 TRIB3 INSIG2 INSIG2 INS INS INPP5K INPP5K SLC2A4 SLC2A4 GRM5 GRM5 NDEL1 NDEL1 PDPK1 PDPK1 GLP2R GLP2R TUSC5 TUSC5 PIK3R1 PIK3R1 AGTRAP AGTRAP LOC111187339 LOC111187339 IGF1R IGF1R PCK1 PCK1 EDNRA EDNRA PTPN1 PTPN1 IGF1 IGF1 NR4A3 NR4A3 SLC25A33 SLC25A33 POU4F2 POU4F2 Ob Ob
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AGTR1Type-1 Angiotensin II receptor; Belongs to the G-protein coupled receptor 1 family. (359 aa)
RAB12Ras-related protein Rab-12 isoform X1. (244 aa)
RAB31Ras-related protein Rab-31 isoform X1. (194 aa)
CHMP5Charged multivesicular body protein 5. (219 aa)
SOCS2Suppressor of cytokine signaling 2. (198 aa)
ACTN2Alpha-actinin-2. (894 aa)
BCAR3Breast cancer anti-estrogen resistance protein 3 isoform X1. (832 aa)
XBP1LOW QUALITY PROTEIN: X-box-binding protein 1. (392 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
PCK2Phosphoenolpyruvate carboxykinase [GTP], mitochondrial isoform X1. (655 aa)
LPIN2Phosphatidate phosphatase LPIN2 isoform X1. (962 aa)
UMODL1Uromodulin-like 1. (1321 aa)
PTPN2Tyrosine-protein phosphatase non-receptor type 2 isoform X3. (474 aa)
DNAI1Dynein intermediate chain 1, axonemal. (693 aa)
LPIN1Phosphatidate phosphatase LPIN1 isoform X1. (946 aa)
LDOC1Protein LDOC1. (146 aa)
KAT2BHistone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (828 aa)
FYNTyrosine-protein kinase. (537 aa)
STXBP4Syntaxin-binding protein 4 isoform X1. (558 aa)
NOD2Nucleotide-binding oligomerization domain-containing protein 2 isoform X1. (1086 aa)
CRHBPCorticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family. (322 aa)
WDTC1WD and tetratricopeptide repeats protein 1 isoform X1. (680 aa)
INSRTyrosine-protein kinase receptor. (1392 aa)
IRS4Insulin receptor substrate 4 isoform X1. (1267 aa)
PRKDCDNA-dependent protein kinase catalytic subunit isoform X1; Belongs to the PI3/PI4-kinase family. (4131 aa)
PRNPMajor prion protein; Belongs to the prion family. (257 aa)
TYK2Tyrosine-protein kinase. (1188 aa)
LOC111165107Cytochrome P450 11B1, mitochondrial isoform X1; Belongs to the cytochrome P450 family. (503 aa)
NGFRTumor necrosis factor receptor superfamily member 16. (427 aa)
CACNB1Voltage-dependent L-type calcium channel subunit beta-1 isoform X1. (597 aa)
STAT5ASignal transducer and activator of transcription. (818 aa)
LOC111166483Signal transducer and activator of transcription. (787 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (723 aa)
CACNA2D1Voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X1. (1097 aa)
MGARPProtein MGARP isoform X1. (240 aa)
SHC1SHC-transforming protein 1 isoform X1. (609 aa)
INSRRTyrosine-protein kinase receptor. (1301 aa)
CA2Carbonic anhydrase 2; Belongs to the alpha-carbonic anhydrase family. (260 aa)
RAB13Ras-related protein Rab-13. (203 aa)
ARHGEF2Rho guanine nucleotide exchange factor 2 isoform X1. (1032 aa)
JAK3Tyrosine-protein kinase. (1104 aa)
ENPP1Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 isoform X1. (925 aa)
CACNA1AVoltage-dependent P/Q-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q- type calcium currents. (2501 aa)
GNRHRGonadotropin-releasing hormone receptor; Belongs to the G-protein coupled receptor 1 family. (328 aa)
GPLD1Phosphatidylinositol-glycan-specific phospholipase D isoform X1. (849 aa)
PKLRPyruvate kinase; Belongs to the pyruvate kinase family. (556 aa)
PDK2Protein-serine/threonine kinase. (407 aa)
PPP1R12AProtein phosphatase 1 regulatory subunit. (1030 aa)
SLC27A1Long-chain fatty acid transport protein 1 isoform X1. (675 aa)
RAB8ARas-related protein Rab-8A. (207 aa)
MAS1Proto-oncogene Mas; Belongs to the G-protein coupled receptor 1 family. (325 aa)
SLC39A14Zinc transporter ZIP14 isoform X1. (510 aa)
USF1Upstream stimulatory factor 1 isoform X1. (310 aa)
FOXO4Forkhead box protein O4. (512 aa)
AGTR2Type-2 angiotensin II receptor; Belongs to the G-protein coupled receptor 1 family. (362 aa)
GPER1G-protein coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (354 aa)
GSK3BGlycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
SYAP1Synapse-associated protein 1 isoform X1. (358 aa)
NCOA5Nuclear receptor coactivator 5 isoform X1. (579 aa)
AGERAdvanced glycosylation end product-specific receptor isoform X1. (631 aa)
OTOP1Otopetrin-1. (606 aa)
IRS1Insulin receptor substrate 1. (1248 aa)
ITGA4Integrin alpha-4 isoform X1; Belongs to the integrin alpha chain family. (1033 aa)
CPEB2LOW QUALITY PROTEIN: cytoplasmic polyadenylation element-binding protein 2. (1043 aa)
NR4A2Nuclear receptor subfamily 4 group A member 2 isoform X1. (598 aa)
GRB14Growth factor receptor-bound protein 14 isoform X1. (540 aa)
INHBBInhibin beta B chain. (407 aa)
STAT6Signal transducer and activator of transcription. (847 aa)
GOT1Aspartate aminotransferase. (413 aa)
LOC111171817C-X-C chemokine receptor type 2-like; Belongs to the G-protein coupled receptor 1 family. (368 aa)
EPHA4Ephrin type-A receptor 4 isoform X1. (986 aa)
APPL1DCC-interacting protein 13-alpha isoform X1. (708 aa)
CAPN10Calpain-10 isoform X1; Belongs to the peptidase C2 family. (704 aa)
JAK2Tyrosine-protein kinase. (1132 aa)
PRKCIProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (707 aa)
RHOQRho-related GTP-binding protein RhoQ. (169 aa)
LHCGRLutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (700 aa)
FOXO1Forkhead box protein O1. (663 aa)
SMARCC1SWI/SNF complex subunit SMARCC1 isoform X1. (1105 aa)
GHSRGrowth hormone secretagogue receptor type 1; Belongs to the G-protein coupled receptor 1 family. (366 aa)
ZFP36L1mRNA decay activator protein ZFP36L1. (338 aa)
RAB15Ras-related protein Rab-15 isoform X1. (212 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1. (461 aa)
PRKCDProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (733 aa)
PCSK9Proprotein convertase subtilisin/kexin type 9 isoform X1. (692 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
IRS2Insulin receptor substrate 2. (1347 aa)
DENND4CDENN domain-containing protein 4C isoform X1. (1958 aa)
TIMELESSProtein timeless homolog isoform X1. (1202 aa)
NR4A1Nuclear receptor subfamily 4 group A member 1. (593 aa)
KLKlotho. (1010 aa)
SLC27A4Long-chain fatty acid transport protein 4. (643 aa)
RARRES2Retinoic acid receptor responder protein 2. (166 aa)
SLC30A10Zinc transporter 10. (485 aa)
APPAmyloid beta A4 protein isoform X1. (767 aa)
SLC2A8Solute carrier family 2, facilitated glucose transporter member 8 isoform X1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (477 aa)
GPR21Probable G-protein coupled receptor 21; Belongs to the G-protein coupled receptor 1 family. (349 aa)
LGMNLegumain. (433 aa)
RAB10Ras-related protein Rab-10. (200 aa)
EPRSBifunctional glutamate/proline--tRNA ligase. (1511 aa)
TBC1D4TBC1 domain family member 4 isoform X4. (1300 aa)
C2CD5C2 domain-containing protein 5 isoform X1. (1051 aa)
PARP1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1013 aa)
PARP6Poly [ADP-ribose] polymerase. (640 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (468 aa)
INSIG1Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. (294 aa)
VIMVimentin; Belongs to the intermediate filament family. (466 aa)
RPE65Retinoid isomerohydrolase. (533 aa)
GLP1RGlucagon-like peptide 1 receptor; Belongs to the G-protein coupled receptor 2 family. (463 aa)
CRHR2Corticotropin-releasing factor receptor 2 isoform X1; Belongs to the G-protein coupled receptor 2 family. (537 aa)
AHCYL1Adenosylhomocysteinase. (530 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
CAV2Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (162 aa)
ZDHHC7Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (308 aa)
CSRP3Cysteine and glycine-rich protein 3 isoform X2. (194 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (294 aa)
NOD1Nucleotide-binding oligomerization domain-containing protein 1 isoform X1. (953 aa)
JAK1Tyrosine-protein kinase. (1153 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit isoform X1. (972 aa)
GSK3AGlycogen synthase kinase-3 alpha; Belongs to the protein kinase superfamily. (483 aa)
PDK4Protein-serine/threonine kinase. (407 aa)
SMPD3Sphingomyelin phosphodiesterase 3 isoform X1. (706 aa)
PTPN22Tyrosine-protein phosphatase non-receptor type 22 isoform X1. (801 aa)
CRHR1Corticotropin-releasing factor receptor 1 isoform X1; Belongs to the G-protein coupled receptor 2 family. (475 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
GHRHRGrowth hormone-releasing hormone receptor isoform X1; Belongs to the G-protein coupled receptor 2 family. (427 aa)
PHIPPH-interacting protein isoform X2. (1650 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (166 aa)
EDN1Endothelin-1. (202 aa)
EIF4EBP2Eukaryotic translation initiation factor 4E-binding protein 2. (120 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
LOC111181964Uncharacterized protein LOC111181964 isoform X1. (833 aa)
ZNF106Zinc finger protein 106 isoform X1. (1917 aa)
SH2B2SH2B adapter protein 2 isoform X1. (703 aa)
SOGA1Protein SOGA1 isoform X1. (1903 aa)
APCAdenomatous polyposis coli protein isoform X1. (2864 aa)
PTPRAReceptor-type tyrosine-protein phosphatase alpha. (802 aa)
RELATranscription factor p65 isoform X1. (562 aa)
GRB10Growth factor receptor-bound protein 10 isoform X1. (588 aa)
FERTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (822 aa)
LOC111182618Somatotropin isoform X1. (262 aa)
GCGRGlucagon receptor isoform X1; Belongs to the G-protein coupled receptor 2 family. (575 aa)
ADRB2Beta-2 adrenergic receptor isoform X1. (400 aa)
CAMK2ACalcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1; Belongs to the protein kinase superfamily. (489 aa)
LPIN3Phosphatidate phosphatase LPIN3 isoform X3. (886 aa)
SRCTyrosine-protein kinase. (562 aa)
TRIB3LOW QUALITY PROTEIN: tribbles homolog 3. (357 aa)
INSIG2Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (229 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
INPP5KInositol polyphosphate 5-phosphatase K isoform X1. (476 aa)
SLC2A4Solute carrier family 2, facilitated glucose transporter member 4 isoform X1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (509 aa)
GRM5Metabotropic glutamate receptor 5 isoform X1. (1208 aa)
NDEL1Nuclear distribution protein nudE-like 1 isoform X1. (346 aa)
PDPK13-phosphoinositide-dependent protein kinase 1 isoform X1. (558 aa)
GLP2RGlucagon-like peptide 2 receptor; Belongs to the G-protein coupled receptor 2 family. (553 aa)
TUSC5Tumor suppressor candidate 5. (204 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
AGTRAPType-1 angiotensin II receptor-associated protein. (148 aa)
LOC111187339LOW QUALITY PROTEIN: growth factor receptor-bound protein 10-like. (665 aa)
IGF1RTyrosine-protein kinase receptor. (1368 aa)
PCK1Phosphoenolpyruvate carboxykinase, cytosolic [GTP] isoform X1. (687 aa)
EDNRAEndothelin-1 receptor isoform X1; Belongs to the G-protein coupled receptor 1 family. (427 aa)
PTPN1Tyrosine-protein phosphatase non-receptor type. (451 aa)
IGF1Insulin-like growth factor I isoform X1. (186 aa)
NR4A3Nuclear receptor subfamily 4 group A member 3 isoform X1. (641 aa)
SLC25A33Solute carrier family 25 member 33; Belongs to the mitochondrial carrier (TC 2.A.29) family. (321 aa)
POU4F2POU domain protein. (407 aa)
ObLeptin isoform X1. (167 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
Server load: medium (44%) [HD]