STRINGSTRING
LOC111178668 LOC111178668 PRKCQ PRKCQ LRRC1 LRRC1 LOC111178931 LOC111178931 LOC111178928 LOC111178928 LOC111178664 LOC111178664 LOC111178657 LOC111178657 HLX HLX LCK LCK TNFSF13B TNFSF13B BMI1 BMI1 PTPN6 PTPN6 ZDHHC21 ZDHHC21 ASS1 ASS1 ITPKB ITPKB DOCK8 DOCK8 IL12A IL12A NRARP NRARP CD27 CD27 SHH SHH IFNG IFNG PDCD1LG2 PDCD1LG2 LOC111175407 LOC111175407 GCNT1 GCNT1 IDO1 IDO1 FGL1 FGL1 RHOA RHOA ZC3H12A ZC3H12A WNT10B WNT10B CD274 CD274 SLC7A1 SLC7A1 TNFSF11 TNFSF11 SOCS5 SOCS5 ADAM8 ADAM8 ARG2 ARG2 ANXA1 ANXA1 HES1 HES1 NCKAP1L NCKAP1L ZBTB1 ZBTB1 TFRC TFRC IGFBP2 IGFBP2 CTLA4 CTLA4 RHOH RHOH HSPD1 HSPD1 BMP4 BMP4 DPP4 DPP4 BCL6 BCL6 MARCH7 MARCH7 IHH IHH ALOX5 ALOX5 CXCL12 CXCL12 GPAM GPAM DLG1 DLG1 CD28 CD28 MAD1L1 MAD1L1 RC3H1 RC3H1 TNFSF4 TNFSF4 ICOS ICOS LEF1 LEF1 CD86 CD86 AGER AGER CARD11 CARD11 AIF1 AIF1 FUT4 FUT4 LOC111169054 LOC111169054 IL12B IL12B LOC111167809 LOC111167809 IL2RG IL2RG IRAK1 IRAK1 SYK SYK DUSP3 DUSP3 CD80 CD80 THY1 THY1 FOXP3 FOXP3 TNFAIP8L2 TNFAIP8L2 LOXL3 LOXL3 VSIG4 VSIG4 SELE SELE SELP SELP EGR3 EGR3 HFE HFE SPTA1 SPTA1 SLAMF1 SLAMF1 ZBTB7B ZBTB7B TNFSF9 TNFSF9 RIPOR2 RIPOR2 PTPRC PTPRC ZBTB16 ZBTB16 SASH3 SASH3 CRTAM CRTAM ERBB2 ERBB2 ILDR2 ILDR2 IL18 IL18 TMIGD2 TMIGD2 PAWR PAWR TIGIT TIGIT IL7 IL7 RASAL3 RASAL3 IL12RB1 IL12RB1 IL27RA IL27RA ST3GAL4 ST3GAL4 FCHO1 FCHO1 DHPS DHPS CCR7 CCR7 LOC111166483 LOC111166483 STAT5A STAT5A TBX21 TBX21 RARA RARA LOC111166170 LOC111166170 TYK2 TYK2 TNFSF14 TNFSF14 MYB MYB VNN1 VNN1 IL1B IL1B TNF TNF Ob Ob SHB SHB IL15 IL15 IL1RL2 IL1RL2 NR4A3 NR4A3 IGF1 IGF1 TMEM131L TMEM131L PCK1 PCK1 PELI1 PELI1 NCK2 NCK2 ITGB2 ITGB2 LOC111187428 LOC111187428 HHLA2 HHLA2 PRKCZ PRKCZ IL21 IL21 PIK3R6 PIK3R6 CCL28 CCL28 IL7R IL7R ZC3H8 ZC3H8 CEBPB CEBPB FLOT2 FLOT2 LOC111187417 LOC111187417 LGALS9 LGALS9 IL6ST IL6ST TNFRSF13C TNFRSF13C NFKBIZ NFKBIZ SOX13 SOX13 ETS1 ETS1 ADORA2A ADORA2A FGL2 FGL2 NOD2 NOD2 PAG1 PAG1 FOXO3 FOXO3 CD40LG CD40LG PLA2G2D PLA2G2D GLMN GLMN HAS2 HAS2 PTPN2 PTPN2 FAM49B FAM49B XBP1 XBP1 FUT9 FUT9 CCL21 CCL21 TWSG1 TWSG1 SOCS1 SOCS1 PLA2G2F PLA2G2F CCL19 CCL19 IGLL1 IGLL1 DLG2 DLG2 CD6 CD6 CCDC88B CCDC88B BAD BAD CD5 CD5 CBLB CBLB EFNB3 EFNB3 ADA ADA AP3B1 AP3B1 ITCH ITCH SIRPA SIRPA SOX12 SOX12 GLI3 GLI3 PPARA PPARA LRRC32 LRRC32 TSPAN32 TSPAN32 ZMIZ1 ZMIZ1 DLG5 DLG5 VSIR VSIR NDFIP1 NDFIP1 RPS3 RPS3 LAX1 LAX1 PRKAR1A PRKAR1A RELA RELA SART1 SART1 LOC111184361 LOC111184361 FADD FADD IGF2 IGF2 CORO1A CORO1A AMBRA1 AMBRA1 CD74 CD74 KAT5 KAT5 CD81 CD81 LOC111182867 LOC111182867 LEP LEP ZP3 ZP3 FOXJ1 FOXJ1 RASGRP1 RASGRP1 GPNMB GPNMB SMAD7 SMAD7 IRF1 IRF1 SOCS6 SOCS6 PTPN22 PTPN22 ADTRP ADTRP PYCARD PYCARD TRAF6 TRAF6 MALT1 MALT1 CD83 CD83 CD44 CD44 PPP3CA PPP3CA LOC111178927 LOC111178927 TNFRSF21 TNFRSF21 IL4I1 IL4I1 TGFB1 TGFB1 BTNL2 BTNL2 IL23R IL23R BCL10 BCL10 LOC111178666 LOC111178666 GATA3 GATA3 IL12RB2 IL12RB2 CAV1 CAV1 CHST2 CHST2 IL20RB IL20RB DUSP10 DUSP10 EPHB6 EPHB6 RC3H2 RC3H2 ABL1 ABL1 FUT7 FUT7 LOC111176900 LOC111176900 LOC111176792 LOC111176792 LOC111178929 LOC111178929 LOC111178925 LOC111178925 LAG3 LAG3 WNK1 WNK1 NCK1 NCK1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC111178668HLA class II histocompatibility antigen, DO alpha chain-like; Belongs to the MHC class II family. (250 aa)
PRKCQProtein kinase C. (665 aa)
LRRC1Leucine-rich repeat-containing protein 1. (395 aa)
LOC111178931HLA class II histocompatibility antigen, DR alpha chain; Belongs to the MHC class II family. (253 aa)
LOC111178928DLA class II histocompatibility antigen, DR-1 beta chain-like. (266 aa)
LOC111178664HLA class II histocompatibility antigen, DM beta chain isoform X1. (263 aa)
LOC111178657Leucine-rich repeat-containing protein 1-like isoform X1. (174 aa)
HLXH2.0-like homeobox protein. (488 aa)
LCKTyrosine-protein kinase. (509 aa)
TNFSF13BTumor necrosis factor ligand superfamily member 13B; Belongs to the tumor necrosis factor family. (283 aa)
BMI1Polycomb complex protein BMI-1. (326 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
ZDHHC21Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (265 aa)
ASS1Argininosuccinate synthase. (412 aa)
ITPKBKinase; Belongs to the inositol phosphokinase (IPK) family. (941 aa)
DOCK8Dedicator of cytokinesis protein 8 isoform X1; Belongs to the DOCK family. (2098 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (222 aa)
NRARPNotch-regulated ankyrin repeat-containing protein. (114 aa)
CD27CD27 antigen isoform X1. (251 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (461 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
PDCD1LG2Programmed cell death 1 ligand 2 isoform X1. (337 aa)
LOC111175407Amine oxidase. (524 aa)
GCNT1beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase isoform X1. (485 aa)
IDO1Indoleamine 2,3-dioxygenase 1 isoform X1. (410 aa)
FGL1Fibrinogen-like protein 1. (315 aa)
RHOATransforming protein RhoA. (193 aa)
ZC3H12AEndoribonuclease ZC3H12A. (583 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
CD274Programmed cell death 1 ligand 1 isoform X2. (312 aa)
SLC7A1High affinity cationic amino acid transporter 1. (629 aa)
TNFSF11Tumor necrosis factor ligand superfamily member 11; Belongs to the tumor necrosis factor family. (322 aa)
SOCS5Suppressor of cytokine signaling 5. (536 aa)
ADAM8Disintegrin and metalloproteinase domain-containing protein 8 isoform X1. (838 aa)
ARG2Arginase. (354 aa)
ANXA1Annexin. (346 aa)
HES1Transcription factor HES-1. (280 aa)
NCKAP1LNck-associated protein 1-like isoform X1. (1156 aa)
ZBTB1Zinc finger and BTB domain-containing protein 1. (713 aa)
TFRCTransferrin receptor protein 1 isoform X1. (772 aa)
IGFBP2Insulin-like growth factor-binding protein 2 isoform X1. (320 aa)
CTLA4Cytotoxic T-lymphocyte protein 4 isoform X1. (223 aa)
RHOHRho-related GTP-binding protein RhoH. (191 aa)
HSPD160 kDa heat shock protein, mitochondrial; Belongs to the chaperonin (HSP60) family. (573 aa)
BMP4Bone morphogenetic protein 4 isoform X2. (408 aa)
DPP4Dipeptidyl peptidase 4 isoform X1; Belongs to the peptidase S9B family. (804 aa)
BCL6B-cell lymphoma 6 protein. (706 aa)
MARCH7E3 ubiquitin-protein ligase MARCH7 isoform X1. (717 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (410 aa)
ALOX5Arachidonate 5-lipoxygenase. (674 aa)
CXCL12Stromal cell-derived factor 1 isoform X1; Belongs to the intercrine alpha (chemokine CxC) family. (119 aa)
GPAMGlycerol-3-phosphate acyltransferase 1, mitochondrial. (877 aa)
DLG1Disks large homolog 1 isoform X1; Belongs to the MAGUK family. (927 aa)
CD28T-cell-specific surface glycoprotein CD28. (265 aa)
MAD1L1Mitotic spindle assembly checkpoint protein MAD1 isoform X2. (735 aa)
RC3H1Roquin-1 isoform X1. (1135 aa)
TNFSF4Tumor necrosis factor ligand superfamily member 4; Belongs to the tumor necrosis factor family. (182 aa)
ICOSInducible T-cell costimulator isoform X1. (227 aa)
LEF1Lymphoid enhancer-binding factor 1 isoform X1. (414 aa)
CD86T-lymphocyte activation antigen CD86 isoform X1. (344 aa)
AGERAdvanced glycosylation end product-specific receptor isoform X1. (631 aa)
CARD11Caspase recruitment domain-containing protein 11 isoform X1. (1154 aa)
AIF1Allograft inflammatory factor 1 isoform X1. (162 aa)
FUT4Alpha-(1,3)-fucosyltransferase 4. (458 aa)
LOC111169054NF-kappa-B-activating protein. (417 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (329 aa)
LOC111167809ephrin-B1 isoform X1; Belongs to the ephrin family. (346 aa)
IL2RGCytokine receptor common subunit gamma isoform X1. (381 aa)
IRAK1Interleukin-1 receptor-associated kinase 1. (725 aa)
SYKTyrosine-protein kinase. (626 aa)
DUSP3Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (185 aa)
CD80T-lymphocyte activation antigen CD80 isoform X1. (295 aa)
THY1Thy-1 membrane glycoprotein. (161 aa)
FOXP3Forkhead box protein P3. (431 aa)
TNFAIP8L2Tumor necrosis factor alpha-induced protein 8-like protein 2 isoform X1. (204 aa)
LOXL3Lysyl oxidase homolog 3 isoform X1. (772 aa)
VSIG4V-set and immunoglobulin domain-containing protein 4. (399 aa)
SELEE-selectin. (531 aa)
SELPP-selectin isoform X1. (768 aa)
EGR3Early growth response protein 3 isoform X1. (387 aa)
HFEHereditary hemochromatosis protein isoform X1; Belongs to the MHC class I family. (356 aa)
SPTA1Spectrin alpha chain, erythrocytic 1 isoform X1. (2417 aa)
SLAMF1Signaling lymphocytic activation molecule isoform X1. (378 aa)
ZBTB7BZinc finger and BTB domain-containing protein 7B. (541 aa)
TNFSF9Tumor necrosis factor ligand superfamily member 9; Belongs to the tumor necrosis factor family. (252 aa)
RIPOR2Rho family-interacting cell polarization regulator 2 isoform X2. (1048 aa)
PTPRCReceptor-type tyrosine-protein phosphatase C isoform X1. (1258 aa)
ZBTB16Zinc finger and BTB domain-containing protein 16. (673 aa)
SASH3SAM and SH3 domain-containing protein 3. (380 aa)
CRTAMCytotoxic and regulatory T-cell molecule isoform X1. (391 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
ILDR2Immunoglobulin-like domain-containing receptor 2. (639 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
TMIGD2Transmembrane and immunoglobulin domain-containing protein 2. (231 aa)
PAWRPRKC apoptosis WT1 regulator protein. (345 aa)
TIGITT-cell immunoreceptor with Ig and ITIM domains. (243 aa)
IL7Interleukin-7 isoform X1. (226 aa)
RASAL3RAS protein activator like-3 isoform X1. (1035 aa)
IL12RB1Interleukin-12 receptor subunit beta-1 isoform X1. (726 aa)
IL27RAInterleukin-27 receptor subunit alpha isoform X1. (656 aa)
ST3GAL4CMP-N-acetylneuraminate-beta-galactosamide- alpha-2,3-sialyltransferase 4 isoform X4; Belongs to the glycosyltransferase 29 family. (341 aa)
FCHO1F-BAR domain only protein 1. (887 aa)
DHPSDeoxyhypusine synthase. (369 aa)
CCR7C-C chemokine receptor type 7; Belongs to the G-protein coupled receptor 1 family. (379 aa)
LOC111166483Signal transducer and activator of transcription. (787 aa)
STAT5ASignal transducer and activator of transcription. (818 aa)
TBX21T-box transcription factor TBX21. (535 aa)
RARARetinoic acid receptor alpha isoform X5. (584 aa)
LOC111166170C-type lectin domain family 4 member G-like isoform X1. (313 aa)
TYK2Tyrosine-protein kinase. (1188 aa)
TNFSF14Tumor necrosis factor ligand superfamily member 14 isoform X1. (241 aa)
MYBTranscriptional activator Myb isoform X3. (761 aa)
VNN1Pantetheinase. (514 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (266 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa)
ObLeptin isoform X1. (167 aa)
SHBSH2 domain-containing adapter protein B. (507 aa)
IL15Interleukin; Belongs to the IL-15/IL-21 family. (180 aa)
IL1RL2Interleukin-1 receptor-like 2 isoform X1. (570 aa)
NR4A3Nuclear receptor subfamily 4 group A member 3 isoform X1. (641 aa)
IGF1Insulin-like growth factor I isoform X1. (186 aa)
TMEM131LTransmembrane protein 131-like isoform X1. (1608 aa)
PCK1Phosphoenolpyruvate carboxykinase, cytosolic [GTP] isoform X1. (687 aa)
PELI1E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (418 aa)
NCK2Cytoplasmic protein. (376 aa)
ITGB2Integrin beta. (769 aa)
LOC111187428Interleukin-1. (118 aa)
HHLA2HERV-H LTR-associating protein 2 isoform X1. (414 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (629 aa)
IL21Interleukin; Belongs to the IL-15/IL-21 family. (146 aa)
PIK3R6Phosphoinositide 3-kinase regulatory subunit 6 isoform X1. (881 aa)
CCL28C-C motif chemokine. (178 aa)
IL7RInterleukin-7 receptor subunit alpha isoform X1. (459 aa)
ZC3H8Zinc finger CCCH domain-containing protein 8 isoform X1. (308 aa)
CEBPBCCAAT/enhancer-binding protein. (345 aa)
FLOT2Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (428 aa)
LOC111187417Tyrosine-protein kinase. (612 aa)
LGALS9Galectin. (356 aa)
IL6STInterleukin-6 receptor subunit beta. (918 aa)
TNFRSF13CTumor necrosis factor receptor superfamily member 13C isoform X1. (221 aa)
NFKBIZNF-kappa-B inhibitor zeta. (726 aa)
SOX13Transcription factor SOX-13. (644 aa)
ETS1Protein C-ets-1 isoform X1. (486 aa)
ADORA2AAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (408 aa)
FGL2Fibroleukin. (440 aa)
NOD2Nucleotide-binding oligomerization domain-containing protein 2 isoform X1. (1086 aa)
PAG1Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 isoform X2. (436 aa)
FOXO3Forkhead box protein O3. (672 aa)
CD40LGCD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. (261 aa)
PLA2G2DPhospholipase A(2). (161 aa)
GLMNGlomulin. (592 aa)
HAS2Hyaluronan synthase 2. (552 aa)
PTPN2Tyrosine-protein phosphatase non-receptor type 2 isoform X3. (474 aa)
FAM49BProtein FAM49B isoform X1. (324 aa)
XBP1LOW QUALITY PROTEIN: X-box-binding protein 1. (392 aa)
FUT9Alpha-(1,3)-fucosyltransferase 9 isoform X1. (368 aa)
CCL21C-C motif chemokine 21 isoform X1. (131 aa)
TWSG1Twisted gastrulation protein homolog 1. (223 aa)
SOCS1Suppressor of cytokine signaling 1. (215 aa)
PLA2G2FPhospholipase A(2). (300 aa)
CCL19C-C motif chemokine. (159 aa)
IGLL1Immunoglobulin lambda-like polypeptide 1 isoform X1. (212 aa)
DLG2Disks large homolog 2 isoform X1. (994 aa)
CD6T-cell differentiation antigen CD6 isoform X1. (675 aa)
CCDC88BCoiled-coil domain-containing protein 88B isoform X1. (1463 aa)
BADBcl2-associated agonist of cell death. (168 aa)
CD5T-cell surface glycoprotein CD5 isoform X1. (500 aa)
CBLBE3 ubiquitin-protein ligase CBL-B. (983 aa)
EFNB3ephrin-B3 isoform X1; Belongs to the ephrin family. (340 aa)
ADAAdenosine deaminase isoform X1. (416 aa)
AP3B1AP-3 complex subunit beta; Belongs to the adaptor complexes large subunit family. (1087 aa)
ITCHE3 ubiquitin-protein ligase. (862 aa)
SIRPATyrosine-protein phosphatase non-receptor type substrate 1 isoform X1. (504 aa)
SOX12Transcription factor SOX. (312 aa)
GLI3Transcriptional activator GLI3 isoform X1. (1587 aa)
PPARAPeroxisome proliferator-activated receptor alpha. (468 aa)
LRRC32Leucine-rich repeat-containing protein 32 isoform X1. (676 aa)
TSPAN32Tetraspanin-32 isoform X1; Belongs to the tetraspanin (TM4SF) family. (571 aa)
ZMIZ1Zinc finger MIZ domain-containing protein 1 isoform X1. (1071 aa)
DLG5Disks large homolog 5 isoform X1; Belongs to the MAGUK family. (1980 aa)
VSIRV-type immunoglobulin domain-containing suppressor of T-cell activation. (311 aa)
NDFIP1NEDD4 family-interacting protein 1. (221 aa)
RPS340S ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family. (243 aa)
LAX1LOW QUALITY PROTEIN: lymphocyte transmembrane adapter 1. (430 aa)
PRKAR1AcAMP-dependent protein kinase type I-alpha regulatory subunit. (380 aa)
RELATranscription factor p65 isoform X1. (562 aa)
SART1U4/U6.U5 tri-snRNP-associated protein 1. (803 aa)
LOC111184361Signal-regulatory protein beta-1-like isoform X1. (412 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (211 aa)
IGF2Insulin-like growth factor II isoform X3. (237 aa)
CORO1ACoronin; Belongs to the WD repeat coronin family. (461 aa)
AMBRA1Activating molecule in BECN1-regulated autophagy protein 1 isoform X1. (1295 aa)
CD74HLA class II histocompatibility antigen gamma chain isoform X1. (278 aa)
KAT5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (546 aa)
CD81Tetraspanin. (236 aa)
LOC111182867CMRF35-like molecule 8 isoform X1. (313 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (166 aa)
ZP3Zona pellucida sperm-binding protein 3. (421 aa)
FOXJ1Forkhead box protein J1. (422 aa)
RASGRP1RAS guanyl-releasing protein 1 isoform X1. (870 aa)
GPNMBTransmembrane glycoprotein NMB. (553 aa)
SMAD7Mothers against decapentaplegic homolog. (426 aa)
IRF1Interferon regulatory factor. (322 aa)
SOCS6Suppressor of cytokine signaling 6. (535 aa)
PTPN22Tyrosine-protein phosphatase non-receptor type 22 isoform X1. (801 aa)
ADTRPAndrogen-dependent TFPI-regulating protein isoform X1. (230 aa)
PYCARDApoptosis-associated speck-like protein containing a CARD. (195 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (561 aa)
MALT1Mucosa-associated lymphoid tissue lymphoma translocation protein 1 isoform X1. (850 aa)
CD83CD83 antigen isoform X1. (195 aa)
CD44CD44 antigen isoform X1. (742 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
LOC111178927HLA class II histocompatibility antigen, DQ alpha 2 chain; Belongs to the MHC class II family. (255 aa)
TNFRSF21Tumor necrosis factor receptor superfamily member 21 isoform X3. (701 aa)
IL4I1L-amino-acid oxidase isoform X1. (653 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
BTNL2Butyrophilin-like protein 2. (454 aa)
IL23RInterleukin-23 receptor. (630 aa)
BCL10B-cell lymphoma/leukemia 10. (233 aa)
LOC111178666HLA class II histocompatibility antigen, DM alpha chain isoform X1; Belongs to the MHC class II family. (261 aa)
GATA3Trans-acting T-cell-specific transcription factor GATA-3 isoform X1. (444 aa)
IL12RB2Interleukin-12 receptor subunit beta-2 isoform X1. (861 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
CHST2Sulfotransferase; Belongs to the sulfotransferase 1 family. (530 aa)
IL20RBInterleukin-20 receptor subunit beta isoform X1. (342 aa)
DUSP10Dual specificity protein phosphatase 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (482 aa)
EPHB6Ephrin type-B receptor 6 isoform X1. (1010 aa)
RC3H2Roquin-2. (1189 aa)
ABL1Tyrosine-protein kinase. (1148 aa)
FUT7Alpha-(1,3)-fucosyltransferase 7. (342 aa)
LOC111176900GTPase IMAP family member 5-like isoform X1. (332 aa)
LOC111176792LOW QUALITY PROTEIN: hyaluronan synthase 2-like. (318 aa)
LOC111178929HLA class II histocompatibility antigen, DRB1-4 beta chain-like isoform X1. (231 aa)
LOC111178925boLa class II histocompatibility antigen, DQB*0101 beta chain-like isoform X2. (276 aa)
LAG3Lymphocyte activation gene 3 protein. (493 aa)
WNK1Serine/threonine-protein kinase WNK1 isoform X1. (2825 aa)
NCK1Cytoplasmic protein. (377 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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