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MMP14 MMP14 TNF TNF LOC111187154 LOC111187154 RER1 RER1 SPTBN1 SPTBN1 DAB2 DAB2 ARHGEF16 ARHGEF16 EPHA2 EPHA2 PIK3R1 PIK3R1 RANGRF RANGRF PDPK1 PDPK1 EGFR EGFR RAMP3 RAMP3 IQSEC2 IQSEC2 STAC3 STAC3 LDLRAP1 LDLRAP1 MRAP MRAP CLTC CLTC EPB41 EPB41 STAC STAC GPC4 GPC4 GOPC GOPC STX8 STX8 ZDHHC5 ZDHHC5 DLG2 DLG2 ATP2B4 ATP2B4 INS INS DPP10 DPP10 PICALM PICALM PPP2R5A PPP2R5A STX3 STX3 LYPD1 LYPD1 PPFIA1 PPFIA1 CLN3 CLN3 HECTD1 HECTD1 GNAI1 GNAI1 LOC111165935 LOC111165935 ABI3 ABI3 ANXA13 ANXA13 VAMP8 VAMP8 PIK3R2 PIK3R2 RACK1 RACK1 STAC2 STAC2 EPB41L2 EPB41L2 STX7 STX7 EZR EZR ITGA3 ITGA3 AR AR EPM2A EPM2A ATP2C1 ATP2C1 SQSTM1 SQSTM1 WNT3A WNT3A WNK3 WNK3 ARHGAP44 ARHGAP44 LOC111167795 LOC111167795 GPER1 GPER1 GRIPAP1 GRIPAP1 ACTB ACTB MRAP2 MRAP2 PLK1 PLK1 CNPY4 CNPY4 NHLRC1 NHLRC1 LOC111181166 LOC111181166 AGR2 AGR2 RAP1A RAP1A TREM2 TREM2 CSRP3 CSRP3 VPS4A VPS4A GPSM2 GPSM2 ZDHHC7 ZDHHC7 CNST CNST ITGB1 ITGB1 PLS1 PLS1 PTPN9 PTPN9 ADAM10 ADAM10 CDK5 CDK5 EFCAB7 EFCAB7 EPHA3 EPHA3 CSK CSK GPC6 GPC6 KIF5B KIF5B SAPCD2 SAPCD2 NUMB NUMB LGALS3 LGALS3 LRRC15 LRRC15 R3HDM1 R3HDM1 R3HDM2 R3HDM2 PKDCC PKDCC RHOQ RHOQ PRKCI PRKCI LZTFL1 LZTFL1 APPL1 APPL1 ACSL3 ACSL3 MISP MISP GRASP GRASP HRAS HRAS LOC111170545 LOC111170545 CIB1 CIB1 PID1 PID1 DLG1 DLG1 NUMA1 NUMA1 VIL1 VIL1 VTI1B VTI1B AKAP5 AKAP5 TMBIM1 TMBIM1 ARF6 ARF6 ZDHHC2 ZDHHC2
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
MMP14Matrix metalloproteinase-14. (582 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa)
LOC111187154Ephrin type-A receptor 2-like. (171 aa)
RER1Protein RER1; Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment. (196 aa)
SPTBN1Spectrin beta chain; Belongs to the spectrin family. (2363 aa)
DAB2Disabled homolog 2 isoform X1. (769 aa)
ARHGEF16Rho guanine nucleotide exchange factor 16 isoform X1. (708 aa)
EPHA2Ephrin type-A receptor 2. (975 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
RANGRFRan guanine nucleotide release factor isoform X1. (186 aa)
PDPK13-phosphoinositide-dependent protein kinase 1 isoform X1. (558 aa)
EGFRReceptor protein-tyrosine kinase. (1209 aa)
RAMP3Receptor activity-modifying protein 3. (151 aa)
IQSEC2IQ motif and SEC7 domain-containing protein 2 isoform X1. (1488 aa)
STAC3SH3 and cysteine-rich domain-containing protein 3 isoform X1. (360 aa)
LDLRAP1LOW QUALITY PROTEIN: low density lipoprotein receptor adapter protein 1. (309 aa)
MRAPMelanocortin-2 receptor accessory protein isoform X1. (197 aa)
CLTCClathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1675 aa)
EPB41Protein 4.1 isoform X2. (891 aa)
STACSH3 and cysteine-rich domain-containing protein isoform X1. (402 aa)
GPC4Glypican-4; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (556 aa)
GOPCGolgi-associated PDZ and coiled-coil motif-containing protein isoform X1. (463 aa)
STX8Syntaxin-8 isoform X1. (236 aa)
ZDHHC5Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (715 aa)
DLG2Disks large homolog 2 isoform X1. (994 aa)
ATP2B4Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1243 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
DPP10Inactive dipeptidyl peptidase 10 isoform X1; Belongs to the peptidase S9B family. (840 aa)
PICALMPhosphatidylinositol-binding clathrin assembly protein isoform X1. (696 aa)
PPP2R5ASerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (487 aa)
STX3Syntaxin-3 isoform X1; Belongs to the syntaxin family. (289 aa)
LYPD1ly6/PLAUR domain-containing protein 1. (141 aa)
PPFIA1Liprin-alpha-1 isoform X4. (1242 aa)
CLN3Battenin. (436 aa)
HECTD1E3 ubiquitin-protein ligase HECTD1 isoform X1. (2610 aa)
GNAI1Guanine nucleotide-binding protein G(I) subunit alpha-1 isoform X1. (354 aa)
LOC111165935Ras-like protein isoform X1. (285 aa)
ABI3ABI gene family member 3 isoform X1. (359 aa)
ANXA13Annexin. (327 aa)
VAMP8Vesicle-associated membrane protein 8. (100 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (723 aa)
RACK1Receptor of activated protein C kinase 1. (317 aa)
STAC2SH3 and cysteine-rich domain-containing protein 2 isoform X1. (409 aa)
EPB41L2Band 4.1-like protein 2 isoform X2. (1063 aa)
STX7Syntaxin-7 isoform X1; Belongs to the syntaxin family. (261 aa)
EZREzrin. (586 aa)
ITGA3Integrin alpha-3 isoform X1; Belongs to the integrin alpha chain family. (1068 aa)
ARAndrogen receptor. (893 aa)
EPM2ALaforin isoform X1. (331 aa)
ATP2C1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1027 aa)
SQSTM1Sequestosome-1. (440 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
WNK3Serine/threonine-protein kinase WNK3 isoform X1. (1780 aa)
ARHGAP44Rho GTPase-activating protein 44 isoform X1. (809 aa)
LOC111167795Rho-related GTP-binding protein RhoG-like isoform X1. (230 aa)
GPER1G-protein coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (354 aa)
GRIPAP1GRIP1-associated protein 1 isoform X1. (842 aa)
ACTBActin, cytoplasmic 1. (375 aa)
MRAP2Melanocortin-2 receptor accessory protein 2. (206 aa)
PLK1Serine/threonine-protein kinase PLK. (604 aa)
CNPY4Protein canopy homolog 4 isoform X1. (230 aa)
NHLRC1E3 ubiquitin-protein ligase NHLRC1. (395 aa)
LOC111181166CAP-Gly domain-containing linker protein 3. (547 aa)
AGR2Anterior gradient protein 2 homolog. (175 aa)
RAP1ARas-related protein Rap-1A. (184 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (294 aa)
CSRP3Cysteine and glycine-rich protein 3 isoform X2. (194 aa)
VPS4AVacuolar protein sorting-associated protein 4A isoform X1; Belongs to the AAA ATPase family. (437 aa)
GPSM2G-protein-signaling modulator 2. (681 aa)
ZDHHC7Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (308 aa)
CNSTConsortin isoform X1. (722 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (798 aa)
PLS1Plastin-1 isoform X1. (630 aa)
PTPN9Tyrosine-protein phosphatase non-receptor type 9. (593 aa)
ADAM10Disintegrin and metalloproteinase domain-containing protein 10. (748 aa)
CDK5Cyclin-dependent-like kinase 5; Belongs to the protein kinase superfamily. (292 aa)
EFCAB7EF-hand calcium-binding domain-containing protein 7 isoform X1. (656 aa)
EPHA3Ephrin type-A receptor 3. (984 aa)
CSKTyrosine-protein kinase. (528 aa)
GPC6Glypican-6; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (555 aa)
KIF5BKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (964 aa)
SAPCD2Suppressor APC domain-containing protein 2. (401 aa)
NUMBProtein numb homolog isoform X1. (653 aa)
LGALS3Galectin. (256 aa)
LRRC15Leucine-rich repeat-containing protein 15. (571 aa)
R3HDM1R3H domain-containing protein 1 isoform X1. (1129 aa)
R3HDM2R3H domain-containing protein 2 isoform X1. (1048 aa)
PKDCCExtracellular tyrosine-protein kinase PKDCC isoform X1. (498 aa)
RHOQRho-related GTP-binding protein RhoQ. (169 aa)
PRKCIProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (707 aa)
LZTFL1Leucine zipper transcription factor-like protein 1 isoform X1. (299 aa)
APPL1DCC-interacting protein 13-alpha isoform X1. (708 aa)
ACSL3long-chain-fatty-acid--CoA ligase 3. (720 aa)
MISPMitotic interactor and substrate of PLK1. (671 aa)
GRASPLOW QUALITY PROTEIN: general receptor for phosphoinositides 1-associated scaffold protein. (399 aa)
HRASGTPase HRas isoform X1. (189 aa)
LOC111170545Rho-related GTP-binding protein RhoG. (191 aa)
CIB1Calcium and integrin-binding protein 1. (191 aa)
PID1PTB-containing, cubilin and LRP1-interacting protein isoform X1. (268 aa)
DLG1Disks large homolog 1 isoform X1; Belongs to the MAGUK family. (927 aa)
NUMA1Nuclear mitotic apparatus protein 1 isoform X1. (2125 aa)
VIL1Villin-1 isoform X1. (827 aa)
VTI1BVesicle transport through interaction with t-SNAREs homolog 1B. (232 aa)
AKAP5A-kinase anchor protein 5. (428 aa)
TMBIM1Protein lifeguard 3; Belongs to the BI1 family. (308 aa)
ARF6ADP-ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family. (175 aa)
ZDHHC2Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (366 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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