STRINGSTRING
BCO2 BCO2 TNF TNF SLC25A33 SLC25A33 PARK7 PARK7 TSPO TSPO DHFR DHFR PPARA PPARA PDGFB PDGFB CLCN3 CLCN3 EIF6 EIF6 F2 F2 PRCP PRCP ZNF205 ZNF205 INS INS VDAC1 VDAC1 ROMO1 ROMO1 THBS1 THBS1 GRB2 GRB2 LOC111181568 LOC111181568 PON3 PON3 ITGAM ITGAM SPHK2 SPHK2 SIRT5 SIRT5 RIPK1 RIPK1 TFAP2A TFAP2A BCL2 BCL2 SIRT2 SIRT2 DUOXA2 DUOXA2 TGFB1 TGFB1 PON2 PON2 PLCG2 PLCG2 LOC111179403 LOC111179403 CDKN1A CDKN1A GADD45A GADD45A TIGAR TIGAR FOXM1 FOXM1 SLC30A10 SLC30A10 APOPT1 APOPT1 LOC111176754 LOC111176754 LOC111174870 LOC111174870 PARL PARL RHOA RHOA TUSC2 TUSC2 PRKCD PRKCD ZC3H12A ZC3H12A NFE2L2 NFE2L2 RNF41 RNF41 XDH XDH GCH1 GCH1 ARG2 ARG2 PIKFYVE PIKFYVE ABCD2 ABCD2 LOC111171171 LOC111171171 HIF1A HIF1A ALOX5 ALOX5 PAX2 PAX2 PID1 PID1 ABCD1 ABCD1 SYK SYK AGPAT4 AGPAT4 HK2 HK2 BECN1 BECN1 MMP8 MMP8 ADGRB1 ADGRB1 BRCA1 BRCA1 PLIN5 PLIN5 ATG5 ATG5 WISP3 WISP3 FOXO3 FOXO3 COQ7 COQ7 LOC111164653 LOC111164653 AATF AATF F2RL1 F2RL1 PINK1 PINK1 BCR BCR
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BCO2Beta,beta-carotene 9',10'-oxygenase isoform X1. (575 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa)
SLC25A33Solute carrier family 25 member 33; Belongs to the mitochondrial carrier (TC 2.A.29) family. (321 aa)
PARK7Protein DJ-1. (189 aa)
TSPOTranslocator protein. (169 aa)
DHFRDihydrofolate reductase isoform X1. (193 aa)
PPARAPeroxisome proliferator-activated receptor alpha. (468 aa)
PDGFBPlatelet-derived growth factor subunit B isoform X1; Belongs to the PDGF/VEGF growth factor family. (278 aa)
CLCN3Chloride channel protein. (866 aa)
EIF6Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)- dependent protein kinase C activity. In tissues responsive to insulin, contro [...] (245 aa)
F2Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (623 aa)
PRCPLysosomal Pro-X carboxypeptidase. (499 aa)
ZNF205Zinc finger protein 205 isoform X1. (592 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
VDAC1Voltage-dependent anion-selective channel protein 1. (283 aa)
ROMO1Reactive oxygen species modulator 1. (79 aa)
THBS1Thrombospondin-1. (1170 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
LOC111181568LOW QUALITY PROTEIN: dual oxidase maturation factor 1-like. (373 aa)
PON3Serum paraoxonase/lactonase 3 isoform X1. (354 aa)
ITGAMIntegrin alpha-M; Belongs to the integrin alpha chain family. (872 aa)
SPHK2Sphingosine kinase 2 isoform X1. (655 aa)
SIRT5NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Modulates ketogenesis through the desuccinyl [...] (344 aa)
RIPK1Receptor-interacting serine/threonine-protein kinase 1 isoform X1. (687 aa)
TFAP2ATranscription factor AP-2-alpha isoform X1. (439 aa)
BCL2Apoptosis regulator Bcl-2. (233 aa)
SIRT2NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (389 aa)
DUOXA2Dual oxidase maturation factor 2. (320 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
PON2Serum paraoxonase/arylesterase 2 isoform X1. (354 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
LOC111179403Cytochrome b-245 light chain isoform X1. (202 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (164 aa)
GADD45AGrowth arrest and DNA damage-inducible protein GADD45 alpha. (165 aa)
TIGARFructose-2,6-bisphosphatase TIGAR isoform X1. (325 aa)
FOXM1Forkhead box protein M1 isoform X1. (761 aa)
SLC30A10Zinc transporter 10. (485 aa)
APOPT1Apoptogenic protein 1, mitochondrial isoform X2. (233 aa)
LOC111176754C-type lectin domain family 7 member A-like isoform X1. (244 aa)
LOC111174870Cytochrome P450 1B1; Belongs to the cytochrome P450 family. (543 aa)
PARLPresenilins-associated rhomboid-like protein, mitochondrial isoform X1. (379 aa)
RHOATransforming protein RhoA. (193 aa)
TUSC2Tumor suppressor candidate 2. (110 aa)
PRKCDProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (733 aa)
ZC3H12AEndoribonuclease ZC3H12A. (583 aa)
NFE2L2Nuclear factor erythroid 2-related factor 2 isoform X1. (622 aa)
RNF41E3 ubiquitin-protein ligase NRDP1 isoform X1. (317 aa)
XDHXanthine dehydrogenase/oxidase isoform X1. (1334 aa)
GCH1GTP cyclohydrolase 1. (249 aa)
ARG2Arginase. (354 aa)
PIKFYVE1-phosphatidylinositol 3-phosphate 5-kinase isoform X1. (2110 aa)
ABCD2ATP-binding cassette sub-family D member 2. (741 aa)
LOC111171171Integrin alpha-M-like. (296 aa)
HIF1AHypoxia-inducible factor 1-alpha isoform X1. (823 aa)
ALOX5Arachidonate 5-lipoxygenase. (674 aa)
PAX2Paired box protein Pax-2 isoform X1. (432 aa)
PID1PTB-containing, cubilin and LRP1-interacting protein isoform X1. (268 aa)
ABCD1ATP-binding cassette sub-family D member 1 isoform X1. (774 aa)
SYKTyrosine-protein kinase. (626 aa)
AGPAT41-acyl-sn-glycerol-3-phosphate acyltransferase delta isoform X1. (835 aa)
HK2Hexokinase-2. (917 aa)
BECN1Beclin-1 isoform X5. (471 aa)
MMP8Neutrophil collagenase isoform X1. (468 aa)
ADGRB1Brain-specific angiogenesis inhibitor 1 isoform X1. (888 aa)
BRCA1Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1866 aa)
PLIN5Perilipin; Belongs to the perilipin family. (454 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
WISP3WNT1-inducible-signaling pathway protein 3. (210 aa)
FOXO3Forkhead box protein O3. (672 aa)
COQ75-demethoxyubiquinone hydroxylase, mitochondrial; Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6- methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. Involved in lifespan determination in a ubiquinone- independent manner. (217 aa)
LOC111164653LOW QUALITY PROTEIN: dihydrofolate reductase-like; Belongs to the dihydrofolate reductase family. (172 aa)
AATFProtein AATF isoform X1. (567 aa)
F2RL1Proteinase-activated receptor 2. (315 aa)
PINK1Serine/threonine-protein kinase PINK1, mitochondrial isoform X1. (584 aa)
BCRBreakpoint cluster region protein isoform X1. (1275 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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