STRINGSTRING
KLF5 KLF5 SRF SRF PPARD PPARD SMAD6 SMAD6 WT1 WT1 NFATC3 NFATC3 SMAD3 SMAD3 RC3H2 RC3H2 SMAD4 SMAD4 TERT TERT GATA3 GATA3 NFKB1 NFKB1 NR1H2 NR1H2 TNF TNF SMAD1 SMAD1 ZNF512B ZNF512B PNPT1 PNPT1 HDAC4 HDAC4 HIF1A HIF1A GNL3 GNL3 ZC3H12A ZC3H12A ZNF512 ZNF512 JUN JUN BMP4 BMP4 RC3H1 RC3H1 LOC111169240 LOC111169240 DROSHA DROSHA MYOCD MYOCD HRAS HRAS LIN28B LIN28B LOC111169295 LOC111169295 BMPR1A BMPR1A TEAD1 TEAD1 BMP2 BMP2 STAT3 STAT3 NGFR NGFR RARA RARA SMARCA4 SMARCA4 KHSRP KHSRP LOC111165935 LOC111165935 ETS1 ETS1 NFATC4 NFATC4 SREBF2 SREBF2 PPARA PPARA PDGFB PDGFB PAPD4 PAPD4 FOSL1 FOSL1 RELA RELA LOC111182889 LOC111182889 EGR1 EGR1 ATOH8 ATOH8 FOXO3 FOXO3 MKL2 MKL2 YY1 YY1 NFIB NFIB TGFB2 TGFB2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
KLF5Krueppel-like factor 5. (454 aa)
SRFSerum response factor isoform X2. (535 aa)
PPARDPeroxisome proliferator-activated receptor delta isoform X1. (441 aa)
SMAD6Mothers against decapentaplegic homolog. (495 aa)
WT1Wilms tumor protein isoform X1. (450 aa)
NFATC3Nuclear factor of activated T-cells, cytoplasmic 3 isoform X1. (1073 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
RC3H2Roquin-2. (1189 aa)
SMAD4Mothers against decapentaplegic homolog. (553 aa)
TERTTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1203 aa)
GATA3Trans-acting T-cell-specific transcription factor GATA-3 isoform X1. (444 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit isoform X1. (972 aa)
NR1H2Oxysterols receptor LXR-beta isoform X1. (450 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
ZNF512BZinc finger protein 512B isoform X1. (928 aa)
PNPT1Polyribonucleotide nucleotidyltransferase 1, mitochondrial. (784 aa)
HDAC4Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1083 aa)
HIF1AHypoxia-inducible factor 1-alpha isoform X1. (823 aa)
GNL3Guanine nucleotide-binding protein-like 3. (547 aa)
ZC3H12AEndoribonuclease ZC3H12A. (583 aa)
ZNF512Zinc finger protein 512 isoform X1. (567 aa)
JUNTranscription factor AP-1; Belongs to the bZIP family. (343 aa)
BMP4Bone morphogenetic protein 4 isoform X2. (408 aa)
RC3H1Roquin-1 isoform X1. (1135 aa)
LOC111169240RE1-silencing transcription factor-like isoform X2. (976 aa)
DROSHARibonuclease 3 isoform X1. (1414 aa)
MYOCDMyocardin isoform X1. (985 aa)
HRASGTPase HRas isoform X1. (189 aa)
LIN28BProtein lin-28 homolog B isoform X1. (270 aa)
LOC111169295RE1-silencing transcription factor-like isoform X1. (981 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
TEAD1Transcriptional enhancer factor TEF-1 isoform X3. (523 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
NGFRTumor necrosis factor receptor superfamily member 16. (427 aa)
RARARetinoic acid receptor alpha isoform X5. (584 aa)
SMARCA4Transcription activator BRG1 isoform X4. (1648 aa)
KHSRPFar upstream element-binding protein 2 isoform X1. (750 aa)
LOC111165935Ras-like protein isoform X1. (285 aa)
ETS1Protein C-ets-1 isoform X1. (486 aa)
NFATC4LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 4. (901 aa)
SREBF2Sterol regulatory element-binding protein 2 isoform X1. (1135 aa)
PPARAPeroxisome proliferator-activated receptor alpha. (468 aa)
PDGFBPlatelet-derived growth factor subunit B isoform X1; Belongs to the PDGF/VEGF growth factor family. (278 aa)
PAPD4poly(A) RNA polymerase GLD2 isoform X1. (484 aa)
FOSL1Fos-related antigen 1. (271 aa)
RELATranscription factor p65 isoform X1. (562 aa)
LOC111182889LOW QUALITY PROTEIN: transcription factor SOX-9-like. (510 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (531 aa)
ATOH8Protein atonal homolog 8 isoform X1. (354 aa)
FOXO3Forkhead box protein O3. (672 aa)
MKL2MKL/myocardin-like protein 2 isoform X1. (1128 aa)
YY1Transcriptional repressor protein YY1. (412 aa)
NFIBNuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (570 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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