(37 nodes) Positive regulation of stem cell proliferation network (Delphinapterus leucas)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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Your Input:
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
	TBX3	T-box transcription factor TBX3 isoform X1. (745 aa)
	NR2E1	Nuclear receptor subfamily 2 group E member 1 isoform X1. (385 aa)
	KAT7	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (611 aa)
	GJA1	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (381 aa)
	PTPRC	Receptor-type tyrosine-protein phosphatase C isoform X1. (1258 aa)
	PDCD2	Programmed cell death protein 2 isoform X1. (344 aa)
	CTNNB1	Catenin beta-1. (781 aa)
	SOX11	Transcription factor SOX. (454 aa)
	YAP1	Transcriptional coactivator YAP1 isoform X1. (511 aa)
	KDR	Vascular endothelial growth factor receptor 2 isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
	CITED1	Cbp/p300-interacting transactivator 1 isoform X1. (359 aa)
	HMX2	Homeobox protein HMX2. (273 aa)
	VEGFC	Vascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (420 aa)
	THPO	Thrombopoietin isoform X1. (324 aa)
	WNT5A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (458 aa)
	FGF9	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	HMGA2	High mobility group protein HMGI-C. (109 aa)
	FGF8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
	TP63	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
	RUNX2	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (524 aa)
	SHOX2	Short stature homeobox protein 2 isoform X1. (329 aa)
	WNT10B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
	IRS2	Insulin receptor substrate 2. (1347 aa)
	WNT1	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
	HNRNPU	Heterogeneous nuclear ribonucleoprotein U isoform X1. (825 aa)
	TERT	Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1203 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
	CCNE1	G1/S-specific cyclin-E1 isoform X1; Belongs to the cyclin family. (410 aa)
	ATXN1L	Ataxin-1-like. (688 aa)
	OSR2	Protein odd-skipped-related 2 isoform X1. (312 aa)
	HOXA3	Homeobox protein Hox-A3. (443 aa)
	ELL3	RNA polymerase II elongation factor ELL3 isoform X2. (397 aa)
	LOC111182889	LOW QUALITY PROTEIN: transcription factor SOX-9-like. (510 aa)
	FGF4	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
	LTBP3	Latent-transforming growth factor beta-binding protein 3 isoform X1. (1557 aa)
	FERMT2	Fermitin family homolog 2 isoform X2. (691 aa)

Your Current Organism:

Delphinapterus leucas

NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CCNE1	CTNNB1	A0A2Y9P687	A0A2Y9MAY9	G1/S-specific cyclin-E1 isoform X1; Belongs to the cyclin family.	Catenin beta-1.	0.475
CITED1	FGF8	A0A2Y9MVR4	A0A2Y9N7L2	Cbp/p300-interacting transactivator 1 isoform X1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.437
CTNNB1	CCNE1	A0A2Y9MAY9	A0A2Y9P687	Catenin beta-1.	G1/S-specific cyclin-E1 isoform X1; Belongs to the cyclin family.	0.475
CTNNB1	FERMT2	A0A2Y9MAY9	A0A2Y9N4C3	Catenin beta-1.	Fermitin family homolog 2 isoform X2.	0.520
CTNNB1	FGF10	A0A2Y9MAY9	A0A2Y9LQ50	Catenin beta-1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.542
CTNNB1	FGF4	A0A2Y9MAY9	A0A2Y9PM63	Catenin beta-1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.510
CTNNB1	FGF8	A0A2Y9MAY9	A0A2Y9N7L2	Catenin beta-1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.510
CTNNB1	FGF9	A0A2Y9MAY9	A0A2Y9N649	Catenin beta-1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.510
CTNNB1	GJA1	A0A2Y9MAY9	A0A2Y9M1N5	Catenin beta-1.	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	0.605
CTNNB1	HMGA2	A0A2Y9MAY9	A0A2Y9N7D2	Catenin beta-1.	High mobility group protein HMGI-C.	0.529
CTNNB1	KAT7	A0A2Y9MAY9	A0A2Y9LV20	Catenin beta-1.	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family.	0.415
CTNNB1	KDR	A0A2Y9MAY9	A0A2Y9MRB1	Catenin beta-1.	Vascular endothelial growth factor receptor 2 isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.873
CTNNB1	LOC111182889	A0A2Y9MAY9	A0A2Y9PEX3	Catenin beta-1.	LOW QUALITY PROTEIN: transcription factor SOX-9-like.	0.861
CTNNB1	RUNX2	A0A2Y9MAY9	A0A2Y9NUN3	Catenin beta-1.	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	0.831
CTNNB1	SOX11	A0A2Y9MAY9	A0A2Y9MJ34	Catenin beta-1.	Transcription factor SOX.	0.504
CTNNB1	TERT	A0A2Y9MAY9	A0A2Y9P149	Catenin beta-1.	Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...]	0.976
CTNNB1	TGFB1	A0A2Y9MAY9	A0A2Y9P5D5	Catenin beta-1.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.692
CTNNB1	WNT1	A0A2Y9MAY9	A0A2Y9NFI8	Catenin beta-1.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.835
CTNNB1	WNT10B	A0A2Y9MAY9	A0A2Y9N9A7	Catenin beta-1.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.678
CTNNB1	WNT5A	A0A2Y9MAY9	A0A2Y9N641	Catenin beta-1.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.776