(10 nodes) Very-low-density lipoprotein particle network (Delphinapterus leucas)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SH3BP2	SH3 domain-binding protein 2 isoform X1. (617 aa)
	APOC3	Apolipoprotein C-III. (99 aa)
	APOA2	Apolipoprotein A-II. (103 aa)
	NR1I3	LOW QUALITY PROTEIN: nuclear receptor subfamily 1 group I member 3. (355 aa)
	PCYOX1	Prenylcysteine oxidase 1. (526 aa)
	LPL	Lipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans. (478 aa)
	VLDLR	Very low-density lipoprotein receptor isoform X1. (873 aa)
	APOC1	LOW QUALITY PROTEIN: apolipoprotein C-I. (87 aa)
	APOC4	Apolipoprotein C-IV. (127 aa)
	LOC111187870	Apolipoprotein L6-like. (341 aa)

Your Current Organism:

Delphinapterus leucas

NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APOA2	APOC1	A0A2Y9LZM5	A0A2Y9NT54	Apolipoprotein A-II.	LOW QUALITY PROTEIN: apolipoprotein C-I.	0.751
APOA2	APOC3	A0A2Y9LZM5	A0A2Y9LYW0	Apolipoprotein A-II.	Apolipoprotein C-III.	0.994
APOA2	APOC4	A0A2Y9LZM5	A0A2Y9P5Q4	Apolipoprotein A-II.	Apolipoprotein C-IV.	0.593
APOA2	LPL	A0A2Y9LZM5	A0A2Y9M8T8	Apolipoprotein A-II.	Lipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans.	0.612
APOA2	VLDLR	A0A2Y9LZM5	A0A2Y9N8K4	Apolipoprotein A-II.	Very low-density lipoprotein receptor isoform X1.	0.520
APOC1	APOA2	A0A2Y9NT54	A0A2Y9LZM5	LOW QUALITY PROTEIN: apolipoprotein C-I.	Apolipoprotein A-II.	0.751
APOC1	APOC3	A0A2Y9NT54	A0A2Y9LYW0	LOW QUALITY PROTEIN: apolipoprotein C-I.	Apolipoprotein C-III.	0.963
APOC1	APOC4	A0A2Y9NT54	A0A2Y9P5Q4	LOW QUALITY PROTEIN: apolipoprotein C-I.	Apolipoprotein C-IV.	0.829
APOC1	LPL	A0A2Y9NT54	A0A2Y9M8T8	LOW QUALITY PROTEIN: apolipoprotein C-I.	Lipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans.	0.636
APOC1	VLDLR	A0A2Y9NT54	A0A2Y9N8K4	LOW QUALITY PROTEIN: apolipoprotein C-I.	Very low-density lipoprotein receptor isoform X1.	0.704
APOC3	APOA2	A0A2Y9LYW0	A0A2Y9LZM5	Apolipoprotein C-III.	Apolipoprotein A-II.	0.994
APOC3	APOC1	A0A2Y9LYW0	A0A2Y9NT54	Apolipoprotein C-III.	LOW QUALITY PROTEIN: apolipoprotein C-I.	0.963
APOC3	APOC4	A0A2Y9LYW0	A0A2Y9P5Q4	Apolipoprotein C-III.	Apolipoprotein C-IV.	0.617
APOC3	LPL	A0A2Y9LYW0	A0A2Y9M8T8	Apolipoprotein C-III.	Lipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans.	0.747
APOC3	PCYOX1	A0A2Y9LYW0	A0A2Y9M4F2	Apolipoprotein C-III.	Prenylcysteine oxidase 1.	0.407
APOC3	VLDLR	A0A2Y9LYW0	A0A2Y9N8K4	Apolipoprotein C-III.	Very low-density lipoprotein receptor isoform X1.	0.549
APOC4	APOA2	A0A2Y9P5Q4	A0A2Y9LZM5	Apolipoprotein C-IV.	Apolipoprotein A-II.	0.593
APOC4	APOC1	A0A2Y9P5Q4	A0A2Y9NT54	Apolipoprotein C-IV.	LOW QUALITY PROTEIN: apolipoprotein C-I.	0.829
APOC4	APOC3	A0A2Y9P5Q4	A0A2Y9LYW0	Apolipoprotein C-IV.	Apolipoprotein C-III.	0.617
LPL	APOA2	A0A2Y9M8T8	A0A2Y9LZM5	Lipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans.	Apolipoprotein A-II.	0.612