STRINGSTRING
CLOCK CLOCK NCOA3 NCOA3 SIM1 SIM1 ARNT ARNT PER2 PER2 PASK PASK HIF1A HIF1A KCNH5 KCNH5 KCNH7 KCNH7 EPAS1 EPAS1 NCOA1 NCOA1 KCNH3 KCNH3 KCNH4 KCNH4 KCNH8 KCNH8 ARNTL ARNTL ARNT2 ARNT2 PDE8A PDE8A ARNTL2 ARNTL2 SIM2 SIM2 AHR AHR NPAS2 NPAS2 PER3 PER3 KCNH1 KCNH1 PER1 PER1 KCNH2 KCNH2 AHRR AHRR NCOA2 NCOA2 PDE8B PDE8B NPAS4 NPAS4 KCNH6 KCNH6 HIF3A HIF3A NPAS1 NPAS1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CLOCKLOW QUALITY PROTEIN: circadian locomoter output cycles protein kaput. (858 aa)
NCOA3Nuclear receptor coactivator. (1406 aa)
SIM1Single-minded homolog 1. (766 aa)
ARNTAryl hydrocarbon receptor nuclear translocator isoform X1. (790 aa)
PER2Period circadian protein homolog 2. (1294 aa)
PASKPAS domain-containing serine/threonine-protein kinase. (1325 aa)
HIF1AHypoxia-inducible factor 1-alpha isoform X1. (823 aa)
KCNH5Potassium voltage-gated channel subfamily H member 5 isoform X1. (988 aa)
KCNH7Potassium voltage-gated channel subfamily H member 7 isoform X1. (1210 aa)
EPAS1Endothelial PAS domain-containing protein 1 isoform X1. (866 aa)
NCOA1Nuclear receptor coactivator. (1441 aa)
KCNH3Potassium voltage-gated channel subfamily H member 3 isoform X1. (1083 aa)
KCNH4Potassium voltage-gated channel subfamily H member 4 isoform X1. (1016 aa)
KCNH8Potassium voltage-gated channel subfamily H member 8. (1106 aa)
ARNTLAryl hydrocarbon receptor nuclear translocator-like protein 1 isoform X1. (631 aa)
ARNT2Aryl hydrocarbon receptor nuclear translocator 2 isoform X1. (717 aa)
PDE8APhosphodiesterase. (657 aa)
ARNTL2Aryl hydrocarbon receptor nuclear translocator-like protein 2 isoform X1. (607 aa)
SIM2LOW QUALITY PROTEIN: single-minded homolog 2. (671 aa)
AHRAryl hydrocarbon receptor; Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates. Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. Involved in cell-cycle regulation. Likely to play an important role in the development and maturation of many tissues. Regulates the circadian clock by inhibiting the basal and circadian expression of the core circadian component PER1. Inhibits PER1 by repressing [...] (845 aa)
NPAS2Neuronal PAS domain-containing protein 2 isoform X1. (822 aa)
PER3Period circadian protein homolog 3 isoform X1. (1151 aa)
KCNH1Potassium voltage-gated channel subfamily H member 1 isoform X1. (988 aa)
PER1Period circadian protein homolog 1 isoform X1. (1267 aa)
KCNH2Potassium voltage-gated channel subfamily H member 2 isoform X2. (1160 aa)
AHRRAryl hydrocarbon receptor repressor. (693 aa)
NCOA2Nuclear receptor coactivator. (1464 aa)
PDE8BPhosphodiesterase. (885 aa)
NPAS4Neuronal PAS domain-containing protein 4. (798 aa)
KCNH6Potassium voltage-gated channel subfamily H member 6 isoform X1. (941 aa)
HIF3AHypoxia-inducible factor 3-alpha isoform X1. (669 aa)
NPAS1Neuronal PAS domain-containing protein 1. (594 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
Server load: low (12%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.