(40 nodes) p53-like transcription factor, DNA-binding domain superfamily network (Delphinapterus leucas)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	STAT3	Signal transducer and activator of transcription. (770 aa)
	TBX15	T-box transcription factor TBX15. (602 aa)
	MYRF	Myelin regulatory factor isoform X1. (1259 aa)
	RELA	Transcription factor p65 isoform X1. (562 aa)
	RBPJL	Recombining binding protein suppressor of hairless-like protein. (516 aa)
	TP73	Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (637 aa)
	REL	Proto-oncogene c-Rel. (594 aa)
	NFATC2	Nuclear factor of activated T-cells, cytoplasmic 2 isoform X1. (943 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (387 aa)
	MGA	MAX gene-associated protein isoform X1. (3114 aa)
	NFATC3	Nuclear factor of activated T-cells, cytoplasmic 3 isoform X1. (1073 aa)
	NFKB1	Nuclear factor NF-kappa-B p105 subunit isoform X1. (972 aa)
	TBX20	T-box transcription factor TBX20. (449 aa)
	NFAT5	Nuclear factor of activated T-cells 5 isoform X1. (1553 aa)
	TBX22	T-box transcription factor TBX22. (522 aa)
	RUNX2	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (524 aa)
	TBR1	T-box brain protein 1. (681 aa)
	TP63	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
	NFKB2	Nuclear factor NF-kappa-B p100 subunit isoform X1. (900 aa)
	MYRFL	Myelin regulatory factor-like protein. (962 aa)
	STAT4	Signal transducer and activator of transcription. (748 aa)
	STAT6	Signal transducer and activator of transcription. (847 aa)
	STAT2	Signal transducer and activator of transcription. (911 aa)
	STAT1	Signal transducer and activator of transcription. (749 aa)
	TBX18	T-box transcription factor TBX18. (612 aa)
	LOC111170864	Recombining binding protein suppressor of hairless isoform X1. (500 aa)
	EOMES	Eomesodermin homolog isoform X1. (711 aa)
	NFATC1	Nuclear factor of activated T-cells, cytoplasmic 1 isoform X1. (928 aa)
	TBX19	T-box transcription factor TBX19 isoform X1. (444 aa)
	TBX6	T-box transcription factor TBX6 isoform X1. (462 aa)
	LOC111166483	Signal transducer and activator of transcription. (787 aa)
	STAT5A	Signal transducer and activator of transcription. (818 aa)
	TBX21	T-box transcription factor TBX21. (535 aa)
	NFATC4	LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 4. (901 aa)
	TBX2	T-box transcription factor TBX2. (713 aa)
	RUNX1	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (480 aa)
	TBX3	T-box transcription factor TBX3 isoform X1. (745 aa)
	TBX5	T-box transcription factor TBX5 isoform X1. (519 aa)
	RUNX3	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (430 aa)
	TBX4	T-box transcription factor TBX4. (555 aa)

Your Current Organism:

Delphinapterus leucas

NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EOMES	RUNX3	A0A2Y9MEE4	A0A2Y9LFL9	Eomesodermin homolog isoform X1.	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	0.518
EOMES	TBX19	A0A2Y9MEE4	A0A2Y9M1D0	Eomesodermin homolog isoform X1.	T-box transcription factor TBX19 isoform X1.	0.588
EOMES	TBX21	A0A2Y9MEE4	A0A2Y9LVI8	Eomesodermin homolog isoform X1.	T-box transcription factor TBX21.	0.505
LOC111166483	STAT1	A0A2Y9LW55	A0A2Y9MPV2	Signal transducer and activator of transcription.	Signal transducer and activator of transcription.	0.852
LOC111166483	STAT2	A0A2Y9LW55	A0A2Y9MYK6	Signal transducer and activator of transcription.	Signal transducer and activator of transcription.	0.910
LOC111166483	STAT3	A0A2Y9LW55	A0A2Y9LX05	Signal transducer and activator of transcription.	Signal transducer and activator of transcription.	0.993
LOC111166483	STAT4	A0A2Y9LW55	A0A2Y9N108	Signal transducer and activator of transcription.	Signal transducer and activator of transcription.	0.792
LOC111166483	STAT5A	A0A2Y9LW55	A0A2Y9LW47	Signal transducer and activator of transcription.	Signal transducer and activator of transcription.	0.996
LOC111166483	STAT6	A0A2Y9LW55	A0A2Y9N001	Signal transducer and activator of transcription.	Signal transducer and activator of transcription.	0.780
LOC111166483	TP53	A0A2Y9LW55	Q8SPZ3	Signal transducer and activator of transcription.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]	0.466
LOC111170864	RBPJL	A0A2Y9MJ12	A0A2Y9PSX2	Recombining binding protein suppressor of hairless isoform X1.	Recombining binding protein suppressor of hairless-like protein.	0.907
LOC111170864	RUNX1	A0A2Y9MJ12	A0A2Y9LIS3	Recombining binding protein suppressor of hairless isoform X1.	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	0.433
LOC111170864	RUNX2	A0A2Y9MJ12	A0A2Y9NUN3	Recombining binding protein suppressor of hairless isoform X1.	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	0.423
LOC111170864	RUNX3	A0A2Y9MJ12	A0A2Y9LFL9	Recombining binding protein suppressor of hairless isoform X1.	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	0.552
LOC111170864	TBX6	A0A2Y9MJ12	A0A2Y9PAU1	Recombining binding protein suppressor of hairless isoform X1.	T-box transcription factor TBX6 isoform X1.	0.438
NFAT5	STAT3	A0A2Y9P163	A0A2Y9LX05	Nuclear factor of activated T-cells 5 isoform X1.	Signal transducer and activator of transcription.	0.437
NFATC1	NFATC2	A0A2Y9MEB2	A0A2Y9QD19	Nuclear factor of activated T-cells, cytoplasmic 1 isoform X1.	Nuclear factor of activated T-cells, cytoplasmic 2 isoform X1.	0.963
NFATC1	NFATC3	A0A2Y9MEB2	A0A2Y9P9Q5	Nuclear factor of activated T-cells, cytoplasmic 1 isoform X1.	Nuclear factor of activated T-cells, cytoplasmic 3 isoform X1.	0.957
NFATC1	RUNX2	A0A2Y9MEB2	A0A2Y9NUN3	Nuclear factor of activated T-cells, cytoplasmic 1 isoform X1.	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	0.689
NFATC1	TP53	A0A2Y9MEB2	Q8SPZ3	Nuclear factor of activated T-cells, cytoplasmic 1 isoform X1.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]	0.412