STRINGSTRING
IL6 IL6 LOC111187198 LOC111187198 PTPN11 PTPN11 IL6ST IL6ST SOCS3 SOCS3 JAK1 JAK1 JAK2 JAK2 STAT1 STAT1 IL6R IL6R CBL CBL STAT3 STAT3 TYK2 TYK2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (208 aa)
LOC111187198Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (617 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (623 aa)
IL6STInterleukin-6 receptor subunit beta. (918 aa)
SOCS3Suppressor of cytokine signaling 3. (237 aa)
JAK1Tyrosine-protein kinase. (1153 aa)
JAK2Tyrosine-protein kinase. (1132 aa)
STAT1Signal transducer and activator of transcription. (749 aa)
IL6RInterleukin-6 receptor subunit alpha isoform X1. (465 aa)
CBLE3 ubiquitin-protein ligase CBL isoform X1. (910 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
TYK2Tyrosine-protein kinase. (1188 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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