STRINGSTRING
IRS1 IRS1 FGF5 FGF5 LOC111187198 LOC111187198 PTPN11 PTPN11 GAB1 GAB1 PIK3R1 PIK3R1 FGF18 FGF18 PDPK1 PDPK1 GAB2 GAB2 FGF3 FGF3 TRIB3 TRIB3 FGF1 FGF1 FGF4 FGF4 LOC111181964 LOC111181964 FGF7 FGF7 GRB2 GRB2 AKT2 AKT2 FLT3LG FLT3LG PIK3CB PIK3CB FGF16 FGF16 FGF23 FGF23 KL KL FGF6 FGF6 FGF20 FGF20 IRS2 IRS2 AKT1 AKT1 FLT3 FLT3 FGF8 FGF8 TLR9 TLR9 FGFR1 FGFR1 FGF9 FGF9 PIK3CA PIK3CA FRS2 FRS2 FGF22 FGF22 FGFR2 FGFR2 SPEM2 SPEM2 FGFR4 FGFR4 LOC111171282 LOC111171282 KLB KLB SPEM1 SPEM1 THEM4 THEM4 PIK3C3 PIK3C3 LOC111169445 LOC111169445 FGF17 FGF17 PIK3R4 PIK3R4 PDE3B PDE3B PIK3R2 PIK3R2 FGFR3 FGFR3 FGF10 FGF10
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IRS1Insulin receptor substrate 1. (1248 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (270 aa)
LOC111187198Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (617 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (623 aa)
GAB1GRB2-associated-binding protein 1 isoform X1. (757 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
PDPK13-phosphoinositide-dependent protein kinase 1 isoform X1. (558 aa)
GAB2GRB2-associated-binding protein 2 isoform X1. (678 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (214 aa)
TRIB3LOW QUALITY PROTEIN: tribbles homolog 3. (357 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (189 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
LOC111181964Uncharacterized protein LOC111181964 isoform X1. (833 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
FLT3LGFms-related tyrosine kinase 3 ligand isoform X1. (328 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (315 aa)
KLKlotho. (1010 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
IRS2Insulin receptor substrate 2. (1347 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
FLT3Receptor-type tyrosine-protein kinase FLT3 isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (993 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
TLR9LOW QUALITY PROTEIN: toll-like receptor 9. (1323 aa)
FGFR1Fibroblast growth factor receptor. (823 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
FRS2Fibroblast growth factor receptor substrate 2. (508 aa)
FGF22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (255 aa)
FGFR2Fibroblast growth factor receptor. (841 aa)
SPEM2LOW QUALITY PROTEIN: uncharacterized protein C17orf74 homolog. (492 aa)
FGFR4Fibroblast growth factor receptor. (801 aa)
LOC111171282Uncharacterized protein C17orf74-like. (436 aa)
KLBLOW QUALITY PROTEIN: beta-klotho. (1046 aa)
SPEM1LOW QUALITY PROTEIN: spermatid maturation protein 1. (269 aa)
THEM4Acyl-coenzyme A thioesterase THEM4. (224 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (887 aa)
LOC111169445Acyl-coenzyme A thioesterase THEM4-like. (174 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (215 aa)
PIK3R4Phosphoinositide 3-kinase regulatory subunit 4. (1358 aa)
PDE3BPhosphodiesterase. (1120 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (723 aa)
FGFR3Fibroblast growth factor receptor. (805 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
Server load: medium (42%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.