STRINGSTRING
FRZB FRZB SOD1 SOD1 B4GALNT4 B4GALNT4 LOC111169415 LOC111169415 SPP2 SPP2 NDN NDN VTI1B VTI1B WDR1 WDR1 CLPB CLPB CSMD1 CSMD1 FETUB FETUB TMSB15A TMSB15A ACTN1 ACTN1 LOC111171268 LOC111171268 VEGFC VEGFC FN1 FN1 TUBA4A TUBA4A KNG1 KNG1 OLA1 OLA1 CD63 CD63 CFL2 CFL2 NHLRC2 NHLRC2 ITIH4 ITIH4 CSMD2 CSMD2 LHFPL6 LHFPL6 AHSG AHSG PLEK2 PLEK2 SERPINA1 SERPINA1 A2ML1 A2ML1 LOC111176120 LOC111176120 QSOX2 QSOX2 ITIH3 ITIH3 TEX264 TEX264 MANF MANF LOC111177292 LOC111177292 CLEC3B CLEC3B RARRES2 RARRES2 APP APP CDC37L1 CDC37L1 SCG3 SCG3 TGFB2 TGFB2 LOC111177522 LOC111177522 GAS6 GAS6 SYTL4 SYTL4 SERBP1 SERBP1 LOC111176736 LOC111176736 SCCPDH SCCPDH TOR4A TOR4A APOOL APOOL VEGFA VEGFA CALM1 CALM1 ISLR ISLR TGFB3 TGFB3 LOC111176454 LOC111176454 LOC111176737 LOC111176737 PROS1 PROS1 BRPF3 BRPF3 BTBD9 BTBD9 ENDOG ENDOG IGSF3 IGSF3 TMX3 TMX3 FAM3C FAM3C TF TF TLN2 TLN2 ISLR2 ISLR2 CD37 CD37 CDNF CDNF MMRN1 MMRN1 LOC111179199 LOC111179199 TGFB1 TGFB1 ACTN4 ACTN4 GTPBP2 GTPBP2 F13A1 F13A1 PHACTR1 PHACTR1 RAB27B RAB27B CLUL1 CLUL1 LGALS3BP LGALS3BP LOC111182630 LOC111182630 APLP1 APLP1 MILR1 MILR1 ANXA7 ANXA7 ANXA11 ANXA11 PCYOX1 PCYOX1 ANXA4 ANXA4 CPAMD8 CPAMD8 PLG PLG TENM1 TENM1 LAMP2 LAMP2 SELP SELP ENDOD1 ENDOD1 PDGFA PDGFA LOC111168748 LOC111168748 ACTG1 ACTG1 PCYOX1L PCYOX1L ANXA6 ANXA6 CFL1 CFL1 FERMT3 FERMT3 THBS1 THBS1 SPARC SPARC LRRC55 LRRC55 ALDOA ALDOA VCL VCL TSPAN18 TSPAN18 SRGN SRGN PSAP PSAP LOC111182177 LOC111182177 IGF2 IGF2 SERPINE1 SERPINE1 PECAM1 PECAM1 LYRM7 LYRM7 SERPING1 SERPING1 APOH APOH TENM4 TENM4 DSTN DSTN TMEM211 TMEM211 PHACTR4 PHACTR4 ACTN2 ACTN2 EXOG EXOG FAM49B FAM49B FAM49A FAM49A HGF HGF CSMD3 CSMD3 TMSB10 TMSB10 APLP2 APLP2 LOC111164621 LOC111164621 QSOX1 QSOX1 STXBP2 STXBP2 ANXA13 ANXA13 PHACTR2 PHACTR2 LOC111164620 LOC111164620 TLNRD1 TLNRD1 HABP4 HABP4 APOA1 APOA1 CD109 CD109 TAGLN TAGLN LHFPL1 LHFPL1 TMSB4X TMSB4X F5 F5 TAGLN2 TAGLN2 TIMP1 TIMP1 CTSW CTSW VEGFB VEGFB LHFPL2 LHFPL2 ANXA10 ANXA10 SFRP4 SFRP4 SERPINF2 SERPINF2 PDGFB PDGFB GTPBP1 GTPBP1 GZMK GZMK CLU CLU PHACTR3 PHACTR3 TAGLN3 TAGLN3 PPBP PPBP FGB FGB LRRC38 LRRC38 ANXA5 ANXA5 PLEK PLEK ANXA3 ANXA3 LOC111187580 LOC111187580 CXCL8 CXCL8 FGA FGA FGG FGG TIMP3 TIMP3 IGF1 IGF1 SZRD1 SZRD1 TLN1 TLN1 ECM1 ECM1 TMSB15B TMSB15B LOC111168337 LOC111168337 LOC111170125 LOC111170125 SYTL3 SYTL3 ITGA2B ITGA2B CFD CFD VEGFD VEGFD FLNA FLNA PCDH7 PCDH7 LOC111169221 LOC111169221 F8 F8 CHID1 CHID1 LY6G6F LY6G6F
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
FRZBSecreted frizzled-related protein 3. (325 aa)
SOD1Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family. (153 aa)
B4GALNT4Beta-1,4-N-acetylgalactosaminyltransferase; Transfers N-acetylgalactosamine (GalNAc) from UDP-GalNAc to N-acetylglucosamine-beta-benzyl with a beta-1,4-linkage to form N,N'- diacetyllactosediamine, GalNAc-beta-1,4-GlcNAc structures in N-linked glycans and probably O-linked glycans. (1046 aa)
LOC111169415Melanoma-associated antigen D2. (594 aa)
SPP2Secreted phosphoprotein 24 isoform X1. (190 aa)
NDNNecdin. (325 aa)
VTI1BVesicle transport through interaction with t-SNAREs homolog 1B. (232 aa)
WDR1WD repeat-containing protein 1. (606 aa)
CLPBCaseinolytic peptidase B protein homolog isoform X1. (677 aa)
CSMD1CUB and sushi domain-containing protein 1. (3564 aa)
FETUBfetuin-B. (384 aa)
TMSB15AThymosin beta-15A. (45 aa)
ACTN1Alpha-actinin-1 isoform X2. (914 aa)
LOC111171268Coagulation factor VIII-like. (177 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (420 aa)
FN1Fibronectin isoform X5. (2478 aa)
TUBA4ATubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (448 aa)
KNG1Kininogen-1 isoform X1. (627 aa)
OLA1Obg-like ATPase 1; Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP. (396 aa)
CD63Tetraspanin. (237 aa)
CFL2Cofilin-2; Belongs to the actin-binding proteins ADF family. (166 aa)
NHLRC2NHL repeat-containing protein 2 isoform X1. (726 aa)
ITIH4Inter-alpha-trypsin inhibitor heavy chain H4 isoform X1. (999 aa)
CSMD2CUB and sushi domain-containing protein 2. (3609 aa)
LHFPL6Lipoma HMGIC fusion partner isoform X1. (200 aa)
AHSGalpha-2-HS-glycoprotein. (360 aa)
PLEK2Pleckstrin-2. (353 aa)
SERPINA1Alpha-1-antitrypsin; Belongs to the serpin family. (421 aa)
A2ML1Alpha-2-macroglobulin-like protein 1. (1445 aa)
LOC111176120LOW QUALITY PROTEIN: serpin A3-8-like; Belongs to the serpin family. (423 aa)
QSOX2Sulfhydryl oxidase. (698 aa)
ITIH3Inter-alpha-trypsin inhibitor heavy chain H3 isoform X1. (989 aa)
TEX264Testis-expressed protein 264 isoform X1. (313 aa)
MANFLOW QUALITY PROTEIN: mesencephalic astrocyte-derived neurotrophic factor. (226 aa)
LOC111177292Alpha-1-acid glycoprotein-like isoform X1. (218 aa)
CLEC3BTetranectin. (202 aa)
RARRES2Retinoic acid receptor responder protein 2. (166 aa)
APPAmyloid beta A4 protein isoform X1. (767 aa)
CDC37L1Hsp90 co-chaperone Cdc37-like 1 isoform X2. (337 aa)
SCG3Secretogranin-3 isoform X1. (471 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
LOC111177522Left-right determination factor. (367 aa)
GAS6Growth arrest-specific protein 6. (671 aa)
SYTL4Synaptotagmin-like protein 4. (672 aa)
SERBP1Plasminogen activator inhibitor 1 RNA-binding protein isoform X1. (407 aa)
LOC111176736Pregnancy zone protein-like. (1486 aa)
SCCPDHSaccharopine dehydrogenase-like oxidoreductase. (429 aa)
TOR4Atorsin-4A. (416 aa)
APOOLMICOS complex subunit; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. (268 aa)
VEGFAVascular endothelial growth factor A isoform X1; Belongs to the PDGF/VEGF growth factor family. (214 aa)
CALM1Calmodulin-1; Belongs to the calmodulin family. (149 aa)
ISLRImmunoglobulin superfamily containing leucine-rich repeat protein. (428 aa)
TGFB3Transforming growth factor beta-3. (456 aa)
LOC111176454Multidrug resistance-associated protein 4 isoform X1. (1325 aa)
LOC111176737Alpha-2-macroglobulin isoform X1. (1479 aa)
PROS1Vitamin K-dependent protein S. (675 aa)
BRPF3Bromodomain and PHD finger-containing protein 3 isoform X1. (1234 aa)
BTBD9BTB/POZ domain-containing protein 9 isoform X1. (637 aa)
ENDOGEndonuclease. (300 aa)
IGSF3Immunoglobulin superfamily member 3. (1191 aa)
TMX3Protein disulfide-isomerase TMX3 isoform X1. (454 aa)
FAM3CProtein FAM3C isoform X1. (234 aa)
TFSerotransferrin; Belongs to the transferrin family. (702 aa)
TLN2Talin-2 isoform X1. (2554 aa)
ISLR2Immunoglobulin superfamily containing leucine-rich repeat protein 2. (747 aa)
CD37Tetraspanin. (370 aa)
CDNFCerebral dopamine neurotrophic factor. (187 aa)
MMRN1Multimerin-1. (1216 aa)
LOC111179199Serotransferrin-like; Belongs to the transferrin family. (706 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
ACTN4Alpha-actinin-4 isoform X5. (933 aa)
GTPBP2GTP-binding protein 2. (602 aa)
F13A1Coagulation factor XIII A chain. (732 aa)
PHACTR1Phosphatase and actin regulator. (577 aa)
RAB27BRas-related protein Rab-27B. (217 aa)
CLUL1Clusterin; Belongs to the clusterin family. (477 aa)
LGALS3BPLOW QUALITY PROTEIN: galectin-3-binding protein. (553 aa)
LOC111182630Platelet endothelial cell adhesion molecule-like isoform X2. (305 aa)
APLP1Amyloid-like protein 1 isoform X1. (647 aa)
MILR1Allergin-1 isoform X1. (318 aa)
ANXA7Annexin. (491 aa)
ANXA11Annexin. (503 aa)
PCYOX1Prenylcysteine oxidase 1. (526 aa)
ANXA4Annexin. (319 aa)
CPAMD8C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8 isoform X1. (1820 aa)
PLGPlasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...] (812 aa)
TENM1Teneurin-1 isoform X1. (2659 aa)
LAMP2Lysosome-associated membrane glycoprotein 2 isoform X1. (411 aa)
SELPP-selectin isoform X1. (768 aa)
ENDOD1Endonuclease domain-containing 1 protein. (500 aa)
PDGFAPlatelet-derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (196 aa)
LOC111168748Annexin. (327 aa)
ACTG1Actin, cytoplasmic 2. (375 aa)
PCYOX1LLOW QUALITY PROTEIN: prenylcysteine oxidase-like. (492 aa)
ANXA6Annexin. (673 aa)
CFL1Cofilin-1; Belongs to the actin-binding proteins ADF family. (166 aa)
FERMT3Fermitin family homolog 3. (663 aa)
THBS1Thrombospondin-1. (1170 aa)
SPARCSPARC. (303 aa)
LRRC55Leucine-rich repeat-containing protein 55. (318 aa)
ALDOAFructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. (364 aa)
VCLVinculin isoform X2. (1134 aa)
TSPAN18Tetraspanin. (330 aa)
SRGNSerglycin. (151 aa)
PSAPProsaposin isoform X1. (559 aa)
LOC111182177Keratin-associated protein 10-2-like. (139 aa)
IGF2Insulin-like growth factor II isoform X3. (237 aa)
SERPINE1Plasminogen activator inhibitor 1; Belongs to the serpin family. (402 aa)
PECAM1Platelet endothelial cell adhesion molecule isoform X1. (701 aa)
LYRM7Complex III assembly factor LYRM7; Belongs to the complex I LYR family. (104 aa)
SERPING1Plasma protease C1 inhibitor; Belongs to the serpin family. (471 aa)
APOHBeta-2-glycoprotein 1 isoform X1. (345 aa)
TENM4Teneurin-4 isoform X1. (2864 aa)
DSTNDestrin; Belongs to the actin-binding proteins ADF family. (165 aa)
TMEM211LOW QUALITY PROTEIN: transmembrane protein 211. (129 aa)
PHACTR4Phosphatase and actin regulator. (740 aa)
ACTN2Alpha-actinin-2. (894 aa)
EXOGNuclease EXOG, mitochondrial isoform X1. (368 aa)
FAM49BProtein FAM49B isoform X1. (324 aa)
FAM49AProtein FAM49A. (323 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (729 aa)
CSMD3CUB and sushi domain-containing protein 3 isoform X5. (3707 aa)
TMSB10Thymosin beta; Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization. Belongs to the thymosin beta family. (42 aa)
APLP2Amyloid-like protein 2 isoform X1. (762 aa)
LOC111164621Platelet glycoprotein 4; Belongs to the CD36 family. (472 aa)
QSOX1Sulfhydryl oxidase. (556 aa)
STXBP2Syntaxin-binding protein 2 isoform X1; Belongs to the STXBP/unc-18/SEC1 family. (593 aa)
ANXA13Annexin. (327 aa)
PHACTR2Phosphatase and actin regulator. (699 aa)
LOC111164620Platelet glycoprotein 4-like; Belongs to the CD36 family. (472 aa)
TLNRD1Mesoderm development candidate 1. (362 aa)
HABP4Intracellular hyaluronan-binding protein 4. (417 aa)
APOA1Apolipoprotein A-I. (265 aa)
CD109CD109 antigen isoform X1. (1440 aa)
TAGLNTransgelin; Belongs to the calponin family. (201 aa)
LHFPL1Lipoma HMGIC fusion partner-like 1 protein isoform X1. (243 aa)
TMSB4XThymosin beta; Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization. Belongs to the thymosin beta family. (44 aa)
F5Coagulation factor V isoform X1; Belongs to the multicopper oxidase family. (2169 aa)
TAGLN2Transgelin; Belongs to the calponin family. (199 aa)
TIMP1Metalloproteinase inhibitor 1. (257 aa)
CTSWCathepsin W isoform X1; Belongs to the peptidase C1 family. (386 aa)
VEGFBVascular endothelial growth factor B isoform X1; Belongs to the PDGF/VEGF growth factor family. (209 aa)
LHFPL2Lipoma HMGIC fusion partner-like 2 protein isoform X1. (228 aa)
ANXA10Annexin A10. (324 aa)
SFRP4Secreted frizzled-related protein 4. (346 aa)
SERPINF2Alpha-2-antiplasmin isoform X1; Belongs to the serpin family. (558 aa)
PDGFBPlatelet-derived growth factor subunit B isoform X1; Belongs to the PDGF/VEGF growth factor family. (278 aa)
GTPBP1GTP-binding protein 1. (669 aa)
GZMKGranzyme K; Belongs to the peptidase S1 family. (264 aa)
CLUClusterin; Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins. (441 aa)
PHACTR3Phosphatase and actin regulator. (560 aa)
TAGLN3Transgelin; Belongs to the calponin family. (199 aa)
PPBPC-X-C motif chemokine. (119 aa)
FGBFibrinogen beta chain isoform X1. (495 aa)
LRRC38Leucine-rich repeat-containing protein 38. (300 aa)
ANXA5Annexin. (370 aa)
PLEKPleckstrin. (350 aa)
ANXA3Annexin. (323 aa)
LOC111187580C-X-C motif chemokine. (112 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (109 aa)
FGAFibrinogen alpha chain. (852 aa)
FGGFibrinogen gamma chain isoform X1. (445 aa)
TIMP3Metalloproteinase inhibitor 3. (211 aa)
IGF1Insulin-like growth factor I isoform X1. (186 aa)
SZRD1SUZ domain-containing protein 1 isoform X5. (171 aa)
TLN1Talin-1. (2541 aa)
ECM1Extracellular matrix protein 1 isoform X1. (544 aa)
TMSB15BThymosin beta; Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization. Belongs to the thymosin beta family. (45 aa)
LOC111168337NADH-cytochrome b5 reductase; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (333 aa)
LOC111170125Myosin light chain 1, skeletal muscle isoform-like isoform X1; Belongs to the calmodulin family. (304 aa)
SYTL3Synaptotagmin-like protein 3 isoform X1. (614 aa)
ITGA2BIntegrin alpha-IIb; Belongs to the integrin alpha chain family. (1034 aa)
CFDComplement factor D; Belongs to the peptidase S1 family. (259 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (354 aa)
FLNAfilamin-A isoform X1. (2647 aa)
PCDH7Protocadherin-7 isoform X1. (1255 aa)
LOC111169221LOW QUALITY PROTEIN: protein FAM3C-like. (227 aa)
F8Coagulation factor VIII; Belongs to the multicopper oxidase family. (2152 aa)
CHID1Chitinase domain-containing protein 1 isoform X1; Belongs to the glycosyl hydrolase 18 family. (393 aa)
LY6G6FLymphocyte antigen 6 complex locus protein G6f. (267 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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