43 items (Delphinapterus leucas) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	EREG	Proepiregulin. (163 aa)
	PIK3R1	Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
	ADAP2	arf-GAP with dual PH domain-containing protein 2 isoform X1. (381 aa)
	RPS27A	ubiquitin-40S ribosomal protein S27a. (156 aa)
	ITCH	E3 ubiquitin-protein ligase. (862 aa)
	NRG3	Pro-neuregulin-3, membrane-bound isoform isoform X2. (725 aa)
	SRC	Tyrosine-protein kinase. (562 aa)
	GRB2	Growth factor receptor-bound protein 2. (217 aa)
	PSENEN	Gamma-secretase subunit PEN-2 isoform X1. (101 aa)
	HBEGF	Proheparin-binding EGF-like growth factor. (208 aa)
	NRG2	Pro-neuregulin-2, membrane-bound isoform isoform X1. (845 aa)
	NRAS	GTPase NRas. (189 aa)
	CSDE1	Cold shock domain-containing protein E1 isoform X1. (798 aa)
	APH1B	Gamma-secretase subunit APH-1B isoform X1. (257 aa)
	WWOX	WW domain-containing oxidoreductase isoform X1. (418 aa)
	PSEN1	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (468 aa)
	NRG4	Pro-neuregulin-4, membrane-bound isoform. (116 aa)
	NEDD4	E3 ubiquitin-protein ligase NEDD4 isoform X3. (1319 aa)
	PSEN2	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (512 aa)
	KRAS	GTPase KRas. (188 aa)
	FNDC3A	Fibronectin type-III domain-containing protein 3A isoform X1. (1198 aa)
	SOS1	Son of sevenless homolog 1 isoform X1. (1333 aa)
	NRG1	Pro-neuregulin-1, membrane-bound isoform isoform X1. (852 aa)
	ERBB3	Receptor tyrosine-protein kinase erbB-3. (1338 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	FNDC3B	Fibronectin type III domain-containing protein 3B isoform X1. (1215 aa)
	ERBB4	Receptor protein-tyrosine kinase. (1308 aa)
	YAP1	Transcriptional coactivator YAP1 isoform X1. (511 aa)
	ERAS	GTPase ERas. (233 aa)
	HRAS	GTPase HRas isoform X1. (189 aa)
	GFAP	Glial fibrillary acidic protein isoform X1; Belongs to the intermediate filament family. (470 aa)
	LOC111169792	Uncharacterized protein LOC111169792. (306 aa)
	ADAP1	arf-GAP with dual PH domain-containing protein 1 isoform X3. (364 aa)
	CSN2	Beta-casein; Important role in determination of the surface properties of the casein micelles; Belongs to the beta-casein family. (239 aa)
	NCSTN	Nicastrin. (709 aa)
	ESR1	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (595 aa)
	SHC1	SHC-transforming protein 1 isoform X1. (609 aa)
	STMN1	Stathmin; Belongs to the stathmin family. (149 aa)
	WWP1	E3 ubiquitin-protein ligase. (922 aa)
	LOC111165935	Ras-like protein isoform X1. (285 aa)
	STAT5A	Signal transducer and activator of transcription. (818 aa)
	MXD4	Max dimerization protein 4. (208 aa)
	BTC	Probetacellulin. (178 aa)

Your Current Organism:

Delphinapterus leucas

NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APH1B	ERBB4	A0A2Y9NW80	A0A2Y9MQV3	Gamma-secretase subunit APH-1B isoform X1.	Receptor protein-tyrosine kinase.	0.417
APH1B	LOC111169792	A0A2Y9NW80	A0A2Y9MCP9	Gamma-secretase subunit APH-1B isoform X1.	Uncharacterized protein LOC111169792.	0.907
APH1B	NCSTN	A0A2Y9NW80	A0A2Y9M755	Gamma-secretase subunit APH-1B isoform X1.	Nicastrin.	0.995
APH1B	PSEN1	A0A2Y9NW80	A0A2Y9NSH6	Gamma-secretase subunit APH-1B isoform X1.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.993
APH1B	PSEN2	A0A2Y9NW80	A0A2Y9NQ86	Gamma-secretase subunit APH-1B isoform X1.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.994
APH1B	PSENEN	A0A2Y9NW80	A0A2Y9PHN4	Gamma-secretase subunit APH-1B isoform X1.	Gamma-secretase subunit PEN-2 isoform X1.	0.995
BTC	ERBB3	A0A2Y9QJ26	A0A2Y9N080	Probetacellulin.	Receptor tyrosine-protein kinase erbB-3.	0.856
BTC	ERBB4	A0A2Y9QJ26	A0A2Y9MQV3	Probetacellulin.	Receptor protein-tyrosine kinase.	0.985
BTC	EREG	A0A2Y9QJ26	A0A2Y9QC21	Probetacellulin.	Proepiregulin.	0.743
BTC	GRB2	A0A2Y9QJ26	A0A2Y9PJ90	Probetacellulin.	Growth factor receptor-bound protein 2.	0.450
BTC	HBEGF	A0A2Y9QJ26	A0A2Y9PFK7	Probetacellulin.	Proheparin-binding EGF-like growth factor.	0.822
BTC	KRAS	A0A2Y9QJ26	A0A2Y9NF08	Probetacellulin.	GTPase KRas.	0.528
BTC	NRG1	A0A2Y9QJ26	A0A2Y9N632	Probetacellulin.	Pro-neuregulin-1, membrane-bound isoform isoform X1.	0.604
BTC	NRG2	A0A2Y9QJ26	A0A2Y9PCK2	Probetacellulin.	Pro-neuregulin-2, membrane-bound isoform isoform X1.	0.604
BTC	NRG4	A0A2Y9QJ26	A0A2Y9NSD7	Probetacellulin.	Pro-neuregulin-4, membrane-bound isoform.	0.533
BTC	PIK3CA	A0A2Y9QJ26	A0A2Y9MZW2	Probetacellulin.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.518
BTC	SRC	A0A2Y9QJ26	A0A2Y9PSD7	Probetacellulin.	Tyrosine-protein kinase.	0.550
CSDE1	ERBB3	A0A2Y9P0H2	A0A2Y9N080	Cold shock domain-containing protein E1 isoform X1.	Receptor tyrosine-protein kinase erbB-3.	0.500
CSDE1	ERBB4	A0A2Y9P0H2	A0A2Y9MQV3	Cold shock domain-containing protein E1 isoform X1.	Receptor protein-tyrosine kinase.	0.500
CSDE1	GRB2	A0A2Y9P0H2	A0A2Y9PJ90	Cold shock domain-containing protein E1 isoform X1.	Growth factor receptor-bound protein 2.	0.565