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CASP8 | Caspase-8; Belongs to the peptidase C14A family. (486 aa) | ||||
LOC111185436 | Tumor necrosis factor receptor superfamily member 10B-like isoform X1. (456 aa) | ||||
LOC111185435 | Tumor necrosis factor receptor superfamily member 10A-like isoform X1. (454 aa) | ||||
LY96 | Lymphocyte antigen 96. (160 aa) | ||||
LOC111184077 | Tumor necrosis factor receptor superfamily member 26-like. (308 aa) | ||||
TICAM2 | TIR domain-containing adapter molecule 2. (235 aa) | ||||
CD14 | Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (372 aa) | ||||
FADD | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (211 aa) | ||||
RIPK1 | Receptor-interacting serine/threonine-protein kinase 1 isoform X1. (687 aa) | ||||
TRADD | Tumor necrosis factor receptor type 1-associated DEATH domain protein. (315 aa) | ||||
TRAF2 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (516 aa) | ||||
TNFSF10 | Tumor necrosis factor ligand superfamily member. (288 aa) | ||||
FAS | Tumor necrosis factor receptor superfamily member 6 isoform X1. (334 aa) | ||||
CFLAR | CASP8 and FADD-like apoptosis regulator isoform X1; Belongs to the peptidase C14A family. (547 aa) | ||||
FASLG | Tumor necrosis factor ligand superfamily member 6; Belongs to the tumor necrosis factor family. (262 aa) |