STRINGSTRING
TRIB1 TRIB1 ASCL2 ASCL2 PLCG1 PLCG1 FNBP4 FNBP4 RAC1 RAC1 LOC111181964 LOC111181964 SHC4 SHC4 GRB2 GRB2 PPP2CA PPP2CA AP2A1 AP2A1 MAPK3 MAPK3 NTF4 NTF4 EGR1 EGR1 AP2S1 AP2S1 VRK3 VRK3 NRAS NRAS NGF NGF PPP2R1A PPP2R1A ID4 ID4 NKPD1 NKPD1 FOSB FOSB RAP1A RAP1A BDNF BDNF CSDE1 CSDE1 MAP2K1 MAP2K1 PIK3CB PIK3CB KIAA1468 KIAA1468 PPP2R5D PPP2R5D MAP2K5 MAP2K5 RRAD RRAD PPP4R4 PPP4R4 BRAF BRAF MAPK14 MAPK14 LOC111165935 LOC111165935 ELK1 ELK1 MAP2K2 MAP2K2 JUNB JUNB NTRK2 NTRK2 PIK3R2 PIK3R2 PCSK6 PCSK6 MAPKAPK2 MAPKAPK2 CRK CRK YWHAB YWHAB RALA RALA ANKRD60 ANKRD60 PIK3R1 PIK3R1 CLTA CLTA MAPK11 MAPK11 DNAL4 DNAL4 ASCL1 ASCL1 PTPRO PTPRO LYL1 LYL1 RIT1 RIT1 SHC1 SHC1 LOC111165956 LOC111165956 NTRK1 NTRK1 RPS6KA3 RPS6KA3 MAPK7 MAPK7 SHC3 SHC3 EGR4 EGR4 PPP2R1B PPP2R1B EGR3 EGR3 JUND JUND NTRK3 NTRK3 FURIN FURIN RALB RALB DUSP3 DUSP3 EGR2 EGR2 PCSK4 PCSK4 HRAS HRAS RPS6KA2 RPS6KA2 ERAS ERAS NAB1 NAB1 IRS1 IRS1 AP2A2 AP2A2 SHC2 SHC2 CREB1 CREB1 AP2M1 AP2M1 PPP2CB PPP2CB FRS2 FRS2 FNDC3B FNDC3B PIK3CA PIK3CA ATF1 ATF1 NAB2 NAB2 DUSP7 DUSP7 DOCK3 DOCK3 SH3GL2 SH3GL2 DUSP4 DUSP4 SOS1 SOS1 MAPKAPK3 MAPKAPK3 RHOA RHOA IRS2 IRS2 FNDC3A FNDC3A RPS6KA5 RPS6KA5 NTF3 NTF3 CHD4 CHD4 KRAS KRAS PCSK5 PCSK5 RAPGEF1 RAPGEF1 LOC111177220 LOC111177220 RALGDS RALGDS ID2 ID2 FOSL1 FOSL1 SRC SRC RPS6KA4 RPS6KA4 KIDINS220 KIDINS220 TRIB2 TRIB2 CRKL CRKL PPP4R1 PPP4R1 ID3 ID3 MAPK1 MAPK1 DUSP6 DUSP6 RPS6KA1 RPS6KA1 CLTC CLTC FYN FYN LOC111163998 LOC111163998 ARC ARC
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TRIB1Tribbles homolog 1. (372 aa)
ASCL2Achaete-scute homolog 2. (191 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa)
FNBP4Formin-binding protein 4. (1013 aa)
RAC1Ras-related C3 botulinum toxin substrate 1. (192 aa)
LOC111181964Uncharacterized protein LOC111181964 isoform X1. (833 aa)
SHC4SHC-transforming protein 4. (630 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
AP2A1AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (1023 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (382 aa)
NTF4Neurotrophin-4; Belongs to the NGF-beta family. (247 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (531 aa)
AP2S1AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (142 aa)
VRK3Inactive serine/threonine-protein kinase VRK3 isoform X1. (447 aa)
NRASGTPase NRas. (189 aa)
NGFBeta-nerve growth factor; Belongs to the NGF-beta family. (241 aa)
PPP2R1ASerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform. (589 aa)
ID4DNA-binding protein inhibitor ID-4. (161 aa)
NKPD1NTPase KAP family P-loop domain-containing protein 1 isoform X2. (720 aa)
FOSBProtein fosB isoform X1. (341 aa)
RAP1ARas-related protein Rap-1A. (184 aa)
BDNFBrain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. (330 aa)
CSDE1Cold shock domain-containing protein E1 isoform X1. (798 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
KIAA1468lisH domain and HEAT repeat-containing protein KIAA1468 homolog isoform X2. (1214 aa)
PPP2R5DSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (602 aa)
MAP2K5Dual specificity mitogen-activated protein kinase kinase 5 isoform X3; Belongs to the protein kinase superfamily. (448 aa)
RRADGTP-binding protein RAD isoform X1. (352 aa)
PPP4R4Serine/threonine-protein phosphatase 4 regulatory subunit 4 isoform X1. (872 aa)
BRAFSerine/threonine-protein kinase B-raf isoform X1. (762 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
LOC111165935Ras-like protein isoform X1. (285 aa)
ELK1LOW QUALITY PROTEIN: ETS domain-containing protein Elk-1. (442 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2 isoform X1; Belongs to the protein kinase superfamily. (400 aa)
JUNBTranscription factor jun-B. (347 aa)
NTRK2Tyrosine-protein kinase receptor. (822 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (723 aa)
PCSK6Proprotein convertase subtilisin/kexin type 6 isoform X1; Belongs to the peptidase S8 family. (967 aa)
MAPKAPK2LOW QUALITY PROTEIN: MAP kinase-activated protein kinase 2; Belongs to the protein kinase superfamily. (414 aa)
CRKAdapter molecule crk isoform X1. (304 aa)
YWHAB14-3-3 protein beta/alpha isoform X1; Belongs to the 14-3-3 family. (246 aa)
RALARas-related protein Ral-A. (206 aa)
ANKRD60LOW QUALITY PROTEIN: ankyrin repeat domain-containing protein 60. (677 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
CLTAClathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (243 aa)
MAPK11Mitogen-activated protein kinase. (366 aa)
DNAL4Dynein light chain. (154 aa)
ASCL1Achaete-scute homolog 1. (225 aa)
PTPROReceptor-type tyrosine-protein phosphatase O isoform X1. (1216 aa)
LYL1Protein lyl-1. (279 aa)
RIT1GTP-binding protein Rit1. (218 aa)
SHC1SHC-transforming protein 1 isoform X1. (609 aa)
LOC111165956Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (445 aa)
NTRK1Tyrosine-protein kinase receptor. (795 aa)
RPS6KA3Ribosomal protein S6 kinase. (740 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (775 aa)
SHC3SHC-transforming protein 3. (588 aa)
EGR4LOW QUALITY PROTEIN: early growth response protein 4. (588 aa)
PPP2R1BSerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform. (601 aa)
EGR3Early growth response protein 3 isoform X1. (387 aa)
JUNDTranscription factor jun-D. (345 aa)
NTRK3Tyrosine-protein kinase receptor. (864 aa)
FURINFurin; Belongs to the peptidase S8 family. (792 aa)
RALBRas-related protein Ral-B. (206 aa)
DUSP3Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (185 aa)
EGR2E3 SUMO-protein ligase EGR2 isoform X1. (422 aa)
PCSK4Proprotein convertase subtilisin/kexin type 4; Belongs to the peptidase S8 family. (779 aa)
HRASGTPase HRas isoform X1. (189 aa)
RPS6KA2Ribosomal protein S6 kinase. (780 aa)
ERASGTPase ERas. (233 aa)
NAB1NGFI-A-binding protein 1 isoform X1. (507 aa)
IRS1Insulin receptor substrate 1. (1248 aa)
AP2A2AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (938 aa)
SHC2SHC-transforming protein 2 isoform X1. (588 aa)
CREB1Cyclic AMP-responsive element-binding protein 1 isoform X1. (341 aa)
AP2M1AP-2 complex subunit mu isoform X1; Belongs to the adaptor complexes medium subunit family. (435 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
FRS2Fibroblast growth factor receptor substrate 2. (508 aa)
FNDC3BFibronectin type III domain-containing protein 3B isoform X1. (1215 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
ATF1Cyclic AMP-dependent transcription factor ATF-1 isoform X1. (336 aa)
NAB2NGFI-A-binding protein 2. (525 aa)
DUSP7Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (419 aa)
DOCK3Dedicator of cytokinesis protein 3 isoform X1; Belongs to the DOCK family. (2071 aa)
SH3GL2endophilin-A1. (352 aa)
DUSP4Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (396 aa)
SOS1Son of sevenless homolog 1 isoform X1. (1333 aa)
MAPKAPK3MAP kinase-activated protein kinase 3 isoform X1; Belongs to the protein kinase superfamily. (384 aa)
RHOATransforming protein RhoA. (193 aa)
IRS2Insulin receptor substrate 2. (1347 aa)
FNDC3AFibronectin type-III domain-containing protein 3A isoform X1. (1198 aa)
RPS6KA5Ribosomal protein S6 kinase. (800 aa)
NTF3Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (265 aa)
CHD4chromodomain-helicase-DNA-binding protein 4 isoform X1. (1940 aa)
KRASGTPase KRas. (188 aa)
PCSK5Proprotein convertase subtilisin/kexin type 5 isoform X2; Belongs to the peptidase S8 family. (1877 aa)
RAPGEF1Rap guanine nucleotide exchange factor 1 isoform X1. (1259 aa)
LOC111177220Non-specific serine/threonine protein kinase. (380 aa)
RALGDSRal guanine nucleotide dissociation stimulator isoform X1. (871 aa)
ID2DNA-binding protein inhibitor ID-2. (134 aa)
FOSL1Fos-related antigen 1. (271 aa)
SRCTyrosine-protein kinase. (562 aa)
RPS6KA4Ribosomal protein S6 kinase. (771 aa)
KIDINS220Kinase D-interacting substrate of 220 kDa isoform X1. (1793 aa)
TRIB2Tribbles homolog 2. (343 aa)
CRKLCrk-like protein. (303 aa)
PPP4R1Serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform X1. (939 aa)
ID3DNA-binding protein inhibitor ID-3. (227 aa)
MAPK1Mitogen-activated protein kinase. (380 aa)
DUSP6Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (381 aa)
RPS6KA1Ribosomal protein S6 kinase. (783 aa)
CLTCClathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1675 aa)
FYNTyrosine-protein kinase. (537 aa)
LOC111163998Ral guanine nucleotide dissociation stimulator-like. (170 aa)
ARCActivity-regulated cytoskeleton-associated protein. (396 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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