STRINGSTRING
CBL CBL BTC BTC LOC111187198 LOC111187198 PXN PXN PTPN11 PTPN11 GAB1 GAB1 EPGN EPGN EREG EREG PIK3R1 PIK3R1 AREG AREG RNF222 RNF222 SPRY1 SPRY1 RPS27A RPS27A EGFR EGFR PTPRT PTPRT SRC SRC LPXN LPXN PLCG1 PLCG1 GRB2 GRB2 HGS HGS HBEGF HBEGF TGFB1I1 TGFB1I1 NRAS NRAS EPN1 EPN1 CSDE1 CSDE1 LRIG2 LRIG2 STAM STAM CSK CSK SPRY2 SPRY2 PTPN3 PTPN3 KRAS KRAS EPS15 EPS15 ARHGEF7 ARHGEF7 FNDC3A FNDC3A LRIG3 LRIG3 SOS1 SOS1 SH3GL2 SH3GL2 LRIG1 LRIG1 AAMP AAMP PIK3CA PIK3CA FNDC3B FNDC3B STAM2 STAM2 SH3KBP1 SH3KBP1 ERAS ERAS HRAS HRAS EPS15L1 EPS15L1 TGFA TGFA SH3GL1 SH3GL1 SHC1 SHC1 SH3GL3 SH3GL3 LOC111165935 LOC111165935 PTPRK PTPRK PTPRM PTPRM PAG1 PAG1 CDC42 CDC42
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CBLE3 ubiquitin-protein ligase CBL isoform X1. (910 aa)
BTCProbetacellulin. (178 aa)
LOC111187198Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (617 aa)
PXNPaxillin isoform X2. (617 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (623 aa)
GAB1GRB2-associated-binding protein 1 isoform X1. (757 aa)
EPGNEpigen. (153 aa)
EREGProepiregulin. (163 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
AREGAmphiregulin isoform X1. (254 aa)
RNF222RING finger protein 222. (206 aa)
SPRY1Protein sprouty homolog 1. (319 aa)
RPS27Aubiquitin-40S ribosomal protein S27a. (156 aa)
EGFRReceptor protein-tyrosine kinase. (1209 aa)
PTPRTReceptor-type tyrosine-protein phosphatase T isoform X1. (1461 aa)
SRCTyrosine-protein kinase. (562 aa)
LPXNLeupaxin isoform X2; Belongs to the paxillin family. (387 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
HGSHepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] (777 aa)
HBEGFProheparin-binding EGF-like growth factor. (208 aa)
TGFB1I1Transforming growth factor beta-1-induced transcript 1 protein isoform X1; Belongs to the paxillin family. (456 aa)
NRASGTPase NRas. (189 aa)
EPN1LOW QUALITY PROTEIN: epsin-1. (576 aa)
CSDE1Cold shock domain-containing protein E1 isoform X1. (798 aa)
LRIG2LOW QUALITY PROTEIN: leucine-rich repeats and immunoglobulin-like domains protein 2. (1065 aa)
STAMSignal transducing adapter molecule 1. (526 aa)
CSKTyrosine-protein kinase. (528 aa)
SPRY2Protein sprouty homolog 2. (315 aa)
PTPN3Tyrosine-protein phosphatase non-receptor type; May act at junctions between the membrane and the cytoskeleton. (949 aa)
KRASGTPase KRas. (188 aa)
EPS15Epidermal growth factor receptor substrate 15 isoform X1. (902 aa)
ARHGEF7Rho guanine nucleotide exchange factor 7 isoform X1. (862 aa)
FNDC3AFibronectin type-III domain-containing protein 3A isoform X1. (1198 aa)
LRIG3Leucine-rich repeats and immunoglobulin-like domains protein 3 isoform X1. (1119 aa)
SOS1Son of sevenless homolog 1 isoform X1. (1333 aa)
SH3GL2endophilin-A1. (352 aa)
LRIG1Leucine-rich repeats and immunoglobulin-like domains protein 1. (1106 aa)
AAMPAngio-associated migratory cell protein isoform X1. (435 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
FNDC3BFibronectin type III domain-containing protein 3B isoform X1. (1215 aa)
STAM2Signal transducing adapter molecule 2 isoform X1. (604 aa)
SH3KBP1SH3 domain-containing kinase-binding protein 1 isoform X1. (628 aa)
ERASGTPase ERas. (233 aa)
HRASGTPase HRas isoform X1. (189 aa)
EPS15L1Epidermal growth factor receptor substrate 15-like 1 isoform X1. (947 aa)
TGFAProtransforming growth factor alpha isoform X1. (176 aa)
SH3GL1endophilin-A2 isoform X1. (403 aa)
SHC1SHC-transforming protein 1 isoform X1. (609 aa)
SH3GL3endophilin-A3 isoform X1. (347 aa)
LOC111165935Ras-like protein isoform X1. (285 aa)
PTPRKReceptor-type tyrosine-protein phosphatase kappa isoform X1. (1485 aa)
PTPRMReceptor-type tyrosine-protein phosphatase mu isoform X2. (1531 aa)
PAG1Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 isoform X2. (436 aa)
CDC42Cell division control protein 42 homolog isoform X2. (191 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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