STRINGSTRING
PTPN3 PTPN3 STAM STAM CDC42 CDC42 PTPRM PTPRM PTPRK PTPRK BTC BTC EPGN EPGN EREG EREG AREG AREG SPRY1 SPRY1 RPS27A RPS27A EGFR EGFR PTPRT PTPRT GRB2 GRB2 SH3GL3 SH3GL3 SH3GL1 SH3GL1 CBL CBL TGFA TGFA EPS15L1 EPS15L1 SH3KBP1 SH3KBP1 STAM2 STAM2 SH3GL2 SH3GL2 EPS15 EPS15 ARHGEF7 ARHGEF7 SPRY2 SPRY2 HGS HGS HBEGF HBEGF EPN1 EPN1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PTPN3Tyrosine-protein phosphatase non-receptor type; May act at junctions between the membrane and the cytoskeleton. (949 aa)
STAMSignal transducing adapter molecule 1. (526 aa)
CDC42Cell division control protein 42 homolog isoform X2. (191 aa)
PTPRMReceptor-type tyrosine-protein phosphatase mu isoform X2. (1531 aa)
PTPRKReceptor-type tyrosine-protein phosphatase kappa isoform X1. (1485 aa)
BTCProbetacellulin. (178 aa)
EPGNEpigen. (153 aa)
EREGProepiregulin. (163 aa)
AREGAmphiregulin isoform X1. (254 aa)
SPRY1Protein sprouty homolog 1. (319 aa)
RPS27Aubiquitin-40S ribosomal protein S27a. (156 aa)
EGFRReceptor protein-tyrosine kinase. (1209 aa)
PTPRTReceptor-type tyrosine-protein phosphatase T isoform X1. (1461 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
SH3GL3endophilin-A3 isoform X1. (347 aa)
SH3GL1endophilin-A2 isoform X1. (403 aa)
CBLE3 ubiquitin-protein ligase CBL isoform X1. (910 aa)
TGFAProtransforming growth factor alpha isoform X1. (176 aa)
EPS15L1Epidermal growth factor receptor substrate 15-like 1 isoform X1. (947 aa)
SH3KBP1SH3 domain-containing kinase-binding protein 1 isoform X1. (628 aa)
STAM2Signal transducing adapter molecule 2 isoform X1. (604 aa)
SH3GL2endophilin-A1. (352 aa)
EPS15Epidermal growth factor receptor substrate 15 isoform X1. (902 aa)
ARHGEF7Rho guanine nucleotide exchange factor 7 isoform X1. (862 aa)
SPRY2Protein sprouty homolog 2. (315 aa)
HGSHepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] (777 aa)
HBEGFProheparin-binding EGF-like growth factor. (208 aa)
EPN1LOW QUALITY PROTEIN: epsin-1. (576 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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