STRINGSTRING
KRAS KRAS HRAS HRAS PDGFRA PDGFRA PDGFA PDGFA PIK3R2 PIK3R2 STAT3 STAT3 LOC111166483 LOC111166483 STAT5A STAT5A GRB7 GRB7 EFS EFS LOC111165935 LOC111165935 CRKL CRKL LOC111187198 LOC111187198 PTPN11 PTPN11 CASS4 CASS4 NCK2 NCK2 PIK3R1 PIK3R1 PDGFB PDGFB CRK CRK SRC SRC RASA1 RASA1 PLCG1 PLCG1 PDGFRB PDGFRB GRB2 GRB2 NRAS NRAS NEDD9 NEDD9 CSDE1 CSDE1 PIK3CB PIK3CB BCAR1 BCAR1 NCK1 NCK1 RAPGEF1 RAPGEF1 FNDC3A FNDC3A SOS1 SOS1 STAT6 STAT6 PIK3CA PIK3CA FNDC3B FNDC3B STAT1 STAT1 ERAS ERAS
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
KRASGTPase KRas. (188 aa)
HRASGTPase HRas isoform X1. (189 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
PDGFAPlatelet-derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (196 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (723 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
LOC111166483Signal transducer and activator of transcription. (787 aa)
STAT5ASignal transducer and activator of transcription. (818 aa)
GRB7Growth factor receptor-bound protein 7 isoform X1. (555 aa)
EFSEmbryonal Fyn-associated substrate isoform X2. (561 aa)
LOC111165935Ras-like protein isoform X1. (285 aa)
CRKLCrk-like protein. (303 aa)
LOC111187198Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (617 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (623 aa)
CASS4Cas scaffolding protein family member 4 isoform X1. (821 aa)
NCK2Cytoplasmic protein. (376 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
PDGFBPlatelet-derived growth factor subunit B isoform X1; Belongs to the PDGF/VEGF growth factor family. (278 aa)
CRKAdapter molecule crk isoform X1. (304 aa)
SRCTyrosine-protein kinase. (562 aa)
RASA1Ras GTPase-activating protein 1 isoform X1. (1040 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1103 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
NRASGTPase NRas. (189 aa)
NEDD9Enhancer of filamentation 1 isoform X1. (829 aa)
CSDE1Cold shock domain-containing protein E1 isoform X1. (798 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
BCAR1Breast cancer anti-estrogen resistance protein 1 isoform X4. (867 aa)
NCK1Cytoplasmic protein. (377 aa)
RAPGEF1Rap guanine nucleotide exchange factor 1 isoform X1. (1259 aa)
FNDC3AFibronectin type-III domain-containing protein 3A isoform X1. (1198 aa)
SOS1Son of sevenless homolog 1 isoform X1. (1333 aa)
STAT6Signal transducer and activator of transcription. (847 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
FNDC3BFibronectin type III domain-containing protein 3B isoform X1. (1215 aa)
STAT1Signal transducer and activator of transcription. (749 aa)
ERASGTPase ERas. (233 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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