STRINGSTRING
CRKL CRKL AP2S1 AP2S1 EGR1 EGR1 ELK1 ELK1 AP2A1 AP2A1 PPP2CA PPP2CA GRB2 GRB2 SHC4 SHC4 LOC111181964 LOC111181964 FNBP4 FNBP4 ASCL2 ASCL2 RPS6KA4 RPS6KA4 FOSL1 FOSL1 MAPKAPK2 MAPKAPK2 CRK CRK YWHAB YWHAB RALA RALA ANKRD60 ANKRD60 PIK3R1 PIK3R1 CLTA CLTA MAPK11 MAPK11 DNAL4 DNAL4 ASCL1 ASCL1 VRK3 VRK3 NRAS NRAS NGF NGF PPP2R1A PPP2R1A ID4 ID4 NKPD1 NKPD1 FOSB FOSB RAP1A RAP1A CSDE1 CSDE1 MAP2K1 MAP2K1 PIK3CB PIK3CB KIAA1468 KIAA1468 PPP2R5D PPP2R5D MAP2K5 MAP2K5 RRAD RRAD PPP4R4 PPP4R4 BRAF BRAF MAPK14 MAPK14 RALGDS RALGDS LOC111177220 LOC111177220 RAPGEF1 RAPGEF1 KRAS KRAS CHD4 CHD4 RPS6KA5 RPS6KA5 IRS2 IRS2 RHOA RHOA MAPKAPK3 MAPKAPK3 SOS1 SOS1 DUSP4 DUSP4 SH3GL2 SH3GL2 DUSP7 DUSP7 NAB2 NAB2 ATF1 ATF1 PIK3CA PIK3CA FRS2 FRS2 PPP2CB PPP2CB AP2M1 AP2M1 CREB1 CREB1 SHC2 SHC2 AP2A2 AP2A2 IRS1 IRS1 NAB1 NAB1 ERAS ERAS RPS6KA2 RPS6KA2 HRAS HRAS EGR2 EGR2 DUSP3 DUSP3 RALB RALB JUND JUND EGR3 EGR3 PPP2R1B PPP2R1B EGR4 EGR4 SHC3 SHC3 MAPK7 MAPK7 RPS6KA3 RPS6KA3 NTRK1 NTRK1 LOC111165956 LOC111165956 SHC1 SHC1 RIT1 RIT1 LYL1 LYL1 PIK3R2 PIK3R2 JUNB JUNB MAP2K2 MAP2K2 MAPK3 MAPK3 LOC111165935 LOC111165935 TRIB1 TRIB1 ARC ARC LOC111163998 LOC111163998 TRIB2 TRIB2 KIDINS220 KIDINS220 ID2 ID2 CLTC CLTC RPS6KA1 RPS6KA1 DUSP6 DUSP6 MAPK1 MAPK1 ID3 ID3 PPP4R1 PPP4R1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CRKLCrk-like protein. (303 aa)
AP2S1AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (142 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (531 aa)
ELK1LOW QUALITY PROTEIN: ETS domain-containing protein Elk-1. (442 aa)
AP2A1AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (1023 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
SHC4SHC-transforming protein 4. (630 aa)
LOC111181964Uncharacterized protein LOC111181964 isoform X1. (833 aa)
FNBP4Formin-binding protein 4. (1013 aa)
ASCL2Achaete-scute homolog 2. (191 aa)
RPS6KA4Ribosomal protein S6 kinase. (771 aa)
FOSL1Fos-related antigen 1. (271 aa)
MAPKAPK2LOW QUALITY PROTEIN: MAP kinase-activated protein kinase 2; Belongs to the protein kinase superfamily. (414 aa)
CRKAdapter molecule crk isoform X1. (304 aa)
YWHAB14-3-3 protein beta/alpha isoform X1; Belongs to the 14-3-3 family. (246 aa)
RALARas-related protein Ral-A. (206 aa)
ANKRD60LOW QUALITY PROTEIN: ankyrin repeat domain-containing protein 60. (677 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
CLTAClathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (243 aa)
MAPK11Mitogen-activated protein kinase. (366 aa)
DNAL4Dynein light chain. (154 aa)
ASCL1Achaete-scute homolog 1. (225 aa)
VRK3Inactive serine/threonine-protein kinase VRK3 isoform X1. (447 aa)
NRASGTPase NRas. (189 aa)
NGFBeta-nerve growth factor; Belongs to the NGF-beta family. (241 aa)
PPP2R1ASerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform. (589 aa)
ID4DNA-binding protein inhibitor ID-4. (161 aa)
NKPD1NTPase KAP family P-loop domain-containing protein 1 isoform X2. (720 aa)
FOSBProtein fosB isoform X1. (341 aa)
RAP1ARas-related protein Rap-1A. (184 aa)
CSDE1Cold shock domain-containing protein E1 isoform X1. (798 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
KIAA1468lisH domain and HEAT repeat-containing protein KIAA1468 homolog isoform X2. (1214 aa)
PPP2R5DSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (602 aa)
MAP2K5Dual specificity mitogen-activated protein kinase kinase 5 isoform X3; Belongs to the protein kinase superfamily. (448 aa)
RRADGTP-binding protein RAD isoform X1. (352 aa)
PPP4R4Serine/threonine-protein phosphatase 4 regulatory subunit 4 isoform X1. (872 aa)
BRAFSerine/threonine-protein kinase B-raf isoform X1. (762 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
RALGDSRal guanine nucleotide dissociation stimulator isoform X1. (871 aa)
LOC111177220Non-specific serine/threonine protein kinase. (380 aa)
RAPGEF1Rap guanine nucleotide exchange factor 1 isoform X1. (1259 aa)
KRASGTPase KRas. (188 aa)
CHD4chromodomain-helicase-DNA-binding protein 4 isoform X1. (1940 aa)
RPS6KA5Ribosomal protein S6 kinase. (800 aa)
IRS2Insulin receptor substrate 2. (1347 aa)
RHOATransforming protein RhoA. (193 aa)
MAPKAPK3MAP kinase-activated protein kinase 3 isoform X1; Belongs to the protein kinase superfamily. (384 aa)
SOS1Son of sevenless homolog 1 isoform X1. (1333 aa)
DUSP4Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (396 aa)
SH3GL2endophilin-A1. (352 aa)
DUSP7Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (419 aa)
NAB2NGFI-A-binding protein 2. (525 aa)
ATF1Cyclic AMP-dependent transcription factor ATF-1 isoform X1. (336 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
FRS2Fibroblast growth factor receptor substrate 2. (508 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
AP2M1AP-2 complex subunit mu isoform X1; Belongs to the adaptor complexes medium subunit family. (435 aa)
CREB1Cyclic AMP-responsive element-binding protein 1 isoform X1. (341 aa)
SHC2SHC-transforming protein 2 isoform X1. (588 aa)
AP2A2AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (938 aa)
IRS1Insulin receptor substrate 1. (1248 aa)
NAB1NGFI-A-binding protein 1 isoform X1. (507 aa)
ERASGTPase ERas. (233 aa)
RPS6KA2Ribosomal protein S6 kinase. (780 aa)
HRASGTPase HRas isoform X1. (189 aa)
EGR2E3 SUMO-protein ligase EGR2 isoform X1. (422 aa)
DUSP3Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (185 aa)
RALBRas-related protein Ral-B. (206 aa)
JUNDTranscription factor jun-D. (345 aa)
EGR3Early growth response protein 3 isoform X1. (387 aa)
PPP2R1BSerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform. (601 aa)
EGR4LOW QUALITY PROTEIN: early growth response protein 4. (588 aa)
SHC3SHC-transforming protein 3. (588 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (775 aa)
RPS6KA3Ribosomal protein S6 kinase. (740 aa)
NTRK1Tyrosine-protein kinase receptor. (795 aa)
LOC111165956Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (445 aa)
SHC1SHC-transforming protein 1 isoform X1. (609 aa)
RIT1GTP-binding protein Rit1. (218 aa)
LYL1Protein lyl-1. (279 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (723 aa)
JUNBTranscription factor jun-B. (347 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2 isoform X1; Belongs to the protein kinase superfamily. (400 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (382 aa)
LOC111165935Ras-like protein isoform X1. (285 aa)
TRIB1Tribbles homolog 1. (372 aa)
ARCActivity-regulated cytoskeleton-associated protein. (396 aa)
LOC111163998Ral guanine nucleotide dissociation stimulator-like. (170 aa)
TRIB2Tribbles homolog 2. (343 aa)
KIDINS220Kinase D-interacting substrate of 220 kDa isoform X1. (1793 aa)
ID2DNA-binding protein inhibitor ID-2. (134 aa)
CLTCClathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1675 aa)
RPS6KA1Ribosomal protein S6 kinase. (783 aa)
DUSP6Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (381 aa)
MAPK1Mitogen-activated protein kinase. (380 aa)
ID3DNA-binding protein inhibitor ID-3. (227 aa)
PPP4R1Serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform X1. (939 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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