STRINGSTRING
FNDC3A FNDC3A IRS2 IRS2 PIK3R3 PIK3R3 PPP2R5C PPP2R5C IL1RAP IL1RAP FLT3 FLT3 NRG3 NRG3 FGF8 FGF8 PTEN PTEN PIK3AP1 PIK3AP1 FGFR1 FGFR1 FGF9 FGF9 NRG1 NRG1 STRN STRN IRAK4 IRAK4 PPP2R5E PPP2R5E PIP5K1B PIP5K1B IL33 IL33 ERBB3 ERBB3 PIK3CA PIK3CA FNDC3B FNDC3B FRS2 FRS2 PPP2CB PPP2CB FGF22 FGF22 ESR2 ESR2 ERBB4 ERBB4 FGFR2 FGFR2 CD28 CD28 SPEM2 SPEM2 IRS1 IRS1 ICOS ICOS FGFR4 FGFR4 LOC111171282 LOC111171282 KLB KLB LOC111170545 LOC111170545 LOC111171396 LOC111171396 SPEM1 SPEM1 CD86 CD86 IER3 IER3 IRAK1 IRAK1 CD80 CD80 THEM4 THEM4 PIP5K1A PIP5K1A LOC111167795 LOC111167795 PDGFRA PDGFRA KIT KIT LOC111169445 LOC111169445 PDGFA PDGFA FGF17 FGF17 PPP2R1B PPP2R1B PIP5K1C PIP5K1C TGFA TGFA ERBB2 ERBB2 ESR1 ESR1 PIK3R2 PIK3R2 PIP4K2B PIP4K2B INSC INSC STRN3 STRN3 FGFR3 FGFR3 VAV1 VAV1 INSR INSR FGF10 FGF10 FYN FYN HGF HGF MYD88 MYD88 KITLG KITLG MAPK1 MAPK1 PPP4R1 PPP4R1 NRG2 NRG2 STRN4 STRN4 PHLPP1 PHLPP1 CD19 CD19 TRAF6 TRAF6 PPP2R1A PPP2R1A FLT3LG FLT3LG FAM102B FAM102B PIK3CB PIK3CB BANK1 BANK1 KIAA1468 KIAA1468 FGF3 FGF3 INS INS RAC2 RAC2 PDGFB PDGFB EGFR EGFR LOC111186752 LOC111186752 GAB2 GAB2 ANKRD60 ANKRD60 FGF18 FGF18 AREG AREG PIK3R1 PIK3R1 EREG EREG EPGN EPGN GAB1 GAB1 PTPN11 PTPN11 LOC111187198 LOC111187198 PIK3CD PIK3CD IL1RL1 IL1RL1 BTC BTC FGF5 FGF5 SRC SRC FGF1 FGF1 PPP2R5A PPP2R5A FGF4 FGF4 FNBP4 FNBP4 RAC1 RAC1 PDGFRB PDGFRB LOC111181964 LOC111181964 PPP2R5B PPP2R5B FGF7 FGF7 GRB2 GRB2 PPP2CA PPP2CA HBEGF HBEGF MAPK3 MAPK3 PHLPP2 PHLPP2 CD276 CD276 PPP2R5D PPP2R5D MET MET WDR64 WDR64 PIP4K2A PIP4K2A NRG4 NRG4 LRRC40 LRRC40 PPP4R4 PPP4R4 FGF16 FGF16 LCK LCK FAM102A FAM102A FGF23 FGF23 KL KL PIP5KL1 PIP5KL1 PIP4K2C PIP4K2C FGF6 FGF6 FGF20 FGF20
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FNDC3AFibronectin type-III domain-containing protein 3A isoform X1. (1198 aa)
IRS2Insulin receptor substrate 2. (1347 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1. (461 aa)
PPP2R5CSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (578 aa)
IL1RAPInterleukin-1 receptor accessory protein isoform X2. (685 aa)
FLT3Receptor-type tyrosine-protein kinase FLT3 isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (993 aa)
NRG3Pro-neuregulin-3, membrane-bound isoform isoform X2. (725 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
PIK3AP1Phosphoinositide 3-kinase adapter protein 1 isoform X1. (806 aa)
FGFR1Fibroblast growth factor receptor. (823 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
NRG1Pro-neuregulin-1, membrane-bound isoform isoform X1. (852 aa)
STRNStriatin isoform X1. (809 aa)
IRAK4Interleukin-1 receptor-associated kinase 4 isoform X1. (460 aa)
PPP2R5ESerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (467 aa)
PIP5K1BPhosphatidylinositol 4-phosphate 5-kinase type-1 beta. (540 aa)
IL33Interleukin-33 isoform X1. (271 aa)
ERBB3Receptor tyrosine-protein kinase erbB-3. (1338 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
FNDC3BFibronectin type III domain-containing protein 3B isoform X1. (1215 aa)
FRS2Fibroblast growth factor receptor substrate 2. (508 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
FGF22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (255 aa)
ESR2Estrogen receptor beta. (558 aa)
ERBB4Receptor protein-tyrosine kinase. (1308 aa)
FGFR2Fibroblast growth factor receptor. (841 aa)
CD28T-cell-specific surface glycoprotein CD28. (265 aa)
SPEM2LOW QUALITY PROTEIN: uncharacterized protein C17orf74 homolog. (492 aa)
IRS1Insulin receptor substrate 1. (1248 aa)
ICOSInducible T-cell costimulator isoform X1. (227 aa)
FGFR4Fibroblast growth factor receptor. (801 aa)
LOC111171282Uncharacterized protein C17orf74-like. (436 aa)
KLBLOW QUALITY PROTEIN: beta-klotho. (1046 aa)
LOC111170545Rho-related GTP-binding protein RhoG. (191 aa)
LOC111171396CD276 antigen-like. (120 aa)
SPEM1LOW QUALITY PROTEIN: spermatid maturation protein 1. (269 aa)
CD86T-lymphocyte activation antigen CD86 isoform X1. (344 aa)
IER3Radiation-inducible immediate-early gene IEX-1. (293 aa)
IRAK1Interleukin-1 receptor-associated kinase 1. (725 aa)
CD80T-lymphocyte activation antigen CD80 isoform X1. (295 aa)
THEM4Acyl-coenzyme A thioesterase THEM4. (224 aa)
PIP5K1APhosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1. (549 aa)
LOC111167795Rho-related GTP-binding protein RhoG-like isoform X1. (230 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (977 aa)
LOC111169445Acyl-coenzyme A thioesterase THEM4-like. (174 aa)
PDGFAPlatelet-derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (196 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (215 aa)
PPP2R1BSerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform. (601 aa)
PIP5K1CPhosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1. (718 aa)
TGFAProtransforming growth factor alpha isoform X1. (176 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (595 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (723 aa)
PIP4K2BPhosphatidylinositol 5-phosphate 4-kinase type-2 beta. (416 aa)
INSCProtein inscuteable homolog. (649 aa)
STRN3Striatin-3 isoform X5. (796 aa)
FGFR3Fibroblast growth factor receptor. (805 aa)
VAV1Proto-oncogene vav isoform X1. (845 aa)
INSRTyrosine-protein kinase receptor. (1392 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
FYNTyrosine-protein kinase. (537 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (729 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
KITLGKit ligand isoform X1. (295 aa)
MAPK1Mitogen-activated protein kinase. (380 aa)
PPP4R1Serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform X1. (939 aa)
NRG2Pro-neuregulin-2, membrane-bound isoform isoform X1. (845 aa)
STRN4Striatin-4. (760 aa)
PHLPP1PH domain leucine-rich repeat-containing protein phosphatase 1. (1697 aa)
CD19B-lymphocyte antigen CD19 isoform X1. (570 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (561 aa)
PPP2R1ASerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform. (589 aa)
FLT3LGFms-related tyrosine kinase 3 ligand isoform X1. (328 aa)
FAM102BProtein FAM102B isoform X1. (377 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
BANK1B-cell scaffold protein with ankyrin repeats isoform X1. (785 aa)
KIAA1468lisH domain and HEAT repeat-containing protein KIAA1468 homolog isoform X2. (1214 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (214 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
RAC2Ras-related C3 botulinum toxin substrate 2 isoform X2. (192 aa)
PDGFBPlatelet-derived growth factor subunit B isoform X1; Belongs to the PDGF/VEGF growth factor family. (278 aa)
EGFRReceptor protein-tyrosine kinase. (1209 aa)
LOC111186752T-cell receptor-associated transmembrane adapter 1. (185 aa)
GAB2GRB2-associated-binding protein 2 isoform X1. (678 aa)
ANKRD60LOW QUALITY PROTEIN: ankyrin repeat domain-containing protein 60. (677 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
AREGAmphiregulin isoform X1. (254 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
EREGProepiregulin. (163 aa)
EPGNEpigen. (153 aa)
GAB1GRB2-associated-binding protein 1 isoform X1. (757 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (623 aa)
LOC111187198Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (617 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (919 aa)
IL1RL1Interleukin-1 receptor-like 1 isoform X1. (592 aa)
BTCProbetacellulin. (178 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (270 aa)
SRCTyrosine-protein kinase. (562 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (189 aa)
PPP2R5ASerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (487 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
FNBP4Formin-binding protein 4. (1013 aa)
RAC1Ras-related C3 botulinum toxin substrate 1. (192 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1103 aa)
LOC111181964Uncharacterized protein LOC111181964 isoform X1. (833 aa)
PPP2R5BSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (497 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
HBEGFProheparin-binding EGF-like growth factor. (208 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (382 aa)
PHLPP2PH domain leucine-rich repeat-containing protein phosphatase 2 isoform X1. (1355 aa)
CD276CD276 antigen. (275 aa)
PPP2R5DSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (602 aa)
METHepatocyte growth factor receptor isoform X1. (1382 aa)
WDR64WD repeat-containing protein 64. (1081 aa)
PIP4K2APhosphatidylinositol 5-phosphate 4-kinase type-2 alpha isoform X1. (461 aa)
NRG4Pro-neuregulin-4, membrane-bound isoform. (116 aa)
LRRC40Leucine-rich repeat-containing protein 40. (602 aa)
PPP4R4Serine/threonine-protein phosphatase 4 regulatory subunit 4 isoform X1. (872 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
LCKTyrosine-protein kinase. (509 aa)
FAM102AProtein FAM102A. (384 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (315 aa)
KLKlotho. (1010 aa)
PIP5KL1Phosphatidylinositol 4-phosphate 5-kinase-like protein 1. (413 aa)
PIP4K2CPhosphatidylinositol 5-phosphate 4-kinase type-2 gamma. (421 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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