STRINGSTRING
ROS1 ROS1 PRDM1 PRDM1 LOC111164829 LOC111164829 STAT3 STAT3 PIK3R2 PIK3R2 LOC111164824 LOC111164824 SHC1 SHC1 JAK3 JAK3 IRS1 IRS1 PIK3CA PIK3CA HDAC1 HDAC1 PTPN6 PTPN6 PTN PTN PTPRZ1 PTPRZ1 PIK3CB PIK3CB LTK LTK PLCG1 PLCG1 MDK MDK HDAC3 HDAC3 EP300 EP300 PIK3R1 PIK3R1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ROS1Tyrosine-protein kinase receptor. (2348 aa)
PRDM1PR domain zinc finger protein 1 isoform X1. (820 aa)
LOC111164829Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (473 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (723 aa)
LOC111164824Histone deacetylase 2-like isoform X1. (260 aa)
SHC1SHC-transforming protein 1 isoform X1. (609 aa)
JAK3Tyrosine-protein kinase. (1104 aa)
IRS1Insulin receptor substrate 1. (1248 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
HDAC1Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (393 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
PTNPleiotrophin isoform X1. (168 aa)
PTPRZ1Receptor-type tyrosine-protein phosphatase zeta isoform X1. (2321 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
LTKLOW QUALITY PROTEIN: leukocyte tyrosine kinase receptor. (922 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa)
MDKMidkine isoform X1. (165 aa)
HDAC3Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (428 aa)
EP300Histone acetyltransferase p300. (2420 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
Server load: low (10%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.